Aliases for ZADH2 Gene

Aliases for ZADH2 Gene

  • Zinc Binding Alcohol Dehydrogenase Domain Containing 2 2 3 5
  • Zinc-Binding Alcohol Dehydrogenase Domain-Containing Protein 2 3 4
  • Prostaglandin Reductase 3 3 4
  • PRG-3 3 4
  • EC 4
  • MGC45594 2
  • ZADH2 5
  • PTGR3 4

External Ids for ZADH2 Gene

Previous GeneCards Identifiers for ZADH2 Gene

  • GC18M071038
  • GC18M071041
  • GC18M072907
  • GC18M069594

Summaries for ZADH2 Gene

GeneCards Summary for ZADH2 Gene

ZADH2 (Zinc Binding Alcohol Dehydrogenase Domain Containing 2) is a Protein Coding gene. Diseases associated with ZADH2 include Retinitis Pigmentosa 42 and Vertical Talus, Congenital. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is VAT1.

UniProtKB/Swiss-Prot Summary for ZADH2 Gene

  • Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZADH2 Gene

Genomics for ZADH2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZADH2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J075199 Promoter/Enhancer 3.1 UCNEbase EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 293 -1.1 -1094 22.8 TBP ZBTB10 SP1 MXD4 FEZF1 CEBPA NR2C1 MNT IKZF1 SMAD5 ZADH2 TSHZ1 ZNF407 piR-55315
GH18J075245 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 12 -39.0 -38953 6 IRF2 GABPA ZNF843 PRDM6 SPI1 POLR2A ZBTB48 NR2F1 REST GATA2 ZNF407 TSHZ1 ZADH2 HSALNG0122498 SMIM21
GH18J075198 Enhancer 0.3 Ensembl dbSUPER 37.8 +11.1 11105 0.8 ZADH2 piR-55315 HSALNG0122491 ZNF407
GH18J075267 Enhancer 0.7 UCNEbase 12 -58.9 -58881 0.7 MAFF ZNF316 MAFK MAFG MEIS2 POLR2A EMSY TSHZ1 ZADH2 HSALNG0122498 SMIM21
GH18J075237 Enhancer 0.6 Ensembl dbSUPER 12.1 -29.2 -29195 1.4 ZNF623 ZBTB8A ZNF558 TSHZ1 ZADH2 HSALNG0122498 SMIM21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZADH2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZADH2

Top Transcription factor binding sites by QIAGEN in the ZADH2 gene promoter:
  • AREB6
  • FOXD3
  • GATA-1
  • GATA-2
  • GATA-3
  • GR
  • GR-alpha
  • GR-beta
  • LCR-F1
  • Sox5

Genomic Locations for ZADH2 Gene

Latest Assembly
14,399 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
14,032 bases
Minus strand

(GRCh37/hg19 by Ensembl)
14,241 bases
Minus strand

Genomic View for ZADH2 Gene

Genes around ZADH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZADH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZADH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZADH2 Gene

Proteins for ZADH2 Gene

  • Protein details for ZADH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prostaglandin reductase 3
    Protein Accession:
    Secondary Accessions:
    • A8KA15
    • B4DZ91

    Protein attributes for ZADH2 Gene

    377 amino acids
    Molecular mass:
    40140 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZADH2 Gene

    Alternative splice isoforms for ZADH2 Gene


neXtProt entry for ZADH2 Gene

Post-translational modifications for ZADH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZADH2 Gene

No data available for DME Specific Peptides for ZADH2 Gene

Domains & Families for ZADH2 Gene

Gene Families for ZADH2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ZADH2 Gene

  • Quinone oxidoreductase/zeta-crystallin

Suggested Antigen Peptide Sequences for ZADH2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52809, highly similar to Zinc-binding alcohol dehydrogenasedomain-containing protein 2 (EC 1.-.-.-) (B4DZ91_HUMAN)
  • ZADH2 protein (Q4G1C4_HUMAN)
  • Zinc-binding alcohol dehydrogenase domain-containing protein 2 (ZADH2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
genes like me logo Genes that share domains with ZADH2: view

Function for ZADH2 Gene

Molecular function for ZADH2 Gene

UniProtKB/Swiss-Prot Function:
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + H(+) + NADPH; Xref=Rhea:RHEA:11912, ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57402, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=; Evidence={ECO:0000250|UniProtKB:Q8BGC4};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:50584, ChEBI:CHEBI:15378, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133408; Evidence={ECO:0000250|UniProtKB:Q8BGC4};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:50588, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133374, ChEBI:CHEBI:133409; Evidence={ECO:0000250|UniProtKB:Q8BGC4};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + H(+) + NADPH; Xref=Rhea:RHEA:50592, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:79072, ChEBI:CHEBI:133411; Evidence={ECO:0000250|UniProtKB:Q8BGC4};.

Enzyme Numbers (IUBMB) for ZADH2 Gene

Phenotypes From GWAS Catalog for ZADH2 Gene

Gene Ontology (GO) - Molecular Function for ZADH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0036132 13-prostaglandin reductase activity ISS --
GO:0047522 15-oxoprostaglandin 13-oxidase activity IEA --
genes like me logo Genes that share ontologies with ZADH2: view
genes like me logo Genes that share phenotypes with ZADH2: view

miRNA for ZADH2 Gene

miRTarBase miRNAs that target ZADH2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZADH2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZADH2 Gene

Localization for ZADH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZADH2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZADH2 gene
Compartment Confidence
peroxisome 4
cytosol 3
mitochondrion 2
nucleus 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZADH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome ISS --
genes like me logo Genes that share ontologies with ZADH2: view

Pathways & Interactions for ZADH2 Gene

PathCards logo

SuperPathways for ZADH2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZADH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006693 prostaglandin metabolic process IEA --
GO:0008150 biological_process ND --
GO:0045599 negative regulation of fat cell differentiation ISS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ZADH2: view

No data available for Pathways by source and SIGNOR curated interactions for ZADH2 Gene

Drugs & Compounds for ZADH2 Gene

(3) Drugs for ZADH2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isopropyl alcohol Approved, Investigational Pharma 0
Propyl alcohol Approved Pharma 0
1-Butanol Experimental Pharma 0

(3) Additional Compounds for ZADH2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Caproic alcohol
  • Hexanol
  • N-Hexyl alcohol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Amyl alcohol, normal
  • Amylalkohol
  • 1-Hydroxymethylpropane
  • 2-Methyl-1-propanol
  • 2-Methylpropanol
  • I-butanol
  • I-butyl alcohol
genes like me logo Genes that share compounds with ZADH2: view

Transcripts for ZADH2 Gene

mRNA/cDNA for ZADH2 Gene

11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZADH2

Alternative Splicing Database (ASD) splice patterns (SP) for ZADH2 Gene

No ASD Table

Relevant External Links for ZADH2 Gene

GeneLoc Exon Structure for

Expression for ZADH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZADH2 Gene

Protein differential expression in normal tissues from HIPED for ZADH2 Gene

This gene is overexpressed in Stomach (7.9) and Heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZADH2 Gene

Protein tissue co-expression partners for ZADH2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZADH2

SOURCE GeneReport for Unigene cluster for ZADH2 Gene:


Evidence on tissue expression from TISSUES for ZADH2 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with ZADH2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZADH2 Gene

Orthologs for ZADH2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZADH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZADH2 30 31
  • 99.29 (n)
(Canis familiaris)
Mammalia ZADH2 30 31
  • 89.74 (n)
(Bos Taurus)
Mammalia ZADH2 30 31
  • 85.15 (n)
(Monodelphis domestica)
Mammalia ZADH2 31
  • 85 (a)
(Mus musculus)
Mammalia Zadh2 30 17 31
  • 84.53 (n)
(Rattus norvegicus)
Mammalia Zadh2 30
  • 84.53 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 25 (a)
(Gallus gallus)
Aves ZADH2 30 31
  • 79.42 (n)
(Anolis carolinensis)
Reptilia ZADH2 31
  • 73 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zadh2 30
  • 73.08 (n)
Str.17735 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.14187 30
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZTA1 31
  • 26 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons NQR 30
  • 52.63 (n)
(Oryza sativa)
Liliopsida Os09g0459800 30
  • 49.42 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 48 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2016 30
Species where no ortholog for ZADH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZADH2 Gene

Gene Tree for ZADH2 (if available)
Gene Tree for ZADH2 (if available)
Evolutionary constrained regions (ECRs) for ZADH2: view image

Paralogs for ZADH2 Gene

(2) SIMAP similar genes for ZADH2 Gene using alignment to 5 proteins:

  • B4DZ91_HUMAN
  • Q4G1C4_HUMAN
genes like me logo Genes that share paralogs with ZADH2: view

Variants for ZADH2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZADH2 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs17056661 - p.Cys323Phe

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZADH2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZADH2 Gene

Variant ID Type Subtype PubMed ID
esv3643133 CNV loss 21293372
nsv1072812 CNV deletion 25765185
nsv833695 CNV gain 17160897

Variation tolerance for ZADH2 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZADH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZADH2 Gene

Disorders for ZADH2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZADH2 Gene - From: COP

Disorder Aliases PubMed IDs
retinitis pigmentosa 42
  • rp42
vertical talus, congenital
  • cvt
- elite association - COSMIC cancer census association via MalaCards
Search ZADH2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZADH2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZADH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZADH2 Gene

Publications for ZADH2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  2. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PMID: 19690890) McDonough CW … Bowden DW (Human genetics 2009) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  5. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3

Products for ZADH2 Gene

Sources for ZADH2 Gene