Aliases for ZBTB10 Gene

Aliases for ZBTB10 Gene

  • Zinc Finger And BTB Domain Containing 10 2 3 5
  • RINZF 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 10 3 4
  • Zinc Finger Protein RIN ZF 3 4
  • Zinc Finger Protein RINZF 3
  • FLJ12752 2
  • ZBTB10 5
  • RINZFC 4

External Ids for ZBTB10 Gene

Previous GeneCards Identifiers for ZBTB10 Gene

  • GC08P081447
  • GC08P081448
  • GC08P081561
  • GC08P076888

Summaries for ZBTB10 Gene

GeneCards Summary for ZBTB10 Gene

ZBTB10 (Zinc Finger And BTB Domain Containing 10) is a Protein Coding gene. An important paralog of this gene is ENSG00000254553.

UniProtKB/Swiss-Prot Summary for ZBTB10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB10 Gene

Genomics for ZBTB10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZBTB10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBTB10

Top Transcription factor binding sites by QIAGEN in the ZBTB10 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GATA-1
  • HNF-4alpha1
  • HNF-4alpha2
  • NF-kappaB

Genomic Locations for ZBTB10 Gene

Genomic Locations for ZBTB10 Gene
chr8:80,485,593-80,526,265
(GRCh38/hg38)
Size:
40,673 bases
Orientation:
Plus strand
chr8:81,397,854-81,438,500
(GRCh37/hg19)
Size:
40,647 bases
Orientation:
Plus strand

Genomic View for ZBTB10 Gene

Genes around ZBTB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB10 Gene

Proteins for ZBTB10 Gene

  • Protein details for ZBTB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DT7-ZBT10_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 10
    Protein Accession:
    Q96DT7
    Secondary Accessions:
    • A4FVD0
    • Q86W96
    • Q8IXI9
    • Q96MH9

    Protein attributes for ZBTB10 Gene

    Size:
    871 amino acids
    Molecular mass:
    94894 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZBTB10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB10 Gene

Post-translational modifications for ZBTB10 Gene

  • Ubiquitination at Lys460
  • Modification sites at PhosphoSitePlus

Other Protein References for ZBTB10 Gene

No data available for DME Specific Peptides for ZBTB10 Gene

Domains & Families for ZBTB10 Gene

Gene Families for ZBTB10 Gene

Protein Domains for ZBTB10 Gene

InterPro:
Blocks:
  • BTB/POZ domain
  • Aspartate carbamoyltransferase, regulatory chain, C-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for ZBTB10 Gene

GenScript: Design optimal peptide antigens:
  • ZBTB10 protein (A8E4L4_HUMAN)
  • Zinc finger protein RIN ZF (ZBT10_HUMAN)
genes like me logo Genes that share domains with ZBTB10: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBTB10 Gene

Function for ZBTB10 Gene

Molecular function for ZBTB10 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB10 Gene

Gene Ontology (GO) - Molecular Function for ZBTB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA,IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB10: view
genes like me logo Genes that share phenotypes with ZBTB10: view

Animal Model Products

CRISPR Products

miRNA for ZBTB10 Gene

miRTarBase miRNAs that target ZBTB10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB10 Gene

Localization for ZBTB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB10 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZBTB10: view

Pathways & Interactions for ZBTB10 Gene

PathCards logo

SuperPathways for ZBTB10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZBTB10: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB10 Gene

Drugs & Compounds for ZBTB10 Gene

No Compound Related Data Available

Transcripts for ZBTB10 Gene

mRNA/cDNA for ZBTB10 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB10

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB10 Gene

No ASD Table

Relevant External Links for ZBTB10 Gene

GeneLoc Exon Structure for
ZBTB10

Expression for ZBTB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBTB10 Gene

This gene is overexpressed in Bone (34.4), Heart (21.7), Liver (6.6), and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBTB10 Gene



Protein tissue co-expression partners for ZBTB10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBTB10

SOURCE GeneReport for Unigene cluster for ZBTB10 Gene:

Hs.591868

Evidence on tissue expression from TISSUES for ZBTB10 Gene

  • Nervous system(4.4)
  • Intestine(2.4)
  • Lung(2)
genes like me logo Genes that share expression patterns with ZBTB10: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB10 Gene

Orthologs for ZBTB10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZBTB10 30 31
  • 99.65 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZBTB10 30 31
  • 95 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZBTB10 30 31
  • 94.71 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zbtb10 30
  • 90.71 (n)
Mouse
(Mus musculus)
Mammalia Zbtb10 30 17 31
  • 89.29 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZBTB10 31
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB10 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZBTB10 30 31
  • 79.72 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 88 (a)
OneToMany
-- 31
  • 76 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zbtb10 30
  • 70.3 (n)
Str.915 30
Zebrafish
(Danio rerio)
Actinopterygii zbtb10 30 31
  • 61.74 (n)
OneToOne
Species where no ortholog for ZBTB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZBTB10 Gene

ENSEMBL:
Gene Tree for ZBTB10 (if available)
TreeFam:
Gene Tree for ZBTB10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB10: view image

Paralogs for ZBTB10 Gene

Paralogs for ZBTB10 Gene

(9) SIMAP similar genes for ZBTB10 Gene using alignment to 2 proteins:

  • ZBT10_HUMAN
  • A8E4L4_HUMAN

Pseudogenes.org Pseudogenes for ZBTB10 Gene

genes like me logo Genes that share paralogs with ZBTB10: view

Variants for ZBTB10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBTB10 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs591989 - p.Pro50Thr
rs593747 - p.Met174Ile

Additional dbSNP identifiers (rs#s) for ZBTB10 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZBTB10 Gene

Variant ID Type Subtype PubMed ID
esv3305015 CNV mobile element insertion 20981092
esv3339644 CNV insertion 20981092
nsv1117835 CNV deletion 24896259

Variation tolerance for ZBTB10 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.93; 74.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB10 Gene

Disorders for ZBTB10 Gene

Additional Disease Information for ZBTB10

No disorders were found for ZBTB10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB10 Gene

Publications for ZBTB10 Gene

  1. ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2. (PMID: 30629181) Bluhm A … Butter F (Nucleic acids research 2019) 2 3
  2. Novel associations for hypothyroidism include known autoimmune risk loci. (PMID: 22493691) Eriksson N … Do CB (PloS one 2012) 3 41
  3. GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. (PMID: 21156786) Pathi SS … Safe S (Molecular cancer research : MCR 2011) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for ZBTB10 Gene

Sources for ZBTB10 Gene