Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chr... See more...
Aliases for ZBTB33 Gene
Aliases for ZBTB33 Gene
External Ids for ZBTB33 Gene
- HGNC: 16682
- Entrez Gene: 10009
- Ensembl: ENSG00000177485
- OMIM: 300329
- UniProtKB: Q86T24
Previous GeneCards Identifiers for ZBTB33 Gene
- GC0XP118139
- GC0XP119166
- GC0XP119268
- GC0XP119384
- GC0XP108838
Summaries for ZBTB33 Gene
-
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]
GeneCards Summary for ZBTB33 Gene
ZBTB33 (Zinc Finger And BTB Domain Containing 33) is a Protein Coding gene. Diseases associated with ZBTB33 include Rett Syndrome and Epithelial Malignant Thymoma. Among its related pathways are Wnt Signaling Pathway and Pluripotency. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and methyl-CpG binding. An important paralog of this gene is ZBTB21.
UniProtKB/Swiss-Prot Summary for ZBTB33 Gene
-
Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).
Additional gene information for ZBTB33 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB33 Gene
Genomics for ZBTB33 Gene
GeneHancer (GH) Regulatory Elements for ZBTB33 Gene
Promoters and enhancers for ZBTB33 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZBTB33 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBTB33
- Top Transcription factor binding sites by QIAGEN in the ZBTB33 gene promoter:
-
- CUTL1
- HNF-4alpha1
- HNF-4alpha2
- IRF-2
- p53
- POU2F1
- POU2F1a
- POU3F1
Genomic Locations for ZBTB33 Gene
Genomic Locations for ZBTB33 Gene
- chrX:120,250,752-120,258,398
- (GRCh38/hg38)
- Size:
- 7,647 bases
- Orientation:
- Plus strand
- chrX:119,384,607-119,392,253
- (GRCh37/hg19)
- Size:
- 7,647 bases
- Orientation:
- Plus strand
Genomic View for ZBTB33 Gene
Genes around ZBTB33 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq24 by HGNC
- Xq24 by Entrez Gene
- Xq24 by Ensembl
ZBTB33 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZBTB33 Gene
Proteins for ZBTB33 Gene
-
Protein details for ZBTB33 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86T24-KAISO_HUMAN
- Recommended name:
- Transcriptional regulator Kaiso
- Protein Accession:
- Q86T24
- B2R5U6
- O00319
- Q7Z361
- Q8IVP6
- Q8N3P0
Protein attributes for ZBTB33 Gene
- Size:
- 672 amino acids
- Molecular mass:
- 74484 Da
- Quaternary structure:
-
- Self-associates. Interacts with CTNND2 (By similarity). Interacts with CTNND1, and this interaction inhibits binding to both methylated and non-methylated DNA. Interacts with NCOR1. Interacts with KPNA2/RCH1, which may mediate nuclear import of this protein. Interacts with CBFA2T3.
Protein Expression for ZBTB33 Gene
Post-translational modifications for ZBTB33 Gene
Other Protein References for ZBTB33 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences ZBTB33 / Kaiso Antibody
- Creative Diagnostics Anti-ZBTB33 monoclonal antibody, clone FQS5779
- Creative Biolabs Recombinant Anti-Human ZBTB33 Antibody and Mouse Anti-ZBTB33 Recombinant Antibody (2B2)
-
Custom Antibody ServicesOriGene Antibodies for ZBTB33
- Novus Biologicals Antibodies for ZBTB33
-
Abcam antibodies for ZBTB33
- Invitrogen Antibodies for ZBTB33 (AFLGC-ZBTB33)
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZBTB33
Protein Products
-
OriGene Purified Proteins for ZBTB33
- Search Origene for MassSpec and Protein Over-expression Lysates for ZBTB33
- Origene Custom Protein Services for ZBTB33
- antibodies-online: Show 4 available ZBTB33 Proteins ranked by validation data
- Compare Top ZBTB33 Proteins
-
Quality Products:
-
Abcam proteins for ZBTB33
Assay Products
- antibodies-online: Show 4 available ZBTB33 Elisa Kits ranked by validation data
- Compare Top ZBTB33 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ZBTB33 Gene
Domains & Families for ZBTB33 Gene
Gene Families for ZBTB33 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZBTB33 Gene
- Blocks:
-
- BTB/POZ domain
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZBTB33 Gene
- GenScript: Design optimal peptide antigens:
-
- Zinc finger and BTB domain-containing protein 33 (KAISO_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBTB33 Gene
Function for ZBTB33 Gene
Molecular function for ZBTB33 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).
- UniProtKB/Swiss-Prot Induction:
- Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI,IEA | 16354688 |
| GO:0008327 | methyl-CpG binding | IDA | 16354688 |
Phenotypes for ZBTB33 Gene
- MGI mutant phenotypes for ZBTB33:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ZBTB33:
Animal Models for ZBTB33 Gene
- MGI Knock Outs for ZBTB33:
-
- Zbtb33 Zbtb33<tm1.1Bird>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZBTB33 - Select products 50% OFF >
- * ZBTB33 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZBTB33
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZBTB33
- genomics-online: gRNA clones - Search for available ZBTB33 gRNA products
- Overview of 120 available ZBTB33 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZBTB33
miRNA for ZBTB33 Gene
- miRTarBase miRNAs that target ZBTB33
-
- hsa-mir-215-5p (MIRT024596)
- hsa-mir-192-5p (MIRT026285)
- hsa-mir-93-5p (MIRT028064)
- hsa-mir-361-5p (MIRT044097)
- hsa-mir-186-5p (MIRT045104)
- hsa-mir-17-5p (MIRT108650)
- hsa-mir-20a-5p (MIRT108651)
- hsa-mir-106a-5p (MIRT108652)
- hsa-mir-214-3p (MIRT108653)
- hsa-mir-106b-5p (MIRT108654)
- hsa-mir-302a-3p (MIRT108655)
- hsa-mir-302b-3p (MIRT108656)
- hsa-mir-302c-3p (MIRT108657)
- hsa-mir-302d-3p (MIRT108658)
- hsa-mir-372-3p (MIRT108659)
- hsa-mir-373-3p (MIRT108660)
- hsa-mir-20b-5p (MIRT108661)
- hsa-mir-520e (MIRT108662)
- hsa-mir-520a-3p (MIRT108664)
- hsa-mir-526b-3p (MIRT108665)
- hsa-mir-520b (MIRT108667)
- hsa-mir-520c-3p (MIRT108668)
- hsa-mir-519d-3p (MIRT108669)
- hsa-mir-520d-3p (MIRT108670)
- hsa-mir-545-5p (MIRT108672)
- hsa-mir-761 (MIRT108674)
- hsa-mir-922 (MIRT108675)
- hsa-mir-302e (MIRT108676)
- hsa-mir-4291 (MIRT108677)
- hsa-mir-3619-5p (MIRT108678)
- hsa-mir-181a-5p (MIRT175455)
- hsa-mir-181b-5p (MIRT175456)
- hsa-mir-181c-5p (MIRT175457)
- hsa-mir-181d-5p (MIRT175460)
- hsa-mir-506-5p (MIRT175463)
- hsa-mir-892c-5p (MIRT175493)
- hsa-mir-320a (MIRT175498)
- hsa-mir-320b (MIRT175499)
- hsa-mir-320c (MIRT175500)
- hsa-mir-1537-5p (MIRT175502)
- hsa-mir-320d (MIRT175503)
- hsa-mir-3153 (MIRT175504)
- hsa-mir-3179 (MIRT175505)
- hsa-mir-3202 (MIRT175508)
- hsa-mir-4426 (MIRT175509)
- hsa-mir-4429 (MIRT175510)
- hsa-mir-4647 (MIRT175512)
- hsa-mir-4662b (MIRT175513)
- hsa-mir-4729 (MIRT175514)
- hsa-mir-4802-3p (MIRT175516)
- hsa-mir-6733-5p (MIRT175518)
- hsa-mir-6739-5p (MIRT175519)
- hsa-mir-6783-5p (MIRT175521)
- hsa-mir-15a-5p (MIRT175524)
- hsa-mir-16-5p (MIRT175525)
- hsa-mir-15b-5p (MIRT175526)
- hsa-mir-195-5p (MIRT175527)
- hsa-mir-513b-3p (MIRT229143)
- hsa-mir-6074 (MIRT229145)
- hsa-mir-4796-3p (MIRT365827)
- hsa-mir-5696 (MIRT365830)
- hsa-mir-4423-3p (MIRT409511)
- hsa-mir-4797-5p (MIRT409512)
- hsa-mir-5582-5p (MIRT409513)
- hsa-mir-6806-5p (MIRT409514)
- hsa-mir-302b-5p (MIRT463616)
- hsa-mir-4533 (MIRT463617)
- hsa-mir-548ah-5p (MIRT463618)
- hsa-mir-3609 (MIRT463619)
- hsa-mir-411-5p (MIRT564803)
- hsa-mir-1279 (MIRT564804)
- hsa-mir-3622a-5p (MIRT564805)
- hsa-mir-6782-3p (MIRT564806)
- hsa-mir-450b-5p (MIRT641133)
- hsa-mir-527 (MIRT641134)
- hsa-mir-518a-5p (MIRT641135)
- hsa-mir-548aw (MIRT641136)
- hsa-mir-1468-3p (MIRT641137)
- hsa-mir-548x-5p (MIRT641138)
- hsa-mir-548g-5p (MIRT641139)
- hsa-mir-548f-5p (MIRT641140)
- hsa-mir-548aj-5p (MIRT641141)
- hsa-mir-3613-3p (MIRT641142)
- hsa-mir-548c-3p (MIRT641143)
Targeted motifs for ZBTB33 Gene
HOMER Transcription Factor Regulatory Elements motif ZBTB33
- Consensus sequence: GGNTCTCGCGAGAAC Submotif: canonical Cell Type: GM12878 GEO ID: GSE32465
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZBTB33
- Browse OriGene Inhibitory RNA Products For ZBTB33
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB33
- genomics-online: shRNA clones - Search for available ZBTB33 shRNA products
- Overview of 120 available ZBTB33 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ZBTB33 - Select products 50% OFF >
- * ZBTB33 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG222263
- MR222263
- MR222263L3
- MR222263L4
- MR230844
- RC207287
- RC207287L1
- RC207287L2
- RC207287L3
- RC207287L4
- RC230416
- RC230416L3
- RC230416L4
- RG207287
- RG230416
- RR212417
- RR212417L3
- RR212417L4
- MR222263L3V
- MR222263L4V
- RC207287L1V
- RC207287L2V
- RC207287L3V
- RC207287L4V
- RC230416L3V
- RC230416L4V
- RR212417L3V
- RR212417L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ZBTB33
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZBTB33
Cell Line Products
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology and Transcription Factor Targets for ZBTB33 Gene
Localization for ZBTB33 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZBTB33 Gene
- Nucleus. Cytoplasm. Note=Also cytoplasmic in cells grown at high densities.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (4)
- Nucleoplasm (4)
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | TAS | 10207085 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for ZBTB33 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Wnt Signaling Pathway and Pluripotency | ||
Pathways by source for ZBTB33 Gene
1 BioSystems pathway for ZBTB33 Gene
Interacting Proteins for ZBTB33 Gene
Selected Interacting proteins:
Q86T24-KAISO_HUMAN
ENSP00000314153
for ZBTB33 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ZBTB33
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0016055 | Wnt signaling pathway | IEA | -- |
| GO:0035556 | intracellular signal transduction | TAS | 10207085 |
| GO:0045892 | negative regulation of transcription, DNA-templated | IMP | 23251453 |
Transcripts for ZBTB33 Gene
mRNA/cDNA for ZBTB33 Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000326624 5211 bps (ENST00000326624.2)
- ENST00000557385 5253 bps (ENST00000557385.2)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZBTB33 - Select products 50% OFF >
- * ZBTB33 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZBTB33
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZBTB33
- genomics-online: gRNA clones - Search for available ZBTB33 gRNA products
- Overview of 120 available ZBTB33 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZBTB33
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZBTB33
- Browse OriGene Inhibitory RNA Products For ZBTB33
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB33
- genomics-online: shRNA clones - Search for available ZBTB33 shRNA products
- Overview of 120 available ZBTB33 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ZBTB33 - Select products 50% OFF >
- * ZBTB33 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG222263
- MR222263
- MR222263L3
- MR222263L4
- MR230844
- RC207287
- RC207287L1
- RC207287L2
- RC207287L3
- RC207287L4
- RC230416
- RC230416L3
- RC230416L4
- RG207287
- RG230416
- RR212417
- RR212417L3
- RR212417L4
- MR222263L3V
- MR222263L4V
- RC207287L1V
- RC207287L2V
- RC207287L3V
- RC207287L4V
- RC230416L3V
- RC230416L4V
- RR212417L3V
- RR212417L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ZBTB33
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZBTB33
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | - |
Relevant External Links for ZBTB33 Gene
- GeneLoc Exon Structure for
- ZBTB33
Expression for ZBTB33 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (32.5), Blymphocyte (15.7), CD8 Tcells (11.1), and CD4 Tcells (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBTB33 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBTB33
SOURCE GeneReport for Unigene cluster for ZBTB33 Gene:
Hs.143604mRNA Expression by UniProt/SwissProt for ZBTB33 Gene:
Q86T24-KAISO_HUMAN
Tissue specificity:
Expressed in vascular endothelium.
Evidence on tissue expression from TISSUES for ZBTB33 Gene
- Nervous system(4.5)
- Lung(4.2)
Primer Products
-
OriGene qPCR primer pairs for ZBTB33
-
OriGene qPCR primer pairs and template standards for ZBTB33
- genomics-online: primer clones - Search for available ZBTB33 Primer products
- Overview of 120 available ZBTB33 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB33 Gene
Orthologs for ZBTB33 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZBTB33 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MGC155143 31 |
|
OneToOne | |
| ZBTB33 30 |
|
||||
| dog (Canis familiaris) |
Mammalia | ZBTB33 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Zbtb33 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Zbtb33 30 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZBTB33 31 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ZBTB33 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZBTB33 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ZBTB33 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | zbtb33 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Kaiso 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zbtb33 31 30 |
|
OneToOne |
- Species where no ortholog for ZBTB33 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ZBTB33 Gene
- ENSEMBL:
- Gene Tree for ZBTB33 (if available)
- TreeFam:
- Gene Tree for ZBTB33 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZBTB33: view image
Paralogs for ZBTB33 Gene
Paralogs for ZBTB33 Gene
Variants for ZBTB33 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBTB33 Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 781643 | Benign: not provided | 120,255,288(+) | C/A | MISSENSE_VARIANT | |
| 783911 | Benign: not provided | 120,254,091(+) | A/G | MISSENSE_VARIANT | |
| rs1057518570 | Uncertain Significance: not specified | 120,253,452(+) | C/G | MISSENSE_VARIANT | |
| rs143114425 | Uncertain Significance: not provided | 120,254,068(+) | A/T | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.42;
42.75% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZBTB33 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB33 Gene
Disorders for ZBTB33 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rett syndrome |
|
|
| epithelial malignant thymoma |
|
|
| cerebellar ataxia, deafness, and narcolepsy, autosomal dominant |
|
|
| immunodeficiency-centromeric instability-facial anomalies syndrome |
|
|
Search ZBTB33 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZBTB33
No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB33 Gene
Publications for ZBTB33 Gene
- Nuclear import of the BTB/POZ transcriptional regulator Kaiso. (PMID: 15564377) Kelly KF … Daniel JM (Journal of cell science 2004) 3 4 23 54
- The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. (PMID: 11445535) Prokhortchouk A … Prokhortchouk E (Genes & development 2001) 3 4 23 54
- Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. (PMID: 23251453) Barrett CW … Williams CS (PloS one 2012) 3 4 54
- A family of human zinc finger proteins that bind methylated DNA and repress transcription. (PMID: 16354688) Filion GJ … Defossez PA (Molecular and cellular biology 2006) 3 4 54
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 54
ExternalLinks
Products for ZBTB33 Gene
- Custom Antibody ServicesOriGene Antibodies for ZBTB33
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ZBTB33
- Search Origene for MassSpec and Protein Over-expression Lysates for ZBTB33
- Origene Custom Protein Services for ZBTB33
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZBTB33
- Browse OriGene Inhibitory RNA Products For ZBTB33
- OriGene qPCR primer pairs for ZBTB33
- OriGene qPCR primer pairs and template standards for ZBTB33
- OriGene CRISPR knockouts for ZBTB33
- MG222263
- MR222263
- MR222263L3
- MR222263L4
- MR230844
- RC207287
- RC207287L1
- RC207287L2
- RC207287L3
- RC207287L4
- RC230416
- RC230416L3
- RC230416L4
- RG207287
- RG230416
- RR212417
- RR212417L3
- RR212417L4
- MR222263L3V
- MR222263L4V
- RC207287L1V
- RC207287L2V
- RC207287L3V
- RC207287L4V
- RC230416L3V
- RC230416L4V
- RR212417L3V
- RR212417L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ZBTB33
- Sino Biological Human cDNA Clone for ZBTB33
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ZBTB33
- Novus Biologicals proteins and lysates for ZBTB33
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ZBTB33
- Abcam proteins for ZBTB33
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for ZBTB33 (AFLGC-ZBTB33)
- VectorBuilder Custom and pre-made DNA vectors for ZBTB33 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ZBTB33 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ZBTB33 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ZBTB33 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ZBTB33
- antibodies-online: Show 11 available ZBTB33 Antibodies ranked by validation data
- Compare Top ZBTB33 Antibodies
- antibodies-online: Show 4 available ZBTB33 Elisa Kits ranked by validation data
- Compare Top ZBTB33 Elisa Kits
- Quality Products:
- antibodies-online: Show 4 available ZBTB33 Proteins ranked by validation data
- Compare Top ZBTB33 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for ZBTB33
- Search Santa Cruz Biotechnology (SCBT) for ZBTB33 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ZBTB33
- genomics-online: cdna clones - Search for available ZBTB33 CDNA products
- Overview of 120 available ZBTB33 gene related products
- orf clones - Search for available ZBTB33 ORF products
- Overview of 120 available ZBTB33 gene related products
- genomics-online: gRNA clones - Search for available ZBTB33 gRNA products
- Overview of 120 available ZBTB33 gene related products
- genomics-online: primer clones - Search for available ZBTB33 Primer products
- Overview of 120 available ZBTB33 gene related products
- genomics-online: shRNA clones - Search for available ZBTB33 shRNA products
- Overview of 120 available ZBTB33 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZBTB33
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZBTB33
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ZBTB33
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB33
Sources for ZBTB33 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody