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Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
YOD1 (YOD1 Deubiquitinase) is a Protein Coding gene. Diseases associated with YOD1 include Brown-Sequard Syndrome. Among its related pathways are Ovarian tumor domain proteases and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include thiol-dependent ubiquitin-specific protease activity and Lys48-specific deubiquitinase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0004843 | thiol-dependent ubiquitin-specific protease activity | IBA,IDA | 19818707 |
GO:0005515 | protein binding | IPI | 19818707 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008234 | cysteine-type peptidase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA,IDA | 27753622 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of proteins | ||
2 | Protein processing in endoplasmic reticulum | ||
3 | Protein ubiquitination | ||
4 | Deubiquitination |
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5 | Ovarian tumor domain proteases |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA | -- |
GO:0006986 | response to unfolded protein | IEA | -- |
GO:0016236 | macroautophagy | IMP | 27753622 |
GO:0016579 | protein deubiquitination | IBA,TAS | -- |
GO:0030433 | ubiquitin-dependent ERAD pathway | IBA,IMP | 19818707 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | YOD1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | YOD1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | YOD1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Yod1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Yod1 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | YOD1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | YOD1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | YOD1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | YOD1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | yod1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | yod1 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG4603 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007001 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | OTU1 30 31 33 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D05599g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ABR233W 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G50670 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0164800 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU02353 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | otu1 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
brown-sequard syndrome |
|
|