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Aliases for YIF1B Gene

Aliases for YIF1B Gene

  • Yip1 Interacting Factor Homolog B, Membrane Trafficking Protein 2 3 5
  • YIP1-Interacting Factor Homolog B 3 4
  • Yip1 Interacting Factor Homolog B (S. Cerevisiae) 2
  • Protein YIF1B 3
  • FinGER8 3

External Ids for YIF1B Gene

Previous GeneCards Identifiers for YIF1B Gene

  • GC19M043488
  • GC19M038794
  • GC19M035242

Summaries for YIF1B Gene

GeneCards Summary for YIF1B Gene

YIF1B (Yip1 Interacting Factor Homolog B, Membrane Trafficking Protein) is a Protein Coding gene. An important paralog of this gene is YIF1A.

Additional gene information for YIF1B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIF1B Gene

Genomics for YIF1B Gene

GeneHancer (GH) Regulatory Elements for YIF1B Gene

Promoters and enhancers for YIF1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I038312 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 -0.3 -347 9.9 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF610 KCNK6 YIF1B HNRNPL C19orf33 ZNF527 ZNF571 ZNF573 ZFP30 ZNF607 ZNF793
GH19I038262 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.5 +51.4 51407 6.7 HDGF PKNOX1 NEUROD1 SIN3A ZNF2 ZNF143 FOS SP3 ZC3H11A REST SPINT2 PIR58569 ZNF527 ZNF571 ZFP30 HNRNPL HKR1 C19orf33 ENSG00000267682 CATSPERG
GH19I038373 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 -58.1 -58119 3.2 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A PSMD8 HNRNPL ZFP30 ZNF571 ZNF793 ZNF607 RN7SL566P ZNF781 ZNF540 ENSG00000267152
GH19I038269 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.4 +46.6 46569 1.7 ARNT SIN3A FEZF1 ZNF2 ZNF213 REST ZNF592 SMARCA4 ZSCAN16 GLIS1 C19orf33 CATSPERG HNRNPL HKR1 ZNF607 ZNF793 LOC100631378 KCNK6 DPF1 YIF1B
GH19I038647 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.5 -342.5 -342520 25.6 ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC ZC3H11A ACTN4 HNRNPL ZFP30 ZNF607 ZNF781 ZNF573 SUPT5H ENSG00000267152 PAK4 RN7SL566P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around YIF1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the YIF1B gene promoter:

Genomic Locations for YIF1B Gene

Genomic Locations for YIF1B Gene
13,714 bases
Minus strand

Genomic View for YIF1B Gene

Genes around YIF1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIF1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIF1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIF1B Gene

Proteins for YIF1B Gene

  • Protein details for YIF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein YIF1B
    Protein Accession:
    Secondary Accessions:
    • H7BXS8
    • Q5JPC2
    • Q8WY70
    • Q96C02
    • Q96IC4

    Protein attributes for YIF1B Gene

    314 amino acids
    Molecular mass:
    34435 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for YIF1B Gene

neXtProt entry for YIF1B Gene

Post-translational modifications for YIF1B Gene

  • Ubiquitination at posLast=123123
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for YIF1B Gene

Domains & Families for YIF1B Gene

Gene Families for YIF1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for YIF1B Gene


Suggested Antigen Peptide Sequences for YIF1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the YIF1 family.
  • Belongs to the YIF1 family.
genes like me logo Genes that share domains with YIF1B: view

Function for YIF1B Gene

Phenotypes From GWAS Catalog for YIF1B Gene

genes like me logo Genes that share phenotypes with YIF1B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for YIF1B

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YIF1B Gene

Localization for YIF1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIF1B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YIF1B gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3
endoplasmic reticulum 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for YIF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030134 COPII-coated ER to Golgi transport vesicle IBA --
genes like me logo Genes that share ontologies with YIF1B: view

Pathways & Interactions for YIF1B Gene

SuperPathways for YIF1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for YIF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
genes like me logo Genes that share ontologies with YIF1B: view

No data available for Pathways by source and SIGNOR curated interactions for YIF1B Gene

Drugs & Compounds for YIF1B Gene

No Compound Related Data Available

Transcripts for YIF1B Gene

Unigene Clusters for YIF1B Gene

Yip1 interacting factor homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for YIF1B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - -
SP9: - -
SP10: -
SP11: - - -
SP12: -

Relevant External Links for YIF1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YIF1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YIF1B Gene

Protein differential expression in normal tissues from HIPED for YIF1B Gene

This gene is overexpressed in Bone (15.7), Breast (14.6), and Platelet (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YIF1B Gene

Protein tissue co-expression partners for YIF1B Gene

NURSA nuclear receptor signaling pathways regulating expression of YIF1B Gene:


SOURCE GeneReport for Unigene cluster for YIF1B Gene:


Evidence on tissue expression from TISSUES for YIF1B Gene

  • Intestine(4.3)
  • Lymph node(4.3)
  • Lung(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with YIF1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YIF1B Gene

Orthologs for YIF1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YIF1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia YIF1B 33 34
  • 99.04 (n)
(Canis familiaris)
Mammalia YIF1B 33 34
  • 91.88 (n)
(Bos Taurus)
Mammalia YIF1B 33 34
  • 91.05 (n)
(Ornithorhynchus anatinus)
Mammalia YIF1B 34
  • 88 (a)
(Mus musculus)
Mammalia Yif1b 33 16 34
  • 87.67 (n)
(Rattus norvegicus)
Mammalia Yif1b 33
  • 86.89 (n)
(Monodelphis domestica)
Mammalia YIF1B 34
  • 81 (a)
(Anolis carolinensis)
Reptilia YIF1B 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia yif1b 33
  • 71.08 (n)
MGC76182 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12281 33
(Danio rerio)
Actinopterygii yif1b 33 34
  • 69.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5484 33 34
  • 56.54 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002175 33
  • 53.61 (n)
(Caenorhabditis elegans)
Secernentea yif-1 34
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIF1 34 36
  • 20 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G59500 33
  • 46.41 (n)
(Oryza sativa)
Liliopsida Os04g0165400 33
  • 46.78 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15300 33
Species where no ortholog for YIF1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YIF1B Gene

Gene Tree for YIF1B (if available)
Gene Tree for YIF1B (if available)

Paralogs for YIF1B Gene

Paralogs for YIF1B Gene

(1) SIMAP similar genes for YIF1B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with YIF1B: view

Variants for YIF1B Gene

Sequence variations from dbSNP and Humsavar for YIF1B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000039999 -- 38,311,827(-) A/G intron_variant
rs1000094952 -- 38,312,057(-) C/A intron_variant
rs1000276430 -- 38,310,598(-) GGGGGGG/GGGGGGGG intron_variant
rs1000387631 -- 38,317,897(-) A/C upstream_transcript_variant
rs1000814974 -- 38,316,043(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for YIF1B Gene

Variant ID Type Subtype PubMed ID
esv3644307 CNV loss 21293372
nsv833822 CNV loss 17160897

Variation tolerance for YIF1B Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YIF1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YIF1B Gene

Disorders for YIF1B Gene

Additional Disease Information for YIF1B

No disorders were found for YIF1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YIF1B Gene

Publications for YIF1B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for YIF1B Gene

Sources for YIF1B Gene

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