Aliases for ZBTB4 Gene
External Ids for ZBTB4 Gene
Previous GeneCards Identifiers for ZBTB4 Gene
GeneCards Summary for ZBTB4 Gene
ZBTB4 (Zinc Finger And BTB Domain Containing 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase binding. An important paralog of this gene is ZBTB38.
UniProtKB/Swiss-Prot Summary for ZBTB4 Gene
Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).