Aliases for ZBP1 Gene
External Ids for ZBP1 Gene
Previous HGNC Symbols for ZBP1 Gene
Previous GeneCards Identifiers for ZBP1 Gene
This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for ZBP1 Gene
ZBP1 (Z-DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with ZBP1 include Allergic Cutaneous Vasculitis and Leukorrhea. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Innate Immune System. Gene Ontology (GO) annotations related to this gene include RNA binding and left-handed Z-DNA binding.
UniProtKB/Swiss-Prot Summary for ZBP1 Gene
Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).