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This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008] See more...
Aliases for ZBTB17 Gene
Aliases for ZBTB17 Gene
External Ids for ZBTB17 Gene
- HGNC: 12936
- Entrez Gene: 7709
- Ensembl: ENSG00000116809
- OMIM: 604084
- UniProtKB: Q13105
Previous HGNC Symbols for ZBTB17 Gene
- ZNF151
- ZNF60
Previous GeneCards Identifiers for ZBTB17 Gene
- GC01M016013
- GC01M016140
- GC01M016268
- GC01M014787
Summaries for ZBTB17 Gene
-
This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZBTB17 Gene
ZBTB17 (Zinc Finger And BTB Domain Containing 17) is a Protein Coding gene. Diseases associated with ZBTB17 include Dilated Cardiomyopathy. Among its related pathways are C-MYC pathway and Validated targets of C-MYC transcriptional repression. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF287.
UniProtKB/Swiss-Prot Summary for ZBTB17 Gene
-
Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).
Additional gene information for ZBTB17 Gene
- Monarch Initiative
- Search for ZBTB17 at DataMed
- Search for ZBTB17 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB17 Gene
Genomics for ZBTB17 Gene
GeneHancer (GH) Regulatory Elements for ZBTB17 Gene
Promoters and enhancers for ZBTB17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZBTB17 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ZBTB17 gene promoter:
-
- AP-1
- c-Fos
- CUTL1
- GR
- GR-alpha
- Max1
- SRY
- STAT3
- USF-1
- USF1
Genomic Locations for ZBTB17 Gene
Genomic Locations for ZBTB17 Gene
- chr1:15,941,869-15,976,132
- (GRCh38/hg38)
- Size:
- 34,264 bases
- Orientation:
- Minus strand
- chr1:16,268,364-16,302,627
- (GRCh37/hg19)
- Size:
- 34,264 bases
- Orientation:
- Minus strand
Genomic View for ZBTB17 Gene
Genes around ZBTB17 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.13 by HGNC
- 1p36.13 by Entrez Gene
- 1p36.13 by Ensembl
ZBTB17 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZBTB17 Gene
Proteins for ZBTB17 Gene
-
Protein details for ZBTB17 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13105-ZBT17_HUMAN
- Recommended name:
- Zinc finger and BTB domain-containing protein 17
- Protein Accession:
- Q13105
- A0AV07
- B4DXB4
- B7ZLQ9
- F5H411
- Q15932
- Q5JYB2
- Q9NUC9
Protein attributes for ZBTB17 Gene
- Size:
- 803 amino acids
- Molecular mass:
- 87928 Da
- Quaternary structure:
-
- Homooligomerizes (via the BTB/POZ domain), multimerization is required for DNA binding. Interacts (via the C-terminal zinc fingers) with GIF1; the interaction results in the recruitment of MYB to the CDKN1A/p21 and CDKN1B promoters and repression of transcription. Interacts with TRAF2, interfering with the binding of UBC13 to TRAF2, and inhibiting TRAF2 E3 ligase activity. Interacts with MYC (via the C-terminal helix-loop-helix motif); the interaction inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. Interacts with BCL6; the interaction inhibits ZBTB17 transactivation activity on target genes involved in cell cycle arrest. Interacts with ZBTB49 isoform 3/ZNF509S1; this interaction blocks ZBTB17-mediated repression of RB1 (PubMed:25245946).
Three dimensional structures from OCA and Proteopedia for ZBTB17 Gene
Protein Expression for ZBTB17 Gene
Post-translational modifications for ZBTB17 Gene
- Undergoes 'Lys-48'-linked polyubiquitination at Lys-397 and Lys-481 and subsequent proteasomal degradation in a TRAF2-dependent manner.
-
Ubiquitination at Lys397 and Lys481
- NX_Q13105 (NX_Q13105-1)
- Modification sites at PhosphoSitePlus
Other Protein References for ZBTB17 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ ZBTB17 Antibody
- Atlas Antibodies Anti-ZBTB17 Antibody
- Creative Diagnostics Anti-ZBTB17 (aa 113-142) polyclonal antibody and Anti-ZBTB17 (aa 84-225) polyclonal antibody
- GeneTex Anti-Miz1 antibody
- Novus Biologicals Antibodies for ZBTB17
-
Abcam antibodies for ZBTB17
- Invitrogen Antibodies for ZBTB17 (AFLGC-ZBTB17)
-
Biorbyt antibodies for ZBTB17
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZBTB17
Protein Products
- G Biosciences Human Miz-1/ZBTB17, Lyophilized
- Atlas Antibodies PrEST Antigen ZBTB17
- Creative Biomart Recombinant Human ZBTB17, His-tagged, Recombinant Human ZBTB17 293 Cell Lysate, and Recombinant Human ZBTB17
- Search Origene for MassSpec and Protein Over-expression Lysates for ZBTB17
- Origene Custom Protein Services for ZBTB17
-
ProSci Proteins for ZBTB17
-
Abcam proteins for ZBTB17
No data available for DME Specific Peptides for ZBTB17 Gene
Domains & Families for ZBTB17 Gene
Gene Families for ZBTB17 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZBTB17 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZBTB17 Gene
- GenScript: Design optimal peptide antigens:
-
- Zinc finger and BTB domain containing 17 (Q5JYB1_HUMAN)
- Zinc finger protein 60 (ZBT17_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q13105- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZBTB17 Gene
Molecular function for ZBTB17 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).
Phenotypes From GWAS Catalog for ZBTB17 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IMP | 9312026 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0001047 | core promoter binding | IDA | 19160485 |
| GO:0001223 | transcription coactivator binding | IPI | 19160485 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IMP | 9312026 |
Phenotypes for ZBTB17 Gene
- MGI mutant phenotypes for ZBTB17:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ZBTB17:
Animal Models for ZBTB17 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for ZBTB17
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZBTB17
- genomics-online: gRNA clones - Search results for available ZBTB17 gene related products
- Applied Biological Materials (abm): CRISPR Clones for ZBTB17 - Select products 50% OFF >
- * ZBTB17 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ZBTB17 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZBTB17
miRNA for ZBTB17 Gene
- miRTarBase miRNAs that target ZBTB17
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ZBTB17
- Browse OriGene Inhibitory RNA Products For ZBTB17
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB17
- genomics-online: shRNA clones - Search results for available ZBTB17 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ZBTB17
- Addgene plasmids for ZBTB17
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZBTB17
- genomics-online: cdna clones - Search results for available ZBTB17 gene related products
- orf clones - Search results for available ZBTB17 gene related products
- Applied Biological Materials (abm): Clones for ZBTB17 - Select products 50% OFF >
- * ZBTB17 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ZBTB17 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB17 Gene
Localization for ZBTB17 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZBTB17 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0032991 | protein-containing complex | IDA | 19160485 |
| GO:0032993 | protein-DNA complex | IMP | 19160485 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZBTB17 Gene
Pathways & Interactions for ZBTB17 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Unfolded Protein Response (UPR) | ||
| 2 | Cell cycle |
.58
|
|
| 3 | Pathways in cancer | ||
| 4 | Small cell lung cancer | ||
| 5 | Transcriptional misregulation in cancer | ||
Pathways by source for ZBTB17 Gene
4 BioSystems pathways for ZBTB17 Gene
4 Reactome pathways for ZBTB17 Gene
4 KEGG pathways for ZBTB17 Gene
Interacting Proteins for ZBTB17 Gene
Selected Interacting proteins:
Q13105-ZBT17_HUMAN
ENSP00000364885
for ZBTB17 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ZBTB17
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001702 | gastrulation with mouth forming second | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007398 | ectoderm development | IEA | -- |
| GO:0008285 | negative regulation of cell proliferation | IDA | 19160485 |
| GO:0036498 | IRE1-mediated unfolded protein response | TAS | -- |
Drugs & Compounds for ZBTB17 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Zinc | Approved, Investigational | Pharma | 2741 |
Drug Products
- G Biosciences Human Miz-1/ZBTB17, Lyophilized
- Atlas Antibodies PrEST Antigen ZBTB17
- Creative Biomart Recombinant Human ZBTB17, His-tagged, Recombinant Human ZBTB17 293 Cell Lysate, and Recombinant Human ZBTB17
Transcripts for ZBTB17 Gene
mRNA/cDNA for ZBTB17 Gene
- (6) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (269) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000375733 2770 bps (ENST00000375733.6)
- ENST00000375743 2745 bps (ENST00000375743.8)
- ENST00000440560 731 bps (ENST00000440560.5)
- ENST00000444358 722 bps (ENST00000444358.1)
- ENST00000462525 776 bps (ENST00000462525.1)
CRISPR Products
-
OriGene CRISPR knockouts for ZBTB17
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZBTB17
- genomics-online: gRNA clones - Search results for available ZBTB17 gene related products
- Applied Biological Materials (abm): CRISPR Clones for ZBTB17 - Select products 50% OFF >
- * ZBTB17 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ZBTB17 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZBTB17
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ZBTB17
- Browse OriGene Inhibitory RNA Products For ZBTB17
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB17
- genomics-online: shRNA clones - Search results for available ZBTB17 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ZBTB17
- Addgene plasmids for ZBTB17
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZBTB17
- genomics-online: cdna clones - Search results for available ZBTB17 gene related products
- orf clones - Search results for available ZBTB17 gene related products
- Applied Biological Materials (abm): Clones for ZBTB17 - Select products 50% OFF >
- * ZBTB17 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ZBTB17 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: |
| ExUns: | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | · | 14d | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP22: | |||||||||||||||||||||||||||||||||||||||||||
| SP23: | - |
Expression for ZBTB17 Gene
This gene is overexpressed in Platelet (43.9) and Adrenal (17.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBTB17 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZBTB17 Gene:
ZBTB17SOURCE GeneReport for Unigene cluster for ZBTB17 Gene:
Hs.433764mRNA Expression by UniProt/SwissProt for ZBTB17 Gene:
Q13105-ZBT17_HUMAN
Tissue specificity:
Expressed in germinal center B-cells.
Evidence on tissue expression from TISSUES for ZBTB17 Gene
- Nervous system(4.9)
- Eye(2.1)
Primer Products
-
OriGene qPCR primer pairs for ZBTB17
- genomics-online: primer clones - Search results for available ZBTB17 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB17 Gene
Orthologs for ZBTB17 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZBTB17 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ZBTB17 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ZBTB17 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Zbtb17 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Zbtb17 17 33 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZBTB17 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZBTB17 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZBTB17 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ZBTB17 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | zbtb17 32 |
|
||
| Str.20427 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14330 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zbtb17 33 |
|
OneToOne | |
| LOC564967 32 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5542 33 |
|
OneToOne |
- Species where no ortholog for ZBTB17 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ZBTB17 Gene
- ENSEMBL:
- Gene Tree for ZBTB17 (if available)
- TreeFam:
- Gene Tree for ZBTB17 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZBTB17: view image
Paralogs for ZBTB17 Gene
Paralogs for ZBTB17 Gene
- ZNF287 5
- ZNF852 5
- ZNF407 5
- ZNF416 5
- MYNN 5
- ZNF17 5
- ZNF214 5
- ZNF233 5
- ZNF417 5
- ZNF285 5
- ZNF527 5
- ZNF587 5
- ZNF34 5
- ZNF530 5
- ZNF426 5
- ZNF592 5
- ZNF136 5
- ZNF774 5
- ZNF333 5
- ZNF572 5
- ZNF697 5
- ZNF467 5
- ZBTB41 5
- ZNF777 5
- ZNF408 5
- ZKSCAN7 5
- GZF1 5
- ZNF768 5
- ZNF644 5
- ZNF155 5
- ZNF776 5
- ZNF507 5
- ZNF627 5
- ZNF687 5
- ZNF319 5
- ZNF398 5
- ZNF222 5
- ZNF670 5
- PRDM2 5
- ZNF547 5
- ZNF646 5
- ZNF230 5
- PRDM4 5
- ENSG00000267022 5
- ZNF223 5
- ZNF625 5
- ZFP57 5
- ZNF707 5
- ZNF746 5
- ENSG00000284691 5
- WIZ 5
- ZNF784 5
- ZNF781 5
- ENSG00000268750 5
- ENSG00000269026 5
- ENSG00000269533 5
(315) SIMAP similar genes for ZBTB17 Gene using alignment to 4 proteins:
- ZBT17_HUMAN
- E7EPQ4_HUMAN
- H0Y6X2_HUMAN
- H7C1K8_HUMAN
- ZBTB7C
- ZBTB25
- KLHL32
- ZNF55
- ZBTB4
- ZNF78L1
- BACH2
- ZFS-5
- ZNF514
- ZNF141
- ZNF426
- ZNF93
- ZNF
- ZNF562
- ZNF782
- ZNF701
- ZNF606
- ZIK1
- ZNF323
- ZNF253
- ZNF112
- ZNF826P
- ZNF664
- ZNF502
- ZNF473
- ZNF181
- ZFP112
- ZFP1
- MYNN
- DKFZp686O1631
- ZNF570
- ZFS-6
- ZFS-4
- ZFS-1
- kr-znf3
- ZSCAN32
- ZNF818P
- ZSCAN10
- ZNF98
- ZNF724P
- ZNF675
- ZNF624
- ZNF544
- ZNF430
- ZNF324
- ZNF28
- ZNF226
- ZFP2
- Nbla00121
- DKFZp434J0650
- ZNF726
- ZNF254
- ZNF737
- ZNF566
- ZNF35
- ZNF204
- ZSCAN5A
- ZSCAN2
- ZNF878
- ZNF846
- ZNF79
- ZNF720
- ZNF714
- ZNF676
- ZNF583
- ZNF493
- ZNF492
- ZNF45
- ZNF431
- ZNF345
- ZNF304
- ZNF287
- ZNF266
- ZNF133
- HZF16
- DKFZp686M04222
- DKFZp666C237
- DKFZp434G1930
- DKFZp313M0722
- BCL6
- ZNF808
- ZNF83
- ZNF85
- ZNF480
- ZNF56
- ZNF283
- ZNF728
- ZNF479
- ZNF420
- ZNF565
- zf30
- ZNF485
- ZNF92
- ZNF90
- ZNF880
- ZNF816
- ZNF813
- ZNF768
- ZNF711
- ZNF671
- ZNF66
- ZNF615
- ZNF585A
- ZNF551
- ZNF550
- ZNF528
- ZNF527
- ZNF484
- ZNF471
- ZNF417
- ZNF285
- ZNF211
- ZNF136
- ZFP28
- KIAA1829
- DKFZp686K03205
- MST154
- GFI1B
- GFI1
- PRDM9
- ZNF585B
- ZNF525
- ZNF778
- PRMD9
- ZNF22
- ZFS-2
- ZNF587B
- HZF17
- DKFZp762K012
- smap-7
- ZSCAN31
- ZNF876P
- ZNF844
- ZNF72
- ZNF561
- ZNF101
- ZNF888
- ZNF879
- ZNF845
- ZNF681
- ZNF564
- ZNF418
- ZNF26
- ZNF197
- ZNF19
- ZNF182
- ZNF10
- ZFP37
- ZFP14
- BCL6B
- GZF1
- ZNF702P
- ZNF697
- ZNF146
- ZNF571
- HZF36
- ZSCAN21
- ZNF558
- ZNF282
- ZNF257
- ZNF124
- ZNF114
- ZNF850
- ZNF841
- ZNF678
- ZNF649
- ZNF626
- ZNF567
- ZNF454
- ZNF331
- ZNF267
- ZNF23
- ZNF223
- HZF14
- FIZ1
- DKFZp686H20223
- DKFZp571N1833
- DKFZp570I0164
- ZNF501
- ZNF833P
- ZNF80
- ZNF589
- ZNF32
- ZNF852
- ZNF805
- HZF30
- A-328A3.4
- ZNF763
- ZNF883
- ZNF73
- ZNF705F
- ZNF705D
- ZNF621
- ZNF600
- ZKSCAN1
- ZFP41
- ZNF814
- ZNF786
- ZNF708
- ZNF665
- ZNF658B
- ZNF658
- ZNF595
- ZNF436
- ZNF384
- ZNF232
- ZNF225
- ZNF160
- ZFP3
- DKFZp686D2168
- HKR1
- ZNF410
- ZNF391
- DKFZp666M039
- ZNF138
- ZNF234
- ZNF75A
- ZNF726P1
- ZNF137P
- ZNF709
- ZNF699
- ZNF569
- ZNF568
- ZNF497
- ZNF429
- ZNF132
- ZKSCAN7
- MAZ
- DKFZp686B16128
- HZF28
- ZNF660
- ZNF625
- ZNF2
- ZNF540
- ZNF705A
- ZNF468
- ZNF33B
- ZNF3
- ZNF263
- ZNF91
- ZNF84
- ZNF835
- ZNF780A
- ZNF700
- ZNF628
- ZNF613
- ZNF43
- ZNF271
- ZNF264
- ZNF229
- ZNF227
- ZNF208
- ZNF16
- ZNF14
- ZNF107
- ZBTB47
- PRDM15
- PRDM10
- DKFZp547L155
- ZNF7
- KLF1
- ZNF771
- ZNF696
- ZNF729
- ZNF573
- CTCFL
- ZNF500
- ZNF761
- ZNF717
- ZNF584
- ZNF534
- ZNF490
- ZNF470
- ZNF347
- ZNF34
- ZNF235
- ZNF135
- ZFP62
- VEZF1
- PRDM16
- MECOM
- HZF40
- ZNF99
- ZNF669
- ZNF213
- ZNF76
- ZNF71
- ZNF616
- ZNF517
- ZFP64
- PLAGL1
- ZNF791
- ZNF705E
- ZNF284
- ZFS-3
- ZBTB48
- ZNF836
- ZNF721
- ZNF563
- ZNF546
- ZNF224
- ZNF770
- DKFZp547H249
- ZNF793
- ZNF710
- ZNF449
- ZNF442
- ZBTB21
- ZNF607
- ZNF599
- ZNF33A
- ZNF30
- ZNF251
- ZNF184
- E4F1
Variants for ZBTB17 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000014596 | -- | 15,973,304(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000034969 | -- | 15,944,717(-) | C/A | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000063228 | -- | 15,951,672(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000200450 | -- | 15,946,088(-) | C/T | intron_variant | |
| rs1000320835 | -- | 15,939,894(-) | C/A | downstream_transcript_variant |
Residual Variation Intolerance Score:
9.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.75;
33.21% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZBTB17 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZBTB17
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB17 Gene
Disorders for ZBTB17 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dilated cardiomyopathy |
|
|
Search ZBTB17 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZBTB17
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB17 Gene
Publications for ZBTB17 Gene
- A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain. (PMID: 17880999) Stead MA … Wright SC (Journal of molecular biology 2007) 3 4 23 56
- A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells. (PMID: 14739298) Sakurai T … Fujita J (The Journal of biological chemistry 2004) 3 4 23 56
- Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1. (PMID: 12244100) Piluso D … Capone JP (The Journal of biological chemistry 2002) 3 4 23 56
- Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc. (PMID: 9308237) Schneider A … Hänel F (Current topics in microbiology and immunology 1997) 3 4 23 56
- An alternative pathway for gene regulation by Myc. (PMID: 9312026) Peukert K … Eilers M (The EMBO journal 1997) 3 4 23 56
ExternalLinks
Products for ZBTB17 Gene
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- Biorbyt antibodies for ZBTB17
Sources for ZBTB17 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23)