This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic sig... See more...

Aliases for YWHAB Gene

Aliases for YWHAB Gene

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta 2 3 5
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Alpha Polypeptide 2 3
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta Polypeptide 2 3
  • 14-3-3 Protein Beta/Alpha 3 4
  • 14-3-3 Alpha 2 3
  • Protein 1054 3 4
  • KCIP-1 3 4
  • Protein Kinase C Inhibitor Protein-1 3
  • Protein Kinase C Inhibitor Protein 1 4
  • Brain Protein 14-3-3, Beta Isoform 3
  • Epididymis Secretory Protein Li 1 3
  • 14-3-3 Beta 2
  • HEL-S-1 3
  • GW128 3
  • YWHAA 3
  • YWHAB 5
  • HS1 3

External Ids for YWHAB Gene

Previous HGNC Symbols for YWHAB Gene

  • YWHAA

Previous GeneCards Identifiers for YWHAB Gene

  • GC20P043242
  • GC20P043202
  • GC20P044152
  • GC20P044199
  • GC20P042947
  • GC20P043515
  • GC20P040256

Summaries for YWHAB Gene

Entrez Gene Summary for YWHAB Gene

  • This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for YWHAB Gene

YWHAB (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta) is a Protein Coding gene. Diseases associated with YWHAB include Chlamydia and Eosinophilic Meningitis. Among its related pathways are Apoptosis Modulation and Signaling and Negative regulation of MAPK pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is YWHAZ.

UniProtKB/Swiss-Prot Summary for YWHAB Gene

  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.

Tocris Summary for YWHAB Gene

  • 14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.

Gene Wiki entry for YWHAB Gene

Additional gene information for YWHAB Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for YWHAB Gene

Genomics for YWHAB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for YWHAB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J044884 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 622.5 +1.5 1467 5.9 CEBPG SP1 CREB1 GATAD2A CTCF PRDM10 ZNF629 TFE3 IKZF1 POLR2A YWHAB ENSG00000286100 NONHSAG031849.2 ZSWIM1 PABPC1L ZSWIM3 SYS1 WFDC5 WFDC12
GH20J044909 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 33.7 +25.0 25043 2.9 HNRNPL GATAD2A CTCF PRDM10 ZNF629 TFE3 RFX1 IKZF1 POLR2A ZNF692 PABPC1L YWHAB ENSG00000271984 JPH2 TOMM34 STK4 STK4-AS1 ZSWIM1 DBNDD2 piR-57460-413
GH20J044896 Enhancer 0.8 ENCODE 22.1 +11.3 11303 1.5 GATAD2A TFE3 RCOR2 RXRB IRF2 GABPA CEBPA SCRT2 SOX13 CEBPB YWHAB NONHSAG031849.2 PABPC1L
GH20J044901 Enhancer 0.6 Ensembl 21.9 +16.3 16299 1.2 CREB1 ATF7 ZNF629 PRDM1 ZBTB17 ATF2 JUND ZNF184 ZNF366 ATF3 YWHAB PABPC1L NONHSAG031849.2
GH20J044860 Enhancer 0.7 Ensembl ENCODE 17.9 -23.1 -23108 3.2 RFX1 ZIC2 PKNOX1 ESR1 NFIC TCF12 ZBTB33 MEIS2 CBFA2T2 CBFA2T3 lnc-YWHAB-1 YWHAB KCNK15 KCNK15-AS1 RIMS4 CCN5 ENSG00000132832 PABPC1L PGBD4P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around YWHAB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for YWHAB

Top Transcription factor binding sites by QIAGEN in the YWHAB gene promoter:
  • aMEF-2
  • CREB
  • E47
  • FOXJ2
  • FOXJ2 (long isoform)
  • Hand1
  • MEF-2
  • MEF-2A
  • POU2F1
  • POU2F1a

Genomic Locations for YWHAB Gene

Genomic Locations for YWHAB Gene
chr20:44,885,702-44,908,532
(GRCh38/hg38)
Size:
22,831 bases
Orientation:
Plus strand
chr20:43,514,317-43,537,173
(GRCh37/hg19)
Size:
22,857 bases
Orientation:
Plus strand

Genomic View for YWHAB Gene

Genes around YWHAB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YWHAB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YWHAB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YWHAB Gene

Proteins for YWHAB Gene

  • Protein details for YWHAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31946-1433B_HUMAN
    Recommended name:
    14-3-3 protein beta/alpha
    Protein Accession:
    P31946
    Secondary Accessions:
    • A8K9K2
    • E1P616

    Protein attributes for YWHAB Gene

    Size:
    246 amino acids
    Molecular mass:
    28082 Da
    Quaternary structure:
    • Homodimer (PubMed:17717073). Interacts with SAMSN1 and PRKCE (By similarity). Interacts with AKAP13 (PubMed:21224381). Interacts with SSH1 and TORC2/CRTC2 (PubMed:15454081, PubMed:15159416). Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis (PubMed:15696159). Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues (PubMed:17717073). Interacts with GAB2 (PubMed:19172738). Interacts with YAP1 (phosphorylated form) (PubMed:17974916). Interacts with the phosphorylated (by AKT1) form of SRPK2 (PubMed:19592491). Interacts with PKA-phosphorylated AANAT (PubMed:11427721). Interacts with MYO1C (PubMed:24636949). Interacts with SIRT2 (PubMed:18249187). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (PubMed:22827337). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (PubMed:15538381). Interacts with SLITRK1 (PubMed:19640509). Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity). Interacts with RIPOR2 (via phosphorylated form) isoform 2; this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (PubMed:25588844). Interacts with MARK2 and MARK3 (PubMed:16959763).
    • (Microbial infection) Interacts with herpes simplex virus 1 protein UL46.
    • (Microbial infection) Probably interacts with Chlamydia trachomatis protein IncG.

    Three dimensional structures from OCA and Proteopedia for YWHAB Gene

    Alternative splice isoforms for YWHAB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YWHAB Gene

Post-translational modifications for YWHAB Gene

  • The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
  • Ubiquitination at Lys11, Lys70, Lys117, and Lys140
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for YWHAB Gene

Domains & Families for YWHAB Gene

Gene Families for YWHAB Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for YWHAB Gene

InterPro:
Blocks:
  • 14-3-3 protein
ProtoNet:

Suggested Antigen Peptide Sequences for YWHAB Gene

GenScript: Design optimal peptide antigens:
  • Protein kinase C inhibitor protein 1 (1433B_HUMAN)
  • 14-3-3 protein beta/alpha (B5BU24_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P31946

UniProtKB/Swiss-Prot:

1433B_HUMAN :
  • Belongs to the 14-3-3 family.
Family:
  • Belongs to the 14-3-3 family.
genes like me logo Genes that share domains with YWHAB: view

Function for YWHAB Gene

Molecular function for YWHAB Gene

UniProtKB/Swiss-Prot Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
GENATLAS Biochemistry:
tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 beta protein,including the phosphorylated form YWHAA (alpha),multifunctional regulator involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase

Phenotypes From GWAS Catalog for YWHAB Gene

Gene Ontology (GO) - Molecular Function for YWHAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 7644510
GO:0008022 protein C-terminus binding IEA --
GO:0019899 enzyme binding IPI 17255105
GO:0019904 protein domain specific binding IEA,IPI 11984006
GO:0042802 identical protein binding IPI 17085597
genes like me logo Genes that share ontologies with YWHAB: view
genes like me logo Genes that share phenotypes with YWHAB: view

Animal Models for YWHAB Gene

MGI Knock Outs for YWHAB:
  • Ywhab Ywhab<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for YWHAB Gene

miRTarBase miRNAs that target YWHAB

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YWHAB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YWHAB Gene

Localization for YWHAB Gene

Subcellular locations from UniProtKB/Swiss-Prot for YWHAB Gene

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Vacuole membrane. Note=(Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG. {ECO:0000269 PubMed:11260479}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YWHAB gene
Compartment Confidence
cytosol 5
extracellular 4
nucleus 4
mitochondrion 3
plasma membrane 2
cytoskeleton 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for YWHAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IDA 10869435
GO:0005739 mitochondrion IEA --
GO:0005773 vacuole IEA --
GO:0005774 vacuolar membrane IEA --
genes like me logo Genes that share ontologies with YWHAB: view

Pathways & Interactions for YWHAB Gene

PathCards logo

SuperPathways for YWHAB Gene

SuperPathway Contained pathways
1 RET signaling
2 Paradoxical activation of RAF signaling by kinase inactive BRAF
3 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
4 mTOR signalling
5 Activation of BH3-only proteins
genes like me logo Genes that share pathways with YWHAB: view

Pathways by source for YWHAB Gene

7 GeneGo (Thomson Reuters) pathways for YWHAB Gene
  • Apoptosis and survival BAD phosphorylation
  • Cell cycle Role of 14-3-3 proteins in cell cycle regulation
  • Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
  • Development IGF-1 receptor signaling
  • Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
2 R&D Systems pathways for YWHAB Gene
2 Tocris pathways for YWHAB Gene
18 Qiagen pathways for YWHAB Gene
  • 14-3-3 and Cell Cycle Regulation
  • 14-3-3 and Regulation of BAD Activity
  • 14-3-3 Induced Apoptosis
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
4 Cell Signaling Technology pathways for YWHAB Gene
2 GeneTex pathways for YWHAB Gene

SIGNOR curated interactions for YWHAB Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for YWHAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0006605 protein targeting IEA --
GO:0016032 viral process IEA --
GO:0035308 negative regulation of protein dephosphorylation IDA 17255105
GO:0035329 hippo signaling TAS --
genes like me logo Genes that share ontologies with YWHAB: view

Drugs & Compounds for YWHAB Gene

(5) Drugs for YWHAB Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 249
Zolpidem Approved Pharma Allosteric regulator, Full agonist 125
Phenethyl isothiocyanate Investigational Pharma Target 12
R18 Pharma 14.3.3 proteins Antagonist, Inhibitor of 14.3.3 proteins 0

(2) Additional Compounds for YWHAB Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Sepiapterin
  • (S)-2-amino-7,8-dihydro-6-(2-Hydroxy-1-oxopropyl)-4(1H)-pteridinone
  • 1-(2-amino-7,8-dihydro-4-Hydroxy-6-pteridinyl)-2-hydroxy-1-propanone
  • 2-amino-6-(S)-Lactoyl-7,8-dihydro-4(3H)-pteridinone
  • 2-amino-7,8-dihydro-6-[(2S)-2-Hydroxy-1-oxopropyl]-4(1H)pteridinone
  • L-Sepiapterin
17094-01-8
Difopein
396834-58-5

(2) Tocris Compounds for YWHAB Gene

Compound Action Cas Number
Difopein High affinity inhibitor of 14.3.3 proteins; induces apoptosis 396834-58-5
R18 Inhibitor of 14.3.3 proteins 211364-78-2

(1) ApexBio Compounds for YWHAB Gene

Compound Action Cas Number
R18 14.3.3 proteins Antagonist 211364-78-2
genes like me logo Genes that share compounds with YWHAB: view

Drug Products

Transcripts for YWHAB Gene

mRNA/cDNA for YWHAB Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YWHAB

Alternative Splicing Database (ASD) splice patterns (SP) for YWHAB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - - - - -
SP3:
SP4: -
SP5: -
SP6:
SP7: - - - - - -
SP8: - - - - - -
SP9: -
SP10: - - -

Relevant External Links for YWHAB Gene

GeneLoc Exon Structure for
YWHAB

Expression for YWHAB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for YWHAB Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for YWHAB Gene



Protein tissue co-expression partners for YWHAB Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for YWHAB

SOURCE GeneReport for Unigene cluster for YWHAB Gene:

Hs.643544

Evidence on tissue expression from TISSUES for YWHAB Gene

  • Nervous system(5)
  • Skin(4.9)
  • Liver(4.8)
  • Blood(4.7)
  • Intestine(4.3)
  • Lung(4.3)
  • Pancreas(4.2)
  • Kidney(3.8)
  • Eye(3.5)
  • Heart(2.9)
  • Muscle(2.8)
  • Spleen(2.8)
  • Lymph node(2.7)
  • Bone(2.6)
  • Stomach(2.6)
  • Adrenal gland(2.5)
  • Thyroid gland(2.4)
  • Bone marrow(2.4)
genes like me logo Genes that share expression patterns with YWHAB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YWHAB Gene

Orthologs for YWHAB Gene

This gene was present in the common ancestor of animals.

Orthologs for YWHAB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia YWHAB 30 31
  • 99.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia YWHAB 30 31
  • 93.72 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia YWHAB 30 31
  • 92.01 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia YWHAB 31
  • 92 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ywhab 30
  • 91.33 (n)
Mouse
(Mus musculus)
Mammalia Ywhab 30 17 31
  • 90.65 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia YWHAB 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves YWHAB 30 31
  • 84.7 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia YWHAB 31
  • 97 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ywhab 30
  • 79.23 (n)
Zebrafish
(Danio rerio)
Actinopterygii ywhabb 31
  • 89 (a)
OneToMany
ywhaba 30 31
  • 80.05 (n)
OneToMany
-- 30
Fruit Fly
(Drosophila melanogaster)
Insecta 14-3-3&zgr; 32
  • 79 (a)
14-3-3zeta 31
  • 78 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ftt-2 31
  • 77 (a)
ManyToMany
par-5 31
  • 75 (a)
ManyToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4900 30
Species where no ortholog for YWHAB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for YWHAB Gene

ENSEMBL:
Gene Tree for YWHAB (if available)
TreeFam:
Gene Tree for YWHAB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for YWHAB: view image

Paralogs for YWHAB Gene

Paralogs for YWHAB Gene

(9) SIMAP similar genes for YWHAB Gene using alignment to 4 proteins:

  • 1433B_HUMAN
  • B5BU24_HUMAN
  • Q4VY19_HUMAN
  • Q4VY20_HUMAN

Pseudogenes.org Pseudogenes for YWHAB Gene

genes like me logo Genes that share paralogs with YWHAB: view

Variants for YWHAB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for YWHAB Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
719598 Benign: not provided 44,901,841(+) G/A INTRON_VARIANT
VAR_064762 - p.Val99Ile

Additional dbSNP identifiers (rs#s) for YWHAB Gene

Structural Variations from Database of Genomic Variants (DGV) for YWHAB Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958
nsv1058850 CNV gain 25217958
nsv1062628 CNV gain 25217958
nsv518547 CNV gain 19592680
nsv586077 CNV gain 21841781
nsv954044 CNV duplication 24416366

Variation tolerance for YWHAB Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YWHAB Gene

Human Gene Mutation Database (HGMD)
YWHAB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
YWHAB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YWHAB Gene

Disorders for YWHAB Gene

MalaCards: The human disease database

(10) MalaCards diseases for YWHAB Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chlamydia
  • chlamydia trachomatis infectious disease
eosinophilic meningitis
schizophrenia 14
  • sczd14
diarrhea 8, secretory sodium, congenital
  • csd
creutzfeldt-jakob disease
  • cjd
- elite association - COSMIC cancer census association via MalaCards
Search YWHAB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for YWHAB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with YWHAB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YWHAB Gene

Publications for YWHAB Gene

  1. Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils. (PMID: 25588844) Gao K … Wu D (Journal of cell science 2015) 3 4
  2. Crystal structure of human myosin 1c--the motor in GLUT4 exocytosis: implications for Ca2+ regulation and 14-3-3 binding. (PMID: 24636949) Münnich S … Manstein DJ (Journal of molecular biology 2014) 3 4
  3. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. (PMID: 23572552) Greninger AL … DeRisi JL (mBio 2013) 3 4
  4. A proteomic perspective of inbuilt viral protein regulation: pUL46 tegument protein is targeted for degradation by ICP0 during herpes simplex virus type 1 infection. (PMID: 23938468) Lin AE … Cristea IM (Molecular & cellular proteomics : MCP 2013) 3 4
  5. A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in α1-adrenergic receptor-induced p38 activation. (PMID: 21224381) Cariolato L … Diviani D (The Journal of biological chemistry 2011) 3 4

Products for YWHAB Gene

  • Addgene plasmids for YWHAB
  • Signalway Proteins for YWHAB

Sources for YWHAB Gene