Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZBTB39 Gene

Aliases for ZBTB39 Gene

  • Zinc Finger And BTB Domain Containing 39 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 39 3
  • KIAA0352 4
  • ZNF922 3

External Ids for ZBTB39 Gene

Previous GeneCards Identifiers for ZBTB39 Gene

  • GC12M055679
  • GC12M057392
  • GC12M054431

Summaries for ZBTB39 Gene

GeneCards Summary for ZBTB39 Gene

ZBTB39 (Zinc Finger And BTB Domain Containing 39) is a Protein Coding gene. An important paralog of this gene is ZBTB16.

UniProtKB/Swiss-Prot for ZBTB39 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB39 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB39 Gene

Genomics for ZBTB39 Gene

GeneHancer (GH) Regulatory Elements for ZBTB39 Gene

Promoters and enhancers for ZBTB39 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I057005 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.1 95 1.6 RB1 ZNF76 SIN3A ZNF335 ZNF143 SMARCA5 ZBTB11 REST ZNF24 ZBTB26 ZBTB39 MYO1A PIR61192
GH12I056220 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 74.7 +783.6 783631 5.7 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 NABP2 RNF41 NEMP1 BAZ2A PAN2 DNAJC14 ANKRD52 PHC1P1 ZBTB39 RN7SL809P
GH12I057109 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 66.8 -104.7 -104741 3.8 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 MCM3 STAT6 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A PAN2 SMARCC2 ANKRD52 CDK4 CTDSP2
GH12I056266 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 40.4 +739.3 739319 2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 COQ10A GC12M056238 NEMP1 PAN2 BAZ2A PHC1P1 ANKRD52 DNAJC14 SMARCC2 RN7SL809P
GH12I057516 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 24.8 -514.6 -514576 8.8 CLOCK FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MBD6 DDIT3 MIR616 NEMP1 BAZ2A RN7SL809P EEF1AKMT3 DTX3 CDK4 CTDSP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB39 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB39 gene promoter:

Genomic Locations for ZBTB39 Gene

Genomic Locations for ZBTB39 Gene
7,681 bases
Minus strand

Genomic View for ZBTB39 Gene

Genes around ZBTB39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB39 Gene

Proteins for ZBTB39 Gene

  • Protein details for ZBTB39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 39
    Protein Accession:
    Secondary Accessions:
    • A7MD38
    • Q9UD98

    Protein attributes for ZBTB39 Gene

    712 amino acids
    Molecular mass:
    79001 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA20809.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZBTB39 Gene

Post-translational modifications for ZBTB39 Gene

No Post-translational modifications

Other Protein References for ZBTB39 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB39 Gene

Domains & Families for ZBTB39 Gene

Gene Families for ZBTB39 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZBTB39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZBTB39: view

Function for ZBTB39 Gene

Molecular function for ZBTB39 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB39 Gene

Gene Ontology (GO) - Molecular Function for ZBTB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB39: view

Phenotypes for ZBTB39 Gene

genes like me logo Genes that share phenotypes with ZBTB39: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB39 Gene

Localization for ZBTB39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB39 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB39 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB39: view

Pathways & Interactions for ZBTB39 Gene

SuperPathways for ZBTB39 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB39: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB39 Gene

Drugs & Compounds for ZBTB39 Gene

No Compound Related Data Available

Transcripts for ZBTB39 Gene

mRNA/cDNA for ZBTB39 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB39 Gene

Zinc finger and BTB domain containing 39:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB39 Gene

No ASD Table

Relevant External Links for ZBTB39 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB39 Gene

Protein differential expression in normal tissues from HIPED for ZBTB39 Gene

This gene is overexpressed in Breast (51.8), Plasma (10.8), and Adipocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB39 Gene

Protein tissue co-expression partners for ZBTB39 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB39 Gene:


SOURCE GeneReport for Unigene cluster for ZBTB39 Gene:


Evidence on tissue expression from TISSUES for ZBTB39 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZBTB39: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB39 Gene

Orthologs for ZBTB39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB39 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZBTB39 33 34
  • 99.25 (n)
(Bos Taurus)
Mammalia ZBTB39 33 34
  • 90.48 (n)
(Canis familiaris)
Mammalia ZBTB39 33
  • 89.78 (n)
(Rattus norvegicus)
Mammalia Zbtb39 33
  • 86.37 (n)
(Mus musculus)
Mammalia Zbtb39 33 16 34
  • 86.03 (n)
(Monodelphis domestica)
Mammalia ZBTB39 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia ZBTB39 34
  • 83 (a)
(Gallus gallus)
Aves ZBTB39 33
  • 75.62 (n)
(Anolis carolinensis)
Reptilia ZBTB39 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb39 33
  • 63.49 (n)
Str.4668 33
(Danio rerio)
Actinopterygii LOC565015 33
  • 51.01 (n)
ZBTB39 34
  • 37 (a)
Species where no ortholog for ZBTB39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB39 Gene

Gene Tree for ZBTB39 (if available)
Gene Tree for ZBTB39 (if available)

Paralogs for ZBTB39 Gene

Paralogs for ZBTB39 Gene

genes like me logo Genes that share paralogs with ZBTB39: view

Variants for ZBTB39 Gene

Sequence variations from dbSNP and Humsavar for ZBTB39 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001627229 -- 57,008,239(-) C/T upstream_transcript_variant
rs1002563611 -- 56,999,040(-) G/A 3_prime_UTR_variant
rs1002699514 -- 56,998,817(-) G/C downstream_transcript_variant
rs1002987967 -- 57,007,916(-) G/A upstream_transcript_variant
rs1003057667 -- 57,008,223(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB39 Gene

Variant ID Type Subtype PubMed ID
nsv832428 CNV gain 17160897
nsv559022 CNV loss 21841781
nsv482992 CNV gain+loss 15286789
esv3580285 CNV loss 25503493

Variation tolerance for ZBTB39 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB39 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB39 Gene

Disorders for ZBTB39 Gene

Additional Disease Information for ZBTB39

No disorders were found for ZBTB39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB39 Gene

Publications for ZBTB39 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for ZBTB39 Gene

Sources for ZBTB39 Gene

Loading form....