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Aliases for ZBED8 Gene
Aliases for ZBED8 Gene
External Ids for ZBED8 Gene
- HGNC: 30804
- Entrez Gene: 63920
- Ensembl: ENSG00000221886
- OMIM: 615253
- UniProtKB: Q8IZ13
Previous HGNC Symbols for ZBED8 Gene
- C5orf54
Summaries for ZBED8 Gene
GeneCards Summary for ZBED8 Gene
ZBED8 (Zinc Finger BED-Type Containing 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBED9.
Additional gene information for ZBED8 Gene
- HGNC(30804)
- Entrez Gene(63920)
- Ensembl(ENSG00000221886)
- OMIM(615253)
- UniProtKB(Q8IZ13)
- Open Targets Platform(ENSG00000221886)
- Monarch Initiative
- Search for ZBED8 at DataMed
- Search for ZBED8 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBED8 Gene
Genomics for ZBED8 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZBED8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZBED8 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBED8
Genomic Locations for ZBED8 Gene
Genomic Locations for ZBED8 Gene
- chr5:160,393,148-160,400,097
- (GRCh38/hg38)
- Size:
- 6,950 bases
- Orientation:
- Minus strand
- chr5:159,820,155-159,827,104
- (GRCh37/hg19)
- Size:
- 6,950 bases
- Orientation:
- Minus strand
Genomic View for ZBED8 Gene
Genes around ZBED8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q33.3 by HGNC
- 5q33.3 by Entrez Gene
- 5q33.3 by Ensembl
ZBED8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZBED8 Gene
Proteins for ZBED8 Gene
-
Protein details for ZBED8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IZ13-ZBED8_HUMAN
- Recommended name:
- Protein ZBED8
- Protein Accession:
- Q8IZ13
- D3DQJ9
- Q9H5S8
- Q9UH87
Protein attributes for ZBED8 Gene
- Size:
- 594 amino acids
- Molecular mass:
- 68327 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- May be derived from an ancient transposon that has lost its ability to translocate. Exhibits a close evolutionary relationship with ZBED5, but does not contain any zinc finger.
Protein Expression for ZBED8 Gene
Post-translational modifications for ZBED8 Gene
Other Protein References for ZBED8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-C5ORF54 (aa 394-574) polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for ZBED8
- Novus Biologicals Antibodies for ZBED8
- Invitrogen Antibodies for ZBED8 (AFLGC-ZBED8)
- antibodies-online: Show 22 available C5orf54 Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for ZBED8
- Search Origene for MassSpec and Protein Over-expression Lysates for ZBED8
- Origene Custom Protein Services for ZBED8
- Novus Biologicals proteins for ZBED8
No data available for DME Specific Peptides for ZBED8 Gene
Domains & Families for ZBED8 Gene
Gene Families for ZBED8 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ZBED8 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZBED8 Gene
- GenScript: Design optimal peptide antigens:
-
- Transposon-derived Buster3 transposase-like protein (CE054_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBED8 Gene
Function for ZBED8 Gene
Phenotypes From GWAS Catalog for ZBED8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21516116 |
Phenotypes for ZBED8 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZBED8 - Select products 50% OFF >
- * ZBED8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZBED8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZBED8
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZBED8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZBED8
- Browse OriGene Inhibitory RNA Products For ZBED8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBED8
Clone Products
- Applied Biological Materials (abm): Clones for ZBED8 - Select products 50% OFF >
- * ZBED8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZBED8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZBED8
Cell Line Products
-
Horizon Cell Lines for ZBED8
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZBED8 Gene
Localization for ZBED8 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 2 |
| plasma membrane | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IBA,IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZBED8 Gene
Pathways & Interactions for ZBED8 Gene
Interacting Proteins for ZBED8 Gene
Selected Interacting proteins:
Q8IZ13-ZBED8_HUMAN
ENSP00000386184
for ZBED8 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ZBED8
No data available for Pathways by source and SIGNOR curated interactions for ZBED8 Gene
Transcripts for ZBED8 Gene
mRNA/cDNA for ZBED8 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000408953 2808 nts (view in UCSC)
- ENST00000523213 2484 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZBED8 - Select products 50% OFF >
- * ZBED8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZBED8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZBED8
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZBED8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZBED8
- Browse OriGene Inhibitory RNA Products For ZBED8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBED8
Clone Products
- Applied Biological Materials (abm): Clones for ZBED8 - Select products 50% OFF >
- * ZBED8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZBED8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZBED8
Relevant External Links for ZBED8 Gene
- GeneLoc Exon Structure for
- ZBED8
Expression for ZBED8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Ovary (Reproductive System)
This gene is overexpressed in Ovary (45.0) and Heart (23.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBED8 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBED8
Evidence on tissue expression from TISSUES for ZBED8 Gene
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs for ZBED8
-
OriGene qPCR primer pairs and template standards for ZBED8
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBED8 Gene
Orthologs for ZBED8 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | C5orf54 31 |
|
OneToOne | |
| C5H5orf54 30 |
|
||||
| Dog (Canis familiaris) |
Mammalia | C5orf54 31 |
|
OneToOne | |
| C4H5orf54 30 |
|
||||
| Cow (Bos Taurus) |
Mammalia | ZBED8 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | BX664605.1 31 |
|
ManyToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany |
- Species where no ortholog for ZBED8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ZBED8 Gene
- ENSEMBL:
- Gene Tree for ZBED8 (if available)
- TreeFam:
- Gene Tree for ZBED8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZBED8: view image
Paralogs for ZBED8 Gene
Paralogs for ZBED8 Gene
(5) SIMAP similar genes for ZBED8 Gene using alignment to 1 proteins:
- ZBED8_HUMAN
Variants for ZBED8 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBED8 Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 789585 | Benign: not provided | 160,394,996(-) | G/T | SYNONYMOUS_VARIANT | |
| rs10515808 | - | p.Ala523Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3607367 | CNV | gain | 21293372 |
| esv3607370 | CNV | gain | 21293372 |
| nsv1015634 | CNV | gain | 25217958 |
| nsv5097 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.38;
54.08% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZBED8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZBED8
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBED8 Gene
Disorders for ZBED8 Gene
Additional Disease Information for ZBED8
No disorders were found for ZBED8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBED8 Gene
Publications for ZBED8 Gene
- ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A … Jern P (PloS one 2013) 2 3 4
- Interspersed repeats and other mementos of transposable elements in mammalian genomes. (PMID: 10607616) Smit AF (Current opinion in genetics & development 1999) 2 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
ExternalLinks
Products for ZBED8 Gene
- Custom Antibody ServicesOriGene Antibodies for ZBED8
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ZBED8
- Search Origene for MassSpec and Protein Over-expression Lysates for ZBED8
- Origene Custom Protein Services for ZBED8
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZBED8
- Browse OriGene Inhibitory RNA Products For ZBED8
- OriGene qPCR primer pairs for ZBED8
- OriGene qPCR primer pairs and template standards for ZBED8
- OriGene CRISPR knockouts for ZBED8
- OriGene ORF clones in human for ZBED8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ZBED8
- Sino Biological Human cDNA Clone for ZBED8
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ZBED8
- Novus Biologicals proteins for ZBED8
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for ZBED8 (AFLGC-ZBED8)
- VectorBuilder Custom and pre-made DNA vectors for ZBED8 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ZBED8 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ZBED8 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ZBED8 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ZBED8
- antibodies-online: Show 22 available C5orf54 Antibodies ranked by validation data
- antibodies-online: Search results for available C5orf54 related products ranked by validation data
- antibodies-online: Search results for available C5orf54 related products ranked by validation data
- Horizon Cell Lines for ZBED8
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZBED8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZBED8
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ZBED8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBED8
Sources for ZBED8 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB