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Aliases for ZBTB10 Gene

Aliases for ZBTB10 Gene

  • Zinc Finger And BTB Domain Containing 10 2 3 5
  • Zinc Finger Protein RIN ZF 3 4
  • RINZF 3 4
  • Zinc Finger And BTB Domain-Containing Protein 10 3
  • Zinc Finger Protein RINZF 3
  • RINZFC 4

External Ids for ZBTB10 Gene

Previous GeneCards Identifiers for ZBTB10 Gene

  • GC08P081447
  • GC08P081448
  • GC08P081561
  • GC08P076888

Summaries for ZBTB10 Gene

GeneCards Summary for ZBTB10 Gene

ZBTB10 (Zinc Finger And BTB Domain Containing 10) is a Protein Coding gene. An important paralog of this gene is ZBTB46.

UniProtKB/Swiss-Prot for ZBTB10 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB10 Gene

Genomics for ZBTB10 Gene

GeneHancer (GH) Regulatory Elements for ZBTB10 Gene

Promoters and enhancers for ZBTB10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J080484 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 654.7 +1.7 1671 5 PKNOX1 CLOCK FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ENSG00000251867 ZBTB10 LOC105375921 TPD52 GC08M080419
GH08J079959 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.4 -525.4 -525437 1.7 SMAD1 NFIB ZNF2 LCORL SCRT2 ZNF350 RCOR1 CHD2 NFIA ZNF331 ZBTB10 ENSG00000254162 RNU7-85P TPD52 ENSG00000272518 MRPS28 ENSG00000276418
GH08J080240 Enhancer 1.1 Ensembl ENCODE 10.5 -244.8 -244818 0.8 ARID4B SIN3A ZNF2 IRF4 ZNF48 ZNF143 RUNX3 NFKBIZ MXD4 REST MIR5708 ENSG00000206649 ZBTB10 ENSG00000251867 RNU6-1213P RNU2-71P LOC105375920 GC08M080196
GH08J080120 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.4 -363.5 -363484 3.3 HDGF PKNOX1 RB1 MZF1 FEZF1 BATF THRB YY1 ATF7 IKZF2 ENSG00000254205 TPD52 ZBTB10 LOC105375918
GH08J080330 Enhancer 0.8 ENCODE 11 -154.9 -154908 0.1 PKNOX1 ZNF133 INSM2 KLF17 MZF1 FEZF1 KLF14 ZNF48 YY1 ZNF213 LOC100216346 ENSG00000253238 RPL13AP18 RPL3P9 RNU6-1213P ZBTB10 ENSG00000251867 GC08M080317 ENSG00000206649
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB10 gene promoter:
  • E2F-5
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • NF-kappaB
  • GATA-1
  • HNF-4alpha1
  • HNF-4alpha2

Genomic Locations for ZBTB10 Gene

Genomic Locations for ZBTB10 Gene
40,647 bases
Plus strand
40,647 bases
Plus strand

Genomic View for ZBTB10 Gene

Genes around ZBTB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB10 Gene

Proteins for ZBTB10 Gene

  • Protein details for ZBTB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • A4FVD0
    • Q86W96
    • Q8IXI9
    • Q96MH9

    Protein attributes for ZBTB10 Gene

    871 amino acids
    Molecular mass:
    94894 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZBTB10 Gene


neXtProt entry for ZBTB10 Gene

Post-translational modifications for ZBTB10 Gene

  • Ubiquitination at isoforms=2, 3, 4460
  • Modification sites at PhosphoSitePlus

Other Protein References for ZBTB10 Gene

No data available for DME Specific Peptides for ZBTB10 Gene

Domains & Families for ZBTB10 Gene

Gene Families for ZBTB10 Gene

Suggested Antigen Peptide Sequences for ZBTB10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB10: view

No data available for UniProtKB/Swiss-Prot for ZBTB10 Gene

Function for ZBTB10 Gene

Molecular function for ZBTB10 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB10 Gene

Gene Ontology (GO) - Molecular Function for ZBTB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB10: view
genes like me logo Genes that share phenotypes with ZBTB10: view

Animal Model Products

miRNA for ZBTB10 Gene

miRTarBase miRNAs that target ZBTB10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB10 Gene

Localization for ZBTB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB10 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZBTB10: view

Pathways & Interactions for ZBTB10 Gene

SuperPathways for ZBTB10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB10: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB10 Gene

Drugs & Compounds for ZBTB10 Gene

No Compound Related Data Available

Transcripts for ZBTB10 Gene

mRNA/cDNA for ZBTB10 Gene

Unigene Clusters for ZBTB10 Gene

Zinc finger and BTB domain containing 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB10 Gene

No ASD Table

Relevant External Links for ZBTB10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBTB10 Gene

This gene is overexpressed in Bone (34.4), Heart (21.7), Liver (6.6), and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBTB10 Gene

Protein tissue co-expression partners for ZBTB10 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB10 Gene:


SOURCE GeneReport for Unigene cluster for ZBTB10 Gene:


Evidence on tissue expression from TISSUES for ZBTB10 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZBTB10: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB10 Gene

Orthologs for ZBTB10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZBTB10 34 33
  • 99.65 (n)
(Canis familiaris)
Mammalia ZBTB10 34 33
  • 95 (n)
(Bos Taurus)
Mammalia ZBTB10 34 33
  • 94.71 (n)
(Rattus norvegicus)
Mammalia Zbtb10 33
  • 90.71 (n)
(Mus musculus)
Mammalia Zbtb10 16 34 33
  • 89.29 (n)
(Monodelphis domestica)
Mammalia ZBTB10 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia ZBTB10 34
  • 63 (a)
(Gallus gallus)
Aves ZBTB10 34 33
  • 79.72 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 88 (a)
-- 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb10 33
  • 70.3 (n)
Str.915 33
(Danio rerio)
Actinopterygii zbtb10 34 33
  • 61.74 (n)
Species where no ortholog for ZBTB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB10 Gene

Gene Tree for ZBTB10 (if available)
Gene Tree for ZBTB10 (if available)
Evolutionary constrained regions (ECRs) for ZBTB10: view image

Paralogs for ZBTB10 Gene

(9) SIMAP similar genes for ZBTB10 Gene using alignment to 2 proteins:

  • A8E4L4_HUMAN Pseudogenes for ZBTB10 Gene

genes like me logo Genes that share paralogs with ZBTB10: view

Variants for ZBTB10 Gene

Sequence variations from dbSNP and Humsavar for ZBTB10 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000001226 -- 80,486,518(+) CCC/CC 5_prime_UTR_variant, intron_variant
rs1000049988 -- 80,510,840(+) C/A intron_variant
rs1000062502 -- 80,495,995(+) TTTT/TTT intron_variant
rs1000092294 -- 80,489,981(+) T/A intron_variant
rs1000132366 -- 80,497,277(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB10 Gene

Variant ID Type Subtype PubMed ID
esv3305015 CNV mobile element insertion 20981092
esv3339644 CNV insertion 20981092
nsv1117835 CNV deletion 24896259

Variation tolerance for ZBTB10 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.93; 74.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB10 Gene

Disorders for ZBTB10 Gene

Additional Disease Information for ZBTB10

No disorders were found for ZBTB10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB10 Gene

Publications for ZBTB10 Gene

  1. Novel associations for hypothyroidism include known autoimmune risk loci. (PMID: 22493691) Eriksson N … Do CB (PloS one 2012) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZBTB10 Gene

Sources for ZBTB10 Gene

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