Aliases for ZBTB17 Gene
External Ids for ZBTB17 Gene
Previous HGNC Symbols for ZBTB17 Gene
Previous GeneCards Identifiers for ZBTB17 Gene
This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZBTB17 Gene
ZBTB17 (Zinc Finger And BTB Domain Containing 17) is a Protein Coding gene. Diseases associated with ZBTB17 include Dilated Cardiomyopathy. Among its related pathways are C-MYC pathway and Validated targets of C-MYC transcriptional repression. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF287.
UniProtKB/Swiss-Prot Summary for ZBTB17 Gene
Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).