Aliases for YWHAZ Gene
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta 2 3 5
- KCIP-1 2 3 4
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Delta Polypeptide 2 3
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta Polypeptide 2 3
- 14-3-3 Protein Zeta/Delta 3 4
- 14-3-3 Delta 2 3
- 14-3-3 Zeta 2 3
- 14-3-3-Zeta 2 3
- Tyrosine 3/Tryptophan 5 -Monooxygenase Activation Protein, Zeta Polypeptide 3
- 14-3-3 Protein/Cytosolic Phospholipase A2 3
- Protein Kinase C Inhibitor Protein-1 3
External Ids for YWHAZ Gene
Previous HGNC Symbols for YWHAZ Gene
Previous GeneCards Identifiers for YWHAZ Gene
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for YWHAZ Gene
YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta) is a Protein Coding gene. Diseases associated with YWHAZ include Epilepsy, Idiopathic Generalized 11 and Ophthalmia Nodosa. Among its related pathways are DNA Double-Strand Break Repair and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is YWHAB.
UniProtKB/Swiss-Prot Summary for YWHAZ Gene
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.