Aliases for ZBED8 Gene

Aliases for ZBED8 Gene

  • Zinc Finger BED-Type Containing 8 2 3 5
  • Buster3 2 3 4
  • Transposon-Derived Buster3 Transposase-Like Protein 3 4
  • Zinc Finger BED Domain-Containing Protein 8 3 4
  • Protein ZBED8 3 4
  • C5orf54 3 4
  • Chromosome 5 Open Reading Frame 54 2
  • ZBED8 5

External Ids for ZBED8 Gene

Previous HGNC Symbols for ZBED8 Gene

  • C5orf54

Summaries for ZBED8 Gene

GeneCards Summary for ZBED8 Gene

ZBED8 (Zinc Finger BED-Type Containing 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBED9.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBED8 Gene

Genomics for ZBED8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZBED8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBED8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBED8

Genomic Locations for ZBED8 Gene

Genomic Locations for ZBED8 Gene
chr5:160,393,148-160,400,097
(GRCh38/hg38)
Size:
6,950 bases
Orientation:
Minus strand
chr5:159,820,155-159,827,104
(GRCh37/hg19)
Size:
6,950 bases
Orientation:
Minus strand

Genomic View for ZBED8 Gene

Genes around ZBED8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBED8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBED8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBED8 Gene

Proteins for ZBED8 Gene

  • Protein details for ZBED8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ13-ZBED8_HUMAN
    Recommended name:
    Protein ZBED8
    Protein Accession:
    Q8IZ13
    Secondary Accessions:
    • D3DQJ9
    • Q9H5S8
    • Q9UH87

    Protein attributes for ZBED8 Gene

    Size:
    594 amino acids
    Molecular mass:
    68327 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May be derived from an ancient transposon that has lost its ability to translocate. Exhibits a close evolutionary relationship with ZBED5, but does not contain any zinc finger.

neXtProt entry for ZBED8 Gene

Post-translational modifications for ZBED8 Gene

  • Ubiquitination at Lys574
  • Modification sites at PhosphoSitePlus

Other Protein References for ZBED8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBED8 Gene

Domains & Families for ZBED8 Gene

Gene Families for ZBED8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZBED8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZBED8 Gene

GenScript: Design optimal peptide antigens:
  • Transposon-derived Buster3 transposase-like protein (CE054_HUMAN)
genes like me logo Genes that share domains with ZBED8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBED8 Gene

Function for ZBED8 Gene

Phenotypes From GWAS Catalog for ZBED8 Gene

Gene Ontology (GO) - Molecular Function for ZBED8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with ZBED8: view
genes like me logo Genes that share phenotypes with ZBED8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBED8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZBED8 Gene

Localization for ZBED8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBED8 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBED8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IBA,IDA --
genes like me logo Genes that share ontologies with ZBED8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZBED8 Gene

Pathways & Interactions for ZBED8 Gene

PathCards logo

SuperPathways for ZBED8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBED8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZBED8 Gene

Drugs & Compounds for ZBED8 Gene

No Compound Related Data Available

Transcripts for ZBED8 Gene

mRNA/cDNA for ZBED8 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBED8

Alternative Splicing Database (ASD) splice patterns (SP) for ZBED8 Gene

No ASD Table

Relevant External Links for ZBED8 Gene

GeneLoc Exon Structure for
ZBED8

Expression for ZBED8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBED8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBED8 Gene

This gene is overexpressed in Ovary (45.0) and Heart (23.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBED8 Gene



Protein tissue co-expression partners for ZBED8 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBED8

Evidence on tissue expression from TISSUES for ZBED8 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZBED8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBED8 Gene

Orthologs for ZBED8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBED8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C5orf54 31
  • 100 (a)
OneToOne
C5H5orf54 30
  • 99.38 (n)
Dog
(Canis familiaris)
Mammalia C5orf54 31
  • 95 (a)
OneToOne
C4H5orf54 30
  • 92.93 (n)
Cow
(Bos Taurus)
Mammalia ZBED8 30 31
  • 91.25 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 29 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii BX664605.1 31
  • 31 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 26 (a)
ManyToMany
Species where no ortholog for ZBED8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZBED8 Gene

ENSEMBL:
Gene Tree for ZBED8 (if available)
TreeFam:
Gene Tree for ZBED8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBED8: view image

Paralogs for ZBED8 Gene

(5) SIMAP similar genes for ZBED8 Gene using alignment to 1 proteins:

  • ZBED8_HUMAN
genes like me logo Genes that share paralogs with ZBED8: view

Variants for ZBED8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBED8 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
789585 Benign: not provided 160,394,996(-) G/T SYNONYMOUS_VARIANT
rs10515808 - p.Ala523Ser

Additional dbSNP identifiers (rs#s) for ZBED8 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZBED8 Gene

Variant ID Type Subtype PubMed ID
esv3607367 CNV gain 21293372
esv3607370 CNV gain 21293372
nsv1015634 CNV gain 25217958
nsv5097 CNV deletion 18451855

Variation tolerance for ZBED8 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBED8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBED8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBED8 Gene

Disorders for ZBED8 Gene

No disorders were found for ZBED8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBED8 Gene

Publications for ZBED8 Gene

  1. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A … Jern P (PloS one 2013) 2 3 4
  2. Interspersed repeats and other mementos of transposable elements in mammalian genomes. (PMID: 10607616) Smit AF (Current opinion in genetics & development 1999) 2 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ZBED8 Gene

Sources for ZBED8 Gene