Aliases for YWHAB Gene
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta 2 3 5
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Alpha Polypeptide 2 3
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta Polypeptide 2 3
- 14-3-3 Protein Beta/Alpha 3 4
- Protein 1054 3 4
- 14-3-3 Alpha 2 3
- KCIP-1 3 4
- Protein Kinase C Inhibitor Protein-1 3
External Ids for YWHAB Gene
Previous HGNC Symbols for YWHAB Gene
Previous GeneCards Identifiers for YWHAB Gene
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for YWHAB Gene
YWHAB (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta) is a Protein Coding gene. Diseases associated with YWHAB include Chlamydia and Eosinophilic Meningitis. Among its related pathways are Role of Calcineurin-dependent NFAT signaling in lymphocytes and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is YWHAZ.
UniProtKB/Swiss-Prot Summary for YWHAB Gene
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.