Aliases for YPEL3 Gene

Aliases for YPEL3 Gene

  • Yippee Like 3 2 3 5
  • Protein Yippee-Like 3 3 4
  • Yippee-Like 3 (Drosophila) 2
  • MGC10500 2
  • YPEL3 5

External Ids for YPEL3 Gene

Previous GeneCards Identifiers for YPEL3 Gene

  • GC16M030011
  • GC16M030103
  • GC16M027764

Summaries for YPEL3 Gene

GeneCards Summary for YPEL3 Gene

YPEL3 (Yippee Like 3) is a Protein Coding gene. An important paralog of this gene is YPEL2.

UniProtKB/Swiss-Prot Summary for YPEL3 Gene

Additional gene information for YPEL3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for YPEL3 Gene

Genomics for YPEL3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for YPEL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around YPEL3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for YPEL3

Top Transcription factor binding sites by QIAGEN in the YPEL3 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun

Genomic Locations for YPEL3 Gene

Genomic Locations for YPEL3 Gene
4,602 bases
Minus strand
4,602 bases
Minus strand

Genomic View for YPEL3 Gene

Genes around YPEL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YPEL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YPEL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL3 Gene

Proteins for YPEL3 Gene

  • Protein details for YPEL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein yippee-like 3
    Protein Accession:
    Secondary Accessions:
    • Q65Z99
    • Q86VK6
    • Q9BSJ4
    • Q9CQB6

    Protein attributes for YPEL3 Gene

    119 amino acids
    Molecular mass:
    13608 Da
    Quaternary structure:
    No Data Available
    • Sequence=EAW79925.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for YPEL3 Gene


neXtProt entry for YPEL3 Gene

Post-translational modifications for YPEL3 Gene

No data available for DME Specific Peptides for YPEL3 Gene

Domains & Families for YPEL3 Gene

Gene Families for YPEL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for YPEL3 Gene

  • Yippee-like protein

Suggested Antigen Peptide Sequences for YPEL3 Gene

GenScript: Design optimal peptide antigens:
  • Protein yippee-like 3 (YPEL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the yippee family.
  • Belongs to the yippee family.
genes like me logo Genes that share domains with YPEL3: view

Function for YPEL3 Gene

Molecular function for YPEL3 Gene

UniProtKB/Swiss-Prot Function:
Involved in proliferation and apoptosis in myeloid precursor cells.

Phenotypes From GWAS Catalog for YPEL3 Gene

Gene Ontology (GO) - Molecular Function for YPEL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with YPEL3: view
genes like me logo Genes that share phenotypes with YPEL3: view

Animal Models for YPEL3 Gene

MGI Knock Outs for YPEL3:
  • Ypel3 Ypel3<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for YPEL3 Gene

miRTarBase miRNAs that target YPEL3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YPEL3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YPEL3 Gene

Localization for YPEL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YPEL3 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YPEL3 gene
Compartment Confidence
nucleus 3
extracellular 2
mitochondrion 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for YPEL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with YPEL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for YPEL3 Gene

Pathways & Interactions for YPEL3 Gene

PathCards logo

SuperPathways for YPEL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YPEL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2000774 positive regulation of cellular senescence IDA 20388804
genes like me logo Genes that share ontologies with YPEL3: view

No data available for Pathways by source and SIGNOR curated interactions for YPEL3 Gene

Drugs & Compounds for YPEL3 Gene

No Compound Related Data Available

Transcripts for YPEL3 Gene

mRNA/cDNA for YPEL3 Gene

6 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YPEL3

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - -
SP6: - -

Relevant External Links for YPEL3 Gene

GeneLoc Exon Structure for

Expression for YPEL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for YPEL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for YPEL3 Gene

This gene is overexpressed in Whole Blood (x8.6).

Protein differential expression in normal tissues from HIPED for YPEL3 Gene

This gene is overexpressed in Platelet (44.9) and Heart (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for YPEL3 Gene

Protein tissue co-expression partners for YPEL3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for YPEL3

SOURCE GeneReport for Unigene cluster for YPEL3 Gene:


mRNA Expression by UniProt/SwissProt for YPEL3 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for YPEL3 Gene

  • Pancreas(4.2)
  • Nervous system(2.5)
  • Lung(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with YPEL3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for YPEL3 Gene

Orthologs for YPEL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia YPEL3 30 31
  • 99.44 (n)
(Canis familiaris)
Mammalia YPEL3 30 31
  • 98.04 (n)
(Bos Taurus)
Mammalia YPEL3 30 31
  • 97.48 (n)
(Mus musculus)
Mammalia Ypel3 30 17 31
  • 95.52 (n)
(Rattus norvegicus)
Mammalia Ypel3 30
  • 95.24 (n)
(Monodelphis domestica)
Mammalia YPEL3 31
  • 90 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9405 30
(Danio rerio)
Actinopterygii ypel3 31
  • 90 (a)
LOC561851 30
  • 78.43 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG15309 31
  • 82 (a)
(Caenorhabditis elegans)
Secernentea F37A8.5 30 31
  • 70.47 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ABR153C 30
  • 54.68 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 30 31
  • 51.77 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05875g 30
  • 49.07 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G11230 30
  • 58.89 (n)
(Hordeum vulgare)
Liliopsida Hv.6839 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 79 (a)
Bread mold
(Neurospora crassa)
Ascomycetes NCU00024 30
  • 60.54 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAPJ691.02 30
  • 47.1 (n)
Species where no ortholog for YPEL3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for YPEL3 Gene

Gene Tree for YPEL3 (if available)
Gene Tree for YPEL3 (if available)
Evolutionary constrained regions (ECRs) for YPEL3: view image

Paralogs for YPEL3 Gene

Paralogs for YPEL3 Gene

(4) SIMAP similar genes for YPEL3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with YPEL3: view

Variants for YPEL3 Gene

Additional dbSNP identifiers (rs#s) for YPEL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for YPEL3 Gene

Variant ID Type Subtype PubMed ID
esv2758642 CNV gain 17122850
nsv1160384 CNV duplication 26073780
nsv833187 CNV loss 17160897

Variation tolerance for YPEL3 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YPEL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for YPEL3 Gene

Disorders for YPEL3 Gene

Additional Disease Information for YPEL3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for YPEL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YPEL3 Gene

Publications for YPEL3 Gene

  1. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K … Shimizu N (Gene 2004) 2 3 4
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Increased Expression of the YPEL3 Gene in Human Colonic Adenocarcinoma Tissue and the Effects on Proliferation, Migration, and Invasion of Colonic Adenocarcinoma Cells In Vitro via the Wnt/b-Catenin Signaling Pathway. (PMID: 29988027) Kong X … Zhang X (Medical science monitor : international medical journal of experimental and clinical research 2018) 3

Products for YPEL3 Gene

Sources for YPEL3 Gene