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Aliases for YEATS4 Gene

Aliases for YEATS4 Gene

  • YEATS Domain Containing 4 2 3 5
  • Glioma-Amplified Sequence 41 3 4
  • NUBI-1 3 4
  • NuBI1 3 4
  • GAS41 3 4
  • YEATS Domain-Containing Protein 4 3
  • NuMA Binding Protein 1 3
  • NuMA-Binding Protein 1 4
  • 4930573H17Rik 3
  • B230215M10Rik 3
  • YAF9 3

External Ids for YEATS4 Gene

Previous GeneCards Identifiers for YEATS4 Gene

  • GC12P068040
  • GC12P069753
  • GC12P066803

Summaries for YEATS4 Gene

Entrez Gene Summary for YEATS4 Gene

  • The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for YEATS4 Gene

YEATS4 (YEATS Domain Containing 4) is a Protein Coding gene. Among its related pathways are Gene Expression and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and structural constituent of cytoskeleton. An important paralog of this gene is YEATS2.

UniProtKB/Swiss-Prot for YEATS4 Gene

  • Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Additional gene information for YEATS4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YEATS4 Gene

Genomics for YEATS4 Gene

GeneHancer (GH) Regulatory Elements for YEATS4 Gene

Promoters and enhancers for YEATS4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I069358 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 592.5 +0.3 302 2.2 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YEATS4 LYZ NUP107 CNOT2 KRT8P39 RAP1B RPL10P12 CPSF6 RN7SL804P
GH12I069357 Enhancer 1.2 Ensembl ENCODE dbSUPER 591.3 -2.0 -1999 0.6 PKNOX1 RAD21 ZBTB40 RFX5 ZNF335 TCF12 ZNF143 ATF7 CREM DEK YEATS4 ENSG00000257764
GH12I069328 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 19.6 -28.2 -28191 6.1 HDGF FOXA2 MLX ARID4B FEZF1 YY1 ZNF766 ZNF548 PAF1 SP5 ENSG00000274979 LYZ NUP107 YEATS4 CNOT2 CPSF6 KRT8P39 CPM GC12M069304
GH12I069348 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 16.5 -10.9 -10862 1.3 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 PAF1 SP5 NFYC MIER2 LYZ YEATS4 ENSG00000257764
GH12I069023 Enhancer 1.2 FANTOM5 Ensembl ENCODE 20.3 -334.9 -334932 2 MXI1 JUN MAX BRCA1 RAD21 RFX5 YY1 POLR2A SMC3 RCOR1 CPSF6 MDM2 YEATS4 FRS2 NUP107 SLC35E3 GC12M069009 GC12M069139
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around YEATS4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the YEATS4 gene promoter:

Genomic Locations for YEATS4 Gene

Genomic Locations for YEATS4 Gene
chr12:69,359,700-69,424,838
(GRCh38/hg38)
Size:
65,139 bases
Orientation:
Plus strand
chr12:69,753,483-69,784,576
(GRCh37/hg19)

Genomic View for YEATS4 Gene

Genes around YEATS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YEATS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YEATS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YEATS4 Gene

Proteins for YEATS4 Gene

  • Protein details for YEATS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95619-YETS4_HUMAN
    Recommended name:
    YEATS domain-containing protein 4
    Protein Accession:
    O95619
    Secondary Accessions:
    • Q9NQD0

    Protein attributes for YEATS4 Gene

    Size:
    227 amino acids
    Molecular mass:
    26499 Da
    Quaternary structure:
    • Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. YEATS4 interacts with MLLT10/AF10. YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1.
    SequenceCaution:
    • Sequence=CAC01935.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for YEATS4 Gene

Post-translational modifications for YEATS4 Gene

  • Ubiquitination at posLast=1717 and posLast=198198
  • Modification sites at PhosphoSitePlus

Other Protein References for YEATS4 Gene

No data available for DME Specific Peptides for YEATS4 Gene

Domains & Families for YEATS4 Gene

Gene Families for YEATS4 Gene

Protein Domains for YEATS4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for YEATS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with YEATS4: view

No data available for UniProtKB/Swiss-Prot for YEATS4 Gene

Function for YEATS4 Gene

Molecular function for YEATS4 Gene

UniProtKB/Swiss-Prot Function:
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Phenotypes From GWAS Catalog for YEATS4 Gene

Gene Ontology (GO) - Molecular Function for YEATS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 9302258
GO:0003700 DNA binding transcription factor activity TAS 9302258
GO:0005200 structural constituent of cytoskeleton NAS 10913114
GO:0005515 protein binding IPI 11903063
GO:0008022 protein C-terminus binding IPI 10913114
genes like me logo Genes that share ontologies with YEATS4: view
genes like me logo Genes that share phenotypes with YEATS4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YEATS4 Gene

Localization for YEATS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YEATS4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YEATS4 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for YEATS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0016363 nuclear matrix NAS 10913114
GO:0031965 nuclear membrane IDA --
GO:0035267 NuA4 histone acetyltransferase complex IDA 14966270
genes like me logo Genes that share ontologies with YEATS4: view

Pathways & Interactions for YEATS4 Gene

genes like me logo Genes that share pathways with YEATS4: view

Gene Ontology (GO) - Biological Process for YEATS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle NAS 10913114
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007010 cytoskeleton organization IEA --
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with YEATS4: view

No data available for SIGNOR curated interactions for YEATS4 Gene

Drugs & Compounds for YEATS4 Gene

(1) Drugs for YEATS4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrochlorothiazide Approved, Vet_approved Pharma Inhibition, Inhibitor 425
genes like me logo Genes that share compounds with YEATS4: view

Transcripts for YEATS4 Gene

mRNA/cDNA for YEATS4 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for YEATS4 Gene

YEATS domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for YEATS4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: -
SP3: -
SP4: - - - -
SP5: - - -

Relevant External Links for YEATS4 Gene

GeneLoc Exon Structure for
YEATS4
ECgene alternative splicing isoforms for
YEATS4

Expression for YEATS4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YEATS4 Gene

Protein differential expression in normal tissues from HIPED for YEATS4 Gene

This gene is overexpressed in Liver (22.0) and Testis (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YEATS4 Gene



Protein tissue co-expression partners for YEATS4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of YEATS4 Gene:

YEATS4

SOURCE GeneReport for Unigene cluster for YEATS4 Gene:

Hs.4029

mRNA Expression by UniProt/SwissProt for YEATS4 Gene:

O95619-YETS4_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
genes like me logo Genes that share expression patterns with YEATS4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for YEATS4 Gene

Orthologs for YEATS4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for YEATS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YEATS4 33 34
  • 99.85 (n)
oppossum
(Monodelphis domestica)
Mammalia YEATS4 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YEATS4 33 34
  • 95.59 (n)
cow
(Bos Taurus)
Mammalia YEATS4 33 34
  • 95.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia YEATS4 34
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yeats4 33
  • 91.48 (n)
mouse
(Mus musculus)
Mammalia Yeats4 33 16 34
  • 88.55 (n)
chicken
(Gallus gallus)
Aves GAS41 34
  • 97 (a)
OneToOne
YEATS4 33
  • 80.32 (n)
lizard
(Anolis carolinensis)
Reptilia YEATS4 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia yeats4 33
  • 82.23 (n)
Str.8404 33
zebrafish
(Danio rerio)
Actinopterygii yeats4 33 34
  • 73.78 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009650 33
  • 59.39 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gas41 33 34
  • 59.22 (n)
worm
(Caenorhabditis elegans)
Secernentea gfl-1 33 34
  • 52.68 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAF9 33 34 36
  • 48.92 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23584g 33
  • 48.81 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL227C 33
  • 45.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 64 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU00359 33
  • 46.58 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes yaf9 33
  • 45.96 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5263 33
Species where no ortholog for YEATS4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YEATS4 Gene

ENSEMBL:
Gene Tree for YEATS4 (if available)
TreeFam:
Gene Tree for YEATS4 (if available)

Paralogs for YEATS4 Gene

Paralogs for YEATS4 Gene

(2) SIMAP similar genes for YEATS4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with YEATS4: view

Variants for YEATS4 Gene

Sequence variations from dbSNP and Humsavar for YEATS4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000028479 -- 69,424,133(+) A/C genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000043088 -- 69,367,220(+) A/G intron_variant
rs1000091378 -- 69,398,087(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000101451 -- 69,423,862(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000146585 -- 69,379,797(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for YEATS4 Gene

Variant ID Type Subtype PubMed ID
dgv490e212 CNV loss 25503493
nsv952201 CNV duplication 24416366

Variation tolerance for YEATS4 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 1.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YEATS4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YEATS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YEATS4 Gene

Disorders for YEATS4 Gene

Additional Disease Information for YEATS4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for YEATS4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YEATS4 Gene

Publications for YEATS4 Gene

  1. Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. (PMID: 11903063) Lauffart B … Still IH (The Biochemical journal 2002) 2 3 4 22 58
  2. Cloning of a novel transcription factor-like gene amplified in human glioma including astrocytoma grade I. (PMID: 9302258) Fischer U … Meese E (Human molecular genetics 1997) 2 3 4 22 58
  3. HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon. (PMID: 18214854) Italiano A … Pedeutour F (International journal of cancer 2008) 3 22 58
  4. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 44 58
  5. Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic. (PMID: 18591461) Turner ST … Boerwinkle E (Hypertension (Dallas, Tex. : 1979) 2008) 3 44 58

Products for YEATS4 Gene

Sources for YEATS4 Gene

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