Aliases for ZBTB1 Gene
External Ids for ZBTB1 Gene
Previous GeneCards Identifiers for ZBTB1 Gene
GeneCards Summary for ZBTB1 Gene
ZBTB1 (Zinc Finger And BTB Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is ZBTB18.
UniProtKB/Swiss-Prot Summary for ZBTB1 Gene
Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity).