LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008] See more...

Aliases for ZACN Gene

Aliases for ZACN Gene

  • Zinc Activated Ion Channel 2 3 5
  • LGICZ 2 3 4
  • ZAC 2 3 4
  • L2 2 3 4
  • Ligand-Gated Ion Channel Zinc-Activated 1 3 4
  • Zinc-Activated Ligand-Gated Ion Channel 3 4
  • Ligand-Gated Ion-Channel Receptor L2 3 4
  • LGICZ1 3 4
  • ZAC1 2 3
  • Ligand-Gated Ion Channel, Zinc Activated 1 2
  • Zinc Activated Ligand-Gated Ion Channel 1 3
  • Zinc Activated Ligand-Gated Ion Channel 2
  • Ligand-Gated Ion Channel Subunit 3
  • ZACN 5

External Ids for ZACN Gene

Previous HGNC Symbols for ZACN Gene

  • LGICZ1

Previous GeneCards Identifiers for ZACN Gene

  • GC17P071588
  • GC17P074075
  • GC17P069504

Summaries for ZACN Gene

Entrez Gene Summary for ZACN Gene

  • LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ZACN Gene

ZACN (Zinc Activated Ion Channel) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include extracellular ligand-gated ion channel activity and ligand-gated ion channel activity. An important paralog of this gene is HTR3C.

UniProtKB/Swiss-Prot Summary for ZACN Gene

Gene Wiki entry for ZACN Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZACN Gene

Genomics for ZACN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZACN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J076070 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 600.7 +0.3 320 3 SP1 GATAD2A PRDM10 ZNF629 REST NFKBIZ ZNF692 POLR2A RCOR2 BACH1 SRP68 GALR2 hsa-miR-5095-232 ZACN lnc-SRP68-1 NUP85 SRSF2 UNK GGA3 NT5C
GH17J075926 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 11.2 -144.9 -144913 1.9 CTCF ATF7 CREB1 POLR2A RAD21 HNF4A THAP11 ZNF143 ATF2 ZNF48 FBF1 GALR2 ZACN SRP68 ENSG00000267543 ENSG00000267426 MRPL38 lnc-SRP68-1
GH17J076207 Enhancer 0.8 Ensembl ENCODE 10.4 +136.8 136840 4 TCF12 YY1 SCRT2 CEBPB RUNX3 SCRT1 BCL11A POLR3A DPF2 ATF3 RNF157 UBE2O FOXJ1 EXOC7 GALR2 SRP68 ZACN AANAT PRPSAP1 ST6GALNAC2
GH17J076049 Enhancer 0.7 Ensembl ENCODE 12.2 -20.8 -20779 2.5 CTBP1 PKNOX1 GATA3 FOS ZNF217 SMARCE1 FOSL2 SRP68 EVPL ZACN CDK3 EXOC7 MRPL38 QRICH2 FBF1 SNODB2083 lnc-EXOC7-1
GH17J075920 Promoter/Enhancer 0.6 EPDnew Ensembl 11.2 -151.7 -151660 0.6 HNRNPL FBF1 UNC13D SRP68 ZACN GALR2 WBP2 EXOC7 TRIM65 ENSG00000267426 MRPL38
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZACN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZACN

Top Transcription factor binding sites by QIAGEN in the ZACN gene promoter:
  • FAC1
  • MyoD
  • RREB-1
  • USF-1
  • USF1
  • YY1

Genomic Locations for ZACN Gene

Genomic Locations for ZACN Gene
chr17:76,071,961-76,083,666
(GRCh38/hg38)
Size:
11,706 bases
Orientation:
Plus strand
chr17:74,068,042-74,079,747
(GRCh37/hg19)
Size:
11,706 bases
Orientation:
Plus strand

Genomic View for ZACN Gene

Genes around ZACN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZACN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZACN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZACN Gene

Proteins for ZACN Gene

  • Protein details for ZACN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q401N2-ZACN_HUMAN
    Recommended name:
    Zinc-activated ligand-gated ion channel
    Protein Accession:
    Q401N2
    Secondary Accessions:
    • Q2TB29
    • Q6ZWK3
    • Q86YW4

    Protein attributes for ZACN Gene

    Size:
    412 amino acids
    Molecular mass:
    45816 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI10598.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAO20969.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=EAW89365.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • The mouse and rat orthologous proteins do not exist.
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for ZACN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZACN Gene

Post-translational modifications for ZACN Gene

Other Protein References for ZACN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZACN Gene

Domains & Families for ZACN Gene

Gene Families for ZACN Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for ZACN Gene

Suggested Antigen Peptide Sequences for ZACN Gene

GenScript: Design optimal peptide antigens:
  • Ligand-gated ion-channel receptor L2 (ZACN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q401N2

UniProtKB/Swiss-Prot:

ZACN_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family.
genes like me logo Genes that share domains with ZACN: view

Function for ZACN Gene

Molecular function for ZACN Gene

UniProtKB/Swiss-Prot Function:
Zinc-activated ligand-gated ion channel.

Phenotypes From GWAS Catalog for ZACN Gene

Gene Ontology (GO) - Molecular Function for ZACN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005216 ion channel activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0008270 zinc ion binding IDA 12381728
GO:0015276 ligand-gated ion channel activity IDA 12381728
genes like me logo Genes that share ontologies with ZACN: view
genes like me logo Genes that share phenotypes with ZACN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZACN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZACN Gene

Localization for ZACN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZACN Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZACN gene
Compartment Confidence
plasma membrane 5
extracellular 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZACN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 16083862
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043005 neuron projection IBA 21873635
genes like me logo Genes that share ontologies with ZACN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZACN Gene

Pathways & Interactions for ZACN Gene

PathCards logo

SuperPathways for ZACN Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZACN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0007165 signal transduction IBA 21873635
GO:0007268 chemical synaptic transmission IBA 21873635
GO:0010043 response to zinc ion IDA 12381728
GO:0034220 ion transmembrane transport IDA 12381728
genes like me logo Genes that share ontologies with ZACN: view

No data available for Pathways by source and SIGNOR curated interactions for ZACN Gene

Drugs & Compounds for ZACN Gene

(4) Drugs for ZACN Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tubocurarine Approved Pharma antagonist 0
Zn<sup>2+</sup> Pharma Allosteric regulator, Negative, Positive, Channel blocker, Inhibition, Potentiation, Agonist, Pore Blocker, Antagonist 0

(2) Additional Compounds for ZACN Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-tubocurarine
Pore Blocker, Antagonist
genes like me logo Genes that share compounds with ZACN: view

Transcripts for ZACN Gene

mRNA/cDNA for ZACN Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZACN

Alternative Splicing Database (ASD) splice patterns (SP) for ZACN Gene

No ASD Table

Relevant External Links for ZACN Gene

GeneLoc Exon Structure for
ZACN

Expression for ZACN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZACN Gene

mRNA differential expression in normal tissues according to GTEx for ZACN Gene

This gene is overexpressed in Colon - Sigmoid (x18.5), Small Intestine - Terminal Ileum (x14.0), and Colon - Transverse (x4.8).

Protein differential expression in normal tissues from HIPED for ZACN Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZACN Gene



Protein tissue co-expression partners for ZACN Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZACN

SOURCE GeneReport for Unigene cluster for ZACN Gene:

Hs.714919

mRNA Expression by UniProt/SwissProt for ZACN Gene:

Q401N2-ZACN_HUMAN
Tissue specificity: Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus.

Evidence on tissue expression from TISSUES for ZACN Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ZACN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZACN Gene

Orthologs for ZACN Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZACN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZACN 30 31
  • 98.07 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZACN 30 31
  • 82.69 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZACN 30 31
  • 79.57 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZACN 31
  • 62 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZACN 31
  • 15 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZACN 31
  • 40 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii ZACN (5 of 5) 31
  • 21 (a)
OneToMany
ZACN (1 of 5) 31
  • 20 (a)
OneToMany
ZACN (4 of 5) 31
  • 20 (a)
OneToMany
ZACN (3 of 5) 31
  • 18 (a)
OneToMany
ZACN (2 of 5) 31
  • 18 (a)
OneToMany
Species where no ortholog for ZACN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZACN Gene

ENSEMBL:
Gene Tree for ZACN (if available)
TreeFam:
Gene Tree for ZACN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZACN: view image

Paralogs for ZACN Gene

Variants for ZACN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZACN Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs2257020 - p.Ala152Thr

Additional dbSNP identifiers (rs#s) for ZACN Gene

Structural Variations from Database of Genomic Variants (DGV) for ZACN Gene

Variant ID Type Subtype PubMed ID
nsv2142 CNV insertion 18451855
nsv509674 CNV insertion 20534489
nsv833546 CNV loss 17160897

Variation tolerance for ZACN Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.41; 81.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZACN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZACN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZACN Gene

Disorders for ZACN Gene

No disorders were found for ZACN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZACN Gene

Publications for ZACN Gene

  1. Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system. (PMID: 16083862) Houtani T … Sugimoto T (Biochemical and biophysical research communications 2005) 2 3 4 23
  2. A novel class of ligand-gated ion channel is activated by Zn2+. (PMID: 12381728) Davies PA … Kirkness EF (The Journal of biological chemistry 2003) 2 3 4 23
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZACN Gene

Sources for ZACN Gene