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Aliases for ZBBX Gene

Aliases for ZBBX Gene

  • Zinc Finger B-Box Domain Containing 2 3 5

External Ids for ZBBX Gene

Previous GeneCards Identifiers for ZBBX Gene

  • GC03M168440
  • GC03M166958
  • GC03M164328

Summaries for ZBBX Gene

GeneCards Summary for ZBBX Gene

ZBBX (Zinc Finger B-Box Domain Containing) is a Protein Coding gene.

Additional gene information for ZBBX Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBBX Gene

Genomics for ZBBX Gene

GeneHancer (GH) Regulatory Elements for ZBBX Gene

Promoters and enhancers for ZBBX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I167380 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +1.0 1046 0.6 PKNOX1 ARID4B NEUROD1 SIN3A YY1 ELK1 ZNF207 ZNF143 RUNX3 REST ZBBX GC03P167149
GH03I167876 Enhancer 0.8 Ensembl ENCODE 10.2 -495.6 -495617 1 ETV1 TAL1 CBFA2T3 NR2F2 GABPA TCF12 FOSL1 JUND POLR2A IKZF1 ZBBX LRRC77P ENSG00000244706 MEMO1P3
GH03I167691 Enhancer 0.8 ENCODE 9.8 -310.2 -310212 0.2 PKNOX1 BACH1 EBF1 BMI1 BATF IRF4 RELA POLR2A NFATC1 ZNF143 SERPINI1 PDCD10 ZBBX HMGN1P8 GC03P167665
GH03I167683 Enhancer 0.6 UCNEbase 10.8 -302.7 -302743 0.2 CTCF ATF4 WDR49 SERPINI1 PDCD10 ZBBX HMGN1P8 GC03P167665
GH03I167684 Enhancer 0.6 ENCODE 10.8 -303.2 -303242 0.2 CTCF ZNF654 CEBPB CEBPG ATF2 RAD21 ATF4 ATF3 CEBPA ZNF143 SERPINI1 WDR49 PDCD10 ZBBX HMGN1P8 GC03P167665
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBBX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBBX gene promoter:

Genomic Locations for ZBBX Gene

Genomic Locations for ZBBX Gene
chr3:167,178,425-167,381,346
(GRCh38/hg38)
Size:
202,922 bases
Orientation:
Minus strand
chr3:166,958,075-167,099,134
(GRCh37/hg19)

Genomic View for ZBBX Gene

Genes around ZBBX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBBX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBBX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBBX Gene

Proteins for ZBBX Gene

  • Protein details for ZBBX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MT70-ZBBX_HUMAN
    Recommended name:
    Zinc finger B-box domain-containing protein 1
    Protein Accession:
    A8MT70
    Secondary Accessions:
    • A8MV69
    • B3KSC1
    • B5MDJ6
    • F2Z370
    • Q9H5T8

    Protein attributes for ZBBX Gene

    Size:
    800 amino acids
    Molecular mass:
    91426 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15532.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZBBX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBBX Gene

Post-translational modifications for ZBBX Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZBBX Gene

Domains & Families for ZBBX Gene

Gene Families for ZBBX Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZBBX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZBBX Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBBX: view

No data available for UniProtKB/Swiss-Prot for ZBBX Gene

Function for ZBBX Gene

Phenotypes From GWAS Catalog for ZBBX Gene

Gene Ontology (GO) - Molecular Function for ZBBX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBBX: view
genes like me logo Genes that share phenotypes with ZBBX: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZBBX Gene

Localization for ZBBX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBBX gene
Compartment Confidence
nucleus 3
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZBBX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ZBBX: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ZBBX Gene

Pathways & Interactions for ZBBX Gene

No Data Available

Interacting Proteins for ZBBX Gene

Gene Ontology (GO) - Biological Process for ZBBX Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZBBX Gene

Drugs & Compounds for ZBBX Gene

No Compound Related Data Available

Transcripts for ZBBX Gene

Unigene Clusters for ZBBX Gene

Zinc finger, B-box domain containing:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBBX Gene

No ASD Table

Relevant External Links for ZBBX Gene

GeneLoc Exon Structure for
ZBBX
ECgene alternative splicing isoforms for
ZBBX

Expression for ZBBX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBBX Gene

mRNA differential expression in normal tissues according to GTEx for ZBBX Gene

This gene is overexpressed in Testis (x12.4), Brain - Cortex (x5.3), Brain - Frontal Cortex (BA9) (x4.4), and Fallopian Tube (x4.2).

Protein differential expression in normal tissues from HIPED for ZBBX Gene

This gene is overexpressed in Monocytes (37.3) and Ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBBX Gene



Protein tissue co-expression partners for ZBBX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBBX Gene:

ZBBX

SOURCE GeneReport for Unigene cluster for ZBBX Gene:

Hs.478143

Evidence on tissue expression from TISSUES for ZBBX Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZBBX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBBX Gene

Orthologs for ZBBX Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBBX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBBX 33 34
  • 98.97 (n)
dog
(Canis familiaris)
Mammalia ZBBX 33 34
  • 84.71 (n)
cow
(Bos Taurus)
Mammalia ZBBX 33 34
  • 83.12 (n)
mouse
(Mus musculus)
Mammalia Zbbx 33 16 34
  • 73.6 (n)
rat
(Rattus norvegicus)
Mammalia Zbbx 33
  • 73.48 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBBX 34
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBBX 34
  • 13 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBBX 34
  • 13 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBBX 34
  • 10 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbbx 33
  • 53.55 (n)
zebrafish
(Danio rerio)
Actinopterygii zbbx 34
  • 11 (a)
OneToOne
Species where no ortholog for ZBBX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBBX Gene

ENSEMBL:
Gene Tree for ZBBX (if available)
TreeFam:
Gene Tree for ZBBX (if available)

Paralogs for ZBBX Gene

No data available for Paralogs for ZBBX Gene

Variants for ZBBX Gene

Sequence variations from dbSNP and Humsavar for ZBBX Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000024565 -- 167,212,354(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000025655 -- 167,302,798(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000032327 -- 167,189,718(-) T/A genic_downstream_transcript_variant, intron_variant
rs1000041397 -- 167,195,673(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000103264 -- 167,254,709(-) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBBX Gene

Variant ID Type Subtype PubMed ID
nsv954506 CNV duplication 24416366
nsv592495 CNV gain 21841781
esv3598562 CNV loss 21293372
esv3598560 CNV loss 21293372
dgv4982n100 CNV gain 25217958

Variation tolerance for ZBBX Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.22; 98.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBBX Gene

Human Gene Mutation Database (HGMD)
ZBBX
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBBX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBBX Gene

Disorders for ZBBX Gene

Additional Disease Information for ZBBX

No disorders were found for ZBBX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBBX Gene

Publications for ZBBX Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58

Products for ZBBX Gene

Sources for ZBBX Gene

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