Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZBTB33 Gene

Aliases for ZBTB33 Gene

  • Zinc Finger And BTB Domain Containing 33 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 33 3 4
  • ZNF348 3 4
  • Transcriptional Regulator Kaiso 3
  • Kaiso Transcription Factor 3
  • WUGSC:H_DJ525N14.1 3
  • ZNF-Kaiso 3
  • KAISO 4

External Ids for ZBTB33 Gene

Previous GeneCards Identifiers for ZBTB33 Gene

  • GC0XP118139
  • GC0XP119166
  • GC0XP119268
  • GC0XP119384
  • GC0XP108838

Summaries for ZBTB33 Gene

Entrez Gene Summary for ZBTB33 Gene

  • This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]

GeneCards Summary for ZBTB33 Gene

ZBTB33 (Zinc Finger And BTB Domain Containing 33) is a Protein Coding gene. Diseases associated with ZBTB33 include Epithelial Malignant Thymoma and Dendritic Cell Thymoma. Among its related pathways are Wnt Signaling Pathway and Pluripotency. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and methyl-CpG binding. An important paralog of this gene is ZBTB38.

UniProtKB/Swiss-Prot for ZBTB33 Gene

  • Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5-CGCG-3 and also binds to the non-methylated consensus sequence 5-CTGCNA-3 also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).

Gene Wiki entry for ZBTB33 Gene

Additional gene information for ZBTB33 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB33 Gene

Genomics for ZBTB33 Gene

GeneHancer (GH) Regulatory Elements for ZBTB33 Gene

Promoters and enhancers for ZBTB33 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ120250 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.4 449 2.4 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A ZNF48 YY1 POLR2B ZNF143 ZBTB33 RHOXF1-AS1 RHOXF1 ENSG00000232042 TMEM255A
GH0XJ120309 Enhancer 1.2 Ensembl ENCODE 12.7 +59.4 59448 2.4 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF213 ZNF416 TMEM255A NKAPP1 UPF3B EEF1A1P30 NKAP LINC01402 RHOXF2B CT47A6 CT47B1 CT47A1
GH0XJ120305 Enhancer 0.9 FANTOM5 dbSUPER 12.7 +55.2 55184 0.2 MEIS2 ATF1 ZNF335 ZNF366 SCRT2 ATF7 PRDM10 KLF13 CREM ZNF639 ZBTB33 NKAPP1 TMEM255A ENSG00000232042
GH0XJ120304 Enhancer 0.5 Ensembl dbSUPER 12.7 +53.9 53949 1 NFE2 ZBTB33 NKAPP1 TMEM255A SLC25A43 ENSG00000232042
GH0XJ120308 Enhancer 0.4 ENCODE 12.7 +58.0 58039 0.1 CTCF ZNF143 EGR2 ZBTB33 NKAPP1 TMEM255A ENSG00000232042
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB33 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB33 gene promoter:
  • HNF-4alpha2
  • HNF-4alpha1
  • CUTL1
  • IRF-2
  • POU3F1
  • POU2F1
  • POU2F1a
  • p53

Genomic Locations for ZBTB33 Gene

Genomic Locations for ZBTB33 Gene
chrX:120,250,752-120,258,398
(GRCh38/hg38)
Size:
7,647 bases
Orientation:
Plus strand
chrX:119,384,607-119,392,253
(GRCh37/hg19)
Size:
7,647 bases
Orientation:
Plus strand

Genomic View for ZBTB33 Gene

Genes around ZBTB33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB33 Gene

Proteins for ZBTB33 Gene

  • Protein details for ZBTB33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T24-KAISO_HUMAN
    Recommended name:
    Transcriptional regulator Kaiso
    Protein Accession:
    Q86T24
    Secondary Accessions:
    • B2R5U6
    • O00319
    • Q7Z361
    • Q8IVP6
    • Q8N3P0

    Protein attributes for ZBTB33 Gene

    Size:
    672 amino acids
    Molecular mass:
    74484 Da
    Quaternary structure:
    • Self-associates. Interacts with CTNND2 (By similarity). Interacts with CTNND1, and this interaction inhibits binding to both methylated and non-methylated DNA. Interacts with NCOR1. Interacts with KPNA2/RCH1, which may mediate nuclear import of this protein. Interacts with CBFA2T3.

    Three dimensional structures from OCA and Proteopedia for ZBTB33 Gene

neXtProt entry for ZBTB33 Gene

Post-translational modifications for ZBTB33 Gene

  • Ubiquitination at isoforms=582, posLast=529529, and isoforms=407
  • Modification sites at PhosphoSitePlus

Other Protein References for ZBTB33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB33 Gene

Domains & Families for ZBTB33 Gene

Gene Families for ZBTB33 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB33 Gene

Suggested Antigen Peptide Sequences for ZBTB33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB33: view

No data available for UniProtKB/Swiss-Prot for ZBTB33 Gene

Function for ZBTB33 Gene

Molecular function for ZBTB33 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5-CGCG-3 and also binds to the non-methylated consensus sequence 5-CTGCNA-3 also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).
UniProtKB/Swiss-Prot Induction:
Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure.

Gene Ontology (GO) - Molecular Function for ZBTB33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16354688
GO:0008327 methyl-CpG binding IDA 16354688
genes like me logo Genes that share ontologies with ZBTB33: view
genes like me logo Genes that share phenotypes with ZBTB33: view

Animal Models for ZBTB33 Gene

MGI Knock Outs for ZBTB33:

Animal Model Products

miRNA for ZBTB33 Gene

miRTarBase miRNAs that target ZBTB33
Targeted motifs for ZBTB33 Gene
HOMER Transcription Factor Regulatory Elements motif ZBTB33
  • Consensus sequence: GGNTCTCGCGAGAAC Submotif: canonical Cell Type: GM12878 GEO ID: GSE32465

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology and Transcription Factor Targets for ZBTB33 Gene

Localization for ZBTB33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB33 Gene

Nucleus. Cytoplasm. Note=Also cytoplasmic in cells grown at high densities.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB33 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleus (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZBTB33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZBTB33: view

Pathways & Interactions for ZBTB33 Gene

genes like me logo Genes that share pathways with ZBTB33: view

Pathways by source for ZBTB33 Gene

1 BioSystems pathway for ZBTB33 Gene

SIGNOR curated interactions for ZBTB33 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ZBTB33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0035556 intracellular signal transduction TAS 10207085
genes like me logo Genes that share ontologies with ZBTB33: view

Drugs & Compounds for ZBTB33 Gene

No Compound Related Data Available

Transcripts for ZBTB33 Gene

mRNA/cDNA for ZBTB33 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(121) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB33 Gene

Zinc finger and BTB domain containing 33:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB33 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for ZBTB33 Gene

GeneLoc Exon Structure for
ZBTB33
ECgene alternative splicing isoforms for
ZBTB33

Expression for ZBTB33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB33 Gene

Protein differential expression in normal tissues from HIPED for ZBTB33 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.5), Blymphocyte (15.7), CD8 Tcells (11.1), and CD4 Tcells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBTB33 Gene



Protein tissue co-expression partners for ZBTB33 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB33 Gene:

ZBTB33

SOURCE GeneReport for Unigene cluster for ZBTB33 Gene:

Hs.143604

mRNA Expression by UniProt/SwissProt for ZBTB33 Gene:

Q86T24-KAISO_HUMAN
Tissue specificity: Expressed in vascular endothelium.

Evidence on tissue expression from TISSUES for ZBTB33 Gene

  • Nervous system(4.5)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZBTB33: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB33 Gene

Orthologs for ZBTB33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB33 34 33
  • 99.85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MGC155143 34
  • 94 (a)
OneToOne
ZBTB33 33
  • 92.48 (n)
dog
(Canis familiaris)
Mammalia ZBTB33 34 33
  • 92.56 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb33 16 34 33
  • 88.29 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb33 33
  • 87.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB33 34
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB33 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB33 34 33
  • 66.97 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB33 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb33 33
  • 63.44 (n)
African clawed frog
(Xenopus laevis)
Amphibia Kaiso 33
zebrafish
(Danio rerio)
Actinopterygii zbtb33 34 33
  • 59.72 (n)
OneToOne
Species where no ortholog for ZBTB33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB33 Gene

ENSEMBL:
Gene Tree for ZBTB33 (if available)
TreeFam:
Gene Tree for ZBTB33 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB33: view image

Paralogs for ZBTB33 Gene

Paralogs for ZBTB33 Gene

genes like me logo Genes that share paralogs with ZBTB33: view

Variants for ZBTB33 Gene

Sequence variations from dbSNP and Humsavar for ZBTB33 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1057518570 uncertain-significance, not specified 120,253,452(+) C/G coding_sequence_variant, missense_variant
rs1000278739 -- 120,252,114(+) C/T intron_variant
rs1000415724 -- 120,252,665(+) A/G intron_variant
rs1000725191 -- 120,255,428(+) T/G coding_sequence_variant, synonymous_variant
rs1001363018 -- 120,249,860(+) C/T upstream_transcript_variant

Variation tolerance for ZBTB33 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB33 Gene

Human Gene Mutation Database (HGMD)
ZBTB33
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB33 Gene

Disorders for ZBTB33 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZBTB33 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
epithelial malignant thymoma
  • squamoid thymoma
dendritic cell thymoma
  • epithelioid thymoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZBTB33

genes like me logo Genes that share disorders with ZBTB33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB33 Gene

Publications for ZBTB33 Gene

  1. Nuclear import of the BTB/POZ transcriptional regulator Kaiso. (PMID: 15564377) Kelly KF … Daniel JM (Journal of cell science 2004) 3 4 22 58
  2. The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. (PMID: 11445535) Prokhortchouk A … Prokhortchouk E (Genes & development 2001) 3 4 22 58
  3. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. (PMID: 23251453) Barrett CW … Williams CS (PloS one 2012) 3 4 58
  4. A family of human zinc finger proteins that bind methylated DNA and repress transcription. (PMID: 16354688) Filion GJ … Defossez PA (Molecular and cellular biology 2006) 3 4 58
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58

Products for ZBTB33 Gene

Sources for ZBTB33 Gene

Content
Loading form....