Aliases for ZBTB25 Gene

Aliases for ZBTB25 Gene

  • Zinc Finger And BTB Domain Containing 25 2 3 5
  • KUP 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 25 3 4
  • Zinc Finger Protein KUP 3 4
  • Zinc Finger Protein 46 3 4
  • C14orf51 3 4
  • ZNF46 3 4
  • Chromosome 14 Open Reading Frame 51 2
  • Zinc Finger Protein 46 (KUP) 2
  • ZBTB25 5

External Ids for ZBTB25 Gene

Previous HGNC Symbols for ZBTB25 Gene

  • ZNF46
  • C14orf51

Previous GeneCards Identifiers for ZBTB25 Gene

  • GC14M064024
  • GC14M064953
  • GC14M045126

Summaries for ZBTB25 Gene

GeneCards Summary for ZBTB25 Gene

ZBTB25 (Zinc Finger And BTB Domain Containing 25) is a Protein Coding gene. Diseases associated with ZBTB25 include Interstitial Nephritis, Karyomegalic. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZBTB49.

UniProtKB/Swiss-Prot Summary for ZBTB25 Gene

Additional gene information for ZBTB25 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB25 Gene

Genomics for ZBTB25 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZBTB25 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB25 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBTB25

Top Transcription factor binding sites by QIAGEN in the ZBTB25 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GATA-2
  • MEF-2A
  • p53
  • POU2F1

Genomic Locations for ZBTB25 Gene

Genomic Locations for ZBTB25 Gene
chr14:64,449,106-64,505,213
(GRCh38/hg38)
Size:
56,108 bases
Orientation:
Minus strand
chr14:64,915,824-64,971,931
(GRCh37/hg19)
Size:
56,108 bases
Orientation:
Minus strand

Genomic View for ZBTB25 Gene

Genes around ZBTB25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB25 Gene

Proteins for ZBTB25 Gene

  • Protein details for ZBTB25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24278-ZBT25_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 25
    Protein Accession:
    P24278
    Secondary Accessions:
    • B3KUX6
    • Q8IYH9

    Protein attributes for ZBTB25 Gene

    Size:
    435 amino acids
    Molecular mass:
    48990 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB25 Gene

Post-translational modifications for ZBTB25 Gene

  • Ubiquitination at Lys405
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZBTB25 Gene

Domains & Families for ZBTB25 Gene

Gene Families for ZBTB25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB25 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • BTB/POZ domain
ProtoNet:

Suggested Antigen Peptide Sequences for ZBTB25 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein KUP (ZBT25_HUMAN)
genes like me logo Genes that share domains with ZBTB25: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBTB25 Gene

Function for ZBTB25 Gene

Molecular function for ZBTB25 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB25 Gene

Gene Ontology (GO) - Molecular Function for ZBTB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA,IDA 2027750
GO:0003700 DNA-binding transcription factor activity TAS 2027750
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ZBTB25: view
genes like me logo Genes that share phenotypes with ZBTB25: view

Animal Model Products

CRISPR Products

miRNA for ZBTB25 Gene

miRTarBase miRNAs that target ZBTB25

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB25

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB25 Gene

Localization for ZBTB25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB25 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA,IDA --
GO:0005737 cytoplasm IDA 2027750
genes like me logo Genes that share ontologies with ZBTB25: view

Pathways & Interactions for ZBTB25 Gene

PathCards logo

SuperPathways for ZBTB25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0010467 gene expression IBA,IEP 2027750
genes like me logo Genes that share ontologies with ZBTB25: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB25 Gene

Drugs & Compounds for ZBTB25 Gene

No Compound Related Data Available

Transcripts for ZBTB25 Gene

mRNA/cDNA for ZBTB25 Gene

9 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB25

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB25 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2: - - - - - -
SP3: - - -

Relevant External Links for ZBTB25 Gene

GeneLoc Exon Structure for
ZBTB25

Expression for ZBTB25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBTB25 Gene

This gene is overexpressed in Uterus (22.3), Esophagus (13.8), Salivary gland (9.9), and Fetal gut (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBTB25 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBTB25

SOURCE GeneReport for Unigene cluster for ZBTB25 Gene:

Hs.654571

mRNA Expression by UniProt/SwissProt for ZBTB25 Gene:

P24278-ZBT25_HUMAN
Tissue specificity: Expressed mainly in hematopoietic cells and testis.

Evidence on tissue expression from TISSUES for ZBTB25 Gene

  • Blood(4.4)
  • Kidney(2.8)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with ZBTB25: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB25 Gene

Orthologs for ZBTB25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB25 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZBTB25 30 31
  • 99.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZBTB25 30 31
  • 93.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZBTB25 30 31
  • 93.64 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zbtb25 30 17 31
  • 90.11 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zbtb25 30
  • 88.51 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZBTB25 31
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB25 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZBTB25 30 31
  • 67.29 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZBTB25 31
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zbtb25 30
  • 65.58 (n)
Str.19326 30
Zebrafish
(Danio rerio)
Actinopterygii zbtb25 30 31
  • 51.33 (n)
OneToOne
Species where no ortholog for ZBTB25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZBTB25 Gene

ENSEMBL:
Gene Tree for ZBTB25 (if available)
TreeFam:
Gene Tree for ZBTB25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB25: view image

Paralogs for ZBTB25 Gene

(26) SIMAP similar genes for ZBTB25 Gene using alignment to 3 proteins:

  • ZBT25_HUMAN
  • G3V2K3_HUMAN
  • G3V351_HUMAN
genes like me logo Genes that share paralogs with ZBTB25: view

Variants for ZBTB25 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBTB25 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
738664 Likely Benign: not provided 64,449,573(-) A/G MISSENSE_VARIANT
747323 Likely Benign: not provided 64,454,836(-) C/G SYNONYMOUS_VARIANT,INTRON_VARIANT
755383 Likely Benign: not provided 64,453,759(-) A/T SYNONYMOUS_VARIANT,INTRON_VARIANT
779686 Benign: not provided 64,449,470(-) C/T MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT
779687 Benign: not provided 64,468,957(-) G/A MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ZBTB25 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZBTB25 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV deletion 23290073
nsv1126366 CNV deletion 24896259
nsv521823 CNV loss 19592680

Variation tolerance for ZBTB25 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB25 Gene

Disorders for ZBTB25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZBTB25 Gene - From: DISEASES

Disorder Aliases PubMed IDs
interstitial nephritis, karyomegalic
  • kmin
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZBTB25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB25 Gene

Publications for ZBTB25 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers. (PMID: 2027750) Chardin P … Gisselbrecht S (Nucleic acids research 1991) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3

Products for ZBTB25 Gene

Sources for ZBTB25 Gene