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Aliases for YWHAG Gene

Aliases for YWHAG Gene

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma 2 3 5
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Gamma Polypeptide 2 3
  • Protein Phosphatase 1, Regulatory Subunit 170 2 3
  • Protein Kinase C Inhibitor Protein 1 3 4
  • KCIP-1 3 4
  • 14-3-3 Protein Gamma 3
  • 14-3-3 Gamma 2
  • 14-3-3GAMMA 3
  • PPP1R170 3
  • EIEE56 3

External Ids for YWHAG Gene

Previous GeneCards Identifiers for YWHAG Gene

  • GC07M074491
  • GC07M075554
  • GC07M075568
  • GC07M075600
  • GC07M075794
  • GC07M075956
  • GC07M071042

Summaries for YWHAG Gene

Entrez Gene Summary for YWHAG Gene

  • This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for YWHAG Gene

YWHAG (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma) is a Protein Coding gene. Diseases associated with YWHAG include Epileptic Encephalopathy, Early Infantile, 56 and Undetermined Early-Onset Epileptic Encephalopathy. Among its related pathways are Gene Expression and Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase C binding. An important paralog of this gene is YWHAH.

UniProtKB/Swiss-Prot for YWHAG Gene

  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Tocris Summary for YWHAG Gene

  • 14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.

Gene Wiki entry for YWHAG Gene

Additional gene information for YWHAG Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YWHAG Gene

Genomics for YWHAG Gene

GeneHancer (GH) Regulatory Elements for YWHAG Gene

Promoters and enhancers for YWHAG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J076356 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.4 420 4.7 CLOCK DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 ZNF610 GLIS1 RCOR2 YWHAG PMS2P3 STAG3L1 POMZP3 SPDYE18 PMS2P9 DTX2P1 FAM185BP LOC100133091 NSUN5P1
GH07J075734 Enhancer 1.1 Ensembl ENCODE 4.4 +624.2 624162 1.1 HDGF PKNOX1 ATF1 ARNT ZFP64 FEZF1 GTF3C2 TCF12 ZNF766 ZFP91 PMS2P3 STAG3L1 NSUN5P1 SPDYE5 DTX2 YWHAG GTF2IP1 HIP1 GC07M075740 GC07M075738
GH07J075670 Enhancer 1 Ensembl ENCODE 4.7 +687.7 687738 1.6 HDAC1 HDGF PKNOX1 ARNT NFXL1 ZBTB40 CHAMP1 E2F8 ATF7 SMARCA5 CCL24 HIP1 YWHAG SPDYE12P ENSG00000279996 GC07M075740 GC07M075738
GH07J075711 Enhancer 0.9 Ensembl ENCODE 5.2 +647.1 647060 1.9 BCOR ASH1L ZNF366 ZSCAN5C ZFP91 SMARCA5 MCM5 CEBPB MEF2B ATF2 DTX2 STAG3L1 HIP1 YWHAG GC07M075740 GC07M075738 ENSG00000279996
GH07J075716 Enhancer 0.8 Ensembl ENCODE 4.8 +641.7 641689 1 FOXA2 CEBPB SP1 ZNF121 JUND CUX1 FOS FOSL2 YWHAG HIP1 GC07M075740 GC07M075738 ENSG00000279996
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around YWHAG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the YWHAG gene promoter:

Genomic Locations for YWHAG Gene

Genomic Locations for YWHAG Gene
32,241 bases
Minus strand

Genomic View for YWHAG Gene

Genes around YWHAG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YWHAG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YWHAG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YWHAG Gene

Proteins for YWHAG Gene

  • Protein details for YWHAG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    14-3-3 protein gamma
    Protein Accession:
    Secondary Accessions:
    • O70457
    • P35214
    • Q6FH52
    • Q9UDP2
    • Q9UN99

    Protein attributes for YWHAG Gene

    247 amino acids
    Molecular mass:
    28303 Da
    Quaternary structure:
    • Homodimer. Interacts with SAMSN1 (By similarity). Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT and SIRT2.Interacts with the Thr-369 phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509).

    Three dimensional structures from OCA and Proteopedia for YWHAG Gene

neXtProt entry for YWHAG Gene

Post-translational modifications for YWHAG Gene

Other Protein References for YWHAG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for YWHAG Gene

Domains & Families for YWHAG Gene

Gene Families for YWHAG Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for YWHAG Gene

Graphical View of Domain Structure for InterPro Entry



1433G_HUMAN :
  • Belongs to the 14-3-3 family.
  • Belongs to the 14-3-3 family.
genes like me logo Genes that share domains with YWHAG: view

Function for YWHAG Gene

Molecular function for YWHAG Gene

UniProtKB/Swiss-Prot Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
GENATLAS Biochemistry:
tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 G, highly expressed in brain,skeletal muscles,heat,located telomeric to D7S1870 at the most telomeric end of the common deletion of WBS1,multifunctional regulator involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase

Phenotypes From GWAS Catalog for YWHAG Gene

Gene Ontology (GO) - Molecular Function for YWHAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005080 protein kinase C binding IPI 10433554
GO:0005159 insulin-like growth factor receptor binding IPI 12482592
GO:0005515 protein binding IPI 11237865
GO:0008426 protein kinase C inhibitor activity NAS 10433554
genes like me logo Genes that share ontologies with YWHAG: view
genes like me logo Genes that share phenotypes with YWHAG: view

Animal Models for YWHAG Gene

MGI Knock Outs for YWHAG:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YWHAG

Clone Products

  • Addgene plasmids for YWHAG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YWHAG Gene

Localization for YWHAG Gene

Subcellular locations from UniProtKB/Swiss-Prot for YWHAG Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YWHAG gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
mitochondrion 3
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for YWHAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion HDA 21423176
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with YWHAG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for YWHAG Gene

Pathways & Interactions for YWHAG Gene

genes like me logo Genes that share pathways with YWHAG: view

Pathways by source for YWHAG Gene

SIGNOR curated interactions for YWHAG Gene

Is activated by:

Gene Ontology (GO) - Biological Process for YWHAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006469 negative regulation of protein kinase activity NAS 10433554
GO:0006605 protein targeting IEA --
GO:0009966 regulation of signal transduction NAS 10433554
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with YWHAG: view

Drugs & Compounds for YWHAG Gene

(2) Drugs for YWHAG Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zolpidem Approved Pharma Full agonist, Allosteric regulator 110
R18 Pharma 14.3.3 proteins Antagonist, Inhibitor of 14.3.3 proteins 0

(2) Additional Compounds for YWHAG Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (S)-2-amino-7,8-dihydro-6-(2-Hydroxy-1-oxopropyl)-4(1H)-pteridinone
  • 1-(2-amino-7,8-dihydro-4-Hydroxy-6-pteridinyl)-2-hydroxy-1-propanone
  • 2-amino-6-(S)-Lactoyl-7,8-dihydro-4(3H)-pteridinone
  • 2-amino-7,8-dihydro-6-[(2S)-2-Hydroxy-1-oxopropyl]-4(1H)pteridinone
  • L-Sepiapterin

(2) Tocris Compounds for YWHAG Gene

Compound Action Cas Number
Difopein High affinity inhibitor of 14.3.3 proteins; induces apoptosis 396834-58-5
R18 Inhibitor of 14.3.3 proteins 211364-78-2

(1) ApexBio Compounds for YWHAG Gene

Compound Action Cas Number
R18 14.3.3 proteins Antagonist 211364-78-2
genes like me logo Genes that share compounds with YWHAG: view

Drug Products

Transcripts for YWHAG Gene

mRNA/cDNA for YWHAG Gene

(451) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for YWHAG Gene

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YWHAG

Clone Products

  • Addgene plasmids for YWHAG

Alternative Splicing Database (ASD) splice patterns (SP) for YWHAG Gene

No ASD Table

Relevant External Links for YWHAG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YWHAG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YWHAG Gene

mRNA differential expression in normal tissues according to GTEx for YWHAG Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.6) and Brain - Anterior cingulate cortex (BA24) (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for YWHAG Gene

Protein tissue co-expression partners for YWHAG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of YWHAG Gene:


SOURCE GeneReport for Unigene cluster for YWHAG Gene:


mRNA Expression by UniProt/SwissProt for YWHAG Gene:

Tissue specificity: Highly expressed in brain, skeletal muscle, and heart.

Evidence on tissue expression from TISSUES for YWHAG Gene

  • Nervous system(5)
  • Muscle(4.6)
  • Blood(4.4)
  • Liver(4.4)
  • Heart(2.5)
  • Intestine(2.3)
  • Spleen(2)
genes like me logo Genes that share expression patterns with YWHAG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for YWHAG Gene

Orthologs for YWHAG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for YWHAG Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia YWHAG 34
  • 100 (a)
(Pan troglodytes)
Mammalia YWHAG 34 33
  • 99.73 (n)
(Bos Taurus)
Mammalia YWHAG 34 33
  • 93.25 (n)
(Mus musculus)
Mammalia Ywhag 16 34 33
  • 92.44 (n)
(Rattus norvegicus)
Mammalia Ywhag 33
  • 92.17 (n)
(Canis familiaris)
Mammalia YWHAG 34 33
  • 90.28 (n)
(Gallus gallus)
Aves YWHAG 34 33
  • 89.88 (n)
(Anolis carolinensis)
Reptilia YWHAG 34
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ywhag 33
  • 81.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69099 33
(Danio rerio)
Actinopterygii ywhag2 34
  • 96 (a)
ywhag1 34
  • 96 (a)
ywhag 33
fruit fly
(Drosophila melanogaster)
Insecta 14-3-3&zgr; 35
  • 75 (a)
(Caenorhabditis elegans)
Secernentea M117.3 34
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BMH1 34
  • 56 (a)
BMH2 34
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 61 (a)
CSA.10834 34
  • 60 (a)
CSA.10888 34
  • 53 (a)
-- 34
  • 51 (a)
CSA.11325 34
  • 51 (a)
-- 34
  • 47 (a)
Species where no ortholog for YWHAG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YWHAG Gene

Gene Tree for YWHAG (if available)
Gene Tree for YWHAG (if available)
Evolutionary constrained regions (ECRs) for YWHAG: view image

Paralogs for YWHAG Gene

Paralogs for YWHAG Gene

(9) SIMAP similar genes for YWHAG Gene using alignment to 1 proteins:

  • 1433G_HUMAN
genes like me logo Genes that share paralogs with YWHAG: view

Variants for YWHAG Gene

Sequence variations from dbSNP and Humsavar for YWHAG Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
VAR_080224 Epileptic encephalopathy, early infantile, 56 (EIEE56) [MIM:617665] p.Glu15Ala
VAR_080226 Epileptic encephalopathy, early infantile, 56 (EIEE56) [MIM:617665] p.Asp129Glu
VAR_080227 Epileptic encephalopathy, early infantile, 56 (EIEE56) [MIM:617665] p.Arg132Cys
rs1000142507 -- 76,358,427(-) A/T intron_variant
rs1000222353 -- 76,351,200(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for YWHAG Gene

Variant ID Type Subtype PubMed ID
dgv120n16 CNV deletion 17901297
esv2422494 CNV duplication 17116639
esv2678206 CNV deletion 23128226
nsv1028665 CNV gain 25217958
nsv1143414 CNV deletion 24896259
nsv1148733 CNV deletion 26484159
nsv428174 CNV gain 18775914
nsv528969 CNV gain 19592680

Variation tolerance for YWHAG Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YWHAG Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YWHAG Gene

Disorders for YWHAG Gene

MalaCards: The human disease database

(5) MalaCards diseases for YWHAG Gene - From: HGMD, OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search YWHAG in MalaCards View complete list of genes associated with diseases


  • Epileptic encephalopathy, early infantile, 56 (EIEE56) [MIM:617665]: A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE56 is an autosomal dominant condition. {ECO:0000269 PubMed:28777935}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for YWHAG

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with YWHAG: view

No data available for Genatlas for YWHAG Gene

Publications for YWHAG Gene

  1. Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23. (PMID: 10486217) Horie M … Tanigami A (Genomics 1999) 2 3 4 22 58
  2. 14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells. (PMID: 10433554) Autieri MV … Carbone CJ (DNA and cell biology 1999) 2 3 4 58
  3. De Novo Mutations in YWHAG Cause Early-Onset Epilepsy. (PMID: 28777935) Guella I … Farrer MJ (American journal of human genetics 2017) 3 4 58
  4. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. (PMID: 23572552) Greninger AL … DeRisi JL (mBio 2013) 3 4 58
  5. Genome-wide association study of severity in multiple sclerosis. (PMID: 21654844) International Multiple Sclerosis Genetics Consortium (Genes and immunity 2011) 3 44 58

Products for YWHAG Gene

Sources for YWHAG Gene

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