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Aliases for ZBTB37 Gene

Aliases for ZBTB37 Gene

  • Zinc Finger And BTB Domain Containing 37 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 37 3
  • D430004I08Rik 3
  • ZNF908 3

External Ids for ZBTB37 Gene

Previous GeneCards Identifiers for ZBTB37 Gene

  • GC01P170569
  • GC01P172103
  • GC01P173837
  • GC01P145062

Summaries for ZBTB37 Gene

GeneCards Summary for ZBTB37 Gene

ZBTB37 (Zinc Finger And BTB Domain Containing 37) is a Protein Coding gene. An important paralog of this gene is ZBTB34.

UniProtKB/Swiss-Prot for ZBTB37 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB37 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB37 Gene

Genomics for ZBTB37 Gene

GeneHancer (GH) Regulatory Elements for ZBTB37 Gene

Promoters and enhancers for ZBTB37 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J173861 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 679.4 -1.3 -1322 10.3 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZBTB37 CENPL GC01M174042 GC01M174043 GC01M174045 GC01M174046 SNORD44 SNORD75 SNORD76 SNORD77
GH01J174020 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.2 +154.2 154183 3.9 HDGF SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 RC3H1 LOC105371620 ZBTB37 ANKRD45 GAS5 RC3H1-IT1
GH01J174158 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.6 +291.3 291262 3.7 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RABGAP1L LOC102724601 RC3H1 ANKRD45 GAS5 ZBTB37 RNU7-78P GC01M174104
GH01J173823 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 -43.5 -43548 3 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC GLIS1 RCOR2 DARS2 CENPL RC3H1 KLHL20 ZBTB37 GAS5
GH01J173526 Enhancer 0.8 ENCODE 14 -340.8 -340800 1 FOXA2 PKNOX1 SMAD1 NFIB BRCA1 RAD21 YY1 GTF3C2 POLR3A EGR1 ZBTB37 RC3H1 ENSG00000238272 PRDX6 SLC9C2 KLHL20 GAS5 PIR59510
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB37 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB37 gene promoter:
  • Ik-2
  • deltaCREB
  • CREB
  • IRF-1
  • Elk-1
  • Evi-1
  • NF-kappaB
  • CUTL1
  • AML1a
  • NF-kappaB1

Genomic Locations for ZBTB37 Gene

Genomic Locations for ZBTB37 Gene
35,468 bases
Plus strand
35,468 bases
Plus strand

Genomic View for ZBTB37 Gene

Genes around ZBTB37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB37 Gene

Proteins for ZBTB37 Gene

  • Protein details for ZBTB37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 37
    Protein Accession:
    Secondary Accessions:
    • Q5TC80
    • Q96M87
    • Q9BQ88

    Protein attributes for ZBTB37 Gene

    503 amino acids
    Molecular mass:
    56055 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZBTB37 Gene


neXtProt entry for ZBTB37 Gene

Post-translational modifications for ZBTB37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZBTB37 Gene

Domains & Families for ZBTB37 Gene

Gene Families for ZBTB37 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB37 Gene

Suggested Antigen Peptide Sequences for ZBTB37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB37: view

No data available for UniProtKB/Swiss-Prot for ZBTB37 Gene

Function for ZBTB37 Gene

Molecular function for ZBTB37 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB37 Gene

Gene Ontology (GO) - Molecular Function for ZBTB37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB37: view
genes like me logo Genes that share phenotypes with ZBTB37: view

Animal Model Products

miRNA for ZBTB37 Gene

miRTarBase miRNAs that target ZBTB37

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB37 Gene

Localization for ZBTB37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB37 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB37 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZBTB37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB37: view

Pathways & Interactions for ZBTB37 Gene

SuperPathways for ZBTB37 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZBTB37: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB37 Gene

Drugs & Compounds for ZBTB37 Gene

No Compound Related Data Available

Transcripts for ZBTB37 Gene

mRNA/cDNA for ZBTB37 Gene

Unigene Clusters for ZBTB37 Gene

Zinc finger and BTB domain containing 37:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB37 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP1: - -
SP2: -

Relevant External Links for ZBTB37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB37 Gene

mRNA differential expression in normal tissues according to GTEx for ZBTB37 Gene

This gene is overexpressed in Testis (x5.9).

Protein differential expression in normal tissues from HIPED for ZBTB37 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBTB37 Gene

Protein tissue co-expression partners for ZBTB37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB37 Gene:


SOURCE GeneReport for Unigene cluster for ZBTB37 Gene:


Evidence on tissue expression from TISSUES for ZBTB37 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZBTB37: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB37 Gene

Orthologs for ZBTB37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB37 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZBTB37 34 33
  • 99.8 (n)
(Ornithorhynchus anatinus)
Mammalia ZBTB37 34
  • 96 (a)
(Canis familiaris)
Mammalia ZBTB37 34 33
  • 93.84 (n)
(Bos Taurus)
Mammalia ZBTB37 34 33
  • 93.37 (n)
(Mus musculus)
Mammalia Zbtb37 16 34 33
  • 91.3 (n)
(Rattus norvegicus)
Mammalia Zbtb37 33
  • 90.57 (n)
(Monodelphis domestica)
Mammalia ZBTB37 34
  • 86 (a)
(Gallus gallus)
Aves ZBTB37 34 33
  • 81.11 (n)
(Anolis carolinensis)
Reptilia ZBTB37 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb37 33
  • 75.15 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53639 33
(Danio rerio)
Actinopterygii zbtb37 34 33
  • 69.36 (n)
Dr.16162 33
Species where no ortholog for ZBTB37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB37 Gene

Gene Tree for ZBTB37 (if available)
Gene Tree for ZBTB37 (if available)
Evolutionary constrained regions (ECRs) for ZBTB37: view image

Paralogs for ZBTB37 Gene

(21) SIMAP similar genes for ZBTB37 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB37: view

Variants for ZBTB37 Gene

Sequence variations from dbSNP and Humsavar for ZBTB37 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000052577 -- 173,872,226(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000056001 -- 173,867,389(+) G/A upstream_transcript_variant
rs1000069678 -- 173,890,212(+) T/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000127752 -- 173,867,669(+) A/G upstream_transcript_variant
rs1000247329 -- 173,868,599(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB37 Gene

Variant ID Type Subtype PubMed ID
dgv118e212 CNV loss 25503493
esv2758978 CNV loss 17122850
nsv831926 CNV gain+loss 17160897

Variation tolerance for ZBTB37 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB37 Gene

Disorders for ZBTB37 Gene

Additional Disease Information for ZBTB37

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZBTB37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB37 Gene

Publications for ZBTB37 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for ZBTB37 Gene

Sources for ZBTB37 Gene

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