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YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]
YY1 (YY1 Transcription Factor) is a Protein Coding gene. Diseases associated with YY1 include Gabriele-De Vries Syndrome and Pregnancy Loss, Recurrent 1. Among its related pathways are E2F transcription factor network and mTOR signaling pathway (Pathway Interaction Database). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is YY2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000400 | four-way junction DNA binding | IDA | 18026119 |
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 9857059 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA,IBA | 21873635 |
GO:0000987 | proximal promoter sequence-specific DNA binding | IMP | 15329343 |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA,ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | IEA,IBA | 21873635 |
GO:0005634 | nucleus | IMP | 22065573 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005667 | transcription factor complex | IEA,IBA | 21873635 |
GO:0005737 | cytoplasm | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,IDA | 9857059 |
GO:0000724 | double-strand break repair via homologous recombination | IMP | 18026119 |
GO:0006281 | DNA repair | IEA | -- |
GO:0006310 | DNA recombination | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chimpanzee (Pan troglodytes) |
Mammalia | YY1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | YY1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | YY1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Yy1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Yy1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | YY1 30 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | yy1 30 |
|
||
Str.829 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | yy1-A-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | yy1a 30 31 |
|
ManyToMany | |
yy1b 31 |
|
ManyToMany | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1785 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | pho 31 32 |
|
ManyToMany | |
phol 31 32 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2999 30 |
|
SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
716403 | Benign: not provided | 100,239,385(+) | G/C | MISSENSE_VARIANT | |
743296 | Likely Benign: not provided | 100,239,274(+) | C/T | SYNONYMOUS_VARIANT | |
759598 | Likely Benign: not provided | 100,262,475(+) | T/C | INTRON_VARIANT | |
795809 | Likely Benign: not provided | 100,239,550(+) | G/A | SYNONYMOUS_VARIANT | |
817604 | Pathogenic: not provided | 100,239,627(+) | AG/A | FRAMESHIFT_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3895n54 | CNV | gain | 21841781 |
dgv3896n54 | CNV | loss | 21841781 |
dgv3897n54 | CNV | gain | 21841781 |
esv22463 | CNV | loss | 19812545 |
esv2749105 | CNV | deletion | 23290073 |
esv2749106 | CNV | deletion | 23290073 |
esv2749108 | CNV | deletion | 23290073 |
esv3635496 | CNV | gain | 21293372 |
esv3635502 | CNV | gain | 21293372 |
nsv1070236 | CNV | deletion | 25765185 |
nsv1131073 | CNV | deletion | 24896259 |
nsv565776 | CNV | loss | 21841781 |
nsv565778 | CNV | gain | 21841781 |
nsv827052 | CNV | gain | 20364138 |
nsv827054 | CNV | gain | 20364138 |
nsv832875 | CNV | loss | 17160897 |
nsv983854 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
gabriele-de vries syndrome |
|
|
pregnancy loss, recurrent 1 |
|
|
grange syndrome |
|
|
burkitt lymphoma |
|
|
fibromuscular dysplasia |
|
|