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Aliases for ZBTB26 Gene

Aliases for ZBTB26 Gene

  • Zinc Finger And BTB Domain Containing 26 2 3 5
  • Zinc Finger Protein 481 2 3 4
  • Zinc Finger Protein Bioref 3 4
  • ZNF481 3 4
  • Zinc Finger And BTB Domain-Containing Protein 26 3
  • Zinc Finger Protein 483 3
  • KIAA1572 4
  • Bioref 3

External Ids for ZBTB26 Gene

Previous HGNC Symbols for ZBTB26 Gene

  • ZNF481

Previous GeneCards Identifiers for ZBTB26 Gene

  • GC09M121057
  • GC09M122759
  • GC09M124717
  • GC09M125677
  • GC09M095295

Summaries for ZBTB26 Gene

GeneCards Summary for ZBTB26 Gene

ZBTB26 (Zinc Finger And BTB Domain Containing 26) is a Protein Coding gene. An important paralog of this gene is ZBTB6.

UniProtKB/Swiss-Prot for ZBTB26 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB26 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB26 Gene

Genomics for ZBTB26 Gene

GeneHancer (GH) Regulatory Elements for ZBTB26 Gene

Promoters and enhancers for ZBTB26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I122930 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.2 -200 3 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZBTB26 RABGAP1 ENSG00000261094
GH09I123304 Enhancer 1.4 Ensembl ENCODE dbSUPER 23.3 -373.4 -373357 1.3 PKNOX1 SMAD1 ATF1 ARNT ZNF48 TCF12 ZNF766 GLIS2 GATA2 E2F8 ZBTB26 RC3H2 STRBP MIR600HG MIR600 GC09M123300 LOC105376265
GH09I122902 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.4 +27.3 27296 3.9 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 GC09P122904 RC3H2 ZBTB26 SNORD90 MRRF RABGAP1 MIR600HG PIR42233
GH09I122263 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 +666.8 666789 3.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RBM18 MRRF LHX6 ZBTB26
GH09I122374 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 10.7 +554.9 554945 4.2 HDGF PKNOX1 ATF1 ARNT ZFP64 TCF12 ZNF766 GATA2 ATF7 RUNX3 PTGS1 ZBTB26 RC3H2 OR1K1 DAB2IP OR1L3 ENSG00000269970 ENSG00000233616
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB26 gene promoter:

Genomic Locations for ZBTB26 Gene

Genomic Locations for ZBTB26 Gene
chr9:122,915,566-122,931,551
(GRCh38/hg38)
Size:
15,986 bases
Orientation:
Minus strand
chr9:125,677,845-125,693,779
(GRCh37/hg19)

Genomic View for ZBTB26 Gene

Genes around ZBTB26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB26 Gene

Proteins for ZBTB26 Gene

  • Protein details for ZBTB26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCK0-ZBT26_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 26
    Protein Accession:
    Q9HCK0
    Secondary Accessions:
    • B3KQ53
    • Q8WTR1

    Protein attributes for ZBTB26 Gene

    Size:
    441 amino acids
    Molecular mass:
    49953 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13398.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZBTB26 Gene

Post-translational modifications for ZBTB26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB26 Gene

No data available for DME Specific Peptides for ZBTB26 Gene

Domains & Families for ZBTB26 Gene

Gene Families for ZBTB26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB26 Gene

Suggested Antigen Peptide Sequences for ZBTB26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB26: view

No data available for UniProtKB/Swiss-Prot for ZBTB26 Gene

Function for ZBTB26 Gene

Molecular function for ZBTB26 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZBTB26: view
genes like me logo Genes that share phenotypes with ZBTB26: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB26 Gene

Localization for ZBTB26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB26 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB26 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZBTB26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB26: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZBTB26 Gene

Pathways & Interactions for ZBTB26 Gene

SuperPathways for ZBTB26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZBTB26: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB26 Gene

Drugs & Compounds for ZBTB26 Gene

No Compound Related Data Available

Transcripts for ZBTB26 Gene

mRNA/cDNA for ZBTB26 Gene

Unigene Clusters for ZBTB26 Gene

Zinc finger and BTB domain containing 26:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB26 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for ZBTB26 Gene

GeneLoc Exon Structure for
ZBTB26
ECgene alternative splicing isoforms for
ZBTB26

Expression for ZBTB26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB26 Gene

Protein differential expression in normal tissues from HIPED for ZBTB26 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB26 Gene



Protein tissue co-expression partners for ZBTB26 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB26 Gene:

ZBTB26

SOURCE GeneReport for Unigene cluster for ZBTB26 Gene:

Hs.5638

mRNA Expression by UniProt/SwissProt for ZBTB26 Gene:

Q9HCK0-ZBT26_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ZBTB26 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZBTB26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB26 Gene

Orthologs for ZBTB26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB26 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia ZBTB26 33
  • 97.51 (n)
cow
(Bos Taurus)
Mammalia ZBTB26 33 34
  • 96.22 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb26 33
  • 95.61 (n)
mouse
(Mus musculus)
Mammalia Zbtb26 33 16 34
  • 95.45 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB26 34
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB26 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB26 33 34
  • 80.75 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb26 33
  • 68.17 (n)
Str.18248 33
zebrafish
(Danio rerio)
Actinopterygii si:ch211-236k19.4 33
  • 60.6 (n)
ZBTB26 34
  • 57 (a)
OneToOne
Species where no ortholog for ZBTB26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB26 Gene

ENSEMBL:
Gene Tree for ZBTB26 (if available)
TreeFam:
Gene Tree for ZBTB26 (if available)

Paralogs for ZBTB26 Gene

(7) SIMAP similar genes for ZBTB26 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB26: view

Variants for ZBTB26 Gene

Sequence variations from dbSNP and Humsavar for ZBTB26 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000114377 -- 122,920,027(-) C/A/T intron_variant
rs1000224103 -- 122,922,589(-) T/C intron_variant
rs1000362056 -- 122,923,512(-) C/T intron_variant
rs1000375108 -- 122,923,077(-) G/A/T intron_variant
rs1000474320 -- 122,928,581(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB26 Gene

Variant ID Type Subtype PubMed ID
esv33734 CNV loss 17666407

Variation tolerance for ZBTB26 Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB26 Gene

Disorders for ZBTB26 Gene

Additional Disease Information for ZBTB26

No disorders were found for ZBTB26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB26 Gene

Publications for ZBTB26 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58

Products for ZBTB26 Gene

Sources for ZBTB26 Gene

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