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Aliases for ZADH2 Gene
Aliases for ZADH2 Gene
External Ids for ZADH2 Gene
- HGNC: 28697
- NCBI Entrez Gene: 284273
- Ensembl: ENSG00000180011
- UniProtKB/Swiss-Prot: Q8N4Q0
Previous GeneCards Identifiers for ZADH2 Gene
- GC18M071038
- GC18M071041
- GC18M072907
- GC18M069594
Summaries for ZADH2 Gene
GeneCards Summary for ZADH2 Gene
ZADH2 (Zinc Binding Alcohol Dehydrogenase Domain Containing 2) is a Protein Coding gene. Diseases associated with ZADH2 include Retinitis Pigmentosa 42 and Vertical Talus, Congenital. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is VAT1.
UniProtKB/Swiss-Prot Summary for ZADH2 Gene
-
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
Additional gene information for ZADH2 Gene
- HGNC (28697)
- NCBI Entrez Gene (284273)
- Ensembl (ENSG00000180011)
- UniProtKB/Swiss-Prot (Q8N4Q0)
- Open Targets Platform(ENSG00000180011)
- Search for ZADH2 at DataMed
- Search for ZADH2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZADH2 Gene
Genomics for ZADH2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZADH2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH18J075199 | Promoter/Enhancer | 3.1 | UCNEbase EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 293 | -1.1 | -1094 | 22.8 | TBP ZBTB10 SP1 MXD4 FEZF1 CEBPA NR2C1 MNT IKZF1 SMAD5 | ZADH2 TSHZ1 ZNF407 piR-55315 | |
| GH18J075245 | Promoter/Enhancer | 1.4 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 12 | -39.0 | -38953 | 6 | IRF2 GABPA ZNF843 PRDM6 SPI1 POLR2A ZBTB48 NR2F1 REST GATA2 | ZNF407 TSHZ1 ZADH2 HSALNG0122498 SMIM21 | |
| GH18J075198 | Enhancer | 0.3 | Ensembl dbSUPER | 37.8 | +11.1 | 11105 | 0.8 | ZADH2 piR-55315 HSALNG0122491 ZNF407 | ||
| GH18J075267 | Enhancer | 0.7 | UCNEbase | 12 | -58.9 | -58881 | 0.7 | MAFF ZNF316 MAFK MAFG MEIS2 POLR2A EMSY | TSHZ1 ZADH2 HSALNG0122498 SMIM21 | |
| GH18J075237 | Enhancer | 0.6 | Ensembl dbSUPER | 12.1 | -29.2 | -29195 | 1.4 | ZNF623 ZBTB8A ZNF558 | TSHZ1 ZADH2 HSALNG0122498 SMIM21 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZADH2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZADH2
- Top Transcription factor binding sites by QIAGEN in the ZADH2 gene promoter:
-
- AREB6
- FOXD3
- GATA-1
- GATA-2
- GATA-3
- GR
- GR-alpha
- GR-beta
- LCR-F1
- Sox5
Genomic Locations for ZADH2 Gene
Latest Assembly
- chr18:75,195,108-75,209,506
- (GRCh38/hg38)
- Size:
- 14,399 bases
- Orientation:
- Minus strand
Previous Assembly
- chr18:72,907,063-72,921,094
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 14,032 bases
- Orientation:
- Minus strand
- chr18:72,907,063-72,921,303
- (GRCh37/hg19 by Ensembl)
- Size:
- 14,241 bases
- Orientation:
- Minus strand
Genomic View for ZADH2 Gene
Genes around ZADH2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q22.3 by HGNC
- 18q22.3 by Entrez Gene
- 18q22.3 by Ensembl
ZADH2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZADH2 Gene
Proteins for ZADH2 Gene
-
Protein details for ZADH2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N4Q0-PTGR3_HUMAN
- Recommended name:
- Prostaglandin reductase 3
- Protein Accession:
- Q8N4Q0
- A8KA15
- B4DZ91
Protein attributes for ZADH2 Gene
- Size:
- 377 amino acids
- Molecular mass:
- 40140 Da
- Quaternary structure:
- No Data Available
Three dimensional structures from OCA and Proteopedia for ZADH2 Gene
Protein Expression for ZADH2 Gene
Post-translational modifications for ZADH2 Gene
Other Protein References for ZADH2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ ZADH2 Antibody
- Novus Biologicals Antibodies for ZADH2
- Invitrogen Antibodies for ZADH2 (AFLGC-Zadh2)
- antibodies-online: Show 11 available ZADH2 Antibodies ranked by validation data
-
Biorbyt antibodies for ZADH2
-
Custom Antibody ServicesProSci Antibodies for ZADH2
- Sino Biological Antibodies for ZADH2
Protein products for research
-
OriGene Purified Proteins for ZADH2
- Search Origene for MassSpec and Protein Over-expression Lysates for ZADH2
- Origene Custom Protein Services for ZADH2
- ProSpec Recombinant Proteins for ZADH2
-
Abcam proteins for ZADH2
Assay products for research
No data available for DME Specific Peptides for ZADH2 Gene
Domains & Families for ZADH2 Gene
Gene Families for ZADH2 Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for ZADH2 Gene
- InterPro:
- Blocks:
-
- Quinone oxidoreductase/zeta-crystallin
- ProtoNet:
Suggested Antigen Peptide Sequences for ZADH2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ52809, highly similar to Zinc-binding alcohol dehydrogenasedomain-containing protein 2 (EC 1.-.-.-) (B4DZ91_HUMAN)
- ZADH2 protein (Q4G1C4_HUMAN)
- Zinc-binding alcohol dehydrogenase domain-containing protein 2 (ZADH2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8N4Q0UniProtKB/Swiss-Prot:
PTGR3_HUMAN :- Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
- Family:
-
- Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Function for ZADH2 Gene
Molecular function for ZADH2 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + H(+) + NADPH; Xref=Rhea:RHEA:11912, ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57402, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.48; Evidence={ECO:0000250|UniProtKB:Q8BGC4};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:50584, ChEBI:CHEBI:15378, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133408; Evidence={ECO:0000250|UniProtKB:Q8BGC4};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:50588, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133374, ChEBI:CHEBI:133409; Evidence={ECO:0000250|UniProtKB:Q8BGC4};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + H(+) + NADPH; Xref=Rhea:RHEA:50592, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:79072, ChEBI:CHEBI:133411; Evidence={ECO:0000250|UniProtKB:Q8BGC4};.
Enzyme Numbers (IUBMB) for ZADH2 Gene
Phenotypes From GWAS Catalog for ZADH2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0036132 | 13-prostaglandin reductase activity | ISS | -- |
| GO:0047522 | 15-oxoprostaglandin 13-oxidase activity | IEA | -- |
Phenotypes for ZADH2 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ZADH2 - Starting at $85 >
- * ZADH2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ZADH2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZADH2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZADH2
miRNA for ZADH2 Gene
- miRTarBase miRNAs that target ZADH2
-
- hsa-miR-192-5p (MIRT026459)
- hsa-miR-93-5p (MIRT028008)
- hsa-miR-21-5p (MIRT030901)
- hsa-let-7b-5p (MIRT032369)
- hsa-miR-27b-3p (MIRT046194)
- hsa-miR-107 (MIRT048302)
- hsa-miR-765 (MIRT483964)
- hsa-miR-4644 (MIRT483965)
- hsa-miR-4306 (MIRT483966)
- hsa-miR-185-5p (MIRT483967)
- hsa-miR-4516 (MIRT483968)
- hsa-miR-5703 (MIRT483969)
- hsa-miR-4434 (MIRT483970)
- hsa-miR-4784 (MIRT483971)
- hsa-miR-3150b-3p (MIRT483972)
- hsa-miR-769-5p (MIRT483973)
- hsa-miR-6770-5p (MIRT483974)
- hsa-miR-4428 (MIRT483975)
- hsa-miR-6736-5p (MIRT499690)
- hsa-miR-4701-3p (MIRT499692)
- hsa-miR-1262 (MIRT499693)
- hsa-miR-542-3p (MIRT499694)
- hsa-miR-661 (MIRT499695)
- hsa-miR-4537 (MIRT499696)
- hsa-miR-6776-5p (MIRT499697)
- hsa-miR-6742-3p (MIRT499698)
- hsa-miR-7703 (MIRT552650)
- hsa-miR-500a-3p (MIRT552651)
- hsa-miR-6720-5p (MIRT552652)
- hsa-miR-6512-3p (MIRT552653)
- hsa-miR-767-5p (MIRT552654)
- hsa-miR-4793-3p (MIRT552655)
- hsa-miR-766-3p (MIRT552656)
- hsa-miR-6849-3p (MIRT552657)
- hsa-miR-1273g-3p (MIRT552658)
- hsa-miR-92b-3p (MIRT552659)
- hsa-miR-92a-3p (MIRT552660)
- hsa-miR-367-3p (MIRT552661)
- hsa-miR-363-3p (MIRT552662)
- hsa-miR-32-5p (MIRT552663)
- hsa-miR-25-3p (MIRT552664)
- hsa-miR-508-5p (MIRT552665)
- mmu-miR-129-5p (MIRT600164)
- mmu-miR-511-5p (MIRT600165)
- hsa-miR-7106-3p (MIRT651408)
- hsa-miR-3121-5p (MIRT651409)
- hsa-miR-4667-3p (MIRT651410)
- hsa-miR-6887-3p (MIRT651411)
- hsa-miR-548ay-3p (MIRT651412)
- hsa-miR-548at-3p (MIRT651413)
- hsa-miR-548as-3p (MIRT651414)
- hsa-miR-548t-3p (MIRT651415)
- hsa-miR-548ap-3p (MIRT651416)
- hsa-miR-548aa (MIRT651417)
- hsa-miR-181a-5p (MIRT651418)
- hsa-miR-181b-5p (MIRT651419)
- hsa-miR-181c-5p (MIRT651420)
- hsa-miR-4262 (MIRT651421)
- hsa-miR-181d-5p (MIRT651422)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZADH2
- Browse OriGene Inhibitory RNA Products For ZADH2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZADH2
Clone products for research
- Applied Biological Materials (abm): Clones for ZADH2 - Starting at $45 >
- * ZADH2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ZADH2
- Addgene plasmids for ZADH2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZADH2
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZADH2 Gene
Localization for ZADH2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZADH2 Gene
- Peroxisome.
| Compartment | Confidence |
|---|---|
| peroxisome | 4 |
| cytosol | 3 |
| mitochondrion | 2 |
| nucleus | 2 |
| golgi apparatus | 1 |
- Golgi apparatus (2)
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005777 | peroxisome | ISS | -- |
Pathways & Interactions for ZADH2 Gene
Interacting Proteins for ZADH2 Gene
GPS-Prot Interaction Network for ZADH2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006693 | prostaglandin metabolic process | IEA | -- |
| GO:0008150 | biological_process | ND | -- |
| GO:0045599 | negative regulation of fat cell differentiation | ISS | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZADH2 Gene
Drugs & Compounds for ZADH2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 1-Hexanol |
|
111-27-3 |
|
|||
| 1-Pentanol |
|
71-41-0 |
|
|||
| Isobutanol |
|
78-83-1 |
|
Transcripts for ZADH2 Gene
mRNA/cDNA for ZADH2 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000322342 7518 nts (view in UCSC)
- ENST00000537114 3205 nts (view in UCSC)
- ENST00000581620 520 nts (view in UCSC)
- ENST00000582437 671 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ZADH2 - Starting at $85 >
- * ZADH2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ZADH2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZADH2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZADH2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZADH2
- Browse OriGene Inhibitory RNA Products For ZADH2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZADH2
Clone products for research
- Applied Biological Materials (abm): Clones for ZADH2 - Starting at $45 >
- * ZADH2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ZADH2
- Addgene plasmids for ZADH2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZADH2
Relevant External Links for ZADH2 Gene
- GeneLoc Exon Structure for
- ZADH2
Expression for ZADH2 Gene
This gene is overexpressed in Stomach (7.9) and Heart (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZADH2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZADH2
SOURCE GeneReport for Unigene cluster for ZADH2 Gene:
Hs.465433Evidence on tissue expression from TISSUES for ZADH2 Gene
- Nervous system(2.3)
Primer products for research
-
OriGene qPCR primer pairs for ZADH2
-
OriGene qPCR primer pairs and template standards for ZADH2
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZADH2 Gene
Orthologs for ZADH2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZADH2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ZADH2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ZADH2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ZADH2 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Zadh2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Zadh2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | ZADH2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ZADH2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | zadh2 30 |
|
||
| Str.17735 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14187 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ZTA1 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | NQR 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os09g0459800 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2016 30 |
|
- Species where no ortholog for ZADH2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for ZADH2 Gene
- ENSEMBL:
- Gene Tree for ZADH2 (if available)
- TreeFam:
- Gene Tree for ZADH2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZADH2: view image
Paralogs for ZADH2 Gene
Paralogs for ZADH2 Gene
(2) SIMAP similar genes for ZADH2 Gene using alignment to 5 proteins:
- ZADH2_HUMAN
- B4DZ91_HUMAN
- J3KTQ8_HUMAN
- J3QQQ7_HUMAN
- Q4G1C4_HUMAN
Variants for ZADH2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZADH2 Gene
| SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs17056661 | - |
p.Cys323Phe |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3643133 | CNV | loss | 21293372 |
| nsv1072812 | CNV | deletion | 25765185 |
| nsv833695 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.11;
51.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZADH2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZADH2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZADH2 Gene
Disorders for ZADH2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 42 |
|
|
| vertical talus, congenital |
|
|
Search ZADH2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZADH2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ZADH2 Gene
Publications for ZADH2 Gene
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
- Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PMID: 19690890) McDonough CW … Bowden DW (Human genetics 2009) 3 41
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
- PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
ExternalLinks
Products for ZADH2 Gene
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- Custom Assay Services
- OriGene Purified Proteins for ZADH2
- Search Origene for MassSpec and Protein Over-expression Lysates for ZADH2
- Origene Custom Protein Services for ZADH2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZADH2
- Browse OriGene Inhibitory RNA Products For ZADH2
- OriGene qPCR primer pairs for ZADH2
- OriGene qPCR primer pairs and template standards for ZADH2
- OriGene CRISPR knockouts for ZADH2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ZADH2
- Sino Biological Human cDNA Clone for ZADH2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for ZADH2
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ZADH2
- Novus Biologicals proteins and lysates for ZADH2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
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- Abcam proteins for ZADH2
- Find your target
- Browse Primary Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for ZADH2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ZADH2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ZADH2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ZADH2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ZADH2
- Addgene plasmids for ZADH2
- antibodies-online: Show 11 available ZADH2 Antibodies ranked by validation data
- antibodies-online: Search results for available ZADH2 related products ranked by validation data
- antibodies-online: Search results for available ZADH2 related products ranked by validation data
- Custom Antibody ServicesProSci Antibodies for ZADH2
- Search for ZADH2 Proteins at ProSci
- Horizon Cell Lines for ZADH2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZADH2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZADH2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ZADH2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZADH2
- Biorbyt antibodies for ZADH2
Sources for ZADH2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB