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Aliases for YPEL4 Gene

Aliases for YPEL4 Gene

  • Yippee Like 4 2 3 5
  • Yippee-Like 4 (Drosophila) 2

External Ids for YPEL4 Gene

Previous GeneCards Identifiers for YPEL4 Gene

  • GC11M057169
  • GC11M057412
  • GC11M053761

Summaries for YPEL4 Gene

GeneCards Summary for YPEL4 Gene

YPEL4 (Yippee Like 4) is a Protein Coding gene. An important paralog of this gene is YPEL2.

Additional gene information for YPEL4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YPEL4 Gene

Genomics for YPEL4 Gene

GeneHancer (GH) Regulatory Elements for YPEL4 Gene

Promoters and enhancers for YPEL4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I057644 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 +2.5 2497 6.6 HDGF SMAD1 ARNT ARID4B SIN3A YBX1 ZNF766 ZNF143 FOS PAF1 CLP1 YPEL4 TIMM10 MED19 SSRP1 PPIAP42 ENSG00000269570 ENSG00000254602 MIR130A
GH11I057774 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.9 -132.0 -131997 16 PKNOX1 FOXA2 SMAD1 MLX SIN3A FEZF1 FOS SP5 NFYC JUNB CTNND1 YPEL4 TIMM10 MED19 SELENOH BTBD18 ENSG00000254732 CLP1 ENSG00000254602 SMTNL1
GH11I057760 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.6 -113.5 -113516 5.3 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 CTNND1 MED19 YPEL4 SELENOH ENSG00000254732 UBE2L6 SMTNL1 BTBD18 PIR53177 TMX2-CTNND1
GH11I057666 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.8 -18.5 -18516 4.6 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B SIN3A YY1 POLR2B ZDHHC5 SSRP1 ENSG00000269570 ZFP91 MED19 YPEL4 ENSG00000254732 SELENOH BTBD18 CTNND1
GH11I057710 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.8 -62.6 -62615 3.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B MED19 PIR45741 TMX2 TMX2-CTNND1 SSRP1 ZFP91 ENSG00000269570 YPEL4 ENSG00000254732 SELENOH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around YPEL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the YPEL4 gene promoter:

Genomic Locations for YPEL4 Gene

Genomic Locations for YPEL4 Gene
4,858 bases
Minus strand

Genomic View for YPEL4 Gene

Genes around YPEL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YPEL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YPEL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL4 Gene

Proteins for YPEL4 Gene

  • Protein details for YPEL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein yippee-like 4
    Protein Accession:
    Secondary Accessions:
    • B3KW92
    • Q2M3U7
    • Q65Z98

    Protein attributes for YPEL4 Gene

    127 amino acids
    Molecular mass:
    14301 Da
    Quaternary structure:
    No Data Available

neXtProt entry for YPEL4 Gene

Post-translational modifications for YPEL4 Gene

No Post-translational modifications

Other Protein References for YPEL4 Gene

No data available for DME Specific Peptides for YPEL4 Gene

Domains & Families for YPEL4 Gene

Gene Families for YPEL4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for YPEL4 Gene

Suggested Antigen Peptide Sequences for YPEL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the yippee family.
  • Belongs to the yippee family.
genes like me logo Genes that share domains with YPEL4: view

Function for YPEL4 Gene

Gene Ontology (GO) - Molecular Function for YPEL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with YPEL4: view
genes like me logo Genes that share phenotypes with YPEL4: view

Animal Models for YPEL4 Gene

MGI Knock Outs for YPEL4:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YPEL4 Gene

Localization for YPEL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YPEL4 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YPEL4 gene
Compartment Confidence
nucleus 4
extracellular 2
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for YPEL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with YPEL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for YPEL4 Gene

Pathways & Interactions for YPEL4 Gene

SuperPathways for YPEL4 Gene

No Data Available

Interacting Proteins for YPEL4 Gene

Gene Ontology (GO) - Biological Process for YPEL4 Gene


No data available for Pathways by source and SIGNOR curated interactions for YPEL4 Gene

Drugs & Compounds for YPEL4 Gene

No Compound Related Data Available

Transcripts for YPEL4 Gene

Unigene Clusters for YPEL4 Gene

Yippee-like 4 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6: -

Relevant External Links for YPEL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YPEL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YPEL4 Gene

mRNA differential expression in normal tissues according to GTEx for YPEL4 Gene

This gene is overexpressed in Brain - Cerebellum (x6.1), Brain - Cerebellar Hemisphere (x5.8), Brain - Cortex (x5.0), and Brain - Frontal Cortex (BA9) (x4.2).

Protein differential expression in normal tissues from HIPED for YPEL4 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for YPEL4 Gene

Protein tissue co-expression partners for YPEL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of YPEL4 Gene:


SOURCE GeneReport for Unigene cluster for YPEL4 Gene:


mRNA Expression by UniProt/SwissProt for YPEL4 Gene:

Tissue specificity: Widely expressed. Detected adult brain, lung, colon, small intestine and ovary, and in fetal brain, lung, liver and spleen.

Evidence on tissue expression from TISSUES for YPEL4 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with YPEL4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for YPEL4 Gene

Orthologs for YPEL4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia YPEL4 33 34
  • 99.74 (n)
(Monodelphis domestica)
Mammalia YPEL4 34
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia YPEL4 34
  • 97 (a)
(Canis familiaris)
Mammalia YPEL4 33 34
  • 92.91 (n)
(Rattus norvegicus)
Mammalia Ypel4 33
  • 91.34 (n)
(Mus musculus)
Mammalia Ypel4 33 16 34
  • 91.08 (n)
(Gallus gallus)
Aves LOC100858042 33
  • 83.06 (n)
YPEL4 34
  • 66 (a)
(Anolis carolinensis)
Reptilia YPEL4 34
  • 96 (a)
(Danio rerio)
Actinopterygii ypel3 33 34
  • 77.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15309 34
  • 76 (a)
(Caenorhabditis elegans)
Secernentea F37A8.5 34
  • 66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 34
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G08990 33
  • 60.3 (n)
(Glycine max)
eudicotyledons Gma.4134 33
(Zea mays)
Liliopsida Zm.5188 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 74 (a)
Species where no ortholog for YPEL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for YPEL4 Gene

Gene Tree for YPEL4 (if available)
Gene Tree for YPEL4 (if available)

Paralogs for YPEL4 Gene

Paralogs for YPEL4 Gene

(4) SIMAP similar genes for YPEL4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with YPEL4: view

Variants for YPEL4 Gene

Sequence variations from dbSNP and Humsavar for YPEL4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000479226 -- 57,651,766(-) C/T upstream_transcript_variant
rs1000703737 -- 57,645,975(-) A/T 3_prime_UTR_variant
rs1001117393 -- 57,646,283(-) C/A intron_variant
rs1001192238 -- 57,646,608(-) C/A intron_variant
rs1001365847 -- 57,648,781(-) C/T 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for YPEL4 Gene

Variant ID Type Subtype PubMed ID
nsv832164 CNV loss 17160897
nsv832163 CNV gain 17160897
nsv477650 CNV novel sequence insertion 20440878
nsv1118211 CNV deletion 24896259
esv992553 CNV deletion 20482838
esv3626505 CNV loss 21293372

Variation tolerance for YPEL4 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 3.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YPEL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YPEL4 Gene

Disorders for YPEL4 Gene

Additional Disease Information for YPEL4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for YPEL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YPEL4 Gene

Publications for YPEL4 Gene

  1. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K … Shimizu N (Gene 2004) 2 3 4 58
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. YPEL4 modulates HAC15 adrenal cell proliferation and is associated with tumor diameter. (PMID: 27333825) Oki K … Gomez-Sanchez CE (Molecular and cellular endocrinology 2016) 3 58

Products for YPEL4 Gene

Sources for YPEL4 Gene

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