This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] See more...

Aliases for ZBP1 Gene

Aliases for ZBP1 Gene

  • Z-DNA Binding Protein 1 2 3 5
  • DLM1 2 3 4
  • DAI 2 3 4
  • Tumor Stroma And Activated Macrophage Protein DLM-1 3 4
  • DNA-Dependent Activator Of IRFs 2 3
  • Z-DNA-Binding Protein 1 3 4
  • C20orf183 3 4
  • DLM-1 2 3
  • DNA-Dependent Activator Of IFN-Regulatory Factors 4
  • Chromosome 20 Open Reading Frame 183 2
  • DJ718J7.3 2
  • ZBP1 5

External Ids for ZBP1 Gene

Previous HGNC Symbols for ZBP1 Gene

  • C20orf183

Previous GeneCards Identifiers for ZBP1 Gene

  • GC20M055907
  • GC20M056817
  • GC20M056864
  • GC20M055602
  • GC20M056178
  • GC20M052960

Summaries for ZBP1 Gene

Entrez Gene Summary for ZBP1 Gene

  • This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ZBP1 Gene

ZBP1 (Z-DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with ZBP1 include Influenza and Zika Virus Congenital Syndrome. Among its related pathways are Necroptosis and Cytosolic sensors of pathogen-associated DNA. Gene Ontology (GO) annotations related to this gene include RNA binding and left-handed Z-DNA binding.

UniProtKB/Swiss-Prot Summary for ZBP1 Gene

  • Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death (PubMed:32200799). Once activated upon Z-RNA-binding, ZBP1 interacts with RIPK3, inducing the complementary pathways of apoptosis, necroptosis and pyroptosis (By similarity). Acts as a key activator of necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members: ZBP1-dependent necroptosis involves RIPK3 stimulation, which phosphorylates and activates MLKL, triggering execution of programmed necrosis (By similarity). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: ZBP1 recognizes and binds Z-RNA structures that are produced in infected nuclei by orthomyxoviruses, such as the influenza A virus (IAV), leading to ZBP1 activation, RIPK3 stimulation and subsequent MLKL phosphorylation, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (PubMed:32200799). ZBP1-dependent cell death in response to IAV infection promotes interleukin-1 alpha (IL1A) induction in an NLRP3-inflammasome-independent manner: IL1A expression is required for the optimal interleukin-1 beta (IL1B) production, and together, these cytokines promote infiltration of inflammatory neutrophils to the lung, leading to the formation of neutrophil extracellular traps (By similarity). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with RIPK3, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity).

Gene Wiki entry for ZBP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBP1 Gene

Genomics for ZBP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZBP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J057617 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 264.4 +0.8 802 4.1 SP1 ZNF207 ZNF600 BCL11A TRIM22 HES1 GABPA IRF4 RUNX1 EBF1 ZBP1 lnc-PMEPA1-3 HSALNG0131183 PCK1
GH20J057624 Enhancer 0.3 ENCODE 250.7 -1.5 -1548 0.1 HLF CTCF ZBP1 lnc-PMEPA1-3 piR-39098-129 PMEPA1
GH20J057388 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.6 +225.2 225200 13.2 LARP7 BCLAF1 SP1 ZNF207 NCOR1 MYC IKZF1 SIX5 ZNF592 POLR2A RBM38 HSALNG0131160 ZBP1 PPP4R1L ENSG00000280387 RBM38-AS1 BMP7 CASS4 PMEPA1 MTRNR2L3
GH20J057679 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -61.3 -61268 4.5 BCLAF1 SP1 BCL11A TARDBP TRIM22 SIX4 SMC3 IRF4 EBF1 CBFB ZBP1 PMEPA1 RBM38 HSALNG0131192 lnc-PMEPA1-2 lnc-ZBP1-2
GH20J057408 Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 +208.0 207975 10 NCOR1 IKZF1 MYC ZNF592 ZMYM3 POLR2A NFIC ZIC2 NONO HES1 RBM38 ENSG00000280387 ZBP1 CTCFL RBM38-AS1 BMP7 HSALNG0131161 HSALNG0131160
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBP1

Top Transcription factor binding sites by QIAGEN in the ZBP1 gene promoter:
  • c-Ets-1
  • E47
  • Elk-1
  • HEN1
  • Ik-1
  • ISGF-3
  • Lmo2
  • Tal-1

Genomic Locations for ZBP1 Gene

Latest Assembly
chr20:57,603,846-57,620,576
(GRCh38/hg38)
Size:
16,731 bases
Orientation:
Minus strand

Previous Assembly
chr20:56,178,908-56,195,482
(GRCh37/hg19 by Entrez Gene)
Size:
16,575 bases
Orientation:
Minus strand

chr20:56,178,902-56,195,632
(GRCh37/hg19 by Ensembl)
Size:
16,731 bases
Orientation:
Minus strand

Genomic View for ZBP1 Gene

Genes around ZBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBP1 Gene

Proteins for ZBP1 Gene

  • Protein details for ZBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H171-ZBP1_HUMAN
    Recommended name:
    Z-DNA-binding protein 1
    Protein Accession:
    Q9H171
    Secondary Accessions:
    • A2A2F7
    • B3KVA1
    • F5GYT1
    • Q5JY39
    • Q9BYW4

    Protein attributes for ZBP1 Gene

    Size:
    429 amino acids
    Molecular mass:
    46343 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts (via RIP homotypic interaction motif) with RIPK3; leading to RIPK3 activation and necroptosis (By similarity). Interacts (via RIP homotypic interaction motif) with RIPK1 (By similarity).
    • (Microbial infection) Interacts with human herpesvirus 1 protein ICP0.

    Three dimensional structures from OCA and Proteopedia for ZBP1 Gene

    Alternative splice isoforms for ZBP1 Gene

neXtProt entry for ZBP1 Gene

Post-translational modifications for ZBP1 Gene

No data available for DME Specific Peptides for ZBP1 Gene

Domains & Families for ZBP1 Gene

Gene Families for ZBP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZBP1 Gene

InterPro:
Blocks:
  • Double-stranded RNA-specific adenosine deaminase (DRADA)

Suggested Antigen Peptide Sequences for ZBP1 Gene

GenScript: Design optimal peptide antigens:
  • Z-DNA binding protein 1 (A2A2F6_HUMAN)
  • Z-DNA binding protein 1 (A2A2F7_HUMAN)
  • Z-DNA binding protein 1 (A2RRL9_HUMAN)
  • cDNA FLJ16296 fis, clone PEBLM2008861, highly similar to Z-DNA-binding protein 1 (B3KVA1_HUMAN)
  • Tumor stroma and activated macrophage protein DLM-1 (ZBP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H171

UniProtKB/Swiss-Prot:

ZBP1_HUMAN :
  • The Z-binding domains recognize and bind left-handed double-stranded Z-RNA structures, but not A-RNA, the right-handed double-stranded RNAs that are structurally very different from Z-RNAs. The second Z-binding domain is essential for sensing influenza A virus (IAV) Z-RNAs.
Domain:
  • The Z-binding domains recognize and bind left-handed double-stranded Z-RNA structures, but not A-RNA, the right-handed double-stranded RNAs that are structurally very different from Z-RNAs. The second Z-binding domain is essential for sensing influenza A virus (IAV) Z-RNAs.
genes like me logo Genes that share domains with ZBP1: view

Function for ZBP1 Gene

Molecular function for ZBP1 Gene

UniProtKB/Swiss-Prot Function:
Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death (PubMed:32200799). Once activated upon Z-RNA-binding, ZBP1 interacts with RIPK3, inducing the complementary pathways of apoptosis, necroptosis and pyroptosis (By similarity). Acts as a key activator of necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members: ZBP1-dependent necroptosis involves RIPK3 stimulation, which phosphorylates and activates MLKL, triggering execution of programmed necrosis (By similarity). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: ZBP1 recognizes and binds Z-RNA structures that are produced in infected nuclei by orthomyxoviruses, such as the influenza A virus (IAV), leading to ZBP1 activation, RIPK3 stimulation and subsequent MLKL phosphorylation, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (PubMed:32200799). ZBP1-dependent cell death in response to IAV infection promotes interleukin-1 alpha (IL1A) induction in an NLRP3-inflammasome-independent manner: IL1A expression is required for the optimal interleukin-1 beta (IL1B) production, and together, these cytokines promote infiltration of inflammatory neutrophils to the lung, leading to the formation of neutrophil extracellular traps (By similarity). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with RIPK3, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity).
UniProtKB/Swiss-Prot EnzymeRegulation:
ZBP1-dependent necroptosis is normally inhibited by RIPK1: RIPK1 inhibits the ZBP1-induced activation of RIPK3 via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis.
GENATLAS Biochemistry:
beta-actin mRNA zipcode binding protein,68kDa,,some homology with KOC,possibly involved in localization of beta-actin at the leading edge of fibroblasts

Phenotypes From GWAS Catalog for ZBP1 Gene

Gene Ontology (GO) - Molecular Function for ZBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 17618271
GO:0003692 left-handed Z-DNA binding NAS 11842111
GO:0003723 RNA binding IEA --
GO:0003725 double-stranded RNA binding ISS --
GO:0005515 protein binding IPI 19590578
genes like me logo Genes that share ontologies with ZBP1: view
genes like me logo Genes that share phenotypes with ZBP1: view

Animal Models for ZBP1 Gene

MGI Knock Outs for ZBP1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBP1

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZBP1 Gene

Localization for ZBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBP1 Gene

Cytoplasm. Nucleus. Note=Mainly cytoplasmic (PubMed:16876127, PubMed:16990255). Accumulates in the nucleus in response to influenza A virus (IAV) infection: senses IAV defective viral genomes RNA in the nucleus (By similarity). {ECO:0000250 UniProtKB:Q9QY24, ECO:0000269 PubMed:16876127, ECO:0000269 PubMed:16990255}.
[Isoform 7]: Cytoplasm. Nucleus. Note=Compared to isoform 1, a higher proportion of this isoform is localized in the nucleus. {ECO:0000269 PubMed:16876127, ECO:0000269 PubMed:16990255}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBP1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
mitochondrion 2
endosome 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 16876127
GO:0005737 cytoplasm IEA,IDA 16876127
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with ZBP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZBP1 Gene

Pathways & Interactions for ZBP1 Gene

genes like me logo Genes that share pathways with ZBP1: view

Gene Ontology (GO) - Biological Process for ZBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002218 activation of innate immune response ISS --
GO:0002376 immune system process IEA --
GO:0006915 apoptotic process IEA --
GO:0012501 programmed cell death IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with ZBP1: view

No data available for SIGNOR curated interactions for ZBP1 Gene

Drugs & Compounds for ZBP1 Gene

No Compound Related Data Available

Transcripts for ZBP1 Gene

mRNA/cDNA for ZBP1 Gene

5 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBP1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for ZBP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: - -
SP8: - - -
SP9:

Relevant External Links for ZBP1 Gene

GeneLoc Exon Structure for
ZBP1

Expression for ZBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBP1 Gene

This gene is overexpressed in Whole Blood (x22.9) and Spleen (x7.8).

Protein differential expression in normal tissues from HIPED for ZBP1 Gene

This gene is overexpressed in Platelet (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBP1 Gene



Protein tissue co-expression partners for ZBP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBP1

SOURCE GeneReport for Unigene cluster for ZBP1 Gene:

Hs.302123

mRNA Expression by UniProt/SwissProt for ZBP1 Gene:

Q9H171-ZBP1_HUMAN
Tissue specificity: Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen (PubMed:11842111). Expressed to a lesser extent in thymus, lung and liver (PubMed:11842111).

Evidence on tissue expression from TISSUES for ZBP1 Gene

  • Spleen(4.4)
  • Blood(4.4)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with ZBP1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBP1 Gene

Orthologs for ZBP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZBP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZBP1 29 30
  • 98.83 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZBP1 29 30
  • 69.85 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zbp1 29 16 30
  • 65.18 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zbp1 29
  • 63.25 (n)
Dog
(Canis familiaris)
Mammalia ZBP1 30
  • 49 (a)
OneToOne
Species where no ortholog for ZBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZBP1 Gene

ENSEMBL:
Gene Tree for ZBP1 (if available)
TreeFam:
Gene Tree for ZBP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBP1: view image
Alliance of Genome Resources:
Additional Orthologs for ZBP1

Paralogs for ZBP1 Gene

No data available for Paralogs for ZBP1 Gene

Variants for ZBP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBP1 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs34917164 Likely Benign: not provided 57,616,331(-) C/A
NM_030776.3(ZBP1):c.172G>T (p.Val58Phe)
MISSENSE_VARIANT,INTRON
rs41304401 Benign: not provided 57,613,163(-) C/T
NM_030776.3(ZBP1):c.670G>A (p.Gly224Ser)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs6099680 Benign: not provided 57,604,597(-) C/T
NM_030776.3(ZBP1):c.1266G>A (p.Gly422=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs16981187 -- p.Asp154His
rs2073145 -- p.Glu88Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZBP1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZBP1 Gene

Variant ID Type Subtype PubMed ID
esv2758802 CNV loss 17122850

Variation tolerance for ZBP1 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.37; 85.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBP1
Leiden Open Variation Database (LOVD)
ZBP1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBP1 Gene

Disorders for ZBP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZBP1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
influenza
  • flu
zika virus congenital syndrome
  • zikv congenital infection
sjogren-larsson syndrome
  • sls
- elite association - COSMIC cancer census association via MalaCards
Search ZBP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZBP1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBP1 Gene

Publications for ZBP1 Gene

  1. Complex regulation of the human gene for the Z-DNA binding protein DLM-1. (PMID: 11842111) Rothenburg S … Haag F (Nucleic acids research 2002) 2 3 4 22
  2. The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA. (PMID: 19095800) Ha SC … Kim KK (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 22
  3. ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains. (PMID: 16990255) Deigendesch N … Rothenburg S (Nucleic acids research 2006) 3 4 22
  4. Intracellular localization of human ZBP1: Differential regulation by the Z-DNA binding domain, Zalpha, in splice variants. (PMID: 16876127) Pham HT … Ahn JH (Biochemical and biophysical research communications 2006) 3 4 22
  5. Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis. (PMID: 32200799) Zhang T … Balachandran S (Cell 2020) 3 4

Products for ZBP1 Gene

Sources for ZBP1 Gene