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Aliases for ZBED5 Gene

Aliases for ZBED5 Gene

  • Zinc Finger BED-Type Containing 5 2 3 5
  • Transposon-Derived Buster1 Transposase-Like Protein 3 4
  • Buster1 3 4
  • Zinc Finger BED Domain-Containing Protein 5 3

External Ids for ZBED5 Gene

Previous GeneCards Identifiers for ZBED5 Gene

  • GC11M010831
  • GC11M010547
  • GC11M010835
  • GC11M010840
  • GC11M010843
  • GC11M010813
  • GC11M010815
  • GC11M010819

Summaries for ZBED5 Gene

Entrez Gene Summary for ZBED5 Gene

  • This gene is unusual in that its coding sequence is mostly derived from Charlie-like DNA transposon; however, it does not appear to be an active DNA transposon as it is not flanked by terminal inverted repeats. The encoded protein is conserved among the mammalian Laurasiatheria branch. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]

GeneCards Summary for ZBED5 Gene

ZBED5 (Zinc Finger BED-Type Containing 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBED9.

Additional gene information for ZBED5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBED5 Gene

Genomics for ZBED5 Gene

GeneHancer (GH) Regulatory Elements for ZBED5 Gene

Promoters and enhancers for ZBED5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I010855 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 570.1 +0.6 604 4.4 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZBED5-AS1 ZBED5 CTR9 LOC101928053 EIF4G2 SNORD97 LOC105376547
GH11I010805 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 67.4 +50.9 50942 5.2 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC GLIS1 NBN NR2C1 EIF4G2 LOC101928053 ZBED5 CTR9 ZBED5-AS1 ENSG00000255125 GC11M010801 SNORD97 GC11M010630
GH11I010897 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 33.1 -41.8 -41789 5.3 PKNOX1 SMAD1 FOXA2 ARNT SIN3A FEZF1 ZNF2 POLR2B ZNF766 FOS ENSG00000250041 ZBED5 CTR9 ZBED5-AS1 EIF4G2 ENSG00000255125 AMPD3 SNORD97 RNF141 LOC105376550
GH11I010933 Enhancer 1.4 Ensembl ENCODE dbSUPER 41.1 -76.5 -76536 4 HDGF CLOCK ZFP64 SIN3A ZNF2 ZNF121 CBX5 ZNF143 ZNF548 RUNX3 ZBED5 CTR9 ENSG00000255125 ZBED5-AS1 ENSG00000250041 LOC105376550
GH11I011840 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.6 -984.7 -984659 5.3 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B USP47 ZBED5 ENSG00000255492
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBED5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBED5 gene promoter:

Genomic Locations for ZBED5 Gene

Genomic Locations for ZBED5 Gene
chr11:10,812,074-10,858,796
(GRCh38/hg38)
Size:
46,723 bases
Orientation:
Minus strand
chr11:10,833,621-10,880,343
(GRCh37/hg19)

Genomic View for ZBED5 Gene

Genes around ZBED5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBED5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBED5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBED5 Gene

Proteins for ZBED5 Gene

  • Protein details for ZBED5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AG3-ZBED5_HUMAN
    Recommended name:
    Zinc finger BED domain-containing protein 5
    Protein Accession:
    Q49AG3
    Secondary Accessions:
    • B2RCC1
    • Q05D82
    • Q86WW3
    • Q9NT24
    • Q9UBJ4

    Protein attributes for ZBED5 Gene

    Size:
    693 amino acids
    Molecular mass:
    78911 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May be derived from an ancient transposon that has lost its ability to translocate.
    SequenceCaution:
    • Sequence=AAH17803.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH47754.1; Type=Frameshift; Positions=495; Evidence={ECO:0000305};

neXtProt entry for ZBED5 Gene

Post-translational modifications for ZBED5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBED5 Gene

No data available for DME Specific Peptides for ZBED5 Gene

Domains & Families for ZBED5 Gene

Gene Families for ZBED5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBED5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZBED5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBED5: view

No data available for UniProtKB/Swiss-Prot for ZBED5 Gene

Function for ZBED5 Gene

Phenotypes From GWAS Catalog for ZBED5 Gene

Gene Ontology (GO) - Molecular Function for ZBED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBED5: view
genes like me logo Genes that share phenotypes with ZBED5: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZBED5 Gene

Localization for ZBED5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBED5 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 2
golgi apparatus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZBED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ZBED5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZBED5 Gene

Pathways & Interactions for ZBED5 Gene

SuperPathways for ZBED5 Gene

No Data Available

Interacting Proteins for ZBED5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000398106%0d%0a9606.ENSP00000341551%0d%0a
Selected Interacting proteins: Q49AG3-ZBED5_HUMAN ENSP00000398106 for ZBED5 Gene via IID MINT STRING

Gene Ontology (GO) - Biological Process for ZBED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZBED5: view

No data available for Pathways by source and SIGNOR curated interactions for ZBED5 Gene

Drugs & Compounds for ZBED5 Gene

No Compound Related Data Available

Transcripts for ZBED5 Gene

Unigene Clusters for ZBED5 Gene

Zinc finger, BED-type containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBED5 Gene

No ASD Table

Relevant External Links for ZBED5 Gene

GeneLoc Exon Structure for
ZBED5
ECgene alternative splicing isoforms for
ZBED5

Expression for ZBED5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBED5 Gene

Protein differential expression in normal tissues from HIPED for ZBED5 Gene

This gene is overexpressed in Lung (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBED5 Gene



Protein tissue co-expression partners for ZBED5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBED5 Gene:

ZBED5

SOURCE GeneReport for Unigene cluster for ZBED5 Gene:

Hs.655066

Evidence on tissue expression from TISSUES for ZBED5 Gene

  • Nervous system(4.8)
  • Lung(4.3)
  • Stomach(2)
genes like me logo Genes that share expression patterns with ZBED5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBED5 Gene

Orthologs for ZBED5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBED5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBED5 33 34
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia ZBED5 33 34
  • 95 (n)
dog
(Canis familiaris)
Mammalia ZBED5 33 34
  • 94.37 (n)
rat
(Rattus norvegicus)
Mammalia Zbed5 33
  • 47.62 (n)
mouse
(Mus musculus)
Mammalia 2410018M08Rik 33 34
  • 47.54 (n)
Zbed5 16
lizard
(Anolis carolinensis)
Reptilia ZBED5 34
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX664605.1 34
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
ManyToMany
Species where no ortholog for ZBED5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBED5 Gene

ENSEMBL:
Gene Tree for ZBED5 (if available)
TreeFam:
Gene Tree for ZBED5 (if available)

Paralogs for ZBED5 Gene

(5) SIMAP similar genes for ZBED5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZBED5: view

Variants for ZBED5 Gene

Sequence variations from dbSNP and Humsavar for ZBED5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000210877 -- 10,852,625(-) C/T downstream_transcript_variant
rs1000595629 -- 10,858,274(-) G/C upstream_transcript_variant
rs1000718328 -- 10,852,422(-) A/C downstream_transcript_variant
rs1000967628 -- 10,858,456(-) G/A upstream_transcript_variant
rs1001709153 -- 10,858,878(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBED5 Gene

Variant ID Type Subtype PubMed ID
nsv483000 CNV loss 15286789

Variation tolerance for ZBED5 Gene

Gene Damage Index Score: 4.60; 65.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBED5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBED5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBED5 Gene

Disorders for ZBED5 Gene

Additional Disease Information for ZBED5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZBED5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBED5 Gene

Publications for ZBED5 Gene

  1. Interspersed repeats and other mementos of transposable elements in mammalian genomes. (PMID: 10607616) Smit AF (Current opinion in genetics & development 1999) 2 3 4 58
  2. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A … Jern P (PloS one 2013) 2 3 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ZBED5 Gene

Sources for ZBED5 Gene

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