Aliases for ZBTB20 Gene
External Ids for ZBTB20 Gene
Previous HGNC Symbols for ZBTB20 Gene
Previous GeneCards Identifiers for ZBTB20 Gene
This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
GeneCards Summary for ZBTB20 Gene
ZBTB20 (Zinc Finger And BTB Domain Containing 20) is a Protein Coding gene. Diseases associated with ZBTB20 include Primrose Syndrome and Major Depressive Disorder. Gene Ontology (GO) annotations related to this gene include proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific. An important paralog of this gene is HIC1.
UniProtKB/Swiss-Prot Summary for ZBTB20 Gene
May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (PubMed:11352661). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).