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Aliases for ZBTB25 Gene

Aliases for ZBTB25 Gene

  • Zinc Finger And BTB Domain Containing 25 2 3 5
  • Zinc Finger Protein KUP 3 4
  • Zinc Finger Protein 46 3 4
  • C14orf51 3 4
  • ZNF46 3 4
  • KUP 3 4
  • Zinc Finger And BTB Domain-Containing Protein 25 3
  • Chromosome 14 Open Reading Frame 51 2
  • Zinc Finger Protein 46 (KUP) 2

External Ids for ZBTB25 Gene

Previous HGNC Symbols for ZBTB25 Gene

  • ZNF46
  • C14orf51

Previous GeneCards Identifiers for ZBTB25 Gene

  • GC14M064024
  • GC14M064953
  • GC14M045126

Summaries for ZBTB25 Gene

GeneCards Summary for ZBTB25 Gene

ZBTB25 (Zinc Finger And BTB Domain Containing 25) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZBTB2.

UniProtKB/Swiss-Prot for ZBTB25 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB25 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB25 Gene

Genomics for ZBTB25 Gene

GeneHancer (GH) Regulatory Elements for ZBTB25 Gene

Promoters and enhancers for ZBTB25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I064499 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 553.5 +0.5 463 9.9 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB1 ZBTB25 LOC102723809 PPP1R36 AKAP5 HSPA2 TEX21P SYNE2 ENSG00000214770
GH14I064538 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 22.8 -35.5 -35534 4.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A BRCA1 ZNF48 YY1 GLIS2 LOC102723809 HSPA2 ZBTB25 ZBTB1 PPP1R36 ENSG00000214770 GCATP1 WDR89 SYNE2 PLEKHG3
GH14I064464 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 10.9 +39.6 39585 2.2 PKNOX1 RB1 ZNF76 ZEB1 ZNF335 GLIS2 EGR1 ZNF143 RUNX3 CEBPB AKAP5 ZBTB1 ZBTB25 PPP1R36 HSPA2
GH14I064618 Enhancer 0.6 ENCODE 21.3 -114.1 -114087 2.1 ZNF680 ZBTB21 ZNF223 ZNF664 ZNF791 ZNF213 POLR2A ZFP3 ZNF629 ZXDB GC14P064620 ZBTB1 ZBTB25 HSPA2 PPP1R36 NUP50P1
GH14I063675 Enhancer 1.2 Ensembl ENCODE 10.2 +827.7 827723 3.5 PKNOX1 CLOCK NEUROD1 FEZF1 ZNF2 BRCA1 ZNF213 E2F8 KLF7 FOS ENSG00000200693 ENSG00000214770 SGPP1 TEX21P RNU7-116P ZBTB25 SYNE2 ENSG00000202182 WDR89 GC14P063658
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB25 gene promoter:

Genomic Locations for ZBTB25 Gene

Genomic Locations for ZBTB25 Gene
chr14:64,449,106-64,505,213
(GRCh38/hg38)
Size:
56,108 bases
Orientation:
Minus strand
chr14:64,915,824-64,971,931
(GRCh37/hg19)

Genomic View for ZBTB25 Gene

Genes around ZBTB25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB25 Gene

Proteins for ZBTB25 Gene

  • Protein details for ZBTB25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24278-ZBT25_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 25
    Protein Accession:
    P24278
    Secondary Accessions:
    • B3KUX6
    • Q8IYH9

    Protein attributes for ZBTB25 Gene

    Size:
    435 amino acids
    Molecular mass:
    48990 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB25 Gene

Post-translational modifications for ZBTB25 Gene

  • Ubiquitination at posLast=405405
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZBTB25 Gene

Domains & Families for ZBTB25 Gene

Gene Families for ZBTB25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZBTB25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB25: view

No data available for UniProtKB/Swiss-Prot for ZBTB25 Gene

Function for ZBTB25 Gene

Molecular function for ZBTB25 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB25 Gene

Gene Ontology (GO) - Molecular Function for ZBTB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA,IEA 2027750
GO:0003700 DNA binding transcription factor activity TAS 2027750
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB25: view
genes like me logo Genes that share phenotypes with ZBTB25: view

Animal Model Products

miRNA for ZBTB25 Gene

miRTarBase miRNAs that target ZBTB25

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB25 Gene

Localization for ZBTB25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB25 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 2027750
genes like me logo Genes that share ontologies with ZBTB25: view

Pathways & Interactions for ZBTB25 Gene

SuperPathways for ZBTB25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010467 gene expression IEP 2027750
genes like me logo Genes that share ontologies with ZBTB25: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB25 Gene

Drugs & Compounds for ZBTB25 Gene

No Compound Related Data Available

Transcripts for ZBTB25 Gene

Unigene Clusters for ZBTB25 Gene

Zinc finger and BTB domain containing 25:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB25 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2: - - - - - -
SP3: - - -

Relevant External Links for ZBTB25 Gene

GeneLoc Exon Structure for
ZBTB25
ECgene alternative splicing isoforms for
ZBTB25

Expression for ZBTB25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB25 Gene

Protein differential expression in normal tissues from HIPED for ZBTB25 Gene

This gene is overexpressed in Uterus (22.3), Esophagus (13.8), Salivary gland (9.9), and Fetal gut (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBTB25 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZBTB25 Gene:

ZBTB25

SOURCE GeneReport for Unigene cluster for ZBTB25 Gene:

Hs.654571

mRNA Expression by UniProt/SwissProt for ZBTB25 Gene:

P24278-ZBT25_HUMAN
Tissue specificity: Expressed mainly in hematopoietic cells and testis.

Evidence on tissue expression from TISSUES for ZBTB25 Gene

  • Blood(4.2)
  • Kidney(2.4)
genes like me logo Genes that share expression patterns with ZBTB25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB25 Gene

Orthologs for ZBTB25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB25 33 34
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia ZBTB25 33 34
  • 93.79 (n)
dog
(Canis familiaris)
Mammalia ZBTB25 33 34
  • 93.64 (n)
mouse
(Mus musculus)
Mammalia Zbtb25 33 16 34
  • 90.11 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb25 33
  • 88.51 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB25 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB25 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB25 33 34
  • 67.29 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB25 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb25 33
  • 65.58 (n)
Str.19326 33
zebrafish
(Danio rerio)
Actinopterygii zbtb25 33 34
  • 51.33 (n)
Species where no ortholog for ZBTB25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB25 Gene

ENSEMBL:
Gene Tree for ZBTB25 (if available)
TreeFam:
Gene Tree for ZBTB25 (if available)

Paralogs for ZBTB25 Gene

Paralogs for ZBTB25 Gene

genes like me logo Genes that share paralogs with ZBTB25: view

Variants for ZBTB25 Gene

Sequence variations from dbSNP and Humsavar for ZBTB25 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000036268 -- 64,472,171(-) A/T genic_downstream_transcript_variant, intron_variant
rs1000133290 -- 64,493,147(-) A/G/T intron_variant
rs1000163932 -- 64,478,551(-) T/C/G genic_downstream_transcript_variant, intron_variant
rs1000169706 -- 64,477,938(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000283333 -- 64,486,506(-) A/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB25 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV deletion 23290073
nsv1126366 CNV deletion 24896259
nsv521823 CNV loss 19592680

Variation tolerance for ZBTB25 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB25 Gene

Disorders for ZBTB25 Gene

Additional Disease Information for ZBTB25

No disorders were found for ZBTB25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB25 Gene

Publications for ZBTB25 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers. (PMID: 2027750) Chardin P … Gisselbrecht S (Nucleic acids research 1991) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZBTB25 Gene

Sources for ZBTB25 Gene

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