Aliases for ZBTB34 Gene

Aliases for ZBTB34 Gene

  • Zinc Finger And BTB Domain Containing 34 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 34 3 4
  • KIAA1993 2 4
  • ZNF918 2 3
  • MGC24652 2
  • ZBTB34 5

External Ids for ZBTB34 Gene

Previous GeneCards Identifiers for ZBTB34 Gene

  • GC09U900570
  • GC09P126703
  • GC09P128662
  • GC09P129622
  • GC09P099236

Summaries for ZBTB34 Gene

GeneCards Summary for ZBTB34 Gene

ZBTB34 (Zinc Finger And BTB Domain Containing 34) is a Protein Coding gene. Diseases associated with ZBTB34 include Acute Salpingitis. An important paralog of this gene is ZBTB37.

UniProtKB/Swiss-Prot Summary for ZBTB34 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB34 Gene

Genomics for ZBTB34 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZBTB34 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB34 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBTB34

Top Transcription factor binding sites by QIAGEN in the ZBTB34 gene promoter:
  • AML1a
  • E47
  • En-1
  • Hand1
  • MRF-2
  • MyoD
  • Nkx6-1
  • Pax-4a
  • Tal-1beta

Genomic Locations for ZBTB34 Gene

Latest Assembly
chr9:126,860,639-126,885,878
(GRCh38/hg38)
Size:
25,240 bases
Orientation:
Plus strand

Previous Assembly
chr9:129,622,918-129,648,157
(GRCh37/hg19 by Entrez Gene)
Size:
25,240 bases
Orientation:
Plus strand

chr9:129,622,944-129,648,157
(GRCh37/hg19 by Ensembl)
Size:
25,214 bases
Orientation:
Plus strand

Genomic View for ZBTB34 Gene

Genes around ZBTB34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB34 Gene

Proteins for ZBTB34 Gene

  • Protein details for ZBTB34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCN2-ZBT34_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 34
    Protein Accession:
    Q8NCN2
    Secondary Accessions:
    • Q38IA7
    • Q5VYE9

    Protein attributes for ZBTB34 Gene

    Size:
    500 amino acids
    Molecular mass:
    55534 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=ABA86591.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAC02702.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for ZBTB34 Gene

Post-translational modifications for ZBTB34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB34 Gene

No data available for DME Specific Peptides for ZBTB34 Gene

Domains & Families for ZBTB34 Gene

Gene Families for ZBTB34 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB34 Gene

Suggested Antigen Peptide Sequences for ZBTB34 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger and BTB domain-containing protein 34 (ZBT34_HUMAN)
genes like me logo Genes that share domains with ZBTB34: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBTB34 Gene

Function for ZBTB34 Gene

Molecular function for ZBTB34 Gene

UniProtKB/Swiss-Prot Function:
May be a transcriptional repressor.

Phenotypes From GWAS Catalog for ZBTB34 Gene

Gene Ontology (GO) - Molecular Function for ZBTB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with ZBTB34: view
genes like me logo Genes that share phenotypes with ZBTB34: view

miRNA for ZBTB34 Gene

miRTarBase miRNAs that target ZBTB34

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB34

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB34 Gene

Localization for ZBTB34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB34 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA,IDA --
genes like me logo Genes that share ontologies with ZBTB34: view

Pathways & Interactions for ZBTB34 Gene

PathCards logo

SuperPathways for ZBTB34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZBTB34: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB34 Gene

Drugs & Compounds for ZBTB34 Gene

No Compound Related Data Available

Transcripts for ZBTB34 Gene

mRNA/cDNA for ZBTB34 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB34

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB34 Gene

No ASD Table

Relevant External Links for ZBTB34 Gene

GeneLoc Exon Structure for
ZBTB34

Expression for ZBTB34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB34 Gene

This gene is overexpressed in Whole Blood (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBTB34 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBTB34

SOURCE GeneReport for Unigene cluster for ZBTB34 Gene:

Hs.177633

mRNA Expression by UniProt/SwissProt for ZBTB34 Gene:

Q8NCN2-ZBT34_HUMAN
Tissue specificity: Expressed in several tissues, including heart, brain, thymus, skeletal muscle, small intestine, testis, kidney, placenta, peripheral blood cells and adult and fetal liver.

Evidence on tissue expression from TISSUES for ZBTB34 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZBTB34: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB34 Gene

Orthologs for ZBTB34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB34 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZBTB34 30 31
  • 99.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZBTB34 30 31
  • 92.6 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZBTB34 31
  • 92 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ZBTB34 30 31
  • 90.13 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zbtb34 30 17 31
  • 88.07 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zbtb34 30
  • 87.87 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB34 31
  • 86 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZBTB34 30 31
  • 79.43 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZBTB34 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zbtb34 30
  • 73.2 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100004439 30
  • 66.67 (n)
zbtb34 31
  • 60 (a)
OneToOne
Species where no ortholog for ZBTB34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZBTB34 Gene

ENSEMBL:
Gene Tree for ZBTB34 (if available)
TreeFam:
Gene Tree for ZBTB34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB34: view image

Paralogs for ZBTB34 Gene

Variants for ZBTB34 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZBTB34 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZBTB34 Gene

Variant ID Type Subtype PubMed ID
esv2465457 CNV insertion 19546169
esv3415514 CNV duplication 20981092
esv3573390 CNV loss 25503493
esv3621766 CNV gain 21293372
esv989100 CNV insertion 20482838
nsv1075673 CNV deletion 25765185
nsv6719 CNV insertion 18451855
nsv825086 CNV gain 20364138
nsv831724 CNV gain 17160897
nsv831726 CNV gain+loss 17160897

Variation tolerance for ZBTB34 Gene

Residual Variation Intolerance Score: 7.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB34

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBTB34 Gene

Disorders for ZBTB34 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZBTB34 Gene - From: COP

Disorder Aliases PubMed IDs
acute salpingitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZBTB34

genes like me logo Genes that share disorders with ZBTB34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB34 Gene

Publications for ZBTB34 Gene

  1. ZBTB34, a novel human BTB/POZ zinc finger protein, is a potential transcriptional repressor. (PMID: 16718364) Qi J … Han ZG (Molecular and cellular biochemistry 2006) 2 3 4
  2. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PMID: 12056414) Ohara O … Koseki H (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ZBTB34 Gene

Sources for ZBTB34 Gene