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Aliases for YLPM1 Gene

Aliases for YLPM1 Gene

  • YLP Motif Containing 1 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 169 2 3
  • Nuclear Protein ZAP3 3 4
  • C14orf170 3 4
  • ZAP113 3 4
  • ZAP3 3 4
  • Chromosome 14 Open Reading Frame 170 2
  • YLP Motif-Containing Protein 1 3
  • PPP1R169 3

External Ids for YLPM1 Gene

Previous HGNC Symbols for YLPM1 Gene

  • C14orf170

Previous GeneCards Identifiers for YLPM1 Gene

  • GC14P074299
  • GC14P075230
  • GC14P055398

Summaries for YLPM1 Gene

GeneCards Summary for YLPM1 Gene

YLPM1 (YLP Motif Containing 1) is a Protein Coding gene. Diseases associated with YLPM1 include Early-Onset Familial Alzheimer Disease. Gene Ontology (GO) annotations related to this gene include 6-phosphofructo-2-kinase activity.

UniProtKB/Swiss-Prot for YLPM1 Gene

  • Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.

Gene Wiki entry for YLPM1 Gene

Additional gene information for YLPM1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YLPM1 Gene

Genomics for YLPM1 Gene

GeneHancer (GH) Regulatory Elements for YLPM1 Gene

Promoters and enhancers for YLPM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I074762 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 566.8 +0.9 916 3.8 HDGF SMAD1 ARNT ZFP64 NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B YY1 YLPM1 ZNF410 ELMSAN1 MLH3 TTLL5 RPS6KL1 ENSG00000258559 ENSG00000258891 NEK9 ABCD4
GH14I073767 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 47.9 -991.8 -991783 7.9 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A ENSG00000258559 YLPM1 RBM25 NT5CP1 PNMA1 PTGR2 LOC100506476 LIN52 DNAL1 ABCD4
GH14I074564 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 27.4 -192.8 -192772 11.5 PKNOX1 SIN3A FEZF1 GLI4 ZBTB7B ZNF213 ZNF416 ZNF143 KLF7 FOS ELMSAN1 ZNF410 YLPM1 ENSG00000258559 FCF1 PROX2 LTBP2 ENSG00000259005 MLH3 ENSG00000259138
GH14I074140 Enhancer 1.4 FANTOM5 Ensembl ENCODE 32.7 -622.8 -622750 0.8 PKNOX1 FEZF1 ZNF2 YY1 ZNF121 GLIS2 ZNF213 KLF7 SP3 RXRA LOC105370563 MLH3 YLPM1 ENSG00000258559 ABCD4 LIN52 ENSG00000259138 ELMSAN1 NEK9 ENSG00000258443
GH14I074880 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 19.3 +120.8 120842 6.5 PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 DLST ZNF410 RPS6KL1 NEK9 YLPM1 PGF TTLL5 ENSG00000258559 FCF1 MLH3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around YLPM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the YLPM1 gene promoter:

Genomic Locations for YLPM1 Gene

Genomic Locations for YLPM1 Gene
chr14:74,763,322-74,859,435
(GRCh38/hg38)
Size:
96,114 bases
Orientation:
Plus strand
chr14:75,230,069-75,322,244
(GRCh37/hg19)

Genomic View for YLPM1 Gene

Genes around YLPM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YLPM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YLPM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YLPM1 Gene

Proteins for YLPM1 Gene

  • Protein details for YLPM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49750-YLPM1_HUMAN
    Recommended name:
    YLP motif-containing protein 1
    Protein Accession:
    P49750
    Secondary Accessions:
    • P49752
    • Q96I64
    • Q9P1V7

    Protein attributes for YLPM1 Gene

    Size:
    1951 amino acids
    Molecular mass:
    219985 Da
    Quaternary structure:
    • Interacts with PPP1CA and NCOA5. Forms a complex with ILF2, ILF3, KHDRBS1, RBMX, NCOA5 and PPP1CA (By similarity).
    SequenceCaution:
    • Sequence=AAC42008.1; Type=Frameshift; Positions=1723; Evidence={ECO:0000305}; Sequence=AAF61275.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for YLPM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YLPM1 Gene

Post-translational modifications for YLPM1 Gene

  • Ubiquitination at posLast=490490
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for YLPM1 Gene

Domains & Families for YLPM1 Gene

Gene Families for YLPM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for YLPM1 Gene

Suggested Antigen Peptide Sequences for YLPM1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with YLPM1: view

No data available for UniProtKB/Swiss-Prot for YLPM1 Gene

Function for YLPM1 Gene

Molecular function for YLPM1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.

Phenotypes From GWAS Catalog for YLPM1 Gene

Gene Ontology (GO) - Molecular Function for YLPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IPI 21078624
genes like me logo Genes that share ontologies with YLPM1: view

Phenotypes for YLPM1 Gene

GenomeRNAi human phenotypes for YLPM1:
genes like me logo Genes that share phenotypes with YLPM1: view

Animal Model Products

miRNA for YLPM1 Gene

miRTarBase miRNAs that target YLPM1

Clone Products

  • Addgene plasmids for YLPM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YLPM1 Gene

Localization for YLPM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YLPM1 Gene

Nucleus. Nucleus speckle. Note=Migrates to nucleolar caps upon blockage of transcription.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YLPM1 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for YLPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 17890166
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with YLPM1: view

Pathways & Interactions for YLPM1 Gene

SuperPathways for YLPM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YLPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with YLPM1: view

No data available for Pathways by source and SIGNOR curated interactions for YLPM1 Gene

Drugs & Compounds for YLPM1 Gene

No Compound Related Data Available

Transcripts for YLPM1 Gene

Unigene Clusters for YLPM1 Gene

YLP motif containing 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for YLPM1

Alternative Splicing Database (ASD) splice patterns (SP) for YLPM1 Gene

No ASD Table

Relevant External Links for YLPM1 Gene

GeneLoc Exon Structure for
YLPM1
ECgene alternative splicing isoforms for
YLPM1

Expression for YLPM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YLPM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YLPM1 Gene

This gene is overexpressed in Nasal epithelium (11.9), Peripheral blood mononuclear cells (8.6), CD8 Tcells (7.7), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YLPM1 Gene



Protein tissue co-expression partners for YLPM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of YLPM1 Gene:

YLPM1

SOURCE GeneReport for Unigene cluster for YLPM1 Gene:

Hs.531111

mRNA Expression by UniProt/SwissProt for YLPM1 Gene:

P49750-YLPM1_HUMAN
Tissue specificity: Expressed in neuronal, neuroblastoma and embryonic kidney cell lines (at protein level).

Evidence on tissue expression from TISSUES for YLPM1 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Skin(4.2)
  • Intestine(3.5)
genes like me logo Genes that share expression patterns with YLPM1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for YLPM1 Gene

Orthologs for YLPM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YLPM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YLPM1 33 34
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia YLPM1 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia YLPM1 33 34
  • 92.57 (n)
rat
(Rattus norvegicus)
Mammalia Ylpm1 33
  • 87.87 (n)
mouse
(Mus musculus)
Mammalia Ylpm1 33 16 34
  • 87.8 (n)
oppossum
(Monodelphis domestica)
Mammalia YLPM1 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YLPM1 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves YLPM1 34
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YLPM1 34
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ylpm1 34
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ZAP3 34
  • 19 (a)
OneToOne
soybean
(Glycine max)
eudicotyledons Gma.6971 33
Species where no ortholog for YLPM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YLPM1 Gene

ENSEMBL:
Gene Tree for YLPM1 (if available)
TreeFam:
Gene Tree for YLPM1 (if available)

Paralogs for YLPM1 Gene

(1) SIMAP similar genes for YLPM1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with YLPM1: view

No data available for Paralogs for YLPM1 Gene

Variants for YLPM1 Gene

Sequence variations from dbSNP and Humsavar for YLPM1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000047216 -- 74,762,751(+) A/G upstream_transcript_variant
rs1000173073 -- 74,814,632(+) T/C/G intron_variant
rs1000179794 -- 74,810,932(+) T/G intron_variant
rs1000205600 -- 74,765,952(+) C/A intron_variant
rs1000219731 -- 74,773,039(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for YLPM1 Gene

Variant ID Type Subtype PubMed ID
esv1004666 CNV loss 20482838
esv3365351 CNV insertion 20981092
esv3581313 CNV loss 25503493
nsv1355 CNV deletion 18451855
nsv826995 CNV loss 20364138
nsv826996 CNV loss 20364138
nsv832832 CNV gain+loss 17160897

Variation tolerance for YLPM1 Gene

Residual Variation Intolerance Score: 1.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YLPM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YLPM1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YLPM1 Gene

Disorders for YLPM1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for YLPM1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
early-onset familial alzheimer disease
  • eofad
- elite association - COSMIC cancer census association via MalaCards
Search YLPM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for YLPM1

genes like me logo Genes that share disorders with YLPM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YLPM1 Gene

Publications for YLPM1 Gene

  1. The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G. (PMID: 17890166) Ulke-Lemée A … Moorhead GB (Biochimica et biophysica acta 2007) 3 4 22 58
  2. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PMID: 7596406) Sherrington R … St George-Hyslop PH (Nature 1995) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58

Products for YLPM1 Gene

  • Addgene plasmids for YLPM1

Sources for YLPM1 Gene

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