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The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14. [provided by RefSeq, May 2010]
YY2 (YY2 Transcription Factor) is a Protein Coding gene. Diseases associated with YY2 include N Syndrome. An important paralog of this gene is YY1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IBA | 21873635 |
GO:0000987 | proximal promoter sequence-specific DNA binding | IDA | 16260628 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 15087442 |
GO:0003677 | DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000785 | chromatin | IBA | -- |
GO:0005634 | nucleus | IEA,IDA | 16260628 |
GO:0005667 | transcription factor complex | IBA | 21873635 |
GO:0031519 | PcG protein complex | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006357 | regulation of transcription by RNA polymerase II | IDA | 16260628 |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 15087442 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | YY2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | LOC102152457 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Yy2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | YY1 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | yy1a 31 |
|
ManyToMany | |
yy1b 31 |
|
ManyToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | pho 31 |
|
ManyToMany | |
phol 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs147081325 | A breast cancer sample |
p.Asp103Asn |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2740003 | CNV | deletion | 23290073 |
nsv476830 | CNV | novel sequence insertion | 20440878 |
Disorder | Aliases | PubMed IDs |
---|---|---|
n syndrome |
|
|