Aliases for YEATS2 Gene
External Ids for YEATS2 Gene
Previous GeneCards Identifiers for YEATS2 Gene
Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]
GeneCards Summary for YEATS2 Gene
YEATS2 (YEATS Domain Containing 2) is a Protein Coding gene. Diseases associated with YEATS2 include Epilepsy, Familial Adult Myoclonic, 4 and Familial Adult Myoclonic Epilepsy. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include TBP-class protein binding. An important paralog of this gene is MLLT1.
UniProtKB/Swiss-Prot Summary for YEATS2 Gene
Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431).