Aliases for ZBTB11 Gene

Aliases for ZBTB11 Gene

  • Zinc Finger And BTB Domain Containing 11 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 11 3 4
  • ZNF-U69274 2 3
  • ZNF913 2 3
  • ZBTB11 5
  • MRT69 3

External Ids for ZBTB11 Gene

Previous GeneCards Identifiers for ZBTB11 Gene

  • GC03M102690
  • GC03M102850
  • GC03M101367
  • GC03M098737

Summaries for ZBTB11 Gene

GeneCards Summary for ZBTB11 Gene

ZBTB11 (Zinc Finger And BTB Domain Containing 11) is a Protein Coding gene. Diseases associated with ZBTB11 include Intellectual Developmental Disorder, Autosomal Recessive 69 and Mowat-Wilson Syndrome. An important paralog of this gene is ZFAT.

UniProtKB/Swiss-Prot Summary for ZBTB11 Gene

Gene Wiki entry for ZBTB11 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB11 Gene

Genomics for ZBTB11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZBTB11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBTB11

Top Transcription factor binding sites by QIAGEN in the ZBTB11 gene promoter:
  • AML1a
  • ATF-2
  • CREB
  • GATA-2
  • GR-alpha
  • HTF
  • Ik-2
  • POU2F1
  • POU2F1a
  • POU3F1

Genomic Locations for ZBTB11 Gene

Genomic Locations for ZBTB11 Gene
chr3:101,648,889-101,677,132
(GRCh38/hg38)
Size:
28,244 bases
Orientation:
Minus strand
chr3:101,367,733-101,396,339
(GRCh37/hg19)
Size:
28,607 bases
Orientation:
Minus strand

Genomic View for ZBTB11 Gene

Genes around ZBTB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB11 Gene

Proteins for ZBTB11 Gene

  • Protein details for ZBTB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95625-ZBT11_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 11
    Protein Accession:
    O95625
    Secondary Accessions:
    • Q2NKP9

    Protein attributes for ZBTB11 Gene

    Size:
    1053 amino acids
    Molecular mass:
    119384 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB11 Gene

Post-translational modifications for ZBTB11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB11 Gene

No data available for DME Specific Peptides for ZBTB11 Gene

Domains & Families for ZBTB11 Gene

Gene Families for ZBTB11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transcription factors

Protein Domains for ZBTB11 Gene

InterPro:
Blocks:
  • BTB/POZ domain
ProtoNet:

Suggested Antigen Peptide Sequences for ZBTB11 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger and BTB domain-containing protein 11 (ZBT11_HUMAN)
genes like me logo Genes that share domains with ZBTB11: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBTB11 Gene

Function for ZBTB11 Gene

Molecular function for ZBTB11 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB11 Gene

Gene Ontology (GO) - Molecular Function for ZBTB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ZBTB11: view
genes like me logo Genes that share phenotypes with ZBTB11: view

Human Phenotype Ontology for ZBTB11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for ZBTB11 Gene

miRTarBase miRNAs that target ZBTB11

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB11 Gene

Localization for ZBTB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB11 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB11 gene
Compartment Confidence
nucleus 5
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with ZBTB11: view

Pathways & Interactions for ZBTB11 Gene

PathCards logo

SuperPathways for ZBTB11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZBTB11: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB11 Gene

Drugs & Compounds for ZBTB11 Gene

No Compound Related Data Available

Transcripts for ZBTB11 Gene

mRNA/cDNA for ZBTB11 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB11

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB11 Gene

No ASD Table

Relevant External Links for ZBTB11 Gene

GeneLoc Exon Structure for
ZBTB11

Expression for ZBTB11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB11 Gene

Protein differential expression in normal tissues from HIPED for ZBTB11 Gene

This gene is overexpressed in Serum (59.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBTB11 Gene



Protein tissue co-expression partners for ZBTB11 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBTB11

SOURCE GeneReport for Unigene cluster for ZBTB11 Gene:

Hs.655286

Evidence on tissue expression from TISSUES for ZBTB11 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with ZBTB11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB11 Gene

Orthologs for ZBTB11 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBTB11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZBTB11 30 31
  • 99.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZBTB11 30 31
  • 91.36 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZBTB11 30 31
  • 91.25 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rpl24 31
  • 89 (a)
OneToOne
Zbtb11 30 17
  • 87.08 (n)
Rat
(Rattus norvegicus)
Mammalia Zbtb11 30
  • 85.84 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZBTB11 31
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB11 31
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZBTB11 30 31
  • 72.2 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZBTB11 31
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zbtb11 30
  • 70.2 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-98p3.1 30
  • 62.45 (n)
ZBTB11 31
  • 52 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CkIIalpha-i1 31
  • 27 (a)
OneToOne
Species where no ortholog for ZBTB11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZBTB11 Gene

ENSEMBL:
Gene Tree for ZBTB11 (if available)
TreeFam:
Gene Tree for ZBTB11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB11: view image

Paralogs for ZBTB11 Gene

(2) SIMAP similar genes for ZBTB11 Gene using alignment to 3 proteins:

  • ZBT11_HUMAN
  • C9J2L2_HUMAN
  • L8E8H7_HUMAN
genes like me logo Genes that share paralogs with ZBTB11: view

Variants for ZBTB11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBTB11 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs1559981249 Pathogenic: INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 69 101,652,500(-) A/C MISSENSE_VARIANT
rs1559982532 Pathogenic: INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 69 101,656,110(-) G/A MISSENSE_VARIANT
VAR_080760 Intellectual developmental disorder, autosomal recessive 69 (MRT69) [MIM:618383] p.His880Gln
VAR_082098 Intellectual developmental disorder, autosomal recessive 69 (MRT69) [MIM:618383] p.His729Tyr
rs33957144 - p.Thr350Asn

Additional dbSNP identifiers (rs#s) for ZBTB11 Gene

Variation tolerance for ZBTB11 Gene

Residual Variation Intolerance Score: 5.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB11 Gene

Disorders for ZBTB11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZBTB11 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZBT11_HUMAN
  • Intellectual developmental disorder, autosomal recessive 69 (MRT69) [MIM:618383]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269 PubMed:28397838, ECO:0000269 PubMed:29893856}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with ZBTB11: view

No data available for Genatlas for ZBTB11 Gene

Publications for ZBTB11 Gene

  1. Biallelic missense variants in ZBTB11 can cause intellectual disability in humans. (PMID: 29893856) Fattahi Z … Najmabadi H (Human molecular genetics 2018) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
  4. Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families. (PMID: 28397838) Harripaul R … Vincent JB (Molecular psychiatry 2018) 4
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3

Products for ZBTB11 Gene

  • Signalway ELISA kits for ZBTB11

Sources for ZBTB11 Gene