Aliases for ZBTB17 Gene
Aliases for ZBTB17 Gene
External Ids for ZBTB17 Gene
- HGNC: 12936
- Entrez Gene: 7709
- Ensembl: ENSG00000116809
- OMIM: 604084
- UniProtKB: Q13105
Previous HGNC Symbols for ZBTB17 Gene
- ZNF151
- ZNF60
Previous GeneCards Identifiers for ZBTB17 Gene
- GC01M016013
- GC01M016140
- GC01M016268
- GC01M014787
Summaries for ZBTB17 Gene
-
This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZBTB17 Gene
ZBTB17 (Zinc Finger And BTB Domain Containing 17) is a Protein Coding gene. Diseases associated with ZBTB17 include Dilated Cardiomyopathy. Among its related pathways are Pathways in cancer and C-MYC pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZBTB24.
UniProtKB/Swiss-Prot for ZBTB17 Gene
-
Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).
Additional gene information for ZBTB17 Gene
- Monarch Initiative
- Search for ZBTB17 at DataMed
- Search for ZBTB17 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB17 Gene
Genomics for ZBTB17 Gene
GeneHancer (GH) Regulatory Elements for ZBTB17 Gene
Promoters and enhancers for ZBTB17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZBTB17 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ZBTB17 Gene
Genomic Locations for ZBTB17 Gene
- chr1:15,941,869-15,976,132
- (GRCh38/hg38)
- Size:
- 34,264 bases
- Orientation:
- Minus strand
- chr1:16,268,364-16,302,627
- (GRCh37/hg19)
Genomic View for ZBTB17 Gene
Genes around ZBTB17 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.13 by Entrez Gene
- 1p36.13 by HGNC
- 1p36.13 by Ensembl
ZBTB17 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZBTB17 Gene
Proteins for ZBTB17 Gene
-
Protein details for ZBTB17 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13105-ZBT17_HUMAN
- Recommended name:
- Zinc finger and BTB domain-containing protein 17
- Protein Accession:
- Q13105
- A0AV07
- B4DXB4
- B7ZLQ9
- F5H411
- Q15932
- Q5JYB2
- Q9NUC9
Protein attributes for ZBTB17 Gene
- Size:
- 803 amino acids
- Molecular mass:
- 87928 Da
- Quaternary structure:
-
- Homooligomerizes (via the BTB/POZ domain), multimerization is required for DNA binding. Interacts (via the C-terminal zinc fingers) with GIF1; the interaction results in the recruitment of MYB to the CDKN1A/p21 and CDKN1B promoters and repression of transcription. Interacts with TRAF2, interfering with the binding of UBC13 to TRAF2, and inhibiting TRAF2 E3 ligase activity. Interacts with MYC (via the C-terminal helix-loop-helix motif); the interaction inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. Interacts with BCL6; the interaction inhibits ZBTB17 transactivation activity on target genes involved in cell cycle arrest. Interacts with ZBTB49 isoform 3/ZNF509S1; this interaction blocks ZBTB17-mediated repression of RB1 (PubMed:25245946).
Three dimensional structures from OCA and Proteopedia for ZBTB17 Gene
Protein Expression for ZBTB17 Gene
Post-translational modifications for ZBTB17 Gene
- Undergoes Lys-48-linked polyubiquitination at Lys-397 and Lys-481 and subsequent proteasomal degradation in a TRAF2-dependent manner.
- Ubiquitination at posLast=481481 and isoforms=2, 3397
- Modification sites at PhosphoSitePlus
Other Protein References for ZBTB17 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ZBTB17 (Miz-1/ZBTB17)
- Novus Biologicals Antibodies for ZBTB17
- Invitrogen Antibodies for ZBTB17
- GeneTex ZBTB17 Antibody for ZBTB17
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZBTB17
Protein Products
-
OriGene Purified Proteins for ZBTB17
- Search Origene for MassSpec and Protein Over-expression Lysates for ZBTB17
- Origene Custom Protein Services for ZBTB17
- Search GeneTex for Proteins for ZBTB17
-
ProSci Proteins for ZBTB17
Assay Products
No data available for DME Specific Peptides for ZBTB17 Gene
Domains & Families for ZBTB17 Gene
Gene Families for ZBTB17 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZBTB17 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZBTB17 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13105- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZBTB17 Gene
Molecular function for ZBTB17 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).
Phenotypes From GWAS Catalog for ZBTB17 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IMP | 9312026 |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0001047 | core promoter binding | IDA | 19160485 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IMP | 9312026 |
| GO:0001223 | transcription coactivator binding | IPI | 19160485 |
Phenotypes for ZBTB17 Gene
- MGI mutant phenotypes for ZBTB17:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ZBTB17:
Animal Models for ZBTB17 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZBTB17
-
CRISPR Products
-
OriGene CRISPR knockouts for ZBTB17
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZBTB17
- genomics-online: gRNA clones - Search results for available ZBTB17 gene related products
- Applied Biological Materials CRISPR for ZBTB17
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZBTB17
- GenScript: Design CRISPR guide RNA sequences for ZBTB17
miRNA for ZBTB17 Gene
- miRTarBase miRNAs that target ZBTB17
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZBTB17
- Browse OriGene Inhibitory RNA Products For ZBTB17
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB17
- genomics-online: shRNA clones - Search results for available ZBTB17 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ZBTB17
- VectorBuilder custom plasmid, inducible vectors for ZBTB17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZBTB17
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ZBTB17
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZBTB17
- genomics-online: cdna clones - Search results for available ZBTB17 gene related products
- orf clones - Search results for available ZBTB17 gene related products
- Applied Biological Materials Clones for ZBTB17
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB17 Gene
Localization for ZBTB17 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZBTB17 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0032991 | protein-containing complex | IDA | 19160485 |
| GO:0032993 | protein-DNA complex | IMP | 19160485 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZBTB17 Gene
Pathways & Interactions for ZBTB17 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Unfolded Protein Response (UPR) | ||
| 2 | Cell cycle |
.58
|
|
| 3 | Pathways in cancer | ||
| 4 | Small cell lung cancer | ||
| 5 | Transcriptional misregulation in cancer | ||
Pathways by source for ZBTB17 Gene
4 BioSystems pathways for ZBTB17 Gene
4 Reactome pathways for ZBTB17 Gene
4 KEGG pathways for ZBTB17 Gene
Interacting Proteins for ZBTB17 Gene
Selected Interacting proteins:
Q13105-ZBT17_HUMAN
ENSP00000364895
for ZBTB17 Gene via
UniProtKB
MINT
IID
STRING
GPS-Prot Interaction Network for ZBTB17
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001702 | gastrulation with mouth forming second | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for SIGNOR curated interactions for ZBTB17 Gene
Drugs & Compounds for ZBTB17 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Zinc | Approved, Investigational | Pharma | 2430 |
Transcripts for ZBTB17 Gene
mRNA/cDNA for ZBTB17 Gene
- (269) Selected AceView cDNA sequences:
- (16) Additional mRNA sequences :
- (13) REFSEQ mRNAs :
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000375733 2770 bps (uc010obr.3)
- ENST00000375743 2745 bps (uc001axl.5)
- ENST00000440560 731 bps (uc057cpn.1)
- ENST00000444358 722 bps (uc057cpo.1)
- ENST00000462525 776 bps (uc057cpm.1)
Unigene Clusters for ZBTB17 Gene
- Zinc finger and BTB domain containing 17:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ZBTB17
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZBTB17
- genomics-online: gRNA clones - Search results for available ZBTB17 gene related products
- Applied Biological Materials CRISPR for ZBTB17
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZBTB17
- GenScript: Design CRISPR guide RNA sequences for ZBTB17
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZBTB17
- Browse OriGene Inhibitory RNA Products For ZBTB17
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB17
- genomics-online: shRNA clones - Search results for available ZBTB17 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ZBTB17
- VectorBuilder custom plasmid, inducible vectors for ZBTB17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZBTB17
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ZBTB17
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZBTB17
- genomics-online: cdna clones - Search results for available ZBTB17 gene related products
- orf clones - Search results for available ZBTB17 gene related products
- Applied Biological Materials Clones for ZBTB17
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: |
| ExUns: | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | · | 14d | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP22: | |||||||||||||||||||||||||||||||||||||||||||
| SP23: | - |
Expression for ZBTB17 Gene
This gene is overexpressed in Platelet (43.9) and Adrenal (17.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBTB17 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZBTB17 Gene:
ZBTB17SOURCE GeneReport for Unigene cluster for ZBTB17 Gene:
Hs.433764mRNA Expression by UniProt/SwissProt for ZBTB17 Gene:
Q13105-ZBT17_HUMAN
Tissue specificity:
Expressed in germinal center B-cells.
Evidence on tissue expression from TISSUES for ZBTB17 Gene
- Nervous system(4.9)
- Eye(2.1)
Primer Products
-
OriGene qPCR primer pairs for ZBTB17
- genomics-online: primer clones - Search results for available ZBTB17 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB17 Gene
Orthologs for ZBTB17 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZBTB17 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ZBTB17 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ZBTB17 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Zbtb17 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Zbtb17 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZBTB17 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZBTB17 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZBTB17 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ZBTB17 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | zbtb17 33 |
|
||
| Str.20427 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14330 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zbtb17 34 |
|
OneToOne | |
| LOC564967 33 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5542 34 |
|
OneToOne |
- Species where no ortholog for ZBTB17 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ZBTB17 Gene
- ENSEMBL:
- Gene Tree for ZBTB17 (if available)
- TreeFam:
- Gene Tree for ZBTB17 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZBTB17: view image
Paralogs for ZBTB17 Gene
(315) SIMAP similar genes for ZBTB17 Gene using alignment to 4 proteins:
- ZBT17_HUMAN
- E7EPQ4_HUMAN
- H0Y6X2_HUMAN
- H7C1K8_HUMAN
- ZBTB7C
- ZBTB25
- KLHL32
- ZNF55
- ZBTB4
- ZNF78L1
- BACH2
- ZFS-5
- ZNF514
- ZNF141
- ZNF426
- ZNF93
- ZNF
- ZNF562
- ZNF782
- ZNF701
- ZNF606
- ZIK1
- ZNF323
- ZNF253
- ZNF112
- ZNF826P
- ZNF664
- ZNF502
- ZNF473
- ZNF181
- ZFP112
- ZFP1
- MYNN
- DKFZp686O1631
- ZNF570
- ZFS-6
- ZFS-4
- ZFS-1
- kr-znf3
- ZSCAN32
- ZNF818P
- ZSCAN10
- ZNF98
- ZNF724P
- ZNF675
- ZNF624
- ZNF544
- ZNF430
- ZNF324
- ZNF28
- ZNF226
- ZFP2
- Nbla00121
- DKFZp434J0650
- ZNF726
- ZNF254
- ZNF737
- ZNF566
- ZNF35
- ZNF204
- ZSCAN5A
- ZSCAN2
- ZNF878
- ZNF846
- ZNF79
- ZNF720
- ZNF714
- ZNF676
- ZNF583
- ZNF493
- ZNF492
- ZNF45
- ZNF431
- ZNF345
- ZNF304
- ZNF287
- ZNF266
- ZNF133
- HZF16
- DKFZp686M04222
- DKFZp666C237
- DKFZp434G1930
- DKFZp313M0722
- BCL6
- ZNF808
- ZNF83
- ZNF85
- ZNF480
- ZNF56
- ZNF283
- ZNF728
- ZNF479
- ZNF420
- ZNF565
- zf30
- ZNF485
- ZNF92
- ZNF90
- ZNF880
- ZNF816
- ZNF813
- ZNF768
- ZNF711
- ZNF671
- ZNF66
- ZNF615
- ZNF585A
- ZNF551
- ZNF550
- ZNF528
- ZNF527
- ZNF484
- ZNF471
- ZNF417
- ZNF285
- ZNF211
- ZNF136
- ZFP28
- KIAA1829
- DKFZp686K03205
- MST154
- GFI1B
- GFI1
- PRDM9
- ZNF585B
- ZNF525
- ZNF778
- PRMD9
- ZNF22
- ZFS-2
- ZNF587B
- HZF17
- DKFZp762K012
- smap-7
- ZSCAN31
- ZNF876P
- ZNF844
- ZNF72
- ZNF561
- ZNF101
- ZNF888
- ZNF879
- ZNF845
- ZNF681
- ZNF564
- ZNF418
- ZNF26
- ZNF197
- ZNF19
- ZNF182
- ZNF10
- ZFP37
- ZFP14
- BCL6B
- GZF1
- ZNF702P
- ZNF697
- ZNF146
- ZNF571
- HZF36
- ZSCAN21
- ZNF558
- ZNF282
- ZNF257
- ZNF124
- ZNF114
- ZNF850
- ZNF841
- ZNF678
- ZNF649
- ZNF626
- ZNF567
- ZNF454
- ZNF331
- ZNF267
- ZNF23
- ZNF223
- HZF14
- FIZ1
- DKFZp686H20223
- DKFZp571N1833
- DKFZp570I0164
- ZNF501
- ZNF833P
- ZNF80
- ZNF589
- ZNF32
- ZNF852
- ZNF805
- HZF30
- A-328A3.4
- ZNF763
- ZNF883
- ZNF73
- ZNF705F
- ZNF705D
- ZNF621
- ZNF600
- ZKSCAN1
- ZFP41
- ZNF814
- ZNF786
- ZNF708
- ZNF665
- ZNF658B
- ZNF658
- ZNF595
- ZNF436
- ZNF384
- ZNF232
- ZNF225
- ZNF160
- ZFP3
- DKFZp686D2168
- HKR1
- ZNF410
- ZNF391
- DKFZp666M039
- ZNF138
- ZNF234
- ZNF75A
- ZNF726P1
- ZNF137P
- ZNF709
- ZNF699
- ZNF569
- ZNF568
- ZNF497
- ZNF429
- ZNF132
- ZKSCAN7
- MAZ
- DKFZp686B16128
- HZF28
- ZNF660
- ZNF625
- ZNF2
- ZNF540
- ZNF705A
- ZNF468
- ZNF33B
- ZNF3
- ZNF263
- ZNF91
- ZNF84
- ZNF835
- ZNF780A
- ZNF700
- ZNF628
- ZNF613
- ZNF43
- ZNF271
- ZNF264
- ZNF229
- ZNF227
- ZNF208
- ZNF16
- ZNF14
- ZNF107
- ZBTB47
- PRDM15
- PRDM10
- DKFZp547L155
- ZNF7
- KLF1
- ZNF771
- ZNF696
- ZNF729
- ZNF573
- CTCFL
- ZNF500
- ZNF761
- ZNF717
- ZNF584
- ZNF534
- ZNF490
- ZNF470
- ZNF347
- ZNF34
- ZNF235
- ZNF135
- ZFP62
- VEZF1
- PRDM16
- MECOM
- HZF40
- ZNF99
- ZNF669
- ZNF213
- ZNF76
- ZNF71
- ZNF616
- ZNF517
- ZFP64
- PLAGL1
- ZNF791
- ZNF705E
- ZNF284
- ZFS-3
- ZBTB48
- ZNF836
- ZNF721
- ZNF563
- ZNF546
- ZNF224
- ZNF770
- DKFZp547H249
- ZNF793
- ZNF710
- ZNF449
- ZNF442
- ZBTB21
- ZNF607
- ZNF599
- ZNF33A
- ZNF30
- ZNF251
- ZNF184
- E4F1
Variants for ZBTB17 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000014596 | -- | 15,973,304(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000034969 | -- | 15,944,717(-) | C/A | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000063228 | -- | 15,951,672(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000200450 | -- | 15,946,088(-) | C/T | intron_variant | |
| rs1000342333 | -- | 15,957,388(-) | T/C | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
9.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.75;
33.21% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZBTB17 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZBTB17
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB17 Gene
Disorders for ZBTB17 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dilated cardiomyopathy |
|
|
Search ZBTB17 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZBTB17
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB17 Gene
Publications for ZBTB17 Gene
- A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain. (PMID: 17880999) Stead MA … Wright SC (Journal of molecular biology 2007) 3 4 22 58
- A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells. (PMID: 14739298) Sakurai T … Fujita J (The Journal of biological chemistry 2004) 3 4 22 58
- Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1. (PMID: 12244100) Piluso D … Capone JP (The Journal of biological chemistry 2002) 3 4 22 58
- An alternative pathway for gene regulation by Myc. (PMID: 9312026) Peukert K … Eilers M (The EMBO journal 1997) 3 4 22 58
- Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc. (PMID: 9308237) Schneider A … Hänel F (Current topics in microbiology and immunology 1997) 3 4 22 58
Products for ZBTB17 Gene
- R&D Systems Antibodies for ZBTB17 (Miz-1/ZBTB17)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ZBTB17
- Search Origene for MassSpec and Protein Over-expression Lysates for ZBTB17
- Origene Custom Protein Services for ZBTB17
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZBTB17
- Browse OriGene Inhibitory RNA Products For ZBTB17
- OriGene qPCR primer pairs for ZBTB17
- OriGene CRISPR knockouts for ZBTB17
- OriGene ORF clones in human for ZBTB17
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ZBTB17
- GenScript: Next-day shipping of latest version cDNA ORF clones for ZBTB17 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ZBTB17
- GenScript Custom Assay Services for ZBTB17
- GenScript Custom overexpressing Cell Line Services for ZBTB17
- GenScript: Design CRISPR guide RNA sequences for ZBTB17
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ZBTB17
- Sino Biological Human cDNA Clone for ZBTB17
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ZBTB17
- Novus Biologicals lysates and proteins for ZBTB17
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for ZBTB17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZBTB17
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ZBTB17
- antibodies-online: Search results for available ZBTB17 related products ranked by validation data
- antibodies-online: Search results for available ZBTB17 related products ranked by validation data
- antibodies-online: Search results for available ZBTB17 related products ranked by validation data
- GeneTex ZBTB17 Antibody for ZBTB17
- Search GeneTex for Proteins for ZBTB17
- Santa Cruz Biotechnology (SCBT) Antibodies for ZBTB17
- Search Santa Cruz Biotechnology (SCBT) for ZBTB17 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ZBTB17
- Search for ZBTB17 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for ZBTB17
- genomics-online: cdna clones - Search results for available ZBTB17 gene related products
- orf clones - Search results for available ZBTB17 gene related products
- genomics-online: gRNA clones - Search results for available ZBTB17 gene related products
- genomics-online: primer clones - Search results for available ZBTB17 gene related products
- genomics-online: shRNA clones - Search results for available ZBTB17 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZBTB17
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZBTB17
- GeneCopoeia miRNA 3'UTR Target clone products for ZBTB17
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB17
Sources for ZBTB17 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas