This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic sig... See more...

Aliases for YWHAB Gene

Aliases for YWHAB Gene

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta 2 3 5
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Alpha Polypeptide 2 3
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta Polypeptide 2 3
  • 14-3-3 Protein Beta/Alpha 3 4
  • Protein 1054 3 4
  • 14-3-3 Alpha 2 3
  • KCIP-1 3 4
  • Protein Kinase C Inhibitor Protein-1 3
  • Protein Kinase C Inhibitor Protein 1 4
  • Brain Protein 14-3-3, Beta Isoform 3
  • Epididymis Secretory Protein Li 1 3
  • 14-3-3 Beta 2
  • HEL-S-1 3
  • GW128 3
  • YWHAA 3
  • HS1 3

External Ids for YWHAB Gene

Previous HGNC Symbols for YWHAB Gene

  • YWHAA

Previous GeneCards Identifiers for YWHAB Gene

  • GC20P043242
  • GC20P043202
  • GC20P044152
  • GC20P044199
  • GC20P042947
  • GC20P043515
  • GC20P040256

Summaries for YWHAB Gene

Entrez Gene Summary for YWHAB Gene

  • This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for YWHAB Gene

YWHAB (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta) is a Protein Coding gene. Diseases associated with YWHAB include Chlamydia and Eosinophilic Meningitis. Among its related pathways are Role of Calcineurin-dependent NFAT signaling in lymphocytes and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is YWHAZ.

UniProtKB/Swiss-Prot Summary for YWHAB Gene

  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.

Tocris Summary for YWHAB Gene

  • 14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.

Gene Wiki entry for YWHAB Gene

Additional gene information for YWHAB Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for YWHAB Gene

Genomics for YWHAB Gene

GeneHancer (GH) Regulatory Elements for YWHAB Gene

Promoters and enhancers for YWHAB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J044884 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 772.5 +1.6 1570 5.9 SP1 ZBTB40 CTCF LCORL ZBTB6 RBPJ SMARCE1 POLR2A USF2 HCFC1 YWHAB ENSG00000286100 NONHSAG031849.2 UBE2C OSER1 PIGT ZSWIM1 PABPC1L JPH2 RPS2P7
GH20J044909 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 33.7 +25.1 25146 2.9 ZBTB40 CTCF LCORL RBPJ SMARCE1 POLR2A NR2F1 NR2F6 MIXL1 CC2D1A PABPC1L YWHAB ENSG00000271984 JPH2 ZSWIM1 TOMM34 STK4 STK4-AS1 DBNDD2 piR-57460-413
GH20J044896 Enhancer 0.8 ENCODE 22.1 +11.4 11406 1.5 MLX ATF1 MIXL1 MYC HLF NFIB ZNF652 ELF3 TFE3 CEBPG YWHAB NONHSAG031849.2 PABPC1L
GH20J044901 Enhancer 0.6 Ensembl 21.9 +16.4 16402 1.2 SP7 PRDM1 CREB1 ZNF629 ATF7 JUND ZBTB17 ZNF366 PAF1 ATF2 YWHAB PABPC1L NONHSAG031849.2
GH20J044860 Enhancer 0.7 Ensembl ENCODE 17.9 -23.0 -23005 3.2 NFIB CBFA2T2 ZIC2 RFX1 PKNOX1 NFIC TCF12 ZBTB33 CBFA2T3 lnc-YWHAB-1 YWHAB KCNK15 KCNK15-AS1 RIMS4 CCN5 ENSG00000132832 PABPC1L PGBD4P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around YWHAB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the YWHAB gene promoter:
  • aMEF-2
  • CREB
  • E47
  • FOXJ2
  • FOXJ2 (long isoform)
  • Hand1
  • MEF-2
  • MEF-2A
  • POU2F1
  • POU2F1a

Genomic Locations for YWHAB Gene

Genomic Locations for YWHAB Gene
chr20:44,885,599-44,908,532
(GRCh38/hg38)
Size:
22,934 bases
Orientation:
Plus strand
chr20:43,514,317-43,537,173
(GRCh37/hg19)
Size:
22,857 bases
Orientation:
Plus strand

Genomic View for YWHAB Gene

Genes around YWHAB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YWHAB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YWHAB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YWHAB Gene

Proteins for YWHAB Gene

  • Protein details for YWHAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31946-1433B_HUMAN
    Recommended name:
    14-3-3 protein beta/alpha
    Protein Accession:
    P31946
    Secondary Accessions:
    • A8K9K2
    • E1P616

    Protein attributes for YWHAB Gene

    Size:
    246 amino acids
    Molecular mass:
    28082 Da
    Quaternary structure:
    • Homodimer (PubMed:17717073). Interacts with SAMSN1 and PRKCE (By similarity). Interacts with AKAP13 (PubMed:21224381). Interacts with SSH1 and TORC2/CRTC2 (PubMed:15454081, PubMed:15159416). Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis (PubMed:15696159). Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues (PubMed:17717073). Interacts with GAB2 (PubMed:19172738). Interacts with YAP1 (phosphorylated form) (PubMed:17974916). Interacts with the phosphorylated (by AKT1) form of SRPK2 (PubMed:19592491). Interacts with PKA-phosphorylated AANAT (PubMed:11427721). Interacts with MYO1C (PubMed:24636949). Interacts with SIRT2 (PubMed:18249187). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (PubMed:22827337). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (PubMed:15538381). Interacts with SLITRK1 (PubMed:19640509). Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity). Interacts with RIPOR2 (via phosphorylated form) isoform 2; this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (PubMed:25588844). Interacts with MARK2 and MARK3 (PubMed:16959763).
    • (Microbial infection) Interacts with herpes simplex virus 1 protein UL46.
    • (Microbial infection) Probably interacts with Chlamydia trachomatis protein IncG.

    Three dimensional structures from OCA and Proteopedia for YWHAB Gene

    Alternative splice isoforms for YWHAB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YWHAB Gene

Post-translational modifications for YWHAB Gene

  • The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
  • Ubiquitination at Lys11, Lys70, Lys117, and Lys140
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for YWHAB Gene

Domains & Families for YWHAB Gene

Gene Families for YWHAB Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for YWHAB Gene

Suggested Antigen Peptide Sequences for YWHAB Gene

GenScript: Design optimal peptide antigens:
  • Protein kinase C inhibitor protein 1 (1433B_HUMAN)
  • 14-3-3 protein beta/alpha (B5BU24_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P31946

UniProtKB/Swiss-Prot:

1433B_HUMAN :
  • Belongs to the 14-3-3 family.
Family:
  • Belongs to the 14-3-3 family.
genes like me logo Genes that share domains with YWHAB: view

Function for YWHAB Gene

Molecular function for YWHAB Gene

UniProtKB/Swiss-Prot Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
GENATLAS Biochemistry:
tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 beta protein,including the phosphorylated form YWHAA (alpha),multifunctional regulator involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase

Phenotypes From GWAS Catalog for YWHAB Gene

Gene Ontology (GO) - Molecular Function for YWHAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 7644510
GO:0008022 protein C-terminus binding IEA --
GO:0019899 enzyme binding IPI 17255105
GO:0019904 protein domain specific binding IEA,IPI 11984006
GO:0042802 identical protein binding IPI 17085597
genes like me logo Genes that share ontologies with YWHAB: view
genes like me logo Genes that share phenotypes with YWHAB: view

Animal Model Products

CRISPR Products

miRNA for YWHAB Gene

miRTarBase miRNAs that target YWHAB

Clone Products

  • Addgene plasmids for YWHAB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YWHAB Gene

Localization for YWHAB Gene

Subcellular locations from UniProtKB/Swiss-Prot for YWHAB Gene

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Vacuole membrane. Note=(Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG. {ECO:0000269 PubMed:11260479}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YWHAB gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for YWHAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IDA 10869435
GO:0005739 mitochondrion IEA --
GO:0005773 vacuole IEA --
GO:0005774 vacuolar membrane IEA --
genes like me logo Genes that share ontologies with YWHAB: view

Pathways & Interactions for YWHAB Gene

PathCards logo

SuperPathways for YWHAB Gene

SuperPathway Contained pathways
1 RET signaling
2 CDK-mediated phosphorylation and removal of Cdc6
.31
3 Paradoxical activation of RAF signaling by kinase inactive BRAF
4 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
5 mTOR signalling
genes like me logo Genes that share pathways with YWHAB: view

Pathways by source for YWHAB Gene

1 R&D Systems pathway for YWHAB Gene
2 Tocris pathways for YWHAB Gene
18 Qiagen pathways for YWHAB Gene
  • 14-3-3 and Cell Cycle Regulation
  • 14-3-3 and Regulation of BAD Activity
  • 14-3-3 Induced Apoptosis
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
4 Cell Signaling Technology pathways for YWHAB Gene
2 GeneTex pathways for YWHAB Gene

SIGNOR curated interactions for YWHAB Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for YWHAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0006605 protein targeting IEA --
GO:0016032 viral process IEA --
GO:0035308 negative regulation of protein dephosphorylation IDA 17255105
GO:0035329 hippo signaling TAS --
genes like me logo Genes that share ontologies with YWHAB: view

Drugs & Compounds for YWHAB Gene

(5) Drugs for YWHAB Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 227
Zolpidem Approved Pharma Full agonist, Allosteric regulator 121
Phenethyl isothiocyanate Investigational Pharma Target 14
R18 Pharma 14.3.3 proteins Antagonist, Inhibitor of 14.3.3 proteins 0

(2) Additional Compounds for YWHAB Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Sepiapterin
  • (S)-2-amino-7,8-dihydro-6-(2-Hydroxy-1-oxopropyl)-4(1H)-pteridinone
  • 1-(2-amino-7,8-dihydro-4-Hydroxy-6-pteridinyl)-2-hydroxy-1-propanone
  • 2-amino-6-(S)-Lactoyl-7,8-dihydro-4(3H)-pteridinone
  • 2-amino-7,8-dihydro-6-[(2S)-2-Hydroxy-1-oxopropyl]-4(1H)pteridinone
  • L-Sepiapterin
17094-01-8
Difopein
396834-58-5

(2) Tocris Compounds for YWHAB Gene

Compound Action Cas Number
Difopein High affinity inhibitor of 14.3.3 proteins; induces apoptosis 396834-58-5
R18 Inhibitor of 14.3.3 proteins 211364-78-2

(1) ApexBio Compounds for YWHAB Gene

Compound Action Cas Number
R18 14.3.3 proteins Antagonist 211364-78-2
genes like me logo Genes that share compounds with YWHAB: view

Transcripts for YWHAB Gene

mRNA/cDNA for YWHAB Gene

CRISPR Products

Clone Products

  • Addgene plasmids for YWHAB

Alternative Splicing Database (ASD) splice patterns (SP) for YWHAB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - - - - -
SP3:
SP4: -
SP5: -
SP6:
SP7: - - - - - -
SP8: - - - - - -
SP9: -
SP10: - - -

Relevant External Links for YWHAB Gene

GeneLoc Exon Structure for
YWHAB
ECgene alternative splicing isoforms for
YWHAB

Expression for YWHAB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YWHAB Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for YWHAB Gene



Protein tissue co-expression partners for YWHAB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of YWHAB Gene:

YWHAB

SOURCE GeneReport for Unigene cluster for YWHAB Gene:

Hs.643544

Evidence on tissue expression from TISSUES for YWHAB Gene

  • Skin(4.9)
  • Nervous system(4.9)
  • Liver(4.7)
  • Blood(4.6)
  • Intestine(4.2)
  • Lung(4.1)
  • Pancreas(3.9)
  • Kidney(3.5)
  • Eye(3.1)
  • Heart(2.5)
  • Spleen(2.2)
  • Lymph node(2.1)
  • Muscle(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with YWHAB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YWHAB Gene

Orthologs for YWHAB Gene

This gene was present in the common ancestor of animals.

Orthologs for YWHAB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YWHAB 33 32
  • 99.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia YWHAB 33 32
  • 93.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia YWHAB 33 32
  • 92.01 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YWHAB 33
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ywhab 32
  • 91.33 (n)
mouse
(Mus musculus)
Mammalia Ywhab 17 33 32
  • 90.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia YWHAB 33
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves YWHAB 33 32
  • 84.7 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YWHAB 33
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ywhab 32
  • 79.23 (n)
zebrafish
(Danio rerio)
Actinopterygii ywhabb 33
  • 89 (a)
OneToMany
ywhaba 33 32
  • 80.05 (n)
OneToMany
-- 32
fruit fly
(Drosophila melanogaster)
Insecta 14-3-3&zgr; 34
  • 79 (a)
14-3-3zeta 33
  • 78 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ftt-2 33
  • 77 (a)
ManyToMany
par-5 33
  • 75 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea Cin.4900 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4900 32
Species where no ortholog for YWHAB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YWHAB Gene

ENSEMBL:
Gene Tree for YWHAB (if available)
TreeFam:
Gene Tree for YWHAB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for YWHAB: view image

Paralogs for YWHAB Gene

Paralogs for YWHAB Gene

(9) SIMAP similar genes for YWHAB Gene using alignment to 4 proteins:

  • 1433B_HUMAN
  • B5BU24_HUMAN
  • Q4VY19_HUMAN
  • Q4VY20_HUMAN

Pseudogenes.org Pseudogenes for YWHAB Gene

genes like me logo Genes that share paralogs with YWHAB: view

Variants for YWHAB Gene

Sequence variations from dbSNP and Humsavar for YWHAB Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000078233 -- 44,887,523(+) T/C intron_variant
rs1000120262 -- 44,885,261(+) G/A upstream_transcript_variant
rs1000317881 -- 44,890,836(+) G/A intron_variant
rs1000483521 -- 44,902,788(+) A/G intron_variant
rs1000575536 -- 44,885,018(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for YWHAB Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958
nsv1058850 CNV gain 25217958
nsv1062628 CNV gain 25217958
nsv518547 CNV gain 19592680
nsv586077 CNV gain 21841781
nsv954044 CNV duplication 24416366

Variation tolerance for YWHAB Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YWHAB Gene

Human Gene Mutation Database (HGMD)
YWHAB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
YWHAB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YWHAB Gene

Disorders for YWHAB Gene

MalaCards: The human disease database

(4) MalaCards diseases for YWHAB Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
chlamydia
  • chlamydia trachomatis infectious disease
eosinophilic meningitis
chronic meningitis
gerstmann-straussler disease
  • gsd
- elite association - COSMIC cancer census association via MalaCards
Search YWHAB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for YWHAB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with YWHAB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YWHAB Gene

Publications for YWHAB Gene

  1. Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils. (PMID: 25588844) Gao K … Wu D (Journal of cell science 2015) 3 4 56
  2. Crystal structure of human myosin 1c--the motor in GLUT4 exocytosis: implications for Ca2+ regulation and 14-3-3 binding. (PMID: 24636949) Münnich S … Manstein DJ (Journal of molecular biology 2014) 3 4 56
  3. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. (PMID: 23572552) Greninger AL … DeRisi JL (mBio 2013) 3 4 56
  4. A proteomic perspective of inbuilt viral protein regulation: pUL46 tegument protein is targeted for degradation by ICP0 during herpes simplex virus type 1 infection. (PMID: 23938468) Lin AE … Cristea IM (Molecular & cellular proteomics : MCP 2013) 3 4 56
  5. A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in α1-adrenergic receptor-induced p38 activation. (PMID: 21224381) Cariolato L … Diviani D (The Journal of biological chemistry 2011) 3 4 56

Products for YWHAB Gene