Aliases for YWHAH Gene
External Ids for YWHAH Gene
Previous HGNC Symbols for YWHAH Gene
Previous GeneCards Identifiers for YWHAH Gene
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
GeneCards Summary for YWHAH Gene
YWHAH (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta) is a Protein Coding gene. Diseases associated with YWHAH include Early-Onset Schizophrenia and Deafness, Autosomal Dominant 64. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and LKB1 signaling events. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and actin binding. An important paralog of this gene is YWHAG.
UniProtKB/Swiss-Prot Summary for YWHAH Gene
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.