This gene is unusual in that its coding sequence is mostly derived from Charlie-like DNA transposon; however, it does not appear to be an active DNA transposon as it is not flanked by terminal inverted repeats. The encoded protein is conserved among the mammalian Laurasiatheria branch. Multiple alternatively spliced variants, encoding the same protein, have been identified. [pr... See more...

Aliases for ZBED5 Gene

Aliases for ZBED5 Gene

  • Zinc Finger BED-Type Containing 5 2 3 5
  • Buster1 2 3 4
  • Transposon-Derived Buster1 Transposase-Like Protein 3 4
  • Zinc Finger BED Domain-Containing Protein 5 3 4
  • ZBED5 5

External Ids for ZBED5 Gene

Previous GeneCards Identifiers for ZBED5 Gene

  • GC11M010831
  • GC11M010547
  • GC11M010835
  • GC11M010840
  • GC11M010843
  • GC11M010813
  • GC11M010826
  • GC11M010847
  • GC11M010850
  • GC11M010854
  • GC11M010815
  • GC11M010819

Summaries for ZBED5 Gene

Entrez Gene Summary for ZBED5 Gene

  • This gene is unusual in that its coding sequence is mostly derived from Charlie-like DNA transposon; however, it does not appear to be an active DNA transposon as it is not flanked by terminal inverted repeats. The encoded protein is conserved among the mammalian Laurasiatheria branch. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]

GeneCards Summary for ZBED5 Gene

ZBED5 (Zinc Finger BED-Type Containing 5) is a Protein Coding gene. Diseases associated with ZBED5 include Exudative Vitreoretinopathy 2, X-Linked. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBED9.

Additional gene information for ZBED5 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBED5 Gene

Genomics for ZBED5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZBED5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBED5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBED5

Top Transcription factor binding sites by QIAGEN in the ZBED5 gene promoter:
  • Arnt
  • CBF(2)
  • En-1
  • HEN1
  • NF-Y
  • NRSF form 1
  • NRSF form 2
  • Pax-5
  • Pax-6
  • YY1

Genomic Locations for ZBED5 Gene

Genomic Locations for ZBED5 Gene
chr11:10,812,074-10,858,796
(GRCh38/hg38)
Size:
46,723 bases
Orientation:
Minus strand
chr11:10,833,621-10,880,343
(GRCh37/hg19)
Size:
46,723 bases
Orientation:
Minus strand

Genomic View for ZBED5 Gene

Genes around ZBED5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBED5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBED5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBED5 Gene

Proteins for ZBED5 Gene

  • Protein details for ZBED5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AG3-ZBED5_HUMAN
    Recommended name:
    Zinc finger BED domain-containing protein 5
    Protein Accession:
    Q49AG3
    Secondary Accessions:
    • B2RCC1
    • Q05D82
    • Q86WW3
    • Q9NT24
    • Q9UBJ4

    Protein attributes for ZBED5 Gene

    Size:
    693 amino acids
    Molecular mass:
    78911 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17803.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH47754.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • May be derived from an ancient transposon that has lost its ability to translocate.

neXtProt entry for ZBED5 Gene

Post-translational modifications for ZBED5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBED5 Gene

No data available for DME Specific Peptides for ZBED5 Gene

Domains & Families for ZBED5 Gene

Gene Families for ZBED5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBED5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZBED5 Gene

GenScript: Design optimal peptide antigens:
  • Transposon-derived Buster1 transposase-like protein (ZBED5_HUMAN)
genes like me logo Genes that share domains with ZBED5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBED5 Gene

Function for ZBED5 Gene

Phenotypes From GWAS Catalog for ZBED5 Gene

Gene Ontology (GO) - Molecular Function for ZBED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBED5: view
genes like me logo Genes that share phenotypes with ZBED5: view

Animal Models for ZBED5 Gene

MGI Knock Outs for ZBED5:
  • Zbed5 Zbed5<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBED5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZBED5 Gene

Localization for ZBED5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBED5 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 2
golgi apparatus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZBED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005654 nucleoplasm IBA --
genes like me logo Genes that share ontologies with ZBED5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZBED5 Gene

Pathways & Interactions for ZBED5 Gene

PathCards logo

SuperPathways for ZBED5 Gene

No Data Available

Interacting Proteins for ZBED5 Gene

Selected Interacting proteins: Q49AG3-ZBED5_HUMAN for ZBED5 Gene via MINT IID

Symbol External ID(s) Details
SMAD4

Gene Ontology (GO) - Biological Process for ZBED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZBED5: view

No data available for Pathways by source and SIGNOR curated interactions for ZBED5 Gene

Drugs & Compounds for ZBED5 Gene

No Compound Related Data Available

Transcripts for ZBED5 Gene

mRNA/cDNA for ZBED5 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBED5

Alternative Splicing Database (ASD) splice patterns (SP) for ZBED5 Gene

No ASD Table

Relevant External Links for ZBED5 Gene

GeneLoc Exon Structure for
ZBED5

Expression for ZBED5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBED5 Gene

Protein differential expression in normal tissues from HIPED for ZBED5 Gene

This gene is overexpressed in Lung (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBED5 Gene



Protein tissue co-expression partners for ZBED5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBED5

SOURCE GeneReport for Unigene cluster for ZBED5 Gene:

Hs.655066

Evidence on tissue expression from TISSUES for ZBED5 Gene

  • Nervous system(4.8)
  • Lung(4.3)
  • Stomach(2)
genes like me logo Genes that share expression patterns with ZBED5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBED5 Gene

Orthologs for ZBED5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBED5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZBED5 30 31
  • 99.66 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZBED5 30 31
  • 95 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZBED5 30 31
  • 94.37 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zbed5 30
  • 47.62 (n)
Mouse
(Mus musculus)
Mammalia 2410018M08Rik 30 31
  • 47.54 (n)
OneToMany
Zbed5 17
Lizard
(Anolis carolinensis)
Reptilia ZBED5 31
  • 43 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii BX664605.1 31
  • 31 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 28 (a)
ManyToMany
Species where no ortholog for ZBED5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZBED5 Gene

ENSEMBL:
Gene Tree for ZBED5 (if available)
TreeFam:
Gene Tree for ZBED5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBED5: view image

Paralogs for ZBED5 Gene

(5) SIMAP similar genes for ZBED5 Gene using alignment to 5 proteins:

  • ZBED5_HUMAN
  • E9PJ57_HUMAN
  • E9PJT5_HUMAN
  • E9PM71_HUMAN
  • E9PNT1_HUMAN
genes like me logo Genes that share paralogs with ZBED5: view

Variants for ZBED5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBED5 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1046297 - p.Ile480Val
rs2232918 - p.Ala17Val
rs2232919 - p.Gln47Arg
rs2232920 - p.Pro77Ser

Additional dbSNP identifiers (rs#s) for ZBED5 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZBED5 Gene

Variant ID Type Subtype PubMed ID
nsv483000 CNV loss 15286789

Variation tolerance for ZBED5 Gene

Gene Damage Index Score: 4.60; 65.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBED5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBED5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBED5 Gene

Disorders for ZBED5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZBED5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
exudative vitreoretinopathy 2, x-linked
  • evr2
- elite association - COSMIC cancer census association via MalaCards
Search ZBED5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZBED5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZBED5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBED5 Gene

Publications for ZBED5 Gene

  1. Interspersed repeats and other mementos of transposable elements in mammalian genomes. (PMID: 10607616) Smit AF (Current opinion in genetics & development 1999) 2 3 4
  2. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A … Jern P (PloS one 2013) 2 3
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for ZBED5 Gene

Sources for ZBED5 Gene