Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017] See more...

Aliases for YEATS2 Gene

Aliases for YEATS2 Gene

  • YEATS Domain Containing 2 2 3 5
  • YEATS Domain-Containing Protein 2 3 4
  • KIAA1197 2 4
  • FLJ10201 2
  • FLJ12841 2
  • FLJ13308 2
  • YEATS2 5
  • FAME4 3

External Ids for YEATS2 Gene

Previous GeneCards Identifiers for YEATS2 Gene

  • GC03P184899
  • GC03P183416
  • GC03P180824

Summaries for YEATS2 Gene

Entrez Gene Summary for YEATS2 Gene

  • Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

GeneCards Summary for YEATS2 Gene

YEATS2 (YEATS Domain Containing 2) is a Protein Coding gene. Diseases associated with YEATS2 include Epilepsy, Familial Adult Myoclonic, 4 and Familial Adult Myoclonic Epilepsy. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include TBP-class protein binding. An important paralog of this gene is MLLT1.

UniProtKB/Swiss-Prot Summary for YEATS2 Gene

  • Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431).

Additional gene information for YEATS2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for YEATS2 Gene

Genomics for YEATS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for YEATS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around YEATS2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for YEATS2

Top Transcription factor binding sites by QIAGEN in the YEATS2 gene promoter:
  • AML1a
  • ATF-2
  • CRE-BP1
  • En-1
  • FOXO1
  • FOXO1a
  • POU2F1
  • POU2F1a

Genomic Locations for YEATS2 Gene

Genomic Locations for YEATS2 Gene
chr3:183,697,797-183,812,625
(GRCh38/hg38)
Size:
114,829 bases
Orientation:
Plus strand
chr3:183,415,606-183,530,413
(GRCh37/hg19)
Size:
114,808 bases
Orientation:
Plus strand

Genomic View for YEATS2 Gene

Genes around YEATS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YEATS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YEATS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YEATS2 Gene

Proteins for YEATS2 Gene

  • Protein details for YEATS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULM3-YETS2_HUMAN
    Recommended name:
    YEATS domain-containing protein 2
    Protein Accession:
    Q9ULM3
    Secondary Accessions:
    • A7E2B9
    • D3DNS9
    • Q641P6
    • Q9NW96

    Protein attributes for YEATS2 Gene

    Size:
    1422 amino acids
    Molecular mass:
    150782 Da
    Quaternary structure:
    • Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, SGF29 and DR1.
    SequenceCaution:
    • Sequence=BAA86511.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for YEATS2 Gene

neXtProt entry for YEATS2 Gene

Post-translational modifications for YEATS2 Gene

  • Ubiquitination at Lys719
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for YEATS2 Gene

Domains & Families for YEATS2 Gene

Gene Families for YEATS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for YEATS2 Gene

InterPro:
Blocks:
  • YEATS family
ProtoNet:

Suggested Antigen Peptide Sequences for YEATS2 Gene

GenScript: Design optimal peptide antigens:
  • YEATS2 protein (Q8N5H6_HUMAN)
  • YEATS domain-containing protein 2 (YETS2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULM3

UniProtKB/Swiss-Prot:

YETS2_HUMAN :
  • The YEATS domain specifically recognizes and binds crotonylated histones.
Domain:
  • The YEATS domain specifically recognizes and binds crotonylated histones.
genes like me logo Genes that share domains with YEATS2: view

Function for YEATS2 Gene

Molecular function for YEATS2 Gene

UniProtKB/Swiss-Prot Function:
Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431).

Phenotypes From GWAS Catalog for YEATS2 Gene

Gene Ontology (GO) - Molecular Function for YEATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18838386
GO:0017025 TBP-class protein binding IPI 18838386
GO:0042393 histone binding IDA 27103431
GO:0140030 modification-dependent protein binding IDA 27103431
genes like me logo Genes that share ontologies with YEATS2: view
genes like me logo Genes that share phenotypes with YEATS2: view

Human Phenotype Ontology for YEATS2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YEATS2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for YEATS2 Gene

Localization for YEATS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YEATS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YEATS2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for YEATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0072686 mitotic spindle IEA --
genes like me logo Genes that share ontologies with YEATS2: view

Pathways & Interactions for YEATS2 Gene

PathCards logo

SuperPathways for YEATS2 Gene

genes like me logo Genes that share pathways with YEATS2: view

Pathways by source for YEATS2 Gene

Gene Ontology (GO) - Biological Process for YEATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 18838386
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0043966 histone H3 acetylation IDA 18838386
GO:0045892 negative regulation of transcription, DNA-templated IDA 18838386
genes like me logo Genes that share ontologies with YEATS2: view

No data available for SIGNOR curated interactions for YEATS2 Gene

Drugs & Compounds for YEATS2 Gene

No Compound Related Data Available

Transcripts for YEATS2 Gene

mRNA/cDNA for YEATS2 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YEATS2

Alternative Splicing Database (ASD) splice patterns (SP) for YEATS2 Gene

No ASD Table

Relevant External Links for YEATS2 Gene

GeneLoc Exon Structure for
YEATS2

Expression for YEATS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for YEATS2 Gene

Protein differential expression in normal tissues from HIPED for YEATS2 Gene

This gene is overexpressed in Breast (56.5) and Heart (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for YEATS2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for YEATS2

SOURCE GeneReport for Unigene cluster for YEATS2 Gene:

Hs.632575

Evidence on tissue expression from TISSUES for YEATS2 Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Lung(4.4)
  • Skin(3.2)
  • Intestine(2.6)
  • Muscle(2.6)
  • Blood(2.3)
  • Eye(2.3)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with YEATS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YEATS2 Gene

Orthologs for YEATS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for YEATS2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia YEATS2 30 31
  • 98.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia YEATS2 30 31
  • 91.08 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia YEATS2 30 31
  • 91.01 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 88 (a)
OneToMany
-- 31
  • 82 (a)
OneToMany
-- 31
  • 79 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Yeats2 30 17 31
  • 84.86 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Yeats2 30
  • 83.62 (n)
Oppossum
(Monodelphis domestica)
Mammalia YEATS2 31
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves YEATS2 30 31
  • 73.62 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia YEATS2 31
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia yeats2 30
  • 65.44 (n)
Str.10908 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68945 30
Zebrafish
(Danio rerio)
Actinopterygii yeats2 30 31
  • 61.17 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta D12 31
  • 11 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea Y105E8B.7 31
  • 16 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAF9 31
  • 25 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 73 (a)
OneToOne
Species where no ortholog for YEATS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for YEATS2 Gene

ENSEMBL:
Gene Tree for YEATS2 (if available)
TreeFam:
Gene Tree for YEATS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for YEATS2: view image

Paralogs for YEATS2 Gene

Paralogs for YEATS2 Gene

(1) SIMAP similar genes for YEATS2 Gene using alignment to 3 proteins:

  • YETS2_HUMAN
  • H0Y6M6_HUMAN
  • Q8N5H6_HUMAN
genes like me logo Genes that share paralogs with YEATS2: view

Variants for YEATS2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for YEATS2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
712703 Benign: not provided 183,756,580(+) C/T SYNONYMOUS_VARIANT
749897 Likely Benign: not provided 183,804,094(+) C/T SYNONYMOUS_VARIANT
774440 Benign: not provided 183,790,881(+) G/A MISSENSE_VARIANT
783410 Benign: not provided 183,758,910(+) C/A MISSENSE_VARIANT
809570 Uncertain Significance: not provided 183,736,731(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for YEATS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for YEATS2 Gene

Variant ID Type Subtype PubMed ID
esv2726292 CNV deletion 23290073
nsv475272 CNV novel sequence insertion 20440878
nsv478634 CNV novel sequence insertion 20440878
nsv507144 OTHER sequence alteration 20534489
nsv592656 CNV gain 21841781
nsv998955 CNV gain 25217958

Variation tolerance for YEATS2 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.87; 95.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YEATS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YEATS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YEATS2 Gene

Disorders for YEATS2 Gene

MalaCards: The human disease database

(10) MalaCards diseases for YEATS2 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

YETS2_HUMAN
  • Epilepsy, familial adult myoclonic, 4 (FAME4) [MIM:615127]: A form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME4 inheritance is autosomal dominant. {ECO:0000269 PubMed:22713812, ECO:0000269 PubMed:31539032}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for YEATS2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with YEATS2: view

No data available for Genatlas for YEATS2 Gene

Publications for YEATS2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
  2. TTTCA repeat insertions in an intron of YEATS2 in benign adult familial myoclonic epilepsy type 4. (PMID: 31539032) Yeetong P … Shotelersuk V (Brain : a journal of neurology 2019) 3 4
  3. YEATS2 is a selective histone crotonylation reader. (PMID: 27103431) Zhao D … Li H (Cell research 2016) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. (PMID: 18838386) Wang YL … Martinez E (The Journal of biological chemistry 2008) 3 4

Products for YEATS2 Gene

Sources for YEATS2 Gene