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Aliases for ZBTB22 Gene

Aliases for ZBTB22 Gene

  • Zinc Finger And BTB Domain Containing 22 2 3 5
  • Zinc Finger Protein 297 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 22A 3 4
  • ZBTB22A 3 4
  • ZNF297 3 4
  • BING1 3 4
  • Zinc Finger And BTB Domain-Containing Protein 22 3
  • Protein BING1 4
  • Fruitless 3
  • ZNF297A 3
  • Fru 3

External Ids for ZBTB22 Gene

Previous HGNC Symbols for ZBTB22 Gene

  • ZNF297

Previous GeneCards Identifiers for ZBTB22 Gene

  • GC06M033391
  • GC06M033282
  • GC06M033023

Summaries for ZBTB22 Gene

GeneCards Summary for ZBTB22 Gene

ZBTB22 (Zinc Finger And BTB Domain Containing 22) is a Protein Coding gene. Diseases associated with ZBTB22 include Lobomycosis and Penis Squamous Cell Carcinoma. An important paralog of this gene is ZBTB43.

UniProtKB/Swiss-Prot for ZBTB22 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB22 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB22 Gene

Genomics for ZBTB22 Gene

GeneHancer (GH) Regulatory Elements for ZBTB22 Gene

Promoters and enhancers for ZBTB22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I033311 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.2 -244 13 CLOCK MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF263 DAXX TAPBP ZBTB22 VPS52 RING1 PHF1 HCG25 PFDN6 WDR46 B3GALT4
GH06I034233 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.7 -924.3 -924314 17.1 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SMIM29 MIR6835 HMGA1 LEMD2 DAXX WDR46 VPS52 TAF11 RGL2 HCG25
GH06I033270 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.9 +42.8 42813 8.4 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 RPS18 VPS52 B3GALT4 PIR43330 BRD2 LEMD2 DAXX RXRB RING1 WDR46
GH06I032965 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.7 +347.3 347273 10.4 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 BRD2 HLA-DMA ENSG00000223837 LEMD2 VPS52 RXRB ATF6B DAXX HCG25 RING1
GH06I033198 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.8 +116.9 116941 4 MLX FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 RXRB RNY4P10 GC06P033199 SLC39A7 DAXX BRD2 WDR46 RGL2 LEMD2 RPS18
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB22 gene promoter:

Genomic Locations for ZBTB22 Gene

Genomic Locations for ZBTB22 Gene
chr6:33,314,405-33,317,942
(GRCh38/hg38)
Size:
3,538 bases
Orientation:
Minus strand
chr6:33,282,182-33,285,719
(GRCh37/hg19)

Genomic View for ZBTB22 Gene

Genes around ZBTB22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for ZBTB22 Gene

  • Protein details for ZBTB22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15209-ZBT22_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 22
    Protein Accession:
    O15209
    Secondary Accessions:
    • B0V007
    • Q5HYV4
    • Q5STL0
    • Q5STR7
    • Q8WV82

    Protein attributes for ZBTB22 Gene

    Size:
    634 amino acids
    Molecular mass:
    65602 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB22 Gene

Post-translational modifications for ZBTB22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB22 Gene

No data available for DME Specific Peptides for ZBTB22 Gene

Domains & Families for ZBTB22 Gene

Gene Families for ZBTB22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZBTB22 Gene

Graphical View of Domain Structure for InterPro Entry

O15209

UniProtKB/Swiss-Prot:

ZBT22_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZBTB22: view

Function for ZBTB22 Gene

Molecular function for ZBTB22 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB22 Gene

Gene Ontology (GO) - Molecular Function for ZBTB22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,TAS --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB22: view
genes like me logo Genes that share phenotypes with ZBTB22: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB22 Gene

Localization for ZBTB22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB22 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB22 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IEA --
genes like me logo Genes that share ontologies with ZBTB22: view

Pathways & Interactions for ZBTB22 Gene

SuperPathways for ZBTB22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB22: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB22 Gene

Drugs & Compounds for ZBTB22 Gene

(1) Drugs for ZBTB22 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved, Vet_approved Pharma Channel blocker 1232
genes like me logo Genes that share compounds with ZBTB22: view

Transcripts for ZBTB22 Gene

mRNA/cDNA for ZBTB22 Gene

Unigene Clusters for ZBTB22 Gene

Zinc finger and BTB domain containing 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB22 Gene

No ASD Table

Relevant External Links for ZBTB22 Gene

GeneLoc Exon Structure for
ZBTB22
ECgene alternative splicing isoforms for
ZBTB22

Expression for ZBTB22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB22 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZBTB22 Gene:

ZBTB22

SOURCE GeneReport for Unigene cluster for ZBTB22 Gene:

Hs.206770

Evidence on tissue expression from TISSUES for ZBTB22 Gene

  • Nervous system(4.7)
  • Liver(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with ZBTB22: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB22 Gene

Orthologs for ZBTB22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB22 33 34
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia ZBTB22 33 34
  • 88.62 (n)
cow
(Bos Taurus)
Mammalia ZBTB22 33 34
  • 86.16 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB22 34
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb22 33 16 34
  • 83.74 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb22 33
  • 83.63 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB22 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb22 33
  • 65.61 (n)
zebrafish
(Danio rerio)
Actinopterygii zbtb22b 33 34
  • 55.64 (n)
ZBTB22 (2 of 2) 34
  • 38 (a)
OneToMany
wufj98b06 33
Species where no ortholog for ZBTB22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB22 Gene

ENSEMBL:
Gene Tree for ZBTB22 (if available)
TreeFam:
Gene Tree for ZBTB22 (if available)

Paralogs for ZBTB22 Gene

genes like me logo Genes that share paralogs with ZBTB22: view

Variants for ZBTB22 Gene

Sequence variations from dbSNP and Humsavar for ZBTB22 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs3130100 benign, not specified 33,315,989(-) T/C coding_sequence_variant, missense_variant
rs1003670609 -- 33,318,090(-) CCCCC/CCCC upstream_transcript_variant
rs1003885439 -- 33,314,867(-) G/A 3_prime_UTR_variant
rs1004961832 -- 33,317,351(-) C/T intron_variant
rs1006445996 -- 33,319,370(-) TTGTT/TT upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB22 Gene

Variant ID Type Subtype PubMed ID
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv472857 CNV novel sequence insertion 20440878
nsv830634 CNV loss 17160897
nsv830635 CNV loss 17160897

Variation tolerance for ZBTB22 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB22 Gene

Human Gene Mutation Database (HGMD)
ZBTB22
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB22 Gene

Disorders for ZBTB22 Gene

MalaCards: The human disease database

(10) MalaCards diseases for ZBTB22 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
lobomycosis
  • cutaneous blastomycosis
penis squamous cell carcinoma
  • epidermoid cell carcinoma of penis
anosognosia
dermatographia
  • dermatographic urticaria
granulomatous amebic encephalitis
  • acanthamoeba encephalitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZBTB22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZBTB22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB22 Gene

Publications for ZBTB22 Gene

  1. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PMID: 9545376) Herberg JA … Trowsdale J (Journal of molecular biology 1998) 3 4 58

Products for ZBTB22 Gene

Sources for ZBTB22 Gene

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