Aliases for YY1 Gene
Aliases for YY1 Gene
External Ids for YY1 Gene
- HGNC: 12856
- Entrez Gene: 7528
- Ensembl: ENSG00000100811
- OMIM: 600013
- UniProtKB: P25490
Previous GeneCards Identifiers for YY1 Gene
- GC14P098216
- GC14P094520
- GC14P098695
- GC14P099774
- GC14P100992
- GC14P101002
- GC14P080888
- GC14P101020
- GC14P101031
- GC14P101051
- GC14P101071
- GC14P101112
- GC14P101161
- GC14P101221
Summaries for YY1 Gene
-
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]
GeneCards Summary for YY1 Gene
YY1 (YY1 Transcription Factor) is a Protein Coding gene. Diseases associated with YY1 include Gabriele-De Vries Syndrome and Pregnancy Loss, Recurrent 1. Among its related pathways are Gene Expression and Translational Control. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is YY2.
UniProtKB/Swiss-Prot for YY1 Gene
-
Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5-CCGCCATNTT-3; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5-GTCT/AGAC-3) within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647).
-
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.
Additional gene information for YY1 Gene
- Monarch Initiative
- Search for YY1 at DataMed
- Search for YY1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YY1 Gene
Genomics for YY1 Gene
GeneHancer (GH) Regulatory Elements for YY1 Gene
Promoters and enhancers for YY1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around YY1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the YY1 gene promoter:
Regulatory Element Products
Genomic Locations for YY1 Gene
Genomic Locations for YY1 Gene
- chr14:100,238,298-100,282,792
- (GRCh38/hg38)
- Size:
- 44,495 bases
- Orientation:
- Plus strand
- chr14:100,704,635-100,749,129
- (GRCh37/hg19)
Genomic View for YY1 Gene
Genes around YY1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.2 by Entrez Gene
- 14q32.2 by HGNC
- 14q32.2 by Ensembl
YY1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for YY1 Gene
Proteins for YY1 Gene
-
Protein details for YY1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25490-TYY1_HUMAN
- Recommended name:
- Transcriptional repressor protein YY1
- Protein Accession:
- P25490
- Q14935
Protein attributes for YY1 Gene
- Size:
- 414 amino acids
- Molecular mass:
- 44713 Da
- Quaternary structure:
-
- Interacts with YAF2 through the region encompassing the first and second zinc fingers (PubMed:9016636). Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80 (PubMed:17721549, PubMed:18026119, PubMed:18922472, PubMed:21303910). Interacts with EED and EZH2; the interactions are indicative for an association with the PRC2/EED-EZH2 complex (PubMed:11158321). Interacts with SFMBT2 (PubMed:23385818). Found in a complex with SMAD1 and SMAD4 (PubMed:15329343). Found in a complex with YY1, SIN3A and HDAC1 (By similarity).
Protein Expression for YY1 Gene
Post-translational modifications for YY1 Gene
- Transiently poly-ADP-ribosylated by PARP1 upon DNA damage, with the effect of decreasing affinity of YY1 to its cognate DNA binding sites.
- Ubiquitinated.
- Ubiquitination at isoforms=332
- Modification sites at PhosphoSitePlus
Other Protein References for YY1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for YY1 (YY1)
-
Custom Antibody ServicesOriGene Antibodies for YY1
- Novus Biologicals Antibodies for YY1
- Invitrogen Antibodies for YY1
- GeneTex YY1 Antibody for YY1
-
Santa Cruz Biotechnology (SCBT) Antibodies for YY1
Protein Products
-
OriGene Purified Proteins for YY1
- Search Origene for MassSpec and Protein Over-expression Lysates for YY1
- Origene Custom Protein Services for YY1
- ProSpec Recombinant Proteins for YY1
- antibodies-online: Search results for 8 available YY1 Proteins ranked by validation data
- Compare Top YY1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for YY1
-
ProSci Proteins for YY1
Assay Products
- antibodies-online: Search results for 6 available YY1 Elisa Kits ranked by validation data
- Compare Top YY1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for YY1 Gene
Domains & Families for YY1 Gene
Gene Families for YY1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for YY1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for YY1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P25490- Family:
-
- Belongs to the YY transcription factor family.
Function for YY1 Gene
Molecular function for YY1 Gene
- UniProtKB/Swiss-Prot Function:
- Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5-CCGCCATNTT-3; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5-GTCT/AGAC-3) within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647).
- UniProtKB/Swiss-Prot Function:
- Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.
- GENATLAS Biochemistry:
- YY1 transcription factor,repressor/activator (Yin Yang) protein,binding to a variety of transcriptor factors,recruiting HDAC2 or HDAC3 for negative regulation of transcription. Interacting with MYC
Phenotypes From GWAS Catalog for YY1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000400 | four-way junction DNA binding | IDA | 18026119 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | IBA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0000987 | proximal promoter sequence-specific DNA binding | IDA | 16260628 |
Phenotypes for YY1 Gene
- MGI mutant phenotypes for YY1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for YY1:
-
- Decreased OCT4 protein expression
- Decreased POU5F1-GFP protein expression
- Decreased NANOG protein expression
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Reduced mammosphere formation
- Decreased viability in esophageal squamous lineage
- Increased Nanog expression
- Decreased viability
- no effect
- Decreased Aire reporter expression
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased hepcidin::fluc mRNA expression
- Decreased viability after Maraba virus infection
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for YY1 Gene
- MGI Knock Outs for YY1:
-
- Yy1 Yy1<tm1Yshi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for YY1
-
CRISPR Products
-
OriGene CRISPR knockouts for YY1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for YY1
- genomics-online: gRNA clones - Search results for available YY1 gene related products
- Applied Biological Materials CRISPR for YY1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for YY1
- GenScript: Design CRISPR guide RNA sequences for YY1
miRNA for YY1 Gene
- miRTarBase miRNAs that target YY1
-
- hsa-mir-34a-5p (MIRT004045)
- hsa-mir-31-5p (MIRT004968)
- hsa-mir-93-5p (MIRT028073)
- hsa-mir-769-3p (MIRT039108)
- hsa-mir-615-3p (MIRT040246)
- hsa-mir-484 (MIRT041821)
- hsa-mir-331-3p (MIRT043278)
- hsa-mir-221-3p (MIRT046848)
- hsa-mir-7-5p (MIRT053022)
- hsa-mir-205-5p (MIRT053768)
- hsa-mir-34b-3p (MIRT054032)
- hsa-mir-34c-5p (MIRT054033)
- hsa-mir-4279 (MIRT463620)
- hsa-mir-1976 (MIRT463621)
- hsa-mir-3653-5p (MIRT463622)
- hsa-mir-6727-3p (MIRT463623)
- hsa-mir-6747-3p (MIRT463624)
- hsa-mir-4722-3p (MIRT463625)
- hsa-mir-4532 (MIRT463626)
- hsa-mir-1247-3p (MIRT463627)
- hsa-mir-548aw (MIRT463628)
- hsa-mir-6790-5p (MIRT463629)
- hsa-mir-4658 (MIRT463630)
- hsa-mir-4758-5p (MIRT463631)
- hsa-mir-1238-5p (MIRT463632)
- hsa-mir-1468-3p (MIRT463633)
- hsa-mir-548x-5p (MIRT463634)
- hsa-mir-548g-5p (MIRT463635)
- hsa-mir-548f-5p (MIRT463636)
- hsa-mir-548aj-5p (MIRT463637)
- hsa-mir-1909-5p (MIRT463638)
- hsa-mir-1208 (MIRT463639)
- hsa-mir-6760-3p (MIRT463640)
- hsa-mir-4496 (MIRT463641)
- hsa-mir-651-3p (MIRT463642)
- hsa-mir-301b-3p (MIRT463643)
- hsa-mir-301a-3p (MIRT463644)
- hsa-mir-3666 (MIRT463645)
- hsa-mir-454-3p (MIRT463646)
- hsa-mir-4295 (MIRT463647)
- hsa-mir-130a-3p (MIRT463648)
- hsa-mir-130b-3p (MIRT463649)
- hsa-mir-19a-3p (MIRT463650)
- hsa-mir-19b-3p (MIRT463651)
- hsa-mir-5007-3p (MIRT520006)
- hsa-mir-27b-5p (MIRT520007)
- hsa-mir-1279 (MIRT520008)
- hsa-mir-5588-3p (MIRT520009)
- hsa-mir-8066 (MIRT520010)
- hsa-mir-183-5p (MIRT533067)
- hsa-mir-892b (MIRT533068)
- hsa-mir-193b-3p (MIRT533069)
- hsa-mir-193a-3p (MIRT533070)
- hsa-mir-491-3p (MIRT552666)
- hsa-mir-568 (MIRT552667)
- hsa-mir-4795-3p (MIRT552668)
- hsa-mir-466 (MIRT552669)
- hsa-mir-4672 (MIRT552670)
- hsa-mir-4729 (MIRT552671)
- hsa-mir-3941 (MIRT552672)
- hsa-mir-6504-3p (MIRT552673)
- hsa-mir-586 (MIRT552674)
- hsa-mir-3976 (MIRT552675)
- hsa-mir-4643 (MIRT552676)
- hsa-mir-4789-3p (MIRT552677)
- hsa-mir-543 (MIRT552678)
- hsa-mir-571 (MIRT552679)
- hsa-mir-219a-1-3p (MIRT552680)
- hsa-let-7c-3p (MIRT561348)
- hsa-mir-3177-5p (MIRT561349)
- hsa-mir-6793-3p (MIRT561350)
- hsa-mir-3613-3p (MIRT561351)
- hsa-mir-338-5p (MIRT561352)
- hsa-mir-548t-5p (MIRT561353)
- hsa-mir-548az-5p (MIRT561354)
- hsa-mir-374b-3p (MIRT564872)
- hsa-mir-5682 (MIRT564873)
- hsa-mir-585-5p (MIRT564874)
- hsa-mir-6507-5p (MIRT564875)
- hsa-mir-511-5p (MIRT574372)
- hsa-mir-3613-5p (MIRT574373)
- hsa-mir-6830-3p (MIRT574374)
- hsa-mir-3133 (MIRT574375)
- hsa-mir-5590-3p (MIRT574376)
- hsa-mir-340-5p (MIRT574377)
- hsa-mir-142-5p (MIRT574378)
- hsa-mir-186-5p (MIRT574379)
- hsa-mir-219a-2-3p (MIRT574380)
- hsa-mir-4522 (MIRT612303)
- hsa-mir-6870-3p (MIRT612304)
- hsa-mir-138-1-3p (MIRT612305)
- hsa-mir-3679-3p (MIRT621586)
- hsa-mir-6840-5p (MIRT621587)
- hsa-mir-2115-5p (MIRT639849)
- hsa-mir-3155b (MIRT639850)
- hsa-mir-3155a (MIRT639851)
- hsa-mir-548o-3p (MIRT639852)
- hsa-mir-5582-3p (MIRT639853)
- hsa-mir-1323 (MIRT639854)
- hsa-mir-1273h-5p (MIRT736908)
- hsa-mir-1299 (MIRT737247)
- hsa-mir-149-3p (MIRT737814)
- hsa-mir-204-3p (MIRT738833)
- hsa-mir-2467-5p (MIRT739344)
- hsa-mir-30b-3p (MIRT739798)
- hsa-mir-3192-5p (MIRT741041)
- hsa-mir-3689a-3p (MIRT742300)
- hsa-mir-3689b-3p (MIRT742370)
- hsa-mir-3689c (MIRT742440)
- hsa-mir-378a-3p (MIRT742742)
- hsa-mir-378b (MIRT742747)
- hsa-mir-378c (MIRT742749)
- hsa-mir-378d (MIRT742751)
- hsa-mir-378e (MIRT742753)
- hsa-mir-378f (MIRT742755)
- hsa-mir-378h (MIRT742772)
- hsa-mir-378i (MIRT742774)
- hsa-mir-422a (MIRT743242)
- hsa-mir-4314 (MIRT743986)
- hsa-mir-4638-3p (MIRT746316)
- hsa-mir-4646-5p (MIRT746443)
- hsa-mir-4728-5p (MIRT747910)
- hsa-mir-4778-5p (MIRT748719)
- hsa-mir-4782-5p (MIRT748809)
- hsa-mir-516b-5p (MIRT749808)
- hsa-mir-5706 (MIRT751390)
- hsa-mir-619-5p (MIRT752548)
- hsa-mir-630 (MIRT752650)
- hsa-mir-6506-5p (MIRT752957)
- hsa-mir-6779-5p (MIRT755544)
- hsa-mir-6780a-5p (MIRT755615)
- hsa-mir-6785-5p (MIRT755905)
- hsa-mir-6799-5p (MIRT756351)
- hsa-mir-6883-5p (MIRT758490)
- hsa-mir-7106-5p (MIRT758906)
- hsa-mir-455-3p (MIRT770469)
- hsa-mir-5689 (MIRT774984)
- hsa-mir-5696 (MIRT775110)
- hsa-mir-6516-5p (MIRT777257)
- hsa-mir-1281 (MIRT783369)
- hsa-mir-129-5p (MIRT783641)
- hsa-mir-1304-3p (MIRT783703)
- hsa-mir-139-3p (MIRT783782)
- hsa-mir-2276-3p (MIRT784294)
- hsa-mir-30c-1-3p (MIRT784525)
- hsa-mir-30c-2-3p (MIRT784537)
- hsa-mir-3122 (MIRT784587)
- hsa-mir-3913-5p (MIRT785441)
- hsa-mir-4294 (MIRT785645)
- hsa-mir-431-5p (MIRT785743)
- hsa-mir-4485-5p (MIRT785994)
- hsa-mir-450a-1-3p (MIRT786048)
- hsa-mir-6513-5p (MIRT788322)
- hsa-mir-6731-5p (MIRT788485)
- hsa-mir-6778-3p (MIRT788679)
- hsa-mir-6788-5p (MIRT788737)
- hsa-mir-6878-5p (MIRT789266)
- hsa-mir-6890-3p (MIRT789341)
- hsa-mir-8085 (MIRT789859)
- hsa-mir-887-5p (MIRT789904)
- hsa-mir-924 (MIRT789954)
Transcription Factor Targets for YY1 Gene
Targeted motifs for YY1 Gene
HOMER Transcription Factor Regulatory Elements motif YY1
- Consensus sequence: CAAGATGGCGGC Submotif: canonical Cell Type: NA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for YY1
- Browse OriGene Inhibitory RNA Products For YY1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YY1
- genomics-online: shRNA clones - Search results for available YY1 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for YY1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for YY1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for YY1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for YY1
- genomics-online: cdna clones - Search results for available YY1 gene related products
- orf clones - Search results for available YY1 gene related products
- Applied Biological Materials Clones for YY1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for YY1 Gene
Localization for YY1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for YY1 Gene
- Nucleus matrix. Note=Associated with the nuclear matrix.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| mitochondrion | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
- Nucleoli fibrillar center (3)
- Nucleoplasm (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IBA,IEA | -- |
| GO:0005634 | nucleus | IMP | 22065573 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for YY1 Gene
Pathways by source for YY1 Gene
7 BioSystems pathways for YY1 Gene
15 Reactome pathways for YY1 Gene
1 PharmGKB pathway for YY1 Gene
1 GeneGo (Thomson Reuters) pathway for YY1 Gene
3 Cell Signaling Technology pathways for YY1 Gene
Interacting Proteins for YY1 Gene
Selected Interacting proteins:
P25490-TYY1_HUMAN
ENSP00000262238
for YY1 Gene via
IID
UniProtKB
MINT
STRING
GPS-Prot Interaction Network for YY1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 9857059 |
| GO:0000724 | double-strand break repair via homologous recombination | IMP | 18026119 |
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006310 | DNA recombination | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
Transcripts for YY1 Gene
mRNA/cDNA for YY1 Gene
- (829) Selected AceView cDNA sequences:
- (12) Additional mRNA sequences :
- (1) REFSEQ mRNAs :
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000262238 6697 bps (uc001ygy.3)
- ENST00000553625 422 bps (uc059fce.1)
- ENST00000554371 636 bps (uc059fcd.1)
- ENST00000554579 826 bps (uc059fch.1)
- ENST00000554804 1114 bps (uc059fcf.1)
Unigene Clusters for YY1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for YY1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for YY1
- genomics-online: gRNA clones - Search results for available YY1 gene related products
- Applied Biological Materials CRISPR for YY1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for YY1
- GenScript: Design CRISPR guide RNA sequences for YY1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for YY1
- Browse OriGene Inhibitory RNA Products For YY1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YY1
- genomics-online: shRNA clones - Search results for available YY1 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for YY1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for YY1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for YY1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for YY1
- genomics-online: cdna clones - Search results for available YY1 gene related products
- orf clones - Search results for available YY1 gene related products
- Applied Biological Materials Clones for YY1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for YY1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Blood (Hematopoietic System)
This gene is overexpressed in CD8 Tcells (11.9), Lung (10.6), Blymphocyte (9.6), and Adrenal (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for YY1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of YY1 Gene:
YY1SOURCE GeneReport for Unigene cluster for YY1 Gene:
Hs.388927Evidence on tissue expression from TISSUES for YY1 Gene
- Nervous system(4.9)
- Liver(4.6)
- Lung(4.5)
- Intestine(3.3)
- Muscle(2.8)
- Blood(2.6)
- Kidney(2.6)
- Heart(2.4)
- Skin(2.2)
- Bone marrow(2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for YY1
-
OriGene qPCR primer pairs for YY1
- genomics-online: primer clones - Search results for available YY1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YY1 Gene
Orthologs for YY1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chimpanzee (Pan troglodytes) |
Mammalia | YY1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | YY1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | YY1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Yy1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Yy1 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | YY1 34 33 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | yy1 33 |
|
||
| Str.829 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | yy1-A-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | yy1a 34 33 |
|
ManyToMany | |
| yy1b 34 |
|
ManyToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1785 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | pho 34 35 |
|
ManyToMany | |
| phol 34 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| Cin.2999 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2999 33 |
|
- Species where no ortholog for YY1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for YY1 Gene
- ENSEMBL:
- Gene Tree for YY1 (if available)
- TreeFam:
- Gene Tree for YY1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for YY1: view image
Paralogs for YY1 Gene
(16) SIMAP similar genes for YY1 Gene using alignment to 4 proteins:
- TYY1_HUMAN
- G3V3M8_HUMAN
- H0YJU4_HUMAN
- H0YJV7_HUMAN
Pseudogenes.org Pseudogenes for YY1 Gene
Variants for YY1 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_065086 | Gabriele-de Vries syndrome (GADEVS) [MIM:617557] | p.Asp380Tyr | |||
| VAR_079203 | Gabriele-de Vries syndrome (GADEVS) [MIM:617557] | p.His320Tyr | |||
| VAR_079204 | Gabriele-de Vries syndrome (GADEVS) [MIM:617557] | p.Lys339Gln | |||
| VAR_079206 | Gabriele-de Vries syndrome (GADEVS) [MIM:617557] | p.Leu366Pro | |||
| VAR_079207 | Gabriele-de Vries syndrome (GADEVS) [MIM:617557] | p.Leu366Val |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3895n54 | CNV | gain | 21841781 |
| dgv3896n54 | CNV | loss | 21841781 |
| dgv3897n54 | CNV | gain | 21841781 |
| esv22463 | CNV | loss | 19812545 |
| esv2749105 | CNV | deletion | 23290073 |
| esv2749106 | CNV | deletion | 23290073 |
| esv2749108 | CNV | deletion | 23290073 |
| esv3635496 | CNV | gain | 21293372 |
| esv3635502 | CNV | gain | 21293372 |
| nsv1070236 | CNV | deletion | 25765185 |
| nsv1131073 | CNV | deletion | 24896259 |
| nsv565776 | CNV | loss | 21841781 |
| nsv565778 | CNV | gain | 21841781 |
| nsv827052 | CNV | gain | 20364138 |
| nsv827054 | CNV | gain | 20364138 |
| nsv832875 | CNV | loss | 17160897 |
| nsv983854 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.51;
43.94% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for YY1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YY1 Gene
Disorders for YY1 Gene
(7) MalaCards diseases for YY1 Gene - From: HGMD, LncRNADisease, OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gabriele-de vries syndrome |
|
|
| pregnancy loss, recurrent 1 |
|
|
| fibromuscular dysplasia |
|
|
| grange syndrome |
|
|
| spherocytosis, type 3 |
|
|
Search YY1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TYY1_HUMAN- Gabriele-de Vries syndrome (GADEVS) [MIM:617557]: An autosomal dominant neurodevelopmental disorder characterized by delayed psychomotor development and intellectual disability. Most patients have behavioral and feeding problems, movement abnormalities, mild distal skeletal anomalies, and dysmorphic facial features. {ECO:0000269 PubMed:21076407, ECO:0000269 PubMed:28575647}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for YY1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for YY1 Gene
Publications for YY1 Gene
- YY1's longer DNA-binding motifs. (PMID: 18950698) Kim Jd … Kim J (Genomics 2009) 3 4 22 58
- YY1 functions with INO80 to activate transcription. (PMID: 17721549) Cai Y … Conaway JW (Nature structural & molecular biology 2007) 3 4 22 58
- Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. (PMID: 9016636) Kalenik JL … Lee TC (Nucleic acids research 1997) 3 4 22 58
- Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site. (PMID: 1946405) Park K … Atchison ML (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4 22 58
- Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein. (PMID: 1655281) Shi Y … Shenk T (Cell 1991) 2 3 4 58
Products for YY1 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for YY1
- antibodies-online: Search results for 147 available YY1 Antibodies ranked by validation data
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- Quality Products:
- antibodies-online: Search results for 8 available YY1 Proteins ranked by validation data
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- Quality Products:
- GeneTex YY1 Antibody for YY1
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- Santa Cruz Biotechnology (SCBT) Antibodies for YY1
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- Santa Cruz Biotechnology (SCBT) CRISPR for YY1
- Search for YY1 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for YY1
- genomics-online: cdna clones - Search results for available YY1 gene related products
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YY1
Sources for YY1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio