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Aliases for YIPF7 Gene

Aliases for YIPF7 Gene

  • Yip1 Domain Family Member 7 2 3 5
  • Five-Pass Transmembrane Protein Localizing In The Golgi Apparatus And The Endoplasmic Reticulum 9 3 4
  • YIP1 Family Member 7 3 4
  • FinGER9 3 4
  • Yip1 Domain Family, Member 7 2
  • Protein YIPF7 3
  • YIP1B 4

External Ids for YIPF7 Gene

Previous GeneCards Identifiers for YIPF7 Gene

  • GC04M044466
  • GC04M044325
  • GC04M043946

Summaries for YIPF7 Gene

GeneCards Summary for YIPF7 Gene

YIPF7 (Yip1 Domain Family Member 7) is a Protein Coding gene. Diseases associated with YIPF7 include De Quervain Disease. An important paralog of this gene is YIPF5.

Additional gene information for YIPF7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIPF7 Gene

Genomics for YIPF7 Gene

GeneHancer (GH) Regulatory Elements for YIPF7 Gene

Promoters and enhancers for YIPF7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I044677 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.5 -473 3 PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 JUNB ZHX2 GUF1 YIPF7 ENSG00000273369 GNPDA2 GC04M044690
GH04I044651 Promoter 0.5 EPDnew 561.9 +26.9 26911 0.1 YIPF7 GUF1 GC04M044655 ENSG00000251159
GH04I044680 Enhancer 0.3 Ensembl 0.8 -2.3 -2345 0.2 FOXA2 YIPF7 GUF1 GC04M044690
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around YIPF7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the YIPF7 gene promoter:

Genomic Locations for YIPF7 Gene

Genomic Locations for YIPF7 Gene
56,587 bases
Minus strand

Genomic View for YIPF7 Gene

Genes around YIPF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIPF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIPF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIPF7 Gene

Proteins for YIPF7 Gene

  • Protein details for YIPF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein YIPF7
    Protein Accession:
    Secondary Accessions:
    • Q3SY21
    • Q3SY22

    Protein attributes for YIPF7 Gene

    280 amino acids
    Molecular mass:
    30632 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for YIPF7 Gene


neXtProt entry for YIPF7 Gene

Post-translational modifications for YIPF7 Gene

  • Glycosylation at isoforms=2, 3, 439

Other Protein References for YIPF7 Gene

No data available for DME Specific Peptides for YIPF7 Gene

Domains & Families for YIPF7 Gene

Gene Families for YIPF7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for YIPF7 Gene


Suggested Antigen Peptide Sequences for YIPF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the YIP1 family.
  • Belongs to the YIP1 family.
genes like me logo Genes that share domains with YIPF7: view

Function for YIPF7 Gene

Phenotypes From GWAS Catalog for YIPF7 Gene

genes like me logo Genes that share phenotypes with YIPF7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for YIPF7 Gene

Localization for YIPF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIPF7 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus, trans-Golgi network membrane. Note=Evenly distributed between cis- and trans-Golgi apparatus. {ECO:0000269 PubMed:27999994}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YIPF7 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for YIPF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with YIPF7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for YIPF7 Gene

Pathways & Interactions for YIPF7 Gene

SuperPathways for YIPF7 Gene

No Data Available

Interacting Proteins for YIPF7 Gene

Gene Ontology (GO) - Biological Process for YIPF7 Gene


No data available for Pathways by source and SIGNOR curated interactions for YIPF7 Gene

Drugs & Compounds for YIPF7 Gene

No Compound Related Data Available

Transcripts for YIPF7 Gene

mRNA/cDNA for YIPF7 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for YIPF7 Gene

Yip1 domain family, member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for YIPF7 Gene

No ASD Table

Relevant External Links for YIPF7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YIPF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YIPF7 Gene

mRNA differential expression in normal tissues according to GTEx for YIPF7 Gene

This gene is overexpressed in Muscle - Skeletal (x35.3).

NURSA nuclear receptor signaling pathways regulating expression of YIPF7 Gene:


SOURCE GeneReport for Unigene cluster for YIPF7 Gene:


Evidence on tissue expression from TISSUES for YIPF7 Gene

  • Muscle(4.1)
genes like me logo Genes that share expression patterns with YIPF7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YIPF7 Gene

Orthologs for YIPF7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for YIPF7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia YIPF7 33 34
  • 98.81 (n)
(Bos Taurus)
Mammalia YIPF7 33 34
  • 88.37 (n)
(Canis familiaris)
Mammalia YIPF7 33 34
  • 84.97 (n)
(Mus musculus)
Mammalia Yipf7 33 16 34
  • 83.6 (n)
(Rattus norvegicus)
Mammalia Yipf7 33
  • 83.46 (n)
(Monodelphis domestica)
Mammalia YIPF7 34
  • 80 (a)
(Gallus gallus)
Aves YIPF7 33 34
  • 71.76 (n)
(Anolis carolinensis)
Reptilia YIPF7 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia yipf7 33
  • 66.53 (n)
(Danio rerio)
Actinopterygii zgc:123321 33
  • 62.62 (n)
YIPF7 34
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12404 34
  • 41 (a)
(Caenorhabditis elegans)
Secernentea F32D8.14 34
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIP1 34
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.977 34
  • 48 (a)
Species where no ortholog for YIPF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YIPF7 Gene

Gene Tree for YIPF7 (if available)
Gene Tree for YIPF7 (if available)

Paralogs for YIPF7 Gene

Paralogs for YIPF7 Gene

(1) SIMAP similar genes for YIPF7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with YIPF7: view

Variants for YIPF7 Gene

Sequence variations from dbSNP and Humsavar for YIPF7 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000008407 -- 44,635,519(-) A/T intron_variant
rs1000075075 -- 44,634,091(-) A/G intron_variant
rs1000141631 -- 44,626,807(-) G/A/T intron_variant
rs1000220018 -- 44,658,604(-) T/C upstream_transcript_variant
rs1000226293 -- 44,652,561(-) A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for YIPF7 Gene

Variant ID Type Subtype PubMed ID
nsv509893 OTHER sequence alteration 20534489
nsv477500 CNV novel sequence insertion 20440878
nsv1013488 CNV loss 25217958

Variation tolerance for YIPF7 Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.50; 64.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YIPF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YIPF7 Gene

Disorders for YIPF7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for YIPF7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
de quervain disease
  • radial styloid tenosynovitis
- elite association - COSMIC cancer census association via MalaCards
Search YIPF7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for YIPF7

genes like me logo Genes that share disorders with YIPF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YIPF7 Gene

Publications for YIPF7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Functional characterisation of the YIPF protein family in mammalian cells. (PMID: 27999994) Kranjc T … Simpson JC (Histochemistry and cell biology 2017) 4 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for YIPF7 Gene

Sources for YIPF7 Gene

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