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Aliases for YIF1B Gene

Aliases for YIF1B Gene

  • Yip1 Interacting Factor Homolog B, Membrane Trafficking Protein 2 3 5
  • YIP1-Interacting Factor Homolog B 3 4
  • Protein YIF1B 3 4
  • Yip1 Interacting Factor Homolog B (S. Cerevisiae) 2
  • FinGER8 3

External Ids for YIF1B Gene

Previous GeneCards Identifiers for YIF1B Gene

  • GC19M043488
  • GC19M038794
  • GC19M035242

Summaries for YIF1B Gene

GeneCards Summary for YIF1B Gene

YIF1B (Yip1 Interacting Factor Homolog B, Membrane Trafficking Protein) is a Protein Coding gene. An important paralog of this gene is YIF1A.

Additional gene information for YIF1B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIF1B Gene

Genomics for YIF1B Gene

GeneHancer (GH) Regulatory Elements for YIF1B Gene

Promoters and enhancers for YIF1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J038312 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 600.7 -0.3 -347 9.9 SP1 ZFX CC2D1A CBFA2T2 NKRF MLLT1 ZNF121 CEBPG GTF2F1 CSDE1 KCNK6 YIF1B HNRNPL C19orf33 ZNF527 ZNF571 ZNF573 ZFP30 ENSG00000269688 ZNF607
GH19J038262 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.5 +51.4 51407 6.7 SP1 ELF3 CBFA2T2 MLLT1 ZNF121 ZNF384 ZSCAN21 MAFK YY1 SP7 C19orf33 SPINT2 PIR58569 HNRNPL ZNF571 ZNF875 ZFP30 ZNF527 CATSPERG ZNF607
GH19J038373 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 -58.0 -58015 3.4 SP1 ZFX ELF3 SIX5 NKRF POLR2A MLLT1 ZNF121 CEBPG RERE PSMD8 HNRNPL ZFP30 ZNF571 ZNF793 ZNF607 RN7SL566P ZNF781 ZNF540 ENSG00000267152
GH19J038233 Enhancer 1 Ensembl ENCODE 16.4 +83.2 83173 0.6 CC2D1A CTCF SP7 KLF14 RAD21 KAT8 GLIS2 ARID2 ZIC2 ZNF143 PPP1R14A YIF1B KCNK6 CATSPERG RYR1 RASGRP4 SPRED3 GGN FAM98C GC19M040618
GH19J038647 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.5 -342.5 -342519 25.6 ZNF473 SP1 ZFX ELF3 ZKSCAN8 MNT CBFA2T2 ZNF148 NKRF POLR2A ACTN4 HNRNPL ZFP30 ZNF607 ZNF781 ZNF573 SUPT5H ENSG00000267152 PAK4 RN7SL566P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around YIF1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the YIF1B gene promoter:
  • AhR
  • Arnt

Genomic Locations for YIF1B Gene

Genomic Locations for YIF1B Gene
chr19:38,303,558-38,317,273
(GRCh38/hg38)
Size:
13,716 bases
Orientation:
Minus strand
chr19:38,794,200-38,807,913
(GRCh37/hg19)
Size:
13,714 bases
Orientation:
Minus strand

Genomic View for YIF1B Gene

Genes around YIF1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIF1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIF1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIF1B Gene

Proteins for YIF1B Gene

  • Protein details for YIF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BJH7-YIF1B_HUMAN
    Recommended name:
    Protein YIF1B
    Protein Accession:
    Q5BJH7
    Secondary Accessions:
    • H7BXS8
    • Q5JPC2
    • Q8WY70
    • Q96C02
    • Q96IC4

    Protein attributes for YIF1B Gene

    Size:
    314 amino acids
    Molecular mass:
    34435 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for YIF1B Gene

neXtProt entry for YIF1B Gene

Post-translational modifications for YIF1B Gene

  • Ubiquitination at isoforms=2, 3, 4, 5, 6123
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for YIF1B Gene

Domains & Families for YIF1B Gene

Gene Families for YIF1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for YIF1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for YIF1B Gene

GenScript: Design optimal peptide antigens:
  • YIP1-interacting factor homolog B (YIF1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5BJH7

UniProtKB/Swiss-Prot:

YIF1B_HUMAN :
  • Belongs to the YIF1 family.
Family:
  • Belongs to the YIF1 family.
genes like me logo Genes that share domains with YIF1B: view

Function for YIF1B Gene

Phenotypes From GWAS Catalog for YIF1B Gene

Gene Ontology (GO) - Molecular Function for YIF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28298427
genes like me logo Genes that share ontologies with YIF1B: view
genes like me logo Genes that share phenotypes with YIF1B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for YIF1B

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YIF1B

Clone Products

  • Applied Biological Materials (abm): Clones for YIF1B - Now 50% OFF >
  • * YIF1B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * YIF1B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YIF1B Gene

Localization for YIF1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIF1B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YIF1B gene
Compartment Confidence
endoplasmic reticulum 3
golgi apparatus 3
plasma membrane 2
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for YIF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IBA 21873635
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030134 COPII-coated ER to Golgi transport vesicle IBA 21873635
genes like me logo Genes that share ontologies with YIF1B: view

Pathways & Interactions for YIF1B Gene

PathCards logo

SuperPathways for YIF1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for YIF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with YIF1B: view

No data available for Pathways by source and SIGNOR curated interactions for YIF1B Gene

Drugs & Compounds for YIF1B Gene

No Compound Related Data Available

Transcripts for YIF1B Gene

Unigene Clusters for YIF1B Gene

Yip1 interacting factor homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YIF1B

Clone Products

  • Applied Biological Materials (abm): Clones for YIF1B - Now 50% OFF >
  • * YIF1B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * YIF1B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for YIF1B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - -
SP9: - -
SP10: -
SP11: - - -
SP12: -

Relevant External Links for YIF1B Gene

GeneLoc Exon Structure for
YIF1B
ECgene alternative splicing isoforms for
YIF1B

Expression for YIF1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YIF1B Gene

Protein differential expression in normal tissues from HIPED for YIF1B Gene

This gene is overexpressed in Bone (15.7), Breast (14.6), and Platelet (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for YIF1B Gene



Protein tissue co-expression partners for YIF1B Gene

NURSA nuclear receptor signaling pathways regulating expression of YIF1B Gene:

YIF1B

SOURCE GeneReport for Unigene cluster for YIF1B Gene:

Hs.280741

Evidence on tissue expression from TISSUES for YIF1B Gene

  • Intestine(4.3)
  • Lymph node(4.3)
  • Lung(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with YIF1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YIF1B Gene

Orthologs for YIF1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YIF1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YIF1B 35 34
  • 99.04 (n)
OneToOne
dog
(Canis familiaris)
Mammalia YIF1B 35 34
  • 91.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia YIF1B 35 34
  • 91.05 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YIF1B 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yif1b 17 35 34
  • 87.67 (n)
rat
(Rattus norvegicus)
Mammalia Yif1b 34
  • 86.89 (n)
oppossum
(Monodelphis domestica)
Mammalia YIF1B 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YIF1B 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia yif1b 34
  • 71.08 (n)
MGC76182 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12281 34
zebrafish
(Danio rerio)
Actinopterygii yif1b 35 34
  • 69.86 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5484 35 34
  • 56.54 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002175 34
  • 53.61 (n)
worm
(Caenorhabditis elegans)
Secernentea yif-1 35
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIF1 37 35
  • 20 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G59500 34
  • 46.41 (n)
rice
(Oryza sativa)
Liliopsida Os04g0165400 34
  • 46.78 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15300 34
sea squirt
(Ciona savignyi)
Ascidiacea Cin.15300 34
Species where no ortholog for YIF1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YIF1B Gene

ENSEMBL:
Gene Tree for YIF1B (if available)
TreeFam:
Gene Tree for YIF1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for YIF1B: view image

Paralogs for YIF1B Gene

Paralogs for YIF1B Gene

(1) SIMAP similar genes for YIF1B Gene using alignment to 6 proteins:

  • YIF1B_HUMAN
  • K7EJQ6_HUMAN
  • K7EPQ7_HUMAN
  • K7ERQ0_HUMAN
  • K7ERY2_HUMAN
  • Q9H5F7_HUMAN
genes like me logo Genes that share paralogs with YIF1B: view

Variants for YIF1B Gene

Sequence variations from dbSNP and Humsavar for YIF1B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000039999 -- 38,311,827(-) A/G intron_variant
rs1000094952 -- 38,312,057(-) C/A intron_variant
rs1000276430 -- 38,310,598(-) GGGGGGG/GGGGGGGG intron_variant
rs1000387631 -- 38,317,897(-) A/C upstream_transcript_variant
rs1000814974 -- 38,316,043(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for YIF1B Gene

Variant ID Type Subtype PubMed ID
esv3644307 CNV loss 21293372
nsv833822 CNV loss 17160897

Variation tolerance for YIF1B Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YIF1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YIF1B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YIF1B Gene

Disorders for YIF1B Gene

Additional Disease Information for YIF1B

No disorders were found for YIF1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YIF1B Gene

Publications for YIF1B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. (PMID: 28298427) Sokolina K … Stagljar I (Molecular systems biology 2017) 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3 58

Products for YIF1B Gene

Sources for YIF1B Gene

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