Free for academic non-profit institutions. Other users need a Commercial license

Aliases for YDJC Gene

Aliases for YDJC Gene

  • YdjC Chitooligosaccharide Deacetylase Homolog 2 3 5
  • YdjC Homolog (Bacterial) 2
  • EC 3.5.1.- 4

External Ids for YDJC Gene

Previous GeneCards Identifiers for YDJC Gene

  • GC22M020312
  • GC22M021982
  • GC22M004940

Summaries for YDJC Gene

GeneCards Summary for YDJC Gene

YDJC (YdjC Chitooligosaccharide Deacetylase Homolog) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds.

UniProtKB/Swiss-Prot for YDJC Gene

  • Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

Additional gene information for YDJC Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YDJC Gene

Genomics for YDJC Gene

GeneHancer (GH) Regulatory Elements for YDJC Gene

Promoters and enhancers for YDJC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I021628 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 557 +0.9 933 2.6 HDGF CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 ZNF207 YDJC GC22M021630 GC22M021629 CCDC116 PI4KAP2
GH22I020978 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.4 +648.8 648761 5.3 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 LZTR1 ENSG00000272829 THAP7-AS1 LOC100420177 PI4KAP2 THAP7 TRMT2A ZDHHC8 ABHD17AP4 ENSG00000273342
GH22I021650 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 12 -22.0 -22006 2.8 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 GATA2 GC22P021989 GC22P021991 MIR130B MIR301B PPIL2 CCDC116 YDJC ABHD17AP4 PIR47183
GH22I020883 Enhancer 1.5 Ensembl ENCODE dbSUPER 9.1 +745.3 745346 3.4 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A YBX1 DMAP1 SNAP29 SERPIND1 LZTR1 DGCR8 TRMT2A PPIL2 RPL8P5 PI4KA LOC100420177 CRKL
GH22I021577 Enhancer 1 ENCODE dbSUPER 12.4 +52.0 51962 1.2 HDGF HNRNPUL1 ZFP64 ZNF213 ZNF138 ZNF680 ZNF654 ZBTB11 CEBPB ZC3H11A IGLV5-52 TOP3B CCDC116 LZTR1 PPIL2 ENSG00000234630 ENSG00000272779 THAP7-AS1 THAP7 ENSG00000225544
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around YDJC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the YDJC gene promoter:

Genomic Locations for YDJC Gene

Genomic Locations for YDJC Gene
chr22:21,628,089-21,630,325
(GRCh38/hg38)
Size:
2,237 bases
Orientation:
Minus strand
chr22:21,982,378-21,984,353
(GRCh37/hg19)

Genomic View for YDJC Gene

Genes around YDJC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YDJC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YDJC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YDJC Gene

Proteins for YDJC Gene

  • Protein details for YDJC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MPS7-YDJC_HUMAN
    Recommended name:
    Carbohydrate deacetylase
    Protein Accession:
    A8MPS7
    Secondary Accessions:
    • Q2YDT4
    • Q4V9R7

    Protein attributes for YDJC Gene

    Size:
    323 amino acids
    Molecular mass:
    34466 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for YDJC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YDJC Gene

Post-translational modifications for YDJC Gene

Other Protein References for YDJC Gene

No data available for DME Specific Peptides for YDJC Gene

Domains & Families for YDJC Gene

Gene Families for YDJC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for YDJC Gene

Suggested Antigen Peptide Sequences for YDJC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MPS7

UniProtKB/Swiss-Prot:

YDJC_HUMAN :
  • Belongs to the YdjC deacetylase family.
Family:
  • Belongs to the YdjC deacetylase family.
genes like me logo Genes that share domains with YDJC: view

Function for YDJC Gene

Molecular function for YDJC Gene

UniProtKB/Swiss-Prot Function:
Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

Enzyme Numbers (IUBMB) for YDJC Gene

Phenotypes From GWAS Catalog for YDJC Gene

Gene Ontology (GO) - Molecular Function for YDJC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0003824 catalytic activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with YDJC: view
genes like me logo Genes that share phenotypes with YDJC: view

Animal Models for YDJC Gene

MGI Knock Outs for YDJC:
  • Ydjc tm1.1(KOMP)Vlcg
  • Ydjc tm1(KOMP)Wtsi

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YDJC Gene

Localization for YDJC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YDJC gene
Compartment Confidence
nucleus 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for YDJC Gene

Pathways & Interactions for YDJC Gene

No Data Available

Gene Ontology (GO) - Biological Process for YDJC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
genes like me logo Genes that share ontologies with YDJC: view

No data available for Pathways by source and SIGNOR curated interactions for YDJC Gene

Drugs & Compounds for YDJC Gene

No Compound Related Data Available

Transcripts for YDJC Gene

Unigene Clusters for YDJC Gene

YdjC homolog (bacterial):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for YDJC Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1:
SP2: -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6:
SP7: - - - -
SP8:
SP9: -
SP10: - - - -
SP11:

Relevant External Links for YDJC Gene

GeneLoc Exon Structure for
YDJC
ECgene alternative splicing isoforms for
YDJC

Expression for YDJC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YDJC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YDJC Gene

This gene is overexpressed in Retina (26.4), Blymphocyte (19.0), CD8 Tcells (7.0), Testis (6.8), and Pancreas (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YDJC Gene



Protein tissue co-expression partners for YDJC Gene

NURSA nuclear receptor signaling pathways regulating expression of YDJC Gene:

YDJC

SOURCE GeneReport for Unigene cluster for YDJC Gene:

Hs.355952

Evidence on tissue expression from TISSUES for YDJC Gene

  • Nervous system(4.3)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with YDJC: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YDJC Gene

Orthologs for YDJC Gene

This gene was present in the common ancestor of chordates.

Orthologs for YDJC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YDJC 33 34
  • 99.69 (n)
mouse
(Mus musculus)
Mammalia Ydjc 33 16 34
  • 84.03 (n)
rat
(Rattus norvegicus)
Mammalia Ydjc 33
  • 83.82 (n)
dog
(Canis familiaris)
Mammalia YDJC 33 34
  • 83.59 (n)
cow
(Bos Taurus)
Mammalia YDJC 34
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YDJC 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves YDJC 33 34
  • 58.36 (n)
lizard
(Anolis carolinensis)
Reptilia YDJC 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ydjc 33
  • 54.05 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33494 33
zebrafish
(Danio rerio)
Actinopterygii ydjc 33 34
  • 55.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToOne
Species where no ortholog for YDJC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YDJC Gene

ENSEMBL:
Gene Tree for YDJC (if available)
TreeFam:
Gene Tree for YDJC (if available)

Paralogs for YDJC Gene

No data available for Paralogs for YDJC Gene

Variants for YDJC Gene

Sequence variations from dbSNP and Humsavar for YDJC Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000611225 -- 21,631,204(-) G/A upstream_transcript_variant
rs1000993326 -- 21,632,244(-) C/T upstream_transcript_variant
rs1001272449 -- 21,630,630(-) G/A upstream_transcript_variant
rs1001329710 -- 21,630,945(-) G/A upstream_transcript_variant
rs1002721986 -- 21,628,618(-) C/G 3_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for YDJC Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER inversion 18451855
nsv516806 CNV loss 19592680
nsv1160730 CNV deletion 26073780

Variation tolerance for YDJC Gene

Gene Damage Index Score: 9.42; 88.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YDJC Gene

Human Gene Mutation Database (HGMD)
YDJC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
YDJC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YDJC Gene

Disorders for YDJC Gene

Additional Disease Information for YDJC

No disorders were found for YDJC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YDJC Gene

Publications for YDJC Gene

  1. Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. (PMID: 21383967) Zhernakova A … Plenge RM (PLoS genetics 2011) 3 44 58
  2. Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois PC … van Heel DA (Nature genetics 2010) 3 44 58
  3. Crystal structure of the YdjC-family protein TTHB029 from Thermus thermophilus HB8: structural relationship with peptidoglycan N-acetylglucosamine deacetylase. (PMID: 18177738) Imagawa T … Tsuge H (Biochemical and biophysical research communications 2008) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for YDJC Gene

Sources for YDJC Gene

Content
Loading form....