Aliases for ZBTB39 Gene

Aliases for ZBTB39 Gene

  • Zinc Finger And BTB Domain Containing 39 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 39 3 4
  • KIAA0352 2 4
  • ZNF922 2 3
  • ZBTB39 5

External Ids for ZBTB39 Gene

Previous GeneCards Identifiers for ZBTB39 Gene

  • GC12M055679
  • GC12M057392
  • GC12M054431

Summaries for ZBTB39 Gene

GeneCards Summary for ZBTB39 Gene

ZBTB39 (Zinc Finger And BTB Domain Containing 39) is a Protein Coding gene. An important paralog of this gene is ZNF462.

UniProtKB/Swiss-Prot Summary for ZBTB39 Gene

Additional gene information for ZBTB39 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB39 Gene

Genomics for ZBTB39 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZBTB39 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB39 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBTB39

Top Transcription factor binding sites by QIAGEN in the ZBTB39 gene promoter:
  • AREB6
  • C/EBPalpha
  • CP2
  • CUTL1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Nkx3-1
  • Nkx3-1 v1
  • TGIF

Genomic Locations for ZBTB39 Gene

Genomic Locations for ZBTB39 Gene
chr12:56,998,836-57,006,546
(GRCh38/hg38)
Size:
7,711 bases
Orientation:
Minus strand
chr12:57,392,617-57,400,297
(GRCh37/hg19)
Size:
7,681 bases
Orientation:
Minus strand

Genomic View for ZBTB39 Gene

Genes around ZBTB39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB39 Gene

Proteins for ZBTB39 Gene

  • Protein details for ZBTB39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15060-ZBT39_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 39
    Protein Accession:
    O15060
    Secondary Accessions:
    • A7MD38
    • Q9UD98

    Protein attributes for ZBTB39 Gene

    Size:
    712 amino acids
    Molecular mass:
    79001 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20809.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZBTB39 Gene

Post-translational modifications for ZBTB39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB39 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB39 Gene

Domains & Families for ZBTB39 Gene

Gene Families for ZBTB39 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB39 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • BTB/POZ domain
ProtoNet:

Suggested Antigen Peptide Sequences for ZBTB39 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger and BTB domain-containing protein 39 (ZBT39_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15060

UniProtKB/Swiss-Prot:

ZBT39_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZBTB39: view

Function for ZBTB39 Gene

Molecular function for ZBTB39 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB39 Gene

Gene Ontology (GO) - Molecular Function for ZBTB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB39: view
genes like me logo Genes that share phenotypes with ZBTB39: view

Animal Model Products

CRISPR Products

miRNA for ZBTB39 Gene

miRTarBase miRNAs that target ZBTB39

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB39

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB39 Gene

Localization for ZBTB39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB39 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB39 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA 21873635
genes like me logo Genes that share ontologies with ZBTB39: view

Pathways & Interactions for ZBTB39 Gene

PathCards logo

SuperPathways for ZBTB39 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZBTB39: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB39 Gene

Drugs & Compounds for ZBTB39 Gene

No Compound Related Data Available

Transcripts for ZBTB39 Gene

mRNA/cDNA for ZBTB39 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB39

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB39 Gene

No ASD Table

Relevant External Links for ZBTB39 Gene

GeneLoc Exon Structure for
ZBTB39

Expression for ZBTB39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB39 Gene

Protein differential expression in normal tissues from HIPED for ZBTB39 Gene

This gene is overexpressed in Breast (51.8), Plasma (10.8), and Adipocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBTB39 Gene



Protein tissue co-expression partners for ZBTB39 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBTB39

SOURCE GeneReport for Unigene cluster for ZBTB39 Gene:

Hs.591025

Evidence on tissue expression from TISSUES for ZBTB39 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZBTB39: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB39 Gene

Orthologs for ZBTB39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB39 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZBTB39 30 31
  • 99.25 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZBTB39 30 31
  • 90.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZBTB39 30
  • 89.78 (n)
Rat
(Rattus norvegicus)
Mammalia Zbtb39 30
  • 86.37 (n)
Mouse
(Mus musculus)
Mammalia Zbtb39 30 17 31
  • 86.03 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZBTB39 31
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB39 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZBTB39 30
  • 75.62 (n)
Lizard
(Anolis carolinensis)
Reptilia ZBTB39 31
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zbtb39 30
  • 63.49 (n)
Str.4668 30
Zebrafish
(Danio rerio)
Actinopterygii LOC565015 30
  • 51.01 (n)
ZBTB39 31
  • 37 (a)
OneToOne
Species where no ortholog for ZBTB39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZBTB39 Gene

ENSEMBL:
Gene Tree for ZBTB39 (if available)
TreeFam:
Gene Tree for ZBTB39 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB39: view image

Paralogs for ZBTB39 Gene

Paralogs for ZBTB39 Gene

genes like me logo Genes that share paralogs with ZBTB39: view

Variants for ZBTB39 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBTB39 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs3741576 - p.Pro689Ala

Additional dbSNP identifiers (rs#s) for ZBTB39 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZBTB39 Gene

Variant ID Type Subtype PubMed ID
esv3580285 CNV loss 25503493
nsv482992 CNV gain+loss 15286789
nsv559022 CNV loss 21841781
nsv832428 CNV gain 17160897

Variation tolerance for ZBTB39 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB39 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB39 Gene

Disorders for ZBTB39 Gene

No disorders were found for ZBTB39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB39 Gene

Publications for ZBTB39 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ZBTB39 Gene

Sources for ZBTB39 Gene