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Aliases for ZAN Gene

Aliases for ZAN Gene

  • Zonadhesin (Gene/Pseudogene) 2 3 5
  • Zonadhesin 2 3

External Ids for ZAN Gene

Previous GeneCards Identifiers for ZAN Gene

  • GC07P098866
  • GC07P099928
  • GC07P099943
  • GC07P099944
  • GC07P099975
  • GC07P100169
  • GC07P100333
  • GC07P099690

Summaries for ZAN Gene

Entrez Gene Summary for ZAN Gene

  • This gene encodes a protein that functions in the species specificity of sperm adhesion to the egg zona pellucida. The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition. An allelic polymorphism in this gene results in both functional and frameshifted alleles; the reference genome represents the functional allele. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for ZAN Gene

ZAN (Zonadhesin (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. An important paralog of this gene is FCGBP.

UniProtKB/Swiss-Prot for ZAN Gene

  • Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.

Additional gene information for ZAN Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZAN Gene

Genomics for ZAN Gene

GeneHancer (GH) Regulatory Elements for ZAN Gene

Promoters and enhancers for ZAN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I100733 Promoter 0.5 EPDnew 550.8 0.0 -7 0.1 ZAN EPO
GH07I100672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 30 -56.6 -56591 8.6 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 GNB2 GC07P100676 TRIM4 ZNF3 GIGYF1 SRRT PCOLCE STAG3L5P PPP1R35 ENSG00000242798
GH07I100681 Enhancer 0.7 dbSUPER 29.2 -51.1 -51054 2 JUN SIN3A ZIC2 HIC1 FOSL1 ZFHX2 GLIS2 POLR2A EGR1 PATZ1 ZAN GIGYF1 MBLAC1 PIR58923 GC07M100687 GC07P100676
GH07I100687 Enhancer 0.7 ENCODE dbSUPER 26.8 -45.3 -45279 0.9 NCOA3 ZFHX2 EGR1 FOS EGR2 ZAN GIGYF1 MUC3A GC07M100687 PIR58923
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZAN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZAN gene promoter:

Genomic Locations for ZAN Gene

Genomic Locations for ZAN Gene
64,215 bases
Plus strand

Genomic View for ZAN Gene

Genes around ZAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZAN Gene

Proteins for ZAN Gene

  • Protein details for ZAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0FKC8
    • D6W5W4
    • O00218
    • Q96L85
    • Q96L86
    • Q96L87
    • Q96L88
    • Q96L89
    • Q96L90
    • Q9BXN9
    • Q9BZ83
    • Q9BZ84
    • Q9BZ85
    • Q9BZ86
    • Q9BZ87
    • Q9BZ88

    Protein attributes for ZAN Gene

    2812 amino acids
    Molecular mass:
    305663 Da
    Quaternary structure:
    • Probably forms covalent oligomers.
    • Sequence=AAC78790.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76487.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76488.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76489.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76490.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76491.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76492.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZAN Gene

neXtProt entry for ZAN Gene

Post-translational modifications for ZAN Gene

  • Glycosylation at isoforms=2, 3, 4, 5, 6, 7333, isoforms=2, 3, 4, 5, 6, 7493, posLast=11121112, posLast=11881188, posLast=16851685, posLast=18041804, posLast=19001900, isoforms=2, 3, 4, 5, 6, 71946, isoforms=2, 3, 4, 5, 6, 72203, posLast=25422542, and posLast=27012701
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZAN Gene

Domains & Families for ZAN Gene

Gene Families for ZAN Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ZAN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The MAM domains probably mediate sperm adhesion to the zona pellucida.
  • The MAM domains probably mediate sperm adhesion to the zona pellucida.
  • During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus.
  • The VWFD domain 2 may mediate covalent oligomerization.
genes like me logo Genes that share domains with ZAN: view

Function for ZAN Gene

Molecular function for ZAN Gene

GENATLAS Biochemistry:
zonadhesin,sperm membrane protein,binding the zona pellucida
UniProtKB/Swiss-Prot Function:
Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.

Phenotypes From GWAS Catalog for ZAN Gene

genes like me logo Genes that share phenotypes with ZAN: view

Animal Models for ZAN Gene

MGI Knock Outs for ZAN:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZAN Gene

Localization for ZAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZAN Gene

Cell membrane; Single-pass type I membrane protein. Note=Exclusively on the apical region of the sperm head. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ZAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS 9126492
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZAN: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ZAN Gene

Pathways & Interactions for ZAN Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with ZAN: view

Pathways by source for ZAN Gene

1 Qiagen pathway for ZAN Gene

Interacting Proteins for ZAN Gene

Gene Ontology (GO) - Biological Process for ZAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007339 binding of sperm to zona pellucida NAS 9126492
GO:0098609 cell-cell adhesion NAS 9126492
genes like me logo Genes that share ontologies with ZAN: view

No data available for SIGNOR curated interactions for ZAN Gene

Drugs & Compounds for ZAN Gene

No Compound Related Data Available

Transcripts for ZAN Gene

mRNA/cDNA for ZAN Gene

Unigene Clusters for ZAN Gene

Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZAN Gene

No ASD Table

Relevant External Links for ZAN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZAN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZAN Gene

mRNA differential expression in normal tissues according to GTEx for ZAN Gene

This gene is overexpressed in Testis (x43.6).

Protein differential expression in normal tissues from HIPED for ZAN Gene

This gene is overexpressed in Pancreas (54.6) and Lung (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZAN Gene

Protein tissue co-expression partners for ZAN Gene

NURSA nuclear receptor signaling pathways regulating expression of ZAN Gene:


SOURCE GeneReport for Unigene cluster for ZAN Gene:


mRNA Expression by UniProt/SwissProt for ZAN Gene:

Tissue specificity: In testis, primarily in haploid spermatids.
genes like me logo Genes that share expression patterns with ZAN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZAN Gene

Orthologs for ZAN Gene

This gene was present in the common ancestor of animals.

Orthologs for ZAN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZAN 33
  • 97.45 (n)
(Bos Taurus)
Mammalia ZAN 33 34
  • 75.03 (n)
(Mus musculus)
Mammalia Zan 33 16 34
  • 70.13 (n)
(Rattus norvegicus)
Mammalia Zan 33
  • 67.95 (n)
(Canis familiaris)
Mammalia ZAN 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia ZAN 34
  • 48 (a)
(Monodelphis domestica)
Mammalia ZAN 34
  • 22 (a)
(Gallus gallus)
Aves ZAN 34
  • 35 (a)
(Anolis carolinensis)
Reptilia ZAN 34
  • 32 (a)
(Danio rerio)
Actinopterygii ZAN 34
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta cv-2 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 14 (a)
Species where no ortholog for ZAN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZAN Gene

Gene Tree for ZAN (if available)
Gene Tree for ZAN (if available)

Paralogs for ZAN Gene

Paralogs for ZAN Gene

(1) SIMAP similar genes for ZAN Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZAN: view

Variants for ZAN Gene

Sequence variations from dbSNP and Humsavar for ZAN Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1060499917 benign, not specified 100,773,855(+) T/TT coding_sequence_variant, frameshift, non_coding_transcript_variant
rs314299 benign, not specified 100,773,850(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs78193191 benign, not specified 100,773,851(+) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000075236 -- 100,761,243(+) G/A intron_variant
rs1000133061 -- 100,766,610(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZAN Gene

Variant ID Type Subtype PubMed ID
dgv1126n67 CNV loss 20364138
dgv11528n54 CNV loss 21841781
dgv11529n54 CNV loss 21841781
dgv11530n54 CNV loss 21841781
dgv11531n54 CNV loss 21841781
dgv11532n54 CNV loss 21841781
dgv11533n54 CNV loss 21841781
dgv1227e199 CNV deletion 23128226
dgv1940e212 CNV loss 25503493
dgv3625n106 CNV deletion 24896259
esv2145665 CNV deletion 18987734
esv22712 CNV loss 19812545
esv2337044 CNV deletion 18987734
esv2648192 CNV deletion 19546169
esv2669885 CNV deletion 23128226
esv2674171 CNV deletion 23128226
esv2734888 CNV deletion 23290073
esv2734892 CNV deletion 23290073
esv2734893 CNV deletion 23290073
esv2759547 CNV gain+loss 17122850
esv2761350 CNV loss 21179565
esv33610 CNV gain+loss 17666407
esv33833 CNV loss 17666407
esv3542157 CNV deletion 23714750
esv3542158 CNV deletion 23714750
esv3572021 CNV loss 25503493
esv3572024 CNV loss 25503493
esv3614304 CNV loss 21293372
esv3614305 CNV loss 21293372
esv3614306 CNV loss 21293372
nsv1020837 CNV loss 25217958
nsv1075983 CNV deletion 25765185
nsv1128350 CNV deletion 24896259
nsv1132079 CNV deletion 24896259
nsv1144196 CNV deletion 24896259
nsv1149912 CNV deletion 26484159
nsv1161590 OTHER complex 26073780
nsv436558 CNV deletion 17901297
nsv442074 CNV loss 18776908
nsv470381 CNV loss 18288195
nsv499699 CNV loss 21111241
nsv514435 CNV loss 21397061
nsv5869 CNV deletion 18451855
nsv607933 CNV gain 21841781
nsv607942 CNV gain+loss 21841781
nsv607944 CNV loss 21841781
nsv607945 CNV loss 21841781
nsv607965 CNV loss 21841781
nsv8184 CNV loss 18304495
nsv831072 CNV loss 17160897
nsv951388 CNV deletion 24416366

Additional Variant Information for ZAN Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZAN Gene

Disorders for ZAN Gene

Additional Disease Information for ZAN

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZAN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZAN Gene

Publications for ZAN Gene

  1. Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution. (PMID: 17033959) Gasper J … Swanson WJ (American journal of human genetics 2006) 2 3 4 22 58
  2. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Glöckner G … Rosenthal A (Genome research 1998) 2 3 4 22 58
  3. Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene (ZAN). (PMID: 9126492) Gao Z … Garbers DL (Genomics 1997) 3 4 22 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Zonadhesin D3-polypeptides vary among species but are similar in Equus species capable of interbreeding. (PMID: 19794156) Tardif S … Hardy DM (Biology of reproduction 2010) 3 22 58

Products for ZAN Gene

Sources for ZAN Gene

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