Aliases for ZBTB32 Gene

Aliases for ZBTB32 Gene

  • Zinc Finger And BTB Domain Containing 32 2 3 5
  • ZNF538 2 3 4
  • FAZF 2 3 4
  • TZFP 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 32 3 4
  • Fanconi Anemia Zinc Finger Protein 3 4
  • Testis Zinc Finger Protein 3 4
  • FANCC-Interacting Protein 3 4
  • Zinc Finger Protein 538 3 4
  • Repressor Of GATA 2 3
  • FAXF 2 3
  • Rog 2 3
  • ZBTB32 5

External Ids for ZBTB32 Gene

Previous GeneCards Identifiers for ZBTB32 Gene

  • GC19P040896
  • GC19P036203
  • GC19P032708
  • GC19P036201
  • GC19P035779
  • GC19P035829
  • GC19P037020
  • GC19P037188
  • GC19P037284
  • GC19P037721
  • GC19P035846
  • GC19P036005
  • GC19P036168
  • GC19P036241
  • GC19P036410
  • GC19P036571
  • GC19P036739
  • GC19P036885

Summaries for ZBTB32 Gene

GeneCards Summary for ZBTB32 Gene

ZBTB32 (Zinc Finger And BTB Domain Containing 32) is a Protein Coding gene. Diseases associated with ZBTB32 include Oral Tuberculosis and Lymph Node Tuberculosis. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription corepressor activity. An important paralog of this gene is ZBTB16.

UniProtKB/Swiss-Prot Summary for ZBTB32 Gene

  • DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).

Gene Wiki entry for ZBTB32 Gene

Additional gene information for ZBTB32 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB32 Gene

Genomics for ZBTB32 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZBTB32 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB32 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBTB32

Top Transcription factor binding sites by QIAGEN in the ZBTB32 gene promoter:
  • AP-2alphaA
  • AP-2beta
  • CUTL1
  • E47
  • GATA-3
  • Ik-2
  • MZF-1
  • NF-kappaB1
  • Roaz
  • Tal-1beta

Genomic Locations for ZBTB32 Gene

Genomic Locations for ZBTB32 Gene
chr19:35,704,481-35,717,048
(GRCh38/hg38)
Size:
12,568 bases
Orientation:
Plus strand
chr19:36,195,429-36,207,940
(GRCh37/hg19)
Size:
12,512 bases
Orientation:
Plus strand

Genomic View for ZBTB32 Gene

Genes around ZBTB32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB32 Gene

Proteins for ZBTB32 Gene

  • Protein details for ZBTB32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Y4-ZBT32_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 32
    Protein Accession:
    Q9Y2Y4
    Secondary Accessions:
    • Q8WVP2

    Protein attributes for ZBTB32 Gene

    Size:
    487 amino acids
    Molecular mass:
    52963 Da
    Quaternary structure:
    • Homodimer (via PTB domain). Interacts with the N-terminal of FANCC. Interacts with ZBTB16. Interacts with GATA3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for ZBTB32 Gene

neXtProt entry for ZBTB32 Gene

Post-translational modifications for ZBTB32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZBTB32 Gene

Domains & Families for ZBTB32 Gene

Gene Families for ZBTB32 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB32 Gene

InterPro:
Blocks:
  • BTB/POZ domain
ProtoNet:

Suggested Antigen Peptide Sequences for ZBTB32 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 538 (ZBT32_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2Y4

UniProtKB/Swiss-Prot:

ZBT32_HUMAN :
  • The C-terminal zinc finger domain functions as a transcriptional transactivator.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The C-terminal zinc finger domain functions as a transcriptional transactivator.
  • The BTB (POZ) domain possesses repressor activity.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZBTB32: view

Function for ZBTB32 Gene

Molecular function for ZBTB32 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).

Phenotypes From GWAS Catalog for ZBTB32 Gene

Gene Ontology (GO) - Molecular Function for ZBTB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IBA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZBTB32: view
genes like me logo Genes that share phenotypes with ZBTB32: view

Animal Models for ZBTB32 Gene

MGI Knock Outs for ZBTB32:

Animal Model Products

CRISPR Products

miRNA for ZBTB32 Gene

miRTarBase miRNAs that target ZBTB32

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB32

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB32 Gene

Localization for ZBTB32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB32 Gene

Nucleus. Note=Located in nuclear speckles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB32 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZBTB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus TAS 10572087
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ZBTB32: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZBTB32 Gene

Pathways & Interactions for ZBTB32 Gene

genes like me logo Genes that share pathways with ZBTB32: view

Pathways by source for ZBTB32 Gene

Gene Ontology (GO) - Biological Process for ZBTB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006366 transcription by RNA polymerase II TAS 10572087
genes like me logo Genes that share ontologies with ZBTB32: view

No data available for SIGNOR curated interactions for ZBTB32 Gene

Drugs & Compounds for ZBTB32 Gene

(1) Drugs for ZBTB32 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZBTB32: view

Transcripts for ZBTB32 Gene

mRNA/cDNA for ZBTB32 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB32

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB32 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - -
SP3: - - -
SP4:

Relevant External Links for ZBTB32 Gene

GeneLoc Exon Structure for
ZBTB32

Expression for ZBTB32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB32 Gene

This gene is overexpressed in Testis (x18.6).

Protein differential expression in normal tissues from HIPED for ZBTB32 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBTB32 Gene



Protein tissue co-expression partners for ZBTB32 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBTB32

SOURCE GeneReport for Unigene cluster for ZBTB32 Gene:

Hs.99430

mRNA Expression by UniProt/SwissProt for ZBTB32 Gene:

Q9Y2Y4-ZBT32_HUMAN
Tissue specificity: Predominantly expressed in testis. Some isoforms are ubiquitously expressed.

Evidence on tissue expression from TISSUES for ZBTB32 Gene

  • Blood(2.4)
genes like me logo Genes that share expression patterns with ZBTB32: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB32 Gene

Orthologs for ZBTB32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB32 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZBTB32 30 31
  • 99.18 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZBTB32 30 31
  • 84.69 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZBTB32 30
  • 84.4 (n)
Rat
(Rattus norvegicus)
Mammalia Zbtb32 30
  • 77.97 (n)
Mouse
(Mus musculus)
Mammalia Zbtb32 30 17 31
  • 77.15 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZBTB32 31
  • 51 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 22 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 30 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii ZBTB32 (1 of 2) 31
  • 52 (a)
OneToMany
ZBTB32 (2 of 2) 31
  • 19 (a)
OneToMany
Species where no ortholog for ZBTB32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZBTB32 Gene

ENSEMBL:
Gene Tree for ZBTB32 (if available)
TreeFam:
Gene Tree for ZBTB32 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB32: view image

Paralogs for ZBTB32 Gene

Variants for ZBTB32 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBTB32 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2227278 - p.Arg174Ser

Additional dbSNP identifiers (rs#s) for ZBTB32 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZBTB32 Gene

Variant ID Type Subtype PubMed ID
esv3644242 CNV gain 21293372
nsv579422 CNV loss 21841781
nsv828544 CNV gain 20364138

Variation tolerance for ZBTB32 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB32 Gene

Disorders for ZBTB32 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ZBTB32 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
oral tuberculosis
  • tuberculosis, oral
lymph node tuberculosis
  • king's evil
fanconi anemia, complementation group a
  • fanca
gastroduodenitis
ornithosis
  • psittacosis
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZBTB32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB32 Gene

Publications for ZBTB32 Gene

  1. Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP. (PMID: 10544010) Lin W … Tang TK (Biochemical and biophysical research communications 1999) 3 4 23
  2. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. (PMID: 10572087) Hoatlin ME … Licht JD (Blood 1999) 2 3 4
  3. Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1. (PMID: 20493880) Stogios PJ … Privé GG (Journal of molecular biology 2010) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein. (PMID: 11964310) Tsuzuki S … Enver T (Blood 2002) 3 23

Products for ZBTB32 Gene

Sources for ZBTB32 Gene