Aliases for YPEL2 Gene

Aliases for YPEL2 Gene

  • Yippee Like 2 2 3 5
  • Protein Yippee-Like 2 3 4
  • DiGeorge Syndrome-Related Protein 3
  • Yippee-Like 2 (Drosophila) 2
  • FKSG4 3

External Ids for YPEL2 Gene

Previous GeneCards Identifiers for YPEL2 Gene

  • GC17P057883
  • GC17P054763
  • GC17P057409
  • GC17P052768

Summaries for YPEL2 Gene

GeneCards Summary for YPEL2 Gene

YPEL2 (Yippee Like 2) is a Protein Coding gene. Diseases associated with YPEL2 include Digeorge Syndrome. An important paralog of this gene is YPEL1.

Additional gene information for YPEL2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for YPEL2 Gene

Genomics for YPEL2 Gene

GeneHancer (GH) Regulatory Elements for YPEL2 Gene

Promoters and enhancers for YPEL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around YPEL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the YPEL2 gene promoter:
  • AML1a
  • ATF-2
  • Evi-1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Zic1

Genomic Locations for YPEL2 Gene

Genomic Locations for YPEL2 Gene
chr17:59,331,655-59,401,734
(GRCh38/hg38)
Size:
70,080 bases
Orientation:
Plus strand
chr17:57,409,050-57,479,095
(GRCh37/hg19)
Size:
70,046 bases
Orientation:
Plus strand

Genomic View for YPEL2 Gene

Genes around YPEL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YPEL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YPEL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL2 Gene

Proteins for YPEL2 Gene

  • Protein details for YPEL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QA6-YPEL2_HUMAN
    Recommended name:
    Protein yippee-like 2
    Protein Accession:
    Q96QA6
    Secondary Accessions:
    • A0PK16
    • A2RUG4
    • Q65ZA0
    • Q8N3W2

    Protein attributes for YPEL2 Gene

    Size:
    119 amino acids
    Molecular mass:
    13577 Da
    Quaternary structure:
    • May interact with FAM168B.

neXtProt entry for YPEL2 Gene

Post-translational modifications for YPEL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for YPEL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for YPEL2 Gene

Domains & Families for YPEL2 Gene

Gene Families for YPEL2 Gene

Protein Domains for YPEL2 Gene

Suggested Antigen Peptide Sequences for YPEL2 Gene

GenScript: Design optimal peptide antigens:
  • Protein yippee-like 2 (YPEL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96QA6

UniProtKB/Swiss-Prot:

YPEL2_HUMAN :
  • Belongs to the yippee family.
Family:
  • Belongs to the yippee family.
genes like me logo Genes that share domains with YPEL2: view

Function for YPEL2 Gene

Phenotypes From GWAS Catalog for YPEL2 Gene

Gene Ontology (GO) - Molecular Function for YPEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with YPEL2: view
genes like me logo Genes that share phenotypes with YPEL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for YPEL2

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YPEL2 Gene

Localization for YPEL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YPEL2 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YPEL2 gene
Compartment Confidence
nucleus 3
extracellular 2
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for YPEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with YPEL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for YPEL2 Gene

Pathways & Interactions for YPEL2 Gene

PathCards logo

SuperPathways for YPEL2 Gene

No Data Available

Interacting Proteins for YPEL2 Gene

Gene Ontology (GO) - Biological Process for YPEL2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for YPEL2 Gene

Drugs & Compounds for YPEL2 Gene

No Compound Related Data Available

Transcripts for YPEL2 Gene

mRNA/cDNA for YPEL2 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL2 Gene

No ASD Table

Relevant External Links for YPEL2 Gene

GeneLoc Exon Structure for
YPEL2
ECgene alternative splicing isoforms for
YPEL2

Expression for YPEL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YPEL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of YPEL2 Gene:

YPEL2

SOURCE GeneReport for Unigene cluster for YPEL2 Gene:

Hs.463613

mRNA Expression by UniProt/SwissProt for YPEL2 Gene:

Q96QA6-YPEL2_HUMAN
Tissue specificity: Widely expressed. Detected in fetal and adult kidney, heart, liver, lung and skeletal muscle.

Evidence on tissue expression from TISSUES for YPEL2 Gene

  • Lung(4.3)
genes like me logo Genes that share expression patterns with YPEL2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for YPEL2 Gene

Orthologs for YPEL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YPEL2 33 32
  • 99.72 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YPEL2 33
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YPEL2 33 32
  • 96.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia YPEL2 33 32
  • 94.12 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ypel2 17 33 32
  • 93.56 (n)
oppossum
(Monodelphis domestica)
Mammalia YPEL2 33
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves YPEL2 33 32
  • 89.92 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YPEL2 33
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ypel2 32
  • 84.31 (n)
zebrafish
(Danio rerio)
Actinopterygii ypel2b 33
  • 97 (a)
OneToMany
ypel2a 33
  • 91 (a)
OneToMany
LOC100004727 32
  • 81.32 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011563 32
  • 73.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15309 33 32
  • 72.92 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F37A8.5 33
  • 72 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 33
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G53940 32
  • 58.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 78 (a)
OneToMany
Species where no ortholog for YPEL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YPEL2 Gene

ENSEMBL:
Gene Tree for YPEL2 (if available)
TreeFam:
Gene Tree for YPEL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for YPEL2: view image

Paralogs for YPEL2 Gene

Paralogs for YPEL2 Gene

(4) SIMAP similar genes for YPEL2 Gene using alignment to 1 proteins:

  • YPEL2_HUMAN
genes like me logo Genes that share paralogs with YPEL2: view

Variants for YPEL2 Gene

Sequence variations from dbSNP and Humsavar for YPEL2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000037500 -- 59,332,237(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000040539 -- 59,377,983(+) A/G intron_variant
rs1000054745 -- 59,391,940(+) G/A intron_variant
rs1000070867 -- 59,400,726(+) G/A 3_prime_UTR_variant
rs1000084767 -- 59,376,449(+) C/A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for YPEL2 Gene

Variant ID Type Subtype PubMed ID
esv2758699 CNV gain 17122850
esv3573764 CNV gain 25503493
esv3582851 CNV loss 25503493
esv7723 CNV gain 19470904
nsv1057152 CNV gain 25217958
nsv1062736 CNV gain 25217958
nsv1109094 CNV deletion 24896259
nsv527058 CNV loss 19592680
nsv833500 CNV loss 17160897

Variation tolerance for YPEL2 Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YPEL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YPEL2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YPEL2 Gene

Disorders for YPEL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for YPEL2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
digeorge syndrome
  • cayler cardiofacial syndrome
- elite association - COSMIC cancer census association via MalaCards
Search YPEL2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for YPEL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with YPEL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YPEL2 Gene

Publications for YPEL2 Gene

  1. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K … Shimizu N (Gene 2004) 2 3 4 56
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 43 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 56
  5. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. (PMID: 24952745) Arking DE … Newton-Cheh C (Nature genetics 2014) 3 56

Products for YPEL2 Gene

Sources for YPEL2 Gene