Aliases for ZBTB16 Gene
External Ids for ZBTB16 Gene
Previous HGNC Symbols for ZBTB16 Gene
Previous GeneCards Identifiers for ZBTB16 Gene
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZBTB16 Gene
ZBTB16 (Zinc Finger And BTB Domain Containing 16) is a Protein Coding gene. Diseases associated with ZBTB16 include Skeletal Defects, Genital Hypoplasia, And Mental Retardation and Acute Promyelocytic Leukemia. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Lymphoid Cell Differentiation Pathways. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and identical protein binding. An important paralog of this gene is ZBTB32.
UniProtKB/Swiss-Prot Summary for ZBTB16 Gene
Acts as a transcriptional repressor (PubMed:24359566). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).