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This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]
YBX1 (Y-Box Binding Protein 1) is a Protein Coding gene. Diseases associated with YBX1 include Spinal Chordoma and Liposarcoma. Among its related pathways are mRNA Splicing - Minor Pathway and MECP2 and Associated Rett Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is YBX3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 18809583 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 18809583 |
GO:0003676 | nucleic acid binding | IEA,IBA | 21873635 |
GO:0003677 | DNA binding | TAS | 2977358 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | TAS,IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005689 | U12-type spliceosomal complex | IDA | 15146077 |
GO:0005737 | cytoplasm | IDA | 24965446 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | mRNA Splicing - Major Pathway |
.79
|
.41
|
2 | PI3K / Akt Signaling | ||
3 | Translational Control | ||
4 | MAPK Erk Pathway |
.32
|
|
5 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
GO:0001701 | in utero embryonic development | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IDA | 18809583 |
GO:0006366 | transcription by RNA polymerase II | TAS | 3174636 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | YBX1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | YBX1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LOC607025 30 |
|
||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | YBX1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ybx1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ybx1 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | YBX1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | YBX1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ybx1 30 |
|
||
Str.8793 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | nsep1-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ybx1 30 31 |
|
OneToOne | |
nsep1 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8781 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | yps 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | cey-1 31 |
|
ManyToMany | |
cey-4 31 |
|
ManyToMany | |||
cey-2 31 |
|
ManyToMany | |||
cey-3 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10127 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
spinal chordoma |
|
|
liposarcoma |
|
|
rett syndrome |
|
|
myxoid liposarcoma |
|
|
ovarian cancer |
|