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Aliases for ZBTB12 Gene

Aliases for ZBTB12 Gene

  • Zinc Finger And BTB Domain Containing 12 2 3 5
  • C6orf46 3 4
  • NG35 3 4
  • G10 3 4
  • Zinc Finger And BTB Domain-Containing Protein 12 3
  • Chromosome 6 Open Reading Frame 46 2
  • HLA-B-Associated Transcript 9 3
  • Protein G10 4
  • D6S59E 3
  • Bat9 3

External Ids for ZBTB12 Gene

Previous HGNC Symbols for ZBTB12 Gene

  • C6orf46

Previous GeneCards Identifiers for ZBTB12 Gene

  • GC06M031972
  • GC06M031975
  • GC06M031868
  • GC06M031653

Summaries for ZBTB12 Gene

GeneCards Summary for ZBTB12 Gene

ZBTB12 (Zinc Finger And BTB Domain Containing 12) is a Protein Coding gene. An important paralog of this gene is ZBTB26.

UniProtKB/Swiss-Prot for ZBTB12 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB12 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB12 Gene

Genomics for ZBTB12 Gene

GeneHancer (GH) Regulatory Elements for ZBTB12 Gene

Promoters and enhancers for ZBTB12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I031901 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.1 96 2.9 HDGF ARNT SIN3A DMAP1 ZNF2 ZNF766 E2F8 ZNF207 ZNF143 KLF13 ZBTB12 C2 C4A STK19B SKIV2L DXO PSORS1C2 VWA7 HLA-C HLA-DQB2
GH06I031774 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 38.8 +125.6 125561 3.8 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF263 SP3 VWA7 GTF2H4 DXO PPT2 EGFL8 ZBTB12 PRRC2A PRRT1 NFKBIL1 C4A
GH06I031619 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.1 +281.1 281140 4 CLOCK ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC GC06P031990 GC06P032044 GC06P032046 GC06P032049 GC06P032051 GC06P032055 GC06P032056 GC06P032063 GC06P032065 GC06P032066
GH06I030907 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.9 +993.9 993910 2.2 CLOCK DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 GTF2H4 VARS2 GC06P031581 MDC1 DDX39B LY6G5B TRIM39 LSM2 PPP1R10 HCG18
GH06I031269 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.9 +630.9 630906 4.4 HDGF PKNOX1 ATF1 SMAD1 ARID4B SIN3A GLI4 ZNF2 IRF4 YY1 HLA-C PIR41455 PSORS1C3 PPT2 TNXB LSM2 PSORS1C2 HCG18 HCG27 ENSG00000229836
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB12 gene promoter:

Genomic Locations for ZBTB12 Gene

Genomic Locations for ZBTB12 Gene
chr6:31,899,204-31,902,367
(GRCh38/hg38)
Size:
3,164 bases
Orientation:
Minus strand
chr6:31,867,384-31,869,769
(GRCh37/hg19)

Genomic View for ZBTB12 Gene

Genes around ZBTB12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for ZBTB12 Gene

  • Protein details for ZBTB12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y330-ZBT12_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 12
    Protein Accession:
    Q9Y330
    Secondary Accessions:
    • B0UY00
    • Q5JQ98

    Protein attributes for ZBTB12 Gene

    Size:
    459 amino acids
    Molecular mass:
    49148 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB12 Gene

Post-translational modifications for ZBTB12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB12 Gene

Domains & Families for ZBTB12 Gene

Gene Families for ZBTB12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB12 Gene

Suggested Antigen Peptide Sequences for ZBTB12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB12: view

No data available for UniProtKB/Swiss-Prot for ZBTB12 Gene

Function for ZBTB12 Gene

Molecular function for ZBTB12 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB12 Gene

Gene Ontology (GO) - Molecular Function for ZBTB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB12: view
genes like me logo Genes that share phenotypes with ZBTB12: view

Animal Model Products

CRISPR Products

miRNA for ZBTB12 Gene

Targeted motifs for ZBTB12 Gene
HOMER Transcription Factor Regulatory Elements motif ZBTB12
  • Consensus sequence: NGNTCTAGAACCNGV Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZBTB12 Gene

Localization for ZBTB12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB12 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for ZBTB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZBTB12 Gene

Pathways & Interactions for ZBTB12 Gene

SuperPathways for ZBTB12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB12: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB12 Gene

Drugs & Compounds for ZBTB12 Gene

No Compound Related Data Available

Transcripts for ZBTB12 Gene

mRNA/cDNA for ZBTB12 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB12 Gene

Zinc finger and BTB domain containing 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB12 Gene

No ASD Table

Relevant External Links for ZBTB12 Gene

GeneLoc Exon Structure for
ZBTB12
ECgene alternative splicing isoforms for
ZBTB12

Expression for ZBTB12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB12 Gene

Protein differential expression in normal tissues from HIPED for ZBTB12 Gene

This gene is overexpressed in Breast (62.8) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB12 Gene



Protein tissue co-expression partners for ZBTB12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB12 Gene:

ZBTB12

SOURCE GeneReport for Unigene cluster for ZBTB12 Gene:

Hs.234027

Evidence on tissue expression from TISSUES for ZBTB12 Gene

  • Lung(4)
genes like me logo Genes that share expression patterns with ZBTB12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB12 Gene

Orthologs for ZBTB12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB12 33 34
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia ZBTB12 33 34
  • 92.08 (n)
dog
(Canis familiaris)
Mammalia ZBTB12 34 33
  • 91.87 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb12 33
  • 89.98 (n)
mouse
(Mus musculus)
Mammalia Zbtb12 16 34 33
  • 89.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB12 34
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
OneToMany
-- 34
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZBTB12 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb12 33
  • 58.73 (n)
Str.17103 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.10817 33
zebrafish
(Danio rerio)
Actinopterygii zbtb12.2 34
  • 36 (a)
OneToOne
Dr.14513 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6329 33
Species where no ortholog for ZBTB12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB12 Gene

ENSEMBL:
Gene Tree for ZBTB12 (if available)
TreeFam:
Gene Tree for ZBTB12 (if available)

Paralogs for ZBTB12 Gene

(2) SIMAP similar genes for ZBTB12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB12: view

Variants for ZBTB12 Gene

Sequence variations from dbSNP and Humsavar for ZBTB12 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000900895 -- 31,899,814(-) C/A 3_prime_UTR_variant
rs1002382850 -- 31,899,623(-) T/C 3_prime_UTR_variant
rs1002455041 -- 31,899,328(-) C/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1003121795 -- 31,898,998(-) G/C downstream_transcript_variant
rs1003195376 -- 31,902,427(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB12 Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv10822 CNV gain 18304495
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv508399 CNV deletion 20534489
nsv509126 CNV insertion 20534489
nsv601960 CNV loss 21841781

Variation tolerance for ZBTB12 Gene

Residual Variation Intolerance Score: 23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 65.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB12 Gene

Disorders for ZBTB12 Gene

Additional Disease Information for ZBTB12

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZBTB12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB12 Gene

Publications for ZBTB12 Gene

  1. A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region. (PMID: 21764829) Png E … Seielstad M (Human molecular genetics 2011) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PMID: 14656967) Xie T … Hood L (Genome research 2003) 3 4 58
  5. TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PMID: 9545376) Herberg JA … Trowsdale J (Journal of molecular biology 1998) 2 3 58

Products for ZBTB12 Gene

Sources for ZBTB12 Gene

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