Aliases for YPEL5 Gene

Aliases for YPEL5 Gene

  • Yippee Like 5 2 3 5
  • Protein Yippee-Like 5 3 4
  • CGI-127 2 3
  • Yippee-Like 5 (Drosophila) 2
  • YPEL5 5

External Ids for YPEL5 Gene

Previous GeneCards Identifiers for YPEL5 Gene

  • GC02P030345
  • GC02P030281
  • GC02P030223
  • GC02P030369

Summaries for YPEL5 Gene

GeneCards Summary for YPEL5 Gene

YPEL5 (Yippee Like 5) is a Protein Coding gene. Among its related pathways are Innate Immune System. An important paralog of this gene is YPEL3.

UniProtKB/Swiss-Prot Summary for YPEL5 Gene

  • Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Required for normal cell proliferation (By similarity).

Additional gene information for YPEL5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for YPEL5 Gene

Genomics for YPEL5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for YPEL5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J030145 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 608.1 +1.4 1378 5.7 SP1 CREB1 GATAD2A PRDM10 ZNF629 TFE3 RFX1 LEF1 IKZF1 KDM1A YPEL5 ENSG00000233862 LOC101929418 NONHSAG027383.2 lnc-LBH-5 ALK LBH piR-58639
GH02J030113 Enhancer 0.9 Ensembl ENCODE 17.1 -31.9 -31895 2.9 CTCF FOXA1 ZIC2 REST RAD21 TRIM22 SCRT2 JUND ZNF444 FOS YPEL5 ENSG00000233862 piR-56580-020 LOC101929418 ALK
GH02J030264 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +119.8 119792 4.4 ZNF512 EGR1 CEBPB ESR1 CTCF ZNF316 FOS JUND NCOR1 NR2F2 SNORA10B LBH YPEL5 piR-31951-013 lnc-YPEL5-5 LCLAT1
GH02J030332 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 7.3 +189.7 189666 7.5 SP1 POLR2A BACH1 LARP7 STAT3 ZNF143 RELA PKNOX1 IKZF2 TRIM22 SNORA10B YPEL5 LBH LINC01936 piR-37170-035 LCLAT1
GH02J030221 Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 6 +78.0 77980 6.3 CEBPG PRDM10 IKZF2 TRIM22 POLR2A ZNF600 EED CEBPB DPF2 RELB HSALNG0013962 YPEL5 LBH HSALNG0013961
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around YPEL5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for YPEL5

Top Transcription factor binding sites by QIAGEN in the YPEL5 gene promoter:
  • ATF6
  • FOXF2
  • FOXO3
  • FOXO3a
  • FOXO3b
  • MZF-1
  • POU2F1a
  • POU6F1 (c2)
  • STAT5A

Genomic Locations for YPEL5 Gene

Genomic Locations for YPEL5 Gene
chr2:30,146,568-30,160,533
(GRCh38/hg38)
Size:
13,966 bases
Orientation:
Plus strand
chr2:30,369,750-30,383,399
(GRCh37/hg19)
Size:
13,650 bases
Orientation:
Plus strand

Genomic View for YPEL5 Gene

Genes around YPEL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YPEL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YPEL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL5 Gene

Proteins for YPEL5 Gene

  • Protein details for YPEL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62699-YPEL5_HUMAN
    Recommended name:
    Protein yippee-like 5
    Protein Accession:
    P62699
    Secondary Accessions:
    • D6W568
    • Q65Z97
    • Q8R174
    • Q9D6M1
    • Q9UMX7
    • Q9Y3C9

    Protein attributes for YPEL5 Gene

    Size:
    121 amino acids
    Molecular mass:
    13842 Da
    Quaternary structure:
    • Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5 (PubMed:29911972). Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (PubMed:29911972). Interacts with RANBP9 and RANBP10 (PubMed:20580816).

neXtProt entry for YPEL5 Gene

Post-translational modifications for YPEL5 Gene

  • Ubiquitination at Lys47
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for YPEL5
  • Boster Bio Antibodies for YPEL5

No data available for DME Specific Peptides for YPEL5 Gene

Domains & Families for YPEL5 Gene

Gene Families for YPEL5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for YPEL5 Gene

InterPro:
Blocks:
  • Yippee-like protein
ProtoNet:

Suggested Antigen Peptide Sequences for YPEL5 Gene

GenScript: Design optimal peptide antigens:
  • Protein yippee-like 5 (YPEL5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62699

UniProtKB/Swiss-Prot:

YPEL5_HUMAN :
  • Belongs to the yippee family.
Family:
  • Belongs to the yippee family.
genes like me logo Genes that share domains with YPEL5: view

Function for YPEL5 Gene

Molecular function for YPEL5 Gene

UniProtKB/Swiss-Prot Function:
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Required for normal cell proliferation (By similarity).

Phenotypes From GWAS Catalog for YPEL5 Gene

Gene Ontology (GO) - Molecular Function for YPEL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20580816
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with YPEL5: view
genes like me logo Genes that share phenotypes with YPEL5: view

Animal Model Products

CRISPR Products

miRNA for YPEL5 Gene

miRTarBase miRNAs that target YPEL5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YPEL5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YPEL5 Gene

Localization for YPEL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YPEL5 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note=Deteted in nucleus and at the centrosome during interphase. During mitosis, detected on the mitotic spindle, at spindle poles and at the midbody. {ECO:0000250 UniProtKB:Q65Z55}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YPEL5 gene
Compartment Confidence
nucleus 5
extracellular 4
cytoskeleton 4
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for YPEL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 29911972
GO:0000922 spindle pole IEA --
GO:0005576 extracellular region TAS --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with YPEL5: view

Pathways & Interactions for YPEL5 Gene

PathCards logo

SuperPathways for YPEL5 Gene

genes like me logo Genes that share pathways with YPEL5: view

Pathways by source for YPEL5 Gene

3 Reactome pathways for YPEL5 Gene

Gene Ontology (GO) - Biological Process for YPEL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation ISS --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with YPEL5: view

No data available for SIGNOR curated interactions for YPEL5 Gene

Drugs & Compounds for YPEL5 Gene

No Compound Related Data Available

Transcripts for YPEL5 Gene

mRNA/cDNA for YPEL5 Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YPEL5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - - - - -
SP10: -
SP11:

Relevant External Links for YPEL5 Gene

GeneLoc Exon Structure for
YPEL5

Expression for YPEL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for YPEL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YPEL5 Gene

This gene is overexpressed in Hair follicle (36.6) and Peripheral blood mononuclear cells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for YPEL5 Gene



Protein tissue co-expression partners for YPEL5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for YPEL5

SOURCE GeneReport for Unigene cluster for YPEL5 Gene:

Hs.515890

Evidence on tissue expression from TISSUES for YPEL5 Gene

  • Nervous system(4.8)
  • Intestine(4.4)
  • Kidney(3.3)
  • Lung(3.3)
  • Blood(2.8)
  • Bone marrow(2.3)
  • Spleen(2.2)
  • Skin(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with YPEL5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YPEL5 Gene

Orthologs for YPEL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia YPEL5 30 31
  • 100 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia YPEL5 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia YPEL5 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia YPEL5 30 31
  • 96.69 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ypel5 30
  • 96.42 (n)
Dog
(Canis familiaris)
Mammalia YPEL5 30 31
  • 96.14 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ypel5 30 17 31
  • 95.87 (n)
OneToOne
Chicken
(Gallus gallus)
Aves YPEL5 30 31
  • 86.5 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia YPEL5 31
  • 100 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ypel5 30
  • 81.82 (n)
Str.5006 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.26158 30
Zebrafish
(Danio rerio)
Actinopterygii ypel5 31
  • 93 (a)
OneToOne
LOC100332089 30
  • 79.89 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10271 30
Fruit Fly
(Drosophila melanogaster)
Insecta Yippee 30 31
  • 66.95 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000780 30
  • 64.62 (n)
Worm
(Caenorhabditis elegans)
Secernentea B0546.3 31
  • 14 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 31
  • 30 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT2G40110 30
  • 48.18 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0698500 30
  • 50.56 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3746 31
  • 74 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1753 30
Species where no ortholog for YPEL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for YPEL5 Gene

ENSEMBL:
Gene Tree for YPEL5 (if available)
TreeFam:
Gene Tree for YPEL5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for YPEL5: view image

Paralogs for YPEL5 Gene

Paralogs for YPEL5 Gene

(4) SIMAP similar genes for YPEL5 Gene using alignment to 1 proteins:

  • YPEL5_HUMAN

Pseudogenes.org Pseudogenes for YPEL5 Gene

genes like me logo Genes that share paralogs with YPEL5: view

Variants for YPEL5 Gene

Additional dbSNP identifiers (rs#s) for YPEL5 Gene

Structural Variations from Database of Genomic Variants (DGV) for YPEL5 Gene

Variant ID Type Subtype PubMed ID
dgv6747n54 CNV gain 21841781
esv2759035 CNV gain 17122850
esv29927 CNV loss 19812545
esv34904 CNV gain 17911159
nsv581259 CNV gain+loss 21841781
nsv953763 CNV duplication 24416366

Variation tolerance for YPEL5 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YPEL5 Gene

Human Gene Mutation Database (HGMD)
YPEL5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
YPEL5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for YPEL5 Gene

Disorders for YPEL5 Gene

Additional Disease Information for YPEL5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for YPEL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YPEL5 Gene

Publications for YPEL5 Gene

  1. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K … Shimizu N (Gene 2004) 2 3 4 23
  2. The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. (PMID: 29911972) Lampert F … Peter M (eLife 2018) 3 4
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 41
  4. YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10. (PMID: 20580816) Hosono K … Minoshima S (Genomics 2010) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4

Products for YPEL5 Gene

Sources for YPEL5 Gene