Aliases for ZBTB3 Gene

Aliases for ZBTB3 Gene

  • Zinc Finger And BTB Domain Containing 3 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 3 3 4

External Ids for ZBTB3 Gene

Previous GeneCards Identifiers for ZBTB3 Gene

  • GC11M062766
  • GC11M062293
  • GC11M062275
  • GC11M061931
  • GC11M062518
  • GC11M058847

Summaries for ZBTB3 Gene

GeneCards Summary for ZBTB3 Gene

ZBTB3 (Zinc Finger And BTB Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is ZBTB46.

UniProtKB/Swiss-Prot Summary for ZBTB3 Gene

Additional gene information for ZBTB3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB3 Gene

Genomics for ZBTB3 Gene

GeneHancer (GH) Regulatory Elements for ZBTB3 Gene

Promoters and enhancers for ZBTB3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J062752 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.2 233 2.5 SP1 ZBTB40 SMARCE1 POLR2A CEBPZ ATF1 FOS CREB1 MYC NFYC ZBTB3 piR-44930 piR-50040 NXF1 WDR74 TTC9C STX5 ENSG00000256690 CSKMT MTA2
GH11J062757 Promoter/Enhancer 0.9 EPDnew ENCODE 750.6 -4.2 -4193 2.5 HLF SP1 ZNF384 ZNF512 POLR2A SOX13 ZNF366 CEBPB ETS1 SIN3A FJ601666-014 RF00017-934 ZBTB3 TTC9C
GH11J062041 Enhancer 1.3 Ensembl ENCODE dbSUPER 11 +708.8 708783 8.4 ZBTB40 SREBF1 SMARCE1 POLR2A ZNF217 RUNX1 CC2D1A ELF1 L3MBTL2 DACH1 CSKMT SNHG1 CPSF7 GANAB TAF6L ENSG00000256690 MTA2 TMEM138 NXF1 TUT1
GH11J062749 Enhancer 0.6 Ensembl ENCODE 0.6 +3.5 3483 2.6 ZNF362 ZNF384 PRDM10 ZBTB33 piR-33614-038 piR-44930 TTC9C HNRNPUL2 HNRNPUL2-BSCL2 TAF6L SNORD22 SLC3A2 SNHG1 AHNAK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB3 gene promoter:
  • E2F
  • E2F-1
  • ER-alpha
  • FOXD1
  • MyoD
  • p300
  • p53
  • RFX1
  • XBP-1
  • ZIC2

Genomic Locations for ZBTB3 Gene

Genomic Locations for ZBTB3 Gene
chr11:62,748,319-62,754,184
(GRCh38/hg38)
Size:
5,866 bases
Orientation:
Minus strand
chr11:62,515,791-62,521,660
(GRCh37/hg19)
Size:
5,870 bases
Orientation:
Minus strand

Genomic View for ZBTB3 Gene

Genes around ZBTB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB3 Gene

Proteins for ZBTB3 Gene

  • Protein details for ZBTB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5J0-ZBTB3_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 3
    Protein Accession:
    Q9H5J0

    Protein attributes for ZBTB3 Gene

    Size:
    574 amino acids
    Molecular mass:
    61827 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB3 Gene

Post-translational modifications for ZBTB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB3 Gene

No data available for DME Specific Peptides for ZBTB3 Gene

Domains & Families for ZBTB3 Gene

Gene Families for ZBTB3 Gene

Protein Domains for ZBTB3 Gene

Suggested Antigen Peptide Sequences for ZBTB3 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger and BTB domain-containing protein 3 (ZBTB3_HUMAN)
genes like me logo Genes that share domains with ZBTB3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBTB3 Gene

Function for ZBTB3 Gene

Molecular function for ZBTB3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB3 Gene

Gene Ontology (GO) - Molecular Function for ZBTB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB3: view
genes like me logo Genes that share phenotypes with ZBTB3: view

Animal Model Products

CRISPR Products

miRNA for ZBTB3 Gene

miRTarBase miRNAs that target ZBTB3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB3 Gene

Localization for ZBTB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB3 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZBTB3: view

Pathways & Interactions for ZBTB3 Gene

PathCards logo

SuperPathways for ZBTB3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IBA 21873635
genes like me logo Genes that share ontologies with ZBTB3: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB3 Gene

Drugs & Compounds for ZBTB3 Gene

No Compound Related Data Available

Transcripts for ZBTB3 Gene

mRNA/cDNA for ZBTB3 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB3 Gene

No ASD Table

Relevant External Links for ZBTB3 Gene

GeneLoc Exon Structure for
ZBTB3
ECgene alternative splicing isoforms for
ZBTB3

Expression for ZBTB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBTB3 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZBTB3 Gene:

ZBTB3

SOURCE GeneReport for Unigene cluster for ZBTB3 Gene:

Hs.147554

Evidence on tissue expression from TISSUES for ZBTB3 Gene

  • Liver(4.1)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with ZBTB3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB3 Gene

Orthologs for ZBTB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB3 33 32
  • 99.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB3 33 32
  • 89.06 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB3 33 32
  • 88.56 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb3 17 33 32
  • 86.63 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb3 32
  • 86.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB3 33
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB3 33
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100536022 32
  • 54.06 (n)
FP074862.4 33
  • 40 (a)
OneToMany
zbtb3 33
  • 37 (a)
OneToMany
Species where no ortholog for ZBTB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB3 Gene

ENSEMBL:
Gene Tree for ZBTB3 (if available)
TreeFam:
Gene Tree for ZBTB3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB3: view image

Paralogs for ZBTB3 Gene

Variants for ZBTB3 Gene

Sequence variations from dbSNP and Humsavar for ZBTB3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
VAR_035600 A breast cancer sample p.His424Leu
VAR_035601 A breast cancer sample p.Ser455Phe
rs1000289029 -- 62,752,162(-) T/C coding_sequence_variant, synonymous_variant
rs1000681755 -- 62,752,487(-) G/A/C coding_sequence_variant, missense_variant
rs1000932774 -- 62,750,633(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB3 Gene

Variant ID Type Subtype PubMed ID
nsv348 CNV deletion 18451855

Variation tolerance for ZBTB3 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.56; 72.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB3 Gene

Disorders for ZBTB3 Gene

Additional Disease Information for ZBTB3

No disorders were found for ZBTB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB3 Gene

Publications for ZBTB3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 56
  5. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. (PMID: 26841866) Varier RA … Vermeulen M (The Journal of biological chemistry 2016) 3 56

Products for ZBTB3 Gene

Sources for ZBTB3 Gene