Aliases for YBX2 Gene
External Ids for YBX2 Gene
Previous GeneCards Identifiers for YBX2 Gene
This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for this gene are located on chromosome 10 and 15. [provided by RefSeq, Feb 2012]
GeneCards Summary for YBX2 Gene
YBX2 (Y-Box Binding Protein 2) is a Protein Coding gene. Diseases associated with YBX2 include Mastocytosis, Cutaneous and Mixed Germ Cell Cancer. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and lipid binding. An important paralog of this gene is YBX1.
UniProtKB/Swiss-Prot Summary for YBX2 Gene
Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity).