The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition ... See more...

Aliases for YY2 Gene

Aliases for YY2 Gene

  • YY2 Transcription Factor 2 3 5
  • ZNF631 2 3 4
  • Transcription Factor Yin Yang 2 2 3
  • Transcription Factor YY2 3 4
  • Zinc Finger Protein 631 3 4
  • Yin And Yang 2 3 4
  • YY-2 4
  • YY2 5

External Ids for YY2 Gene

Previous GeneCards Identifiers for YY2 Gene

  • GC0XU900516
  • GC0XP021634
  • GC0XP021784
  • GC0XP019615
  • GC0XP021874

Summaries for YY2 Gene

Entrez Gene Summary for YY2 Gene

  • The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14. [provided by RefSeq, May 2010]

GeneCards Summary for YY2 Gene

YY2 (YY2 Transcription Factor) is a Protein Coding gene. Diseases associated with YY2 include N Syndrome. An important paralog of this gene is YY1.

UniProtKB/Swiss-Prot Summary for YY2 Gene

  • Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for YY2 Gene

Genomics for YY2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for YY2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ021658 Promoter/Enhancer 1 Ensembl ENCODE 49.7 -197.3 -197286 1.8 ZNF623 ZNF433 HNF4A REST ZBTB21 AEBP2 ZNF140 ZC3H11A ZNF560 ZBTB8A HSALNG0136946 HSALNG0136947 KLHL34 YY2 SMPX
GH0XJ021838 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 18.8 -16.0 -15986 2.4 TBP MXD4 SP1 SIX5 NR2C1 MNT DEK SMAD5 IRF2 ZFP64 ENSG00000275681 MBTPS2 YY2
GH0XJ021925 Enhancer 1.1 FANTOM5 ENCODE 34.6 +70.8 70782 2.7 FEZF1 CEBPA IKZF1 IRF2 BRCA1 ZEB1 CEBPB FOXA2 ZNF639 MAX piR-43105-691 YY2 lnc-SMS-4 SMS
GH0XJ021798 Enhancer 1 Ensembl ENCODE 18.2 -56.1 -56146 3.1 FEZF1 ZNF639 SMAD4 RARA ZNF843 STAT3 BCL6 JUND FOSL1 USF2 YY2 lnc-MBTPS2-2 piR-43105-689 MBTPS2 SMPX
GH0XJ021939 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 7.9 +86.6 86563 5.8 ZBTB10 IKZF1 SMAD5 HES1 BHLHE40 CTCF ZIC2 ZNF610 ZNF395 MAX SMS piR-61945-525 YY2 CYTH1P1 lnc-SMS-1 PHEX
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around YY2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for YY2

Top Transcription factor binding sites by QIAGEN in the YY2 gene promoter:
  • AML1a
  • E47
  • FOXC1
  • IRF-1
  • NRSF form 1
  • NRSF form 2
  • STAT1
  • STAT1alpha
  • STAT1beta
  • Tal-1beta

Genomic Locations for YY2 Gene

Latest Assembly
chrX:21,855,987-21,858,740
(GRCh38/hg38)
Size:
2,754 bases
Orientation:
Plus strand

Previous Assembly
chrX:21,874,105-21,876,858
(GRCh37/hg19 by Entrez Gene)
Size:
2,754 bases
Orientation:
Plus strand

chrX:21,874,105-21,876,845
(GRCh37/hg19 by Ensembl)
Size:
2,741 bases
Orientation:
Plus strand

Genomic View for YY2 Gene

Genes around YY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YY2 Gene

Proteins for YY2 Gene

  • Protein details for YY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15391-TYY2_HUMAN
    Recommended name:
    Transcription factor YY2
    Protein Accession:
    O15391
    Secondary Accessions:
    • B2RP10
    • Q6Q1S4

    Protein attributes for YY2 Gene

    Size:
    372 amino acids
    Molecular mass:
    41347 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placental mammals. It is encoded by a single exon found in an intron of the gene MBTPS2.

neXtProt entry for YY2 Gene

Post-translational modifications for YY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for YY2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for YY2 Gene

Domains & Families for YY2 Gene

Gene Families for YY2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for YY2 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for YY2 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 631 (TYY2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15391

UniProtKB/Swiss-Prot:

TYY2_HUMAN :
  • Belongs to the YY transcription factor family.
Family:
  • Belongs to the YY transcription factor family.
genes like me logo Genes that share domains with YY2: view

Function for YY2 Gene

Molecular function for YY2 Gene

UniProtKB/Swiss-Prot Function:
Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation.

Phenotypes From GWAS Catalog for YY2 Gene

Gene Ontology (GO) - Molecular Function for YY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000987 proximal promoter sequence-specific DNA binding IDA 16260628
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 15087442
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with YY2: view
genes like me logo Genes that share phenotypes with YY2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YY2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YY2 Gene

Localization for YY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YY2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YY2 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for YY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0005634 nucleus IEA,IDA 16260628
GO:0005667 transcription factor complex IBA 21873635
GO:0031519 PcG protein complex IBA 21873635
genes like me logo Genes that share ontologies with YY2: view

Pathways & Interactions for YY2 Gene

PathCards logo

SuperPathways for YY2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IDA 16260628
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 15087442
genes like me logo Genes that share ontologies with YY2: view

No data available for Pathways by source and SIGNOR curated interactions for YY2 Gene

Drugs & Compounds for YY2 Gene

No Compound Related Data Available

Transcripts for YY2 Gene

mRNA/cDNA for YY2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YY2

Alternative Splicing Database (ASD) splice patterns (SP) for YY2 Gene

No ASD Table

Relevant External Links for YY2 Gene

GeneLoc Exon Structure for
YY2

Expression for YY2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for YY2 Gene

Protein differential expression in normal tissues from HIPED for YY2 Gene

This gene is overexpressed in CD8 Tcells (22.9), Placenta (13.7), NK cells (12.7), Testis (8.3), and Blymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for YY2 Gene



Protein tissue co-expression partners for YY2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for YY2

SOURCE GeneReport for Unigene cluster for YY2 Gene:

Hs.673601

mRNA Expression by UniProt/SwissProt for YY2 Gene:

O15391-TYY2_HUMAN
Tissue specificity: Expressed in kidney, liver, spleen and testis but not in colon.

Evidence on tissue expression from TISSUES for YY2 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with YY2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for YY2 Gene

Orthologs for YY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for YY2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia YY2 30
  • 98.84 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 79 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LOC102152457 30
  • 75.05 (n)
Mouse
(Mus musculus)
Mammalia Yy2 30 17 31
  • 66.48 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 50 (a)
OneToMany
Chicken
(Gallus gallus)
Aves YY1 31
  • 72 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 72 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii yy1a 31
  • 57 (a)
ManyToMany
yy1b 31
  • 54 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta pho 31
  • 27 (a)
ManyToMany
phol 31
  • 19 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 44 (a)
OneToMany
Species where no ortholog for YY2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for YY2 Gene

ENSEMBL:
Gene Tree for YY2 (if available)
TreeFam:
Gene Tree for YY2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for YY2: view image

Paralogs for YY2 Gene

Paralogs for YY2 Gene

(4) SIMAP similar genes for YY2 Gene using alignment to 1 proteins:

  • TYY2_HUMAN
genes like me logo Genes that share paralogs with YY2: view

Variants for YY2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for YY2 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs147081325 A breast cancer sample p.Asp103Asn

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for YY2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for YY2 Gene

Variant ID Type Subtype PubMed ID
esv2740003 CNV deletion 23290073
nsv476830 CNV novel sequence insertion 20440878

Variation tolerance for YY2 Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YY2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YY2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YY2 Gene

Disorders for YY2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for YY2 Gene - From: COP

Disorder Aliases PubMed IDs
n syndrome
  • nsx
- elite association - COSMIC cancer census association via MalaCards
Search YY2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for YY2

genes like me logo Genes that share disorders with YY2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YY2 Gene

Publications for YY2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4
  2. Molecular cloning and functional characterization of the transcription factor YY2. (PMID: 15087442) Nguyen N … Seto E (The Journal of biological chemistry 2004) 3 4 23
  3. Transcriptional activity of the novel identified human yy2 promoter is modified by DNA methylation. (PMID: 19026728) Klar M … Dame C (Gene 2009) 3 23
  4. Rapid evolution of a recently retroposed transcription factor YY2 in mammalian genomes. (PMID: 16377127) Luo C … Kim J (Genomics 2006) 3 4
  5. Enhanceosome formation over the beta interferon promoter underlies a remote-control mechanism mediated by YY1 and YY2. (PMID: 16260628) Klar M … Bode J (Molecular and cellular biology 2005) 3 4

Products for YY2 Gene

Sources for YY2 Gene