Free for academic non-profit institutions. Other users need a Commercial license
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function... See more...
Aliases for YY1 Gene
Aliases for YY1 Gene
External Ids for YY1 Gene
- HGNC: 12856
- Entrez Gene: 7528
- Ensembl: ENSG00000100811
- OMIM: 600013
- UniProtKB: P25490
Previous GeneCards Identifiers for YY1 Gene
- GC14P098216
- GC14P094520
- GC14P098695
- GC14P099774
- GC14P100992
- GC14P101002
- GC14P080888
- GC14P101020
- GC14P101031
- GC14P101051
- GC14P101071
- GC14P101112
- GC14P101161
- GC14P101221
Summaries for YY1 Gene
-
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]
GeneCards Summary for YY1 Gene
YY1 (YY1 Transcription Factor) is a Protein Coding gene. Diseases associated with YY1 include Gabriele-De Vries Syndrome and Pregnancy Loss, Recurrent 1. Among its related pathways are E2F transcription factor network and mTOR signaling pathway (Pathway Interaction Database). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is YY2.
UniProtKB/Swiss-Prot Summary for YY1 Gene
-
Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647).
-
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.
Additional gene information for YY1 Gene
- HGNC(12856)
- Entrez Gene(7528)
- Ensembl(ENSG00000100811)
- OMIM(600013)
- UniProtKB(P25490)
- Open Targets Platform(ENSG00000100811)
- Monarch Initiative
- Search for YY1 at DataMed
- Search for YY1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for YY1 Gene
Genomics for YY1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for YY1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around YY1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for YY1
- Top Transcription factor binding sites by QIAGEN in the YY1 gene promoter:
-
- AP-2alpha
- AP-2alpha isoform 2
- AP-2alpha isoform 3
- AP-2alpha isoform 4
- AP-2alphaA
- ATF
- c-Myc
- Max1
- NF-kappaB1
- TBP
Genomic Locations for YY1 Gene
Genomic Locations for YY1 Gene
- chr14:100,238,298-100,282,788
- (GRCh38/hg38)
- Size:
- 44,491 bases
- Orientation:
- Plus strand
- chr14:100,704,635-100,749,129
- (GRCh37/hg19)
- Size:
- 44,495 bases
- Orientation:
- Plus strand
Genomic View for YY1 Gene
Genes around YY1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.2 by HGNC
- 14q32.2 by Entrez Gene
- 14q32.2 by Ensembl
YY1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for YY1 Gene
Proteins for YY1 Gene
-
Protein details for YY1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25490-TYY1_HUMAN
- Recommended name:
- Transcriptional repressor protein YY1
- Protein Accession:
- P25490
- Q14935
Protein attributes for YY1 Gene
- Size:
- 414 amino acids
- Molecular mass:
- 44713 Da
- Quaternary structure:
-
- Interacts with YAF2 through the region encompassing the first and second zinc fingers (PubMed:9016636). Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80 (PubMed:17721549, PubMed:18026119, PubMed:18922472, PubMed:21303910). Interacts with EED and EZH2; the interactions are indicative for an association with the PRC2/EED-EZH2 complex (PubMed:11158321). Interacts with SFMBT2 (PubMed:23385818). Found in a complex with SMAD1 and SMAD4 (PubMed:15329343). Found in a complex with YY1, SIN3A and HDAC1 (By similarity).
Protein Expression for YY1 Gene
Post-translational modifications for YY1 Gene
- Transiently poly-ADP-ribosylated by PARP1 upon DNA damage, with the effect of decreasing affinity of YY1 to its cognate DNA binding sites.
- Ubiquitinated.
-
Ubiquitination at Lys332
- NX_P25490 (NX_P25490-1)
- Modification sites at PhosphoSitePlus
Other Protein References for YY1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences YY1 Monoclonal Antibody (LS-B5551) and YY1 Monoclonal Antibody (LS-B5549)
- G Biosciences Immunotag™ YY1 Antibody
- Creative Diagnostics Anti-YY1 monoclonal antibody, clone 2294DU7.6.34.7
- Creative Biolabs Recombinant Anti-Human YY1 Antibody and Mouse Anti-YY1 Recombinant Antibody (3248C3a)
-
Custom Antibody ServicesOriGene Antibodies for YY1
- Novus Biologicals Antibodies for YY1
-
Abcam antibodies for YY1
- Invitrogen Antibodies for YY1 (AFLGC-YY1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for YY1
- Sino Biological Antibodies for YY1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for YY1
- Origene Custom Protein Services for YY1
- ProSpec Recombinant Proteins for YY1
- antibodies-online: Show 10 available YY1 Proteins ranked by validation data
- Compare Top YY1 Proteins
-
Quality Products:
-
ProSci Proteins for YY1
-
Abcam proteins for YY1
Assay Products
- RayBiotech Human YY1 ELISA
- antibodies-online: Show 7 available YY1 Elisa Kits ranked by validation data
- Compare Top YY1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for YY1 Gene
Domains & Families for YY1 Gene
Gene Families for YY1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for YY1 Gene
- InterPro:
- Blocks:
-
- C2H2-type zinc finger signature
- ProtoNet:
Suggested Antigen Peptide Sequences for YY1 Gene
- GenScript: Design optimal peptide antigens:
-
- Yin and yang 1 (TYY1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P25490- Family:
-
- Belongs to the YY transcription factor family.
Function for YY1 Gene
Molecular function for YY1 Gene
- UniProtKB/Swiss-Prot Function:
- Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647).
- UniProtKB/Swiss-Prot Function:
- Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.
- GENATLAS Biochemistry:
- YY1 transcription factor,repressor/activator (Yin Yang) protein,binding to a variety of transcriptor factors,recruiting HDAC2 or HDAC3 for negative regulation of transcription. Interacting with MYC
Phenotypes From GWAS Catalog for YY1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000400 | four-way junction DNA binding | IDA | 18026119 |
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 9857059 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA,IBA | 21873635 |
| GO:0000987 | proximal promoter sequence-specific DNA binding | IMP | 15329343 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA,ISS | -- |
Phenotypes for YY1 Gene
- MGI mutant phenotypes for YY1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for YY1:
-
- Decreased hepcidin::fluc mRNA expression
- no effect
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- shRNA abundance <= 25%
- Reduced mammosphere formation
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased Nanog expression
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased viability after Maraba virus infection
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased POU5F1-GFP protein expression
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Decreased Aire reporter expression
- Increased epidermal growth factor (EGF) endosome number, increased epidermal growth factor (EGF) endosome elongation
Animal Models for YY1 Gene
- MGI Knock Outs for YY1:
-
- Yy1 Yy1<tm1Yshi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for YY1 - Select products 50% OFF >
- * YY1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for YY1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for YY1
-
Santa Cruz Biotechnology (SCBT) CRISPR for YY1
miRNA for YY1 Gene
- miRTarBase miRNAs that target YY1
-
- mmu-miR-29c-3p (MIRT003554)
- hsa-miR-34a-5p (MIRT004045)
- hsa-miR-31-5p (MIRT004968)
- mmu-miR-17-5p (MIRT010106)
- hsa-miR-93-5p (MIRT028073)
- hsa-miR-769-3p (MIRT039108)
- hsa-miR-615-3p (MIRT040246)
- hsa-miR-484 (MIRT041821)
- hsa-miR-331-3p (MIRT043278)
- hsa-miR-221-3p (MIRT046848)
- hsa-miR-7-5p (MIRT053022)
- hsa-miR-205-5p (MIRT053768)
- hsa-miR-34b-3p (MIRT054032)
- hsa-miR-34c-5p (MIRT054033)
- mmu-miR-21a-5p (MIRT054766)
- hsa-miR-4279 (MIRT463620)
- hsa-miR-1976 (MIRT463621)
- hsa-miR-3653-5p (MIRT463622)
- hsa-miR-6727-3p (MIRT463623)
- hsa-miR-6747-3p (MIRT463624)
- hsa-miR-4722-3p (MIRT463625)
- hsa-miR-4532 (MIRT463626)
- hsa-miR-1247-3p (MIRT463627)
- hsa-miR-548aw (MIRT463628)
- hsa-miR-6790-5p (MIRT463629)
- hsa-miR-4658 (MIRT463630)
- hsa-miR-4758-5p (MIRT463631)
- hsa-miR-1238-5p (MIRT463632)
- hsa-miR-1468-3p (MIRT463633)
- hsa-miR-548x-5p (MIRT463634)
- hsa-miR-548g-5p (MIRT463635)
- hsa-miR-548f-5p (MIRT463636)
- hsa-miR-548aj-5p (MIRT463637)
- hsa-miR-1909-5p (MIRT463638)
- hsa-miR-1208 (MIRT463639)
- hsa-miR-6760-3p (MIRT463640)
- hsa-miR-4496 (MIRT463641)
- hsa-miR-651-3p (MIRT463642)
- hsa-miR-301b-3p (MIRT463643)
- hsa-miR-301a-3p (MIRT463644)
- hsa-miR-3666 (MIRT463645)
- hsa-miR-454-3p (MIRT463646)
- hsa-miR-4295 (MIRT463647)
- hsa-miR-130a-3p (MIRT463648)
- hsa-miR-130b-3p (MIRT463649)
- hsa-miR-19a-3p (MIRT463650)
- hsa-miR-19b-3p (MIRT463651)
- hsa-miR-5007-3p (MIRT520006)
- hsa-miR-27b-5p (MIRT520007)
- hsa-miR-1279 (MIRT520008)
- hsa-miR-5588-3p (MIRT520009)
- hsa-miR-8066 (MIRT520010)
- hsa-miR-183-5p (MIRT533067)
- hsa-miR-892b (MIRT533068)
- hsa-miR-193b-3p (MIRT533069)
- hsa-miR-193a-3p (MIRT533070)
- hsa-miR-491-3p (MIRT552666)
- hsa-miR-568 (MIRT552667)
- hsa-miR-4795-3p (MIRT552668)
- hsa-miR-466 (MIRT552669)
- hsa-miR-4672 (MIRT552670)
- hsa-miR-4729 (MIRT552671)
- hsa-miR-3941 (MIRT552672)
- hsa-miR-6504-3p (MIRT552673)
- hsa-miR-586 (MIRT552674)
- hsa-miR-3976 (MIRT552675)
- hsa-miR-4643 (MIRT552676)
- hsa-miR-4789-3p (MIRT552677)
- hsa-miR-543 (MIRT552678)
- hsa-miR-571 (MIRT552679)
- hsa-miR-219a-1-3p (MIRT552680)
- hsa-let-7c-3p (MIRT561348)
- hsa-miR-3177-5p (MIRT561349)
- hsa-miR-6793-3p (MIRT561350)
- hsa-miR-3613-3p (MIRT561351)
- hsa-miR-338-5p (MIRT561352)
- hsa-miR-548t-5p (MIRT561353)
- hsa-miR-548az-5p (MIRT561354)
- hsa-miR-374b-3p (MIRT564872)
- hsa-miR-5682 (MIRT564873)
- hsa-miR-585-5p (MIRT564874)
- hsa-miR-6507-5p (MIRT564875)
- hsa-miR-511-5p (MIRT574372)
- hsa-miR-3613-5p (MIRT574373)
- hsa-miR-6830-3p (MIRT574374)
- hsa-miR-3133 (MIRT574375)
- hsa-miR-5590-3p (MIRT574376)
- hsa-miR-340-5p (MIRT574377)
- hsa-miR-142-5p (MIRT574378)
- hsa-miR-186-5p (MIRT574379)
- hsa-miR-219a-2-3p (MIRT574380)
- hsa-miR-4522 (MIRT612303)
- hsa-miR-6870-3p (MIRT612304)
- hsa-miR-138-1-3p (MIRT612305)
- hsa-miR-3679-3p (MIRT621586)
- hsa-miR-6840-5p (MIRT621587)
- hsa-miR-2115-5p (MIRT639849)
- hsa-miR-3155b (MIRT639850)
- hsa-miR-3155a (MIRT639851)
- hsa-miR-548o-3p (MIRT639852)
- hsa-miR-5582-3p (MIRT639853)
- hsa-miR-1323 (MIRT639854)
- hsa-miR-1273h-5p (MIRT736908)
- hsa-miR-1299 (MIRT737247)
- hsa-miR-149-3p (MIRT737814)
- hsa-miR-204-3p (MIRT738833)
- hsa-miR-2467-5p (MIRT739344)
- hsa-miR-30b-3p (MIRT739798)
- hsa-miR-3192-5p (MIRT741041)
- hsa-miR-3689a-3p (MIRT742300)
- hsa-miR-3689b-3p (MIRT742370)
- hsa-miR-3689c (MIRT742440)
- hsa-miR-378a-3p (MIRT742742)
- hsa-miR-378b (MIRT742747)
- hsa-miR-378c (MIRT742749)
- hsa-miR-378d (MIRT742751)
- hsa-miR-378e (MIRT742753)
- hsa-miR-378f (MIRT742755)
- hsa-miR-378h (MIRT742772)
- hsa-miR-378i (MIRT742774)
- hsa-miR-422a (MIRT743242)
- hsa-miR-4314 (MIRT743986)
- hsa-miR-4638-3p (MIRT746316)
- hsa-miR-4646-5p (MIRT746443)
- hsa-miR-4728-5p (MIRT747910)
- hsa-miR-4778-5p (MIRT748719)
- hsa-miR-4782-5p (MIRT748809)
- hsa-miR-516b-5p (MIRT749808)
- hsa-miR-5706 (MIRT751390)
- hsa-miR-619-5p (MIRT752548)
- hsa-miR-630 (MIRT752650)
- hsa-miR-6506-5p (MIRT752957)
- hsa-miR-6779-5p (MIRT755544)
- hsa-miR-6780a-5p (MIRT755615)
- hsa-miR-6785-5p (MIRT755905)
- hsa-miR-6799-5p (MIRT756351)
- hsa-miR-6883-5p (MIRT758490)
- hsa-miR-7106-5p (MIRT758906)
- hsa-miR-455-3p (MIRT770469)
- hsa-miR-5689 (MIRT774984)
- hsa-miR-5696 (MIRT775110)
- hsa-miR-6516-5p (MIRT777257)
- hsa-miR-1281 (MIRT783369)
- hsa-miR-129-5p (MIRT783641)
- hsa-miR-1304-3p (MIRT783703)
- hsa-miR-139-3p (MIRT783782)
- hsa-miR-2276-3p (MIRT784294)
- hsa-miR-30c-1-3p (MIRT784525)
- hsa-miR-30c-2-3p (MIRT784537)
- hsa-miR-3122 (MIRT784587)
- hsa-miR-3913-5p (MIRT785441)
- hsa-miR-4294 (MIRT785645)
- hsa-miR-431-5p (MIRT785743)
- hsa-miR-4485-5p (MIRT785994)
- hsa-miR-450a-1-3p (MIRT786048)
- hsa-miR-6513-5p (MIRT788322)
- hsa-miR-6731-5p (MIRT788485)
- hsa-miR-6778-3p (MIRT788679)
- hsa-miR-6788-5p (MIRT788737)
- hsa-miR-6878-5p (MIRT789266)
- hsa-miR-6890-3p (MIRT789341)
- hsa-miR-8085 (MIRT789859)
- hsa-miR-887-5p (MIRT789904)
- hsa-miR-924 (MIRT789954)
Transcription Factor Targets for YY1 Gene
Targeted motifs for YY1 Gene
HOMER Transcription Factor Regulatory Elements motif YY1
- Consensus sequence: CAAGATGGCGGC Submotif: canonical Cell Type: NA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for YY1
- Browse OriGene Inhibitory RNA Products For YY1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YY1
Clone Products
- Applied Biological Materials (abm): Clones for YY1 - Select products 50% OFF >
- * YY1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for YY1
- Addgene plasmids for YY1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for YY1
No data available for Enzyme Numbers (IUBMB) for YY1 Gene
Localization for YY1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for YY1 Gene
- Nucleus matrix. Note=Associated with the nuclear matrix.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Nucleoli fibrillar center (3)
- Nucleoplasm (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IEA,IBA | 21873635 |
| GO:0005634 | nucleus | IMP | 22065573 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IEA,IBA | 21873635 |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for YY1 Gene
Pathways by source for YY1 Gene
7 BioSystems pathways for YY1 Gene
15 Reactome pathways for YY1 Gene
1 PharmGKB pathway for YY1 Gene
1 GeneGo (Thomson Reuters) pathway for YY1 Gene
- Development_TGF-beta receptor signaling
3 Cell Signaling Technology pathways for YY1 Gene
Interacting Proteins for YY1 Gene
Selected Interacting proteins:
P25490-TYY1_HUMAN
ENSP00000262238
for YY1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for YY1
SIGNOR curated interactions for YY1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,IDA | 9857059 |
| GO:0000724 | double-strand break repair via homologous recombination | IMP | 18026119 |
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006310 | DNA recombination | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
Transcripts for YY1 Gene
mRNA/cDNA for YY1 Gene
- 1 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262238 6534 nts (view in UCSC)
- ENST00000553625 422 nts (view in UCSC)
- ENST00000554371 636 nts (view in UCSC)
- ENST00000554579 826 nts (view in UCSC)
- ENST00000554804 1114 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for YY1 - Select products 50% OFF >
- * YY1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for YY1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for YY1
-
Santa Cruz Biotechnology (SCBT) CRISPR for YY1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for YY1
- Browse OriGene Inhibitory RNA Products For YY1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YY1
Clone Products
- Applied Biological Materials (abm): Clones for YY1 - Select products 50% OFF >
- * YY1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for YY1
- Addgene plasmids for YY1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for YY1
Relevant External Links for YY1 Gene
- GeneLoc Exon Structure for
- YY1
Expression for YY1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Blood (Hematopoietic System)
This gene is overexpressed in CD8 Tcells (11.9), Lung (10.6), Blymphocyte (9.6), and Adrenal (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for YY1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for YY1
SOURCE GeneReport for Unigene cluster for YY1 Gene:
Hs.388927Evidence on tissue expression from TISSUES for YY1 Gene
- Nervous system(4.9)
- Liver(4.7)
- Lung(4.6)
- Intestine(3.8)
- Kidney(3.3)
- Muscle(3.3)
- Blood(3.2)
- Skin(3.1)
- Heart(3)
- Thyroid gland(2.9)
- Bone marrow(2.8)
- Lymph node(2.8)
- Stomach(2.7)
- Spleen(2.7)
- Pancreas(2.4)
- Bone(2.4)
- Adrenal gland(2.4)
- Eye(2.3)
Primer Products
-
OriGene qPCR primer pairs for YY1
-
OriGene qPCR primer pairs and template standards for YY1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YY1 Gene
Orthologs for YY1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chimpanzee (Pan troglodytes) |
Mammalia | YY1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | YY1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | YY1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Yy1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Yy1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | YY1 30 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | yy1 30 |
|
||
| Str.829 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | yy1-A-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | yy1a 30 31 |
|
ManyToMany | |
| yy1b 31 |
|
ManyToMany | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1785 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | pho 31 32 |
|
ManyToMany | |
| phol 31 32 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2999 30 |
|
- Species where no ortholog for YY1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for YY1 Gene
- ENSEMBL:
- Gene Tree for YY1 (if available)
- TreeFam:
- Gene Tree for YY1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for YY1: view image
Paralogs for YY1 Gene
(16) SIMAP similar genes for YY1 Gene using alignment to 4 proteins:
- TYY1_HUMAN
- G3V3M8_HUMAN
- H0YJU4_HUMAN
- H0YJV7_HUMAN
Pseudogenes.org Pseudogenes for YY1 Gene
Variants for YY1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for YY1 Gene
| SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 716403 | Benign: not provided | 100,239,385(+) | G/C | MISSENSE_VARIANT | |
| 743296 | Likely Benign: not provided | 100,239,274(+) | C/T | SYNONYMOUS_VARIANT | |
| 759598 | Likely Benign: not provided | 100,262,475(+) | T/C | INTRON_VARIANT | |
| 795809 | Likely Benign: not provided | 100,239,550(+) | G/A | SYNONYMOUS_VARIANT | |
| 817604 | Pathogenic: not provided | 100,239,627(+) | AG/A | FRAMESHIFT_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3895n54 | CNV | gain | 21841781 |
| dgv3896n54 | CNV | loss | 21841781 |
| dgv3897n54 | CNV | gain | 21841781 |
| esv22463 | CNV | loss | 19812545 |
| esv2749105 | CNV | deletion | 23290073 |
| esv2749106 | CNV | deletion | 23290073 |
| esv2749108 | CNV | deletion | 23290073 |
| esv3635496 | CNV | gain | 21293372 |
| esv3635502 | CNV | gain | 21293372 |
| nsv1070236 | CNV | deletion | 25765185 |
| nsv1131073 | CNV | deletion | 24896259 |
| nsv565776 | CNV | loss | 21841781 |
| nsv565778 | CNV | gain | 21841781 |
| nsv827052 | CNV | gain | 20364138 |
| nsv827054 | CNV | gain | 20364138 |
| nsv832875 | CNV | loss | 17160897 |
| nsv983854 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.51;
43.94% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for YY1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YY1 Gene
Disorders for YY1 Gene
(15) MalaCards diseases for YY1 Gene - From: LncRNADisease, UniProtKB/Swiss-Prot, OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gabriele-de vries syndrome |
|
|
| pregnancy loss, recurrent 1 |
|
|
| grange syndrome |
|
|
| burkitt lymphoma |
|
|
| fibromuscular dysplasia |
|
|
Search YY1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TYY1_HUMAN- Gabriele-de Vries syndrome (GADEVS) [MIM:617557]: An autosomal dominant neurodevelopmental disorder characterized by delayed psychomotor development and intellectual disability. Most patients have behavioral and feeding problems, movement abnormalities, mild distal skeletal anomalies, and dysmorphic facial features. {ECO:0000269 PubMed:21076407, ECO:0000269 PubMed:28575647}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for YY1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for YY1 Gene
Publications for YY1 Gene
- YY1's longer DNA-binding motifs. (PMID: 18950698) Kim Jd … Kim J (Genomics 2009) 3 4 23
- YY1 functions with INO80 to activate transcription. (PMID: 17721549) Cai Y … Conaway JW (Nature structural & molecular biology 2007) 3 4 23
- Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. (PMID: 9016636) Kalenik JL … Lee TC (Nucleic acids research 1997) 3 4 23
- Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator. (PMID: 8942976) Houbaviy HB … Burley SK (Proceedings of the National Academy of Sciences of the United States of America 1996) 3 4 23
- Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site. (PMID: 1946405) Park K … Atchison ML (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4 23
ExternalLinks
Products for YY1 Gene
- View all 3 R&D Systems YY1 (YY1) Products
- View all 2 R&D Systems YY1 (YY1) Primary Antibodies
- View all R&D Systems YY1 (YY1) cDNA Clones
- Learn more about R&D Systems custom YY1 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for YY1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for YY1
- Origene Custom Protein Services for YY1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for YY1
- Browse OriGene Inhibitory RNA Products For YY1
- OriGene qPCR primer pairs for YY1
- OriGene qPCR primer pairs and template standards for YY1
- OriGene CRISPR knockouts for YY1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For YY1
- Sino Biological Human cDNA Clone for YY1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for YY1
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for YY1
- Novus Biologicals proteins and lysates for YY1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for YY1
- Abcam proteins for YY1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for YY1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for YY1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for YY1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for YY1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for YY1
- Addgene plasmids for YY1
- antibodies-online: Show 90 available YY1 Antibodies ranked by validation data
- Compare Top YY1 Antibodies
- antibodies-online: Show 7 available YY1 Elisa Kits ranked by validation data
- Compare Top YY1 Elisa Kits
- Quality Products:
- antibodies-online: Show 10 available YY1 Proteins ranked by validation data
- Compare Top YY1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for YY1
- Search Santa Cruz Biotechnology (SCBT) for YY1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for YY1
- Search for YY1 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for YY1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for YY1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for YY1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for YY1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YY1
Sources for YY1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157)