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ZBTB17 Gene(Protein Coding)

Zinc Finger And BTB Domain Containing 17

GCID:
GC01M015943
GIFtS:
50
Genes Participants
UDN Logo

Aliases for ZBTB17 Gene

Aliases for ZBTB17 Gene

  • Zinc Finger And BTB Domain Containing 17 2 3 5
  • Zinc Finger Protein 60 2 3 4
  • Zinc Finger Protein 151 (PHZ-67) 2 3
  • ZNF151 3 4
  • MIZ-1 3 4
  • ZNF60 3 4
  • Zinc Finger And BTB Domain-Containing Protein 17 3
  • Myc-Interacting Zinc Finger Protein 1 4
  • Myc-Interacting Zn Finger Protein-1 3
  • Zinc Finger Protein 151 4
  • PHZ-67 3
  • MIZ1 4

External Ids for ZBTB17 Gene

Previous HGNC Symbols for ZBTB17 Gene

  • ZNF151
  • ZNF60

Previous GeneCards Identifiers for ZBTB17 Gene

  • GC01M016013
  • GC01M016140
  • GC01M016268
  • GC01M014787

Summaries for ZBTB17 Gene

Entrez Gene Summary for ZBTB17 Gene

  • This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZBTB17 Gene

ZBTB17 (Zinc Finger And BTB Domain Containing 17) is a Protein Coding gene. Diseases associated with ZBTB17 include Split-Hand/Foot Malformation 1 and Dilated Cardiomyopathy. Among its related pathways are Unfolded Protein Response (UPR) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZBTB49.

UniProtKB/Swiss-Prot for ZBTB17 Gene

  • Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).

Gene Wiki entry for ZBTB17 Gene

Additional gene information for ZBTB17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB17 Gene

Genomics for ZBTB17 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for ZBTB17 Gene

Promoters and enhancers for ZBTB17 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01I015974 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.5 491 2.7 HDGF PKNOX1 MLX ARNT ARID4B SIN3A ZNF2 ZBTB7B IRF4 YY1 TBC1D3P6 ZBTB17 HSPB7 CROCCP3 LINC01772 CROCC SRARP ENSG00000234607
GH01I016902 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 47.7 -928.9 -928918 4.9 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000272426 CROCC ZBTB17 CROCCP3 LINC01772 RPL22P3 ARHGEF19 MFAP2 NBPF1 NECAP2
GH01I015846 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 31.6 +126.4 126433 6.4 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MEF2D SPEN FLJ37453 ENSG00000237938 ZBTB17 ARHGEF19 HSPB7 CLCNKA NECAP2 RPS16P1 RPL22P3
GH01I015829 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 34 +142.1 142131 9.6 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000237938 ZBTB17 SPEN ARHGEF19 CLCNKA NECAP2 FLJ37453 HSPB7 RPS16P1 RPL22P3
GH01I016729 Enhancer 1.2 ENCODE dbSUPER 40.4 -751.4 -751409 0.2 HNRNPUL1 ARNT FEZF1 GLI4 ZNF2 ETS1 GTF3C2 ZNF121 ZNF213 ZNF548 GC01P016729 TRG-CCC5-1 TRV-CAC13-1 SPEN ENSG00000237938 CROCC CROCCP3 RPS16P1 ZBTB17 RPL22P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB17 gene promoter:

Genomic Locations for ZBTB17 Gene

Genomic Locations for ZBTB17 Gene
chr1:15,941,869-15,976,132
(GRCh38/hg38)
Size:
34,264 bases
Orientation:
Minus strand
chr1:16,268,364-16,302,627
(GRCh37/hg19)

Genomic View for ZBTB17 Gene

Genes around ZBTB17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB17 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZBTB17 Gene

Proteins for ZBTB17 Gene

Products:

  1. Antibody
  2. Protein
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  • Protein details for ZBTB17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13105-ZBT17_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 17
    Protein Accession:
    Q13105
    Secondary Accessions:
    • A0AV07
    • B4DXB4
    • B7ZLQ9
    • F5H411
    • Q15932
    • Q5JYB2
    • Q9NUC9

    Protein attributes for ZBTB17 Gene

    Size:
    803 amino acids
    Molecular mass:
    87928 Da
    Quaternary structure:
    • Homooligomerizes (via the BTB/POZ domain), multimerization is required for DNA binding. Interacts (via the C-terminal zinc fingers) with GIF1; the interaction results in the recruitment of MYB to the CDKN1A/p21 and CDKN1B promoters and repression of transcription. Interacts with TRAF2, interfering with the binding of UBC13 to TRAF2, and inhibiting TRAF2 E3 ligase activity. Interacts with MYC (via the C-terminal helix-loop-helix motif); the interaction inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. Interacts with BCL6; the interaction inhibits ZBTB17 transactivation activity on target genes involved in cell cycle arrest. Interacts with ZBTB49 isoform 3/ZNF509S1; this interaction blocks ZBTB17-mediated repression of RB1 (PubMed:25245946).

    Three dimensional structures from OCA and Proteopedia for ZBTB17 Gene

    Alternative splice isoforms for ZBTB17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB17 Gene

Protein Expression for ZBTB17 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZBTB17 Gene

  • Undergoes Lys-48-linked polyubiquitination at Lys-397 and Lys-481 and subsequent proteasomal degradation in a TRAF2-dependent manner.
  • Ubiquitination at posLast=397397 and isoforms=2, 3481
  • Modification sites at PhosphoSitePlus

Other Protein References for ZBTB17 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ZBTB17 (Miz-1/ZBTB17)
  • Abcam antibodies for ZBTB17

No data available for DME Specific Peptides for ZBTB17 Gene

Domains & Families for ZBTB17 Gene

Gene Families for ZBTB17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB17 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZBTB17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13105

UniProtKB/Swiss-Prot:

ZBT17_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZBTB17: view

Function for ZBTB17 Gene

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  2. CRISPR
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  4. Inhibitory RNA
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  6. Cell Line

Molecular function for ZBTB17 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).

Phenotypes From GWAS Catalog for ZBTB17 Gene

Gene Ontology (GO) - Molecular Function for ZBTB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP 9312026
GO:0001047 core promoter binding IDA 19160485
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP 9312026
GO:0001223 transcription coactivator binding IPI 19160485
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP 19160485
genes like me logo Genes that share ontologies with ZBTB17: view
genes like me logo Genes that share phenotypes with ZBTB17: view

Animal Models for ZBTB17 Gene

MGI Knock Outs for ZBTB17:

Animal Model Products

miRNA for ZBTB17 Gene

miRTarBase miRNAs that target ZBTB17

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB17 Gene

Localization for ZBTB17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB17 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB17 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZBTB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0032993 protein-DNA complex IMP 19160485
GO:0043234 protein complex IDA 19160485
genes like me logo Genes that share ontologies with ZBTB17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZBTB17 Gene

Pathways & Interactions for ZBTB17 Gene

genes like me logo Genes that share pathways with ZBTB17: view

Gene Ontology (GO) - Biological Process for ZBTB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001702 gastrulation with mouth forming second IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with ZBTB17: view

No data available for SIGNOR curated interactions for ZBTB17 Gene

Drugs & Compounds for ZBTB17 Gene

Products:

  1. Drug

(1) Drugs for ZBTB17 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 2430
genes like me logo Genes that share compounds with ZBTB17: view

Transcripts for ZBTB17 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ZBTB17 Gene

(13) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(269) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB17 Gene

Zinc finger and BTB domain containing 17:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^
SP1: - - - - - - - - - - - - - -
SP2:
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6:
SP7:
SP8:
SP9: - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - -
SP14: - - - - - -
SP15:
SP16: - - - - - -
SP17: - - -
SP18: - - - - - -
SP19:
SP20: - - - -
SP21:
SP22:
SP23:

ExUns: 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1:
SP2: - - - - -
SP3:
SP4:
SP5:
SP6: -
SP7: - - - -
SP8: - - - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - - - - - - - - - - - -
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23: -

Relevant External Links for ZBTB17 Gene

GeneLoc Exon Structure for
ZBTB17
ECgene alternative splicing isoforms for
ZBTB17

Expression for ZBTB17 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB17 Gene

mRNA expression in normal human tissues for ZBTB17 Gene
mRNA expression by BioGPS for ZBTB17 GenemRNA expression by GTEx for ZBTB17 Gene

Protein differential expression in normal tissues from HIPED for ZBTB17 Gene

This gene is overexpressed in Platelet (43.9) and Adrenal (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB17 Gene



Protein tissue co-expression partners for ZBTB17 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB17 Gene:

ZBTB17

SOURCE GeneReport for Unigene cluster for ZBTB17 Gene:

Hs.433764

mRNA Expression by UniProt/SwissProt for ZBTB17 Gene:

Q13105-ZBT17_HUMAN
Tissue specificity: Expressed in germinal center B-cells.

Evidence on tissue expression from TISSUES for ZBTB17 Gene

  • Nervous system(4.9)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with ZBTB17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB17 Gene

Orthologs for ZBTB17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZBTB17 33 34
  • 99.42 (n)
dog
(Canis familiaris)
 Mammalia ZBTB17 33 34
  • 90.84 (n)
cow
(Bos Taurus)
 Mammalia ZBTB17 33 34
  • 90.13 (n)
rat
(Rattus norvegicus)
 Mammalia Zbtb17 33
  • 86.82 (n)
mouse
(Mus musculus)
 Mammalia Zbtb17 33 16 34
  • 86.02 (n)
oppossum
(Monodelphis domestica)
 Mammalia ZBTB17 34
  • 79 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ZBTB17 34
  • 69 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ZBTB17 33 34
  • 76.37 (n)
lizard
(Anolis carolinensis)
 Reptilia ZBTB17 34
  • 65 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia zbtb17 33
  • 72.35 (n)
Str.20427 33
African clawed frog
(Xenopus laevis)
 Amphibia Xl.14330 33
zebrafish
(Danio rerio)
 Actinopterygii zbtb17 34
  • 61 (a)
 OneToOne
LOC564967 33
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.5542 34
  • 17 (a)
 OneToOne
Species where no ortholog for ZBTB17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB17 Gene

ENSEMBL:
Gene Tree for ZBTB17 (if available)
TreeFam:
Gene Tree for ZBTB17 (if available)

Paralogs for ZBTB17 Gene

Paralogs for ZBTB17 Gene

(315) SIMAP similar genes for ZBTB17 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZBTB17: view

Variants for ZBTB17 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for ZBTB17 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000014596 -- 15,973,304(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000034969 -- 15,944,717(-) C/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000063228 -- 15,951,672(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000200450 -- 15,946,088(-) C/T intron_variant
rs1000342333 -- 15,957,388(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB17 Gene

Variant ID Type Subtype PubMed ID
nsv508936 CNV insertion 20534489
nsv833647 CNV loss 17160897
nsv833758 CNV gain+loss 17160897
nsv954843 CNV deletion 24416366

Variation tolerance for ZBTB17 Gene

Residual Variation Intolerance Score: 9.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB17 Gene

Disorders for ZBTB17 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZBTB17 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
split-hand/foot malformation 1
  • shfm1
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZBTB17

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZBTB17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB17 Gene

Publications for ZBTB17 Gene

  1. A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain. (PMID: 17880999) Stead MA … Wright SC (Journal of molecular biology 2007) 3 4 22 58
  2. A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells. (PMID: 14739298) Sakurai T … Fujita J (The Journal of biological chemistry 2004) 3 4 22 58
  3. Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1. (PMID: 12244100) Piluso D … Capone JP (The Journal of biological chemistry 2002) 3 4 22 58
  4. Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc. (PMID: 9308237) Schneider A … Hänel F (Current topics in microbiology and immunology 1997) 3 4 22 58
  5. An alternative pathway for gene regulation by Myc. (PMID: 9312026) Peukert K … Eilers M (The EMBO journal 1997) 3 4 22 58

Products for ZBTB17 Gene

Sources for ZBTB17 Gene