Aliases for YWHAE Gene
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon 2 3 5
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Epsilon Polypeptide 2 3
- 14-3-3 Protein Epsilon 3 4
- 14-3-3 Epsilon 2 3
- 14-3-3E 3 4
- Tyrosine 3/Tryptophan 5 -Monooxygenase Activation Protein, Epsilon Polypeptide 3
- Mitochondrial Import Stimulation Factor L Subunit 3
External Ids for YWHAE Gene
Previous GeneCards Identifiers for YWHAE Gene
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
GeneCards Summary for YWHAE Gene
YWHAE (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon) is a Protein Coding gene. Diseases associated with YWHAE include Endometrial Stromal Sarcoma and Kidney Clear Cell Sarcoma. Among its related pathways are Apoptosis Modulation and Signaling and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is YWHAZ.
UniProtKB/Swiss-Prot Summary for YWHAE Gene
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326).
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.