This gene is located in the region associated with DiGeorge syndrome on chromosome 22. The encoded protein localizes to the centrosome and nucleolus and may play a role in the regulation of cell division. [provided by RefSeq, Feb 2015] See more...

Aliases for YPEL1 Gene

Aliases for YPEL1 Gene

  • Yippee Like 1 2 3 5
  • Protein Yippee-Like 1 3 4
  • Yippee (Drosophila) Homolog-Like 1 2
  • DiGeorge Syndrome-Related Protein 3
  • Yippee-Like 1 (Drosophila) 2
  • FKSG3 3
  • YPEL1 5

External Ids for YPEL1 Gene

Previous GeneCards Identifiers for YPEL1 Gene

  • GC22M018753
  • GC22M020379
  • GC22M020377
  • GC22M020381
  • GC22M022051
  • GC22M005009

Summaries for YPEL1 Gene

Entrez Gene Summary for YPEL1 Gene

  • This gene is located in the region associated with DiGeorge syndrome on chromosome 22. The encoded protein localizes to the centrosome and nucleolus and may play a role in the regulation of cell division. [provided by RefSeq, Feb 2015]

GeneCards Summary for YPEL1 Gene

YPEL1 (Yippee Like 1) is a Protein Coding gene. Diseases associated with YPEL1 include Digeorge Syndrome and Benign Epilepsy With Centrotemporal Spikes. An important paralog of this gene is YPEL2.

UniProtKB/Swiss-Prot Summary for YPEL1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for YPEL1 Gene

Genomics for YPEL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for YPEL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around YPEL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for YPEL1

Top Transcription factor binding sites by QIAGEN in the YPEL1 gene promoter:
  • AhR
  • AP-4
  • AREB6
  • Arnt
  • CREB
  • deltaCREB
  • ER-alpha
  • MyoD
  • RFX1

Genomic Locations for YPEL1 Gene

Genomic Locations for YPEL1 Gene
chr22:21,697,536-21,735,794
(GRCh38/hg38)
Size:
38,259 bases
Orientation:
Minus strand
chr22:22,051,825-22,090,123
(GRCh37/hg19)
Size:
38,299 bases
Orientation:
Minus strand

Genomic View for YPEL1 Gene

Genes around YPEL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YPEL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YPEL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL1 Gene

Proteins for YPEL1 Gene

  • Protein details for YPEL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60688-YPEL1_HUMAN
    Recommended name:
    Protein yippee-like 1
    Protein Accession:
    O60688
    Secondary Accessions:
    • Q65ZA1
    • Q6GLI6

    Protein attributes for YPEL1 Gene

    Size:
    119 amino acids
    Molecular mass:
    13575 Da
    Quaternary structure:
    No Data Available

neXtProt entry for YPEL1 Gene

Post-translational modifications for YPEL1 Gene

No Post-translational modifications

Other Protein References for YPEL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for YPEL1

No data available for DME Specific Peptides for YPEL1 Gene

Domains & Families for YPEL1 Gene

Gene Families for YPEL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for YPEL1 Gene

InterPro:
Blocks:
  • Yippee-like protein
ProtoNet:

Suggested Antigen Peptide Sequences for YPEL1 Gene

GenScript: Design optimal peptide antigens:
  • Protein yippee-like 1 (YPEL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60688

UniProtKB/Swiss-Prot:

YPEL1_HUMAN :
  • Belongs to the yippee family.
Family:
  • Belongs to the yippee family.
genes like me logo Genes that share domains with YPEL1: view

Function for YPEL1 Gene

Molecular function for YPEL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in epithelioid conversion of fibroblasts.

Phenotypes From GWAS Catalog for YPEL1 Gene

Gene Ontology (GO) - Molecular Function for YPEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with YPEL1: view
genes like me logo Genes that share phenotypes with YPEL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YPEL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YPEL1 Gene

Localization for YPEL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YPEL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YPEL1 gene
Compartment Confidence
nucleus 3
extracellular 2
mitochondrion 2
cytoskeleton 1
cytosol 0

Gene Ontology (GO) - Cellular Components for YPEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with YPEL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for YPEL1 Gene

Pathways & Interactions for YPEL1 Gene

PathCards logo

SuperPathways for YPEL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YPEL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for YPEL1 Gene

Drugs & Compounds for YPEL1 Gene

No Compound Related Data Available

Transcripts for YPEL1 Gene

mRNA/cDNA for YPEL1 Gene

1 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YPEL1

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: - -
SP2: -
SP3:
SP4: -

Relevant External Links for YPEL1 Gene

GeneLoc Exon Structure for
YPEL1

Expression for YPEL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for YPEL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for YPEL1 Gene

This gene is overexpressed in Testis (x17.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for YPEL1

SOURCE GeneReport for Unigene cluster for YPEL1 Gene:

Hs.517436

Evidence on tissue expression from TISSUES for YPEL1 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with YPEL1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YPEL1 Gene

Orthologs for YPEL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia YPEL1 30 31
  • 99.44 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia YPEL1 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia YPEL1 30 31
  • 91.6 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ypel1 30 17 31
  • 90.4 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia YPEL1 30 31
  • 89.92 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ypel1 30
  • 89.55 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia YPEL1 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves YPEL1 30
  • 84.59 (n)
Lizard
(Anolis carolinensis)
Reptilia YPEL1 31
  • 100 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ypel1 30
  • 82.63 (n)
Str.9858 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.23559 30
Zebrafish
(Danio rerio)
Actinopterygii ypel1 30 31
  • 84.03 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG15309 31 32
  • 88 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea F37A8.5 31 32
  • 73 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 31
  • 36 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G27745 30
  • 61.56 (n)
Rice
(Oryza sativa)
Liliopsida Os11g0551800 30
  • 62.24 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 79 (a)
OneToMany
Species where no ortholog for YPEL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for YPEL1 Gene

ENSEMBL:
Gene Tree for YPEL1 (if available)
TreeFam:
Gene Tree for YPEL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for YPEL1: view image

Paralogs for YPEL1 Gene

Paralogs for YPEL1 Gene

(4) SIMAP similar genes for YPEL1 Gene using alignment to 2 proteins:

  • YPEL1_HUMAN
  • B5MCX2_HUMAN

Pseudogenes.org Pseudogenes for YPEL1 Gene

genes like me logo Genes that share paralogs with YPEL1: view

Variants for YPEL1 Gene

Additional dbSNP identifiers (rs#s) for YPEL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for YPEL1 Gene

Variant ID Type Subtype PubMed ID
dgv1293e212 CNV loss 25503493
esv2678585 CNV deletion 23128226
esv3557950 CNV deletion 23714750
nsv1060548 CNV gain 25217958
nsv191511 CNV deletion 16902084
nsv510804 CNV deletion 20534489
nsv588322 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv955499 CNV deletion 24416366

Variation tolerance for YPEL1 Gene

Residual Variation Intolerance Score: 45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YPEL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YPEL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for YPEL1 Gene

Disorders for YPEL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for YPEL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
digeorge syndrome
  • cayler cardiofacial syndrome
benign epilepsy with centrotemporal spikes
  • centrotemporal epilepsy
- elite association - COSMIC cancer census association via MalaCards
Search YPEL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for YPEL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with YPEL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YPEL1 Gene

Publications for YPEL1 Gene

  1. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K … Shimizu N (Gene 2004) 2 3 4
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 41
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for YPEL1 Gene

Sources for YPEL1 Gene