Aliases for ZBTB11 Gene

Aliases for ZBTB11 Gene

  • Zinc Finger And BTB Domain Containing 11 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 11 3 4
  • ZNF-U69274 3
  • ZNF913 3
  • MRT69 3

External Ids for ZBTB11 Gene

Previous GeneCards Identifiers for ZBTB11 Gene

  • GC03M102690
  • GC03M102850
  • GC03M101367
  • GC03M098737

Summaries for ZBTB11 Gene

GeneCards Summary for ZBTB11 Gene

ZBTB11 (Zinc Finger And BTB Domain Containing 11) is a Protein Coding gene. Diseases associated with ZBTB11 include Intellectual Developmental Disorder, Autosomal Recessive 69. An important paralog of this gene is ZFAT.

UniProtKB/Swiss-Prot Summary for ZBTB11 Gene

Gene Wiki entry for ZBTB11 Gene

Additional gene information for ZBTB11 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB11 Gene

Genomics for ZBTB11 Gene

GeneHancer (GH) Regulatory Elements for ZBTB11 Gene

Promoters and enhancers for ZBTB11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB11 gene promoter:
  • AML1a
  • ATF-2
  • CREB
  • GATA-2
  • GR-alpha
  • HTF
  • Ik-2
  • POU2F1
  • POU2F1a
  • POU3F1

Genomic Locations for ZBTB11 Gene

Genomic Locations for ZBTB11 Gene
chr3:101,648,889-101,677,495
(GRCh38/hg38)
Size:
28,607 bases
Orientation:
Minus strand
chr3:101,367,733-101,396,339
(GRCh37/hg19)
Size:
28,607 bases
Orientation:
Minus strand

Genomic View for ZBTB11 Gene

Genes around ZBTB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB11 Gene

Proteins for ZBTB11 Gene

  • Protein details for ZBTB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95625-ZBT11_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 11
    Protein Accession:
    O95625
    Secondary Accessions:
    • Q2NKP9

    Protein attributes for ZBTB11 Gene

    Size:
    1053 amino acids
    Molecular mass:
    119384 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB11 Gene

Post-translational modifications for ZBTB11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB11 Gene

No data available for DME Specific Peptides for ZBTB11 Gene

Domains & Families for ZBTB11 Gene

Gene Families for ZBTB11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transcription factors

Protein Domains for ZBTB11 Gene

Suggested Antigen Peptide Sequences for ZBTB11 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger and BTB domain-containing protein 11 (ZBT11_HUMAN)
genes like me logo Genes that share domains with ZBTB11: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBTB11 Gene

Function for ZBTB11 Gene

Molecular function for ZBTB11 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ZBTB11: view
genes like me logo Genes that share phenotypes with ZBTB11: view

Human Phenotype Ontology for ZBTB11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for ZBTB11 Gene

miRTarBase miRNAs that target ZBTB11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB11 Gene

Localization for ZBTB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB11 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZBTB11: view

Pathways & Interactions for ZBTB11 Gene

PathCards logo

SuperPathways for ZBTB11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZBTB11: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB11 Gene

Drugs & Compounds for ZBTB11 Gene

No Compound Related Data Available

Transcripts for ZBTB11 Gene

mRNA/cDNA for ZBTB11 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(112) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB11 Gene

No ASD Table

Relevant External Links for ZBTB11 Gene

GeneLoc Exon Structure for
ZBTB11
ECgene alternative splicing isoforms for
ZBTB11

Expression for ZBTB11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB11 Gene

Protein differential expression in normal tissues from HIPED for ZBTB11 Gene

This gene is overexpressed in Serum (59.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBTB11 Gene



Protein tissue co-expression partners for ZBTB11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB11 Gene:

ZBTB11

SOURCE GeneReport for Unigene cluster for ZBTB11 Gene:

Hs.655286
genes like me logo Genes that share expression patterns with ZBTB11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB11 Gene

Orthologs for ZBTB11 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBTB11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB11 33 32
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB11 33 32
  • 91.36 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB11 33 32
  • 91.25 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl24 33
  • 89 (a)
OneToOne
Zbtb11 17 32
  • 87.08 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb11 32
  • 85.84 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB11 33
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB11 33
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB11 33 32
  • 72.2 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB11 33
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb11 32
  • 70.2 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-98p3.1 32
  • 62.45 (n)
ZBTB11 33
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CkIIalpha-i1 33
  • 27 (a)
OneToOne
Species where no ortholog for ZBTB11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB11 Gene

ENSEMBL:
Gene Tree for ZBTB11 (if available)
TreeFam:
Gene Tree for ZBTB11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB11: view image

Paralogs for ZBTB11 Gene

(2) SIMAP similar genes for ZBTB11 Gene using alignment to 3 proteins:

  • ZBT11_HUMAN
  • C9J2L2_HUMAN
  • L8E8H7_HUMAN
genes like me logo Genes that share paralogs with ZBTB11: view

Variants for ZBTB11 Gene

Sequence variations from dbSNP and Humsavar for ZBTB11 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1559981249 pathogenic, INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 69 101,652,500(-) A/C coding_sequence_variant, missense_variant
rs1559982532 pathogenic, INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 69 101,656,110(-) G/A coding_sequence_variant, missense_variant
rs1000083406 -- 101,675,936(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000097668 -- 101,666,497(-) C/A/T 5_prime_UTR_variant, intron_variant
rs1000202168 -- 101,675,494(-) T/G genic_upstream_transcript_variant, intron_variant

Variation tolerance for ZBTB11 Gene

Residual Variation Intolerance Score: 5.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB11 Gene

Disorders for ZBTB11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZBTB11 Gene - From: OMIM, ClinVar, GTR, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZBTB11

genes like me logo Genes that share disorders with ZBTB11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB11 Gene

Publications for ZBTB11 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56
  3. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 56
  4. Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS. (PMID: 30471916) Lum KK … Cristea IM (Cell systems 2018) 3 56
  5. Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families. (PMID: 28397838) Harripaul R … Vincent JB (Molecular psychiatry 2018) 4 56

Products for ZBTB11 Gene

Sources for ZBTB11 Gene