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This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of m... See more...
Aliases for YBX1 Gene
Aliases for YBX1 Gene
External Ids for YBX1 Gene
- HGNC: 8014
- Entrez Gene: 4904
- Ensembl: ENSG00000065978
- OMIM: 154030
- UniProtKB: P67809
Previous HGNC Symbols for YBX1 Gene
- NSEP1
Previous GeneCards Identifiers for YBX1 Gene
- GC01P042818
- GC01P042920
- GC01P043148
- GC01P041268
Summaries for YBX1 Gene
-
This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]
GeneCards Summary for YBX1 Gene
YBX1 (Y-Box Binding Protein 1) is a Protein Coding gene. Diseases associated with YBX1 include Spinal Chordoma and Liposarcoma. Among its related pathways are mRNA Splicing - Minor Pathway and MECP2 and Associated Rett Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is YBX3.
UniProtKB/Swiss-Prot Summary for YBX1 Gene
-
DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:8188694, PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:8188694, PubMed:18809583). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673).
Additional gene information for YBX1 Gene
- HGNC(8014)
- Entrez Gene(4904)
- Ensembl(ENSG00000065978)
- OMIM(154030)
- UniProtKB(P67809)
- Open Targets Platform(ENSG00000065978)
- Search for YBX1 at DataMed
- Search for YBX1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for YBX1 Gene
Genomics for YBX1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for YBX1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around YBX1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for YBX1
- Top Transcription factor binding sites by QIAGEN in the YBX1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- CBF(2)
- FAC1
- LCR-F1
- Max1
- NF-1
- NF-Y
- YY1
Genomic Locations for YBX1 Gene
Genomic Locations for YBX1 Gene
- chr1:42,682,418-42,703,805
- (GRCh38/hg38)
- Size:
- 21,388 bases
- Orientation:
- Plus strand
- chr1:43,148,066-43,168,020
- (GRCh37/hg19)
- Size:
- 19,955 bases
- Orientation:
- Plus strand
Genomic View for YBX1 Gene
Genes around YBX1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.2 by HGNC
- 1p34.2 by Entrez Gene
- 1p34.2 by Ensembl
YBX1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for YBX1 Gene
Proteins for YBX1 Gene
-
Protein details for YBX1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P67809-YBOX1_HUMAN
- Recommended name:
- Y-box-binding protein 1
- Protein Accession:
- P67809
- P16990
- P16991
- Q14972
- Q15325
- Q5FVF0
Protein attributes for YBX1 Gene
- Size:
- 324 amino acids
- Molecular mass:
- 35924 Da
- Quaternary structure:
-
- Homodimer in the presence of ATP (PubMed:10817758, PubMed:11851341). Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1 (PubMed:19029303). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (PubMed:15146077). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Interacts with IGF2BP1 and RBBP6 (PubMed:17289661, PubMed:18851979). Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs) (PubMed:19029303). Interacts with AKT1, MBNL1, SFRS9, SFRS12, ALYREF/THOC4, MSH2, XRCC5, WRN and NCL (PubMed:12604611, PubMed:14559993, PubMed:14718551, PubMed:15806160, PubMed:18335541). Interacts (via C-terminus) with APEX1 (via N-terminus); the interaction is increased with APEX1 acetylated at 'Lys-6' and 'Lys-7' (PubMed:18809583). Interacts with AGO1 and AGO2 (PubMed:17932509). Interacts with ANKRD2 (PubMed:15136035). Interacts with DERA (PubMed:25229427). Interacts with FMR1; this interaction occurs in association with polyribosome (By similarity). Interacts with ZBTB7B (By similarity). Interacts with HDGF (isoform 1) (PubMed:26845719). Interacts with ELAVL1; leading to ELAVL1 recruitment on C5-methylcytosine (m5C)-containing mRNAs and subsequent mRNA stability (PubMed:31358969).
- SequenceCaution:
-
- Sequence=AAA35750.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAA59949.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAA61308.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for YBX1 Gene
Post-translational modifications for YBX1 Gene
- Ubiquitinated by RBBP6; leading to a decrease of YBX1 transcactivational ability.
- In the absence of phosphorylation the protein is retained in the cytoplasm.
- Cleaved by a 20S proteasomal protease in response to agents that damage DNA. Cleavage takes place in the absence of ubiquitination and ATP. The resulting N-terminal fragment accumulates in the nucleus (By similarity).
-
Ubiquitination at Lys137, Lys170, and Lys264
- NX_P67809 (NX_P67809-1)
- Modification sites at PhosphoSitePlus
Other Protein References for YBX1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ YB1 Antibody
- NSJ Bioreagents YB1 Antibody
- Novus Biologicals Antibodies for YBX1
-
Abcam antibodies for YBX1
- Invitrogen Antibodies for YBX1 (AFLGC-YBX1)
- antibodies-online: Show 41 available YBX1 Antibodies ranked by validation data
- Compare Top YBX1 Antibodies
-
Recommended
- 124 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 51 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 57 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
-
Boster Bio Antibodies for YBX1
-
Santa Cruz Biotechnology (SCBT) Antibodies for YBX1
- Sino Biological Antibodies for YBX1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for YBX1
- Origene Custom Protein Services for YBX1
- ProSpec Recombinant Proteins for YBX1
-
Abcam proteins for YBX1
Assay Products
- antibodies-online: Show 7 available YBX1 Elisa Kits ranked by validation data
- Compare Top YBX1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for YBX1 Gene
Domains & Families for YBX1 Gene
Gene Families for YBX1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for YBX1 Gene
- InterPro:
- Blocks:
-
- Cold-shock DNA-binding domain
- Cold shock protein
- ProtoNet:
Suggested Antigen Peptide Sequences for YBX1 Gene
- GenScript: Design optimal peptide antigens:
-
- YBX1 protein (A0JLU4_HUMAN)
- YBX1 protein (Q05D43_HUMAN)
- YB-1 protein (Q15905_HUMAN)
- YBX1 protein (Q6PKI6_HUMAN)
- Y-box-binding protein 1 (YBOX1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P67809UniProtKB/Swiss-Prot:
YBOX1_HUMAN :- In the CSD domain, Trp-65 specifically recognizes C5-methylcytosine (m5C) modification through its indole ring.
- Belongs to the YBX1 family.
- Domain:
-
- In the CSD domain, Trp-65 specifically recognizes C5-methylcytosine (m5C) modification through its indole ring.
- Family:
-
- Belongs to the YBX1 family.
Function for YBX1 Gene
Molecular function for YBX1 Gene
- UniProtKB/Swiss-Prot Function:
- DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:8188694, PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:8188694, PubMed:18809583). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673).
Phenotypes From GWAS Catalog for YBX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 18809583 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 18809583 |
| GO:0003676 | nucleic acid binding | IEA,IBA | 21873635 |
| GO:0003677 | DNA binding | TAS | 2977358 |
Phenotypes for YBX1 Gene
- MGI mutant phenotypes for YBX1:
-
inferred from 3 alleles
- nervous system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for YBX1:
-
- no effect
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- shRNA abundance <= 25%
- Increased Nanog expression
- Increased shRNA abundance (Z-score > 2)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Increased virus production
- Decreased HIV-1 infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for YBX1 - Select products 50% OFF >
- * YBX1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for YBX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for YBX1
-
Santa Cruz Biotechnology (SCBT) CRISPR for YBX1
miRNA for YBX1 Gene
- miRTarBase miRNAs that target YBX1
-
- hsa-miR-137 (MIRT007092)
- hsa-miR-124-3p (MIRT022450)
- hsa-miR-16-5p (MIRT031527)
- hsa-miR-1307-3p (MIRT035821)
- hsa-miR-1292-5p (MIRT035829)
- hsa-miR-1296-5p (MIRT036078)
- hsa-miR-935 (MIRT036695)
- hsa-miR-744-5p (MIRT037523)
- hsa-miR-615-3p (MIRT039737)
- hsa-miR-605-5p (MIRT040476)
- hsa-miR-484 (MIRT041860)
- hsa-miR-106b-5p (MIRT044272)
- hsa-miR-149-5p (MIRT045400)
- hsa-miR-34a-5p (MIRT047343)
- hsa-miR-25-3p (MIRT050297)
- hsa-miR-20a-5p (MIRT050595)
- hsa-miR-4451 (MIRT341355)
- hsa-miR-6744-5p (MIRT341357)
- hsa-miR-6832-5p (MIRT341358)
- hsa-miR-4650-3p (MIRT463786)
- hsa-miR-8069 (MIRT463787)
- hsa-miR-6831-3p (MIRT463788)
- hsa-miR-1537-3p (MIRT463789)
- hsa-miR-3529-5p (MIRT463790)
- hsa-miR-379-5p (MIRT463791)
- mmu-miR-1896 (MIRT588444)
- mmu-miR-149-5p (MIRT588445)
- mmu-miR-3064-5p (MIRT588446)
- mmu-miR-3085-3p (MIRT588447)
- mmu-miR-3087-3p (MIRT588448)
- mmu-miR-3470b (MIRT588449)
- mmu-miR-465c-5p (MIRT588450)
- mmu-miR-465b-5p (MIRT588451)
- mmu-miR-465a-5p (MIRT588452)
- mmu-miR-129-5p (MIRT588453)
- hsa-miR-382-5p (MIRT731079)
Transcription Factor Targets for YBX1 Gene
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for YBX1
- Browse OriGene Inhibitory RNA Products For YBX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YBX1
Clone Products
- Applied Biological Materials (abm): Clones for YBX1 - Select products 50% OFF >
- * YBX1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for YBX1
- Addgene plasmids for YBX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for YBX1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for YBX1 Gene
Localization for YBX1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for YBX1 Gene
- Cytoplasm. Nucleus. Cytoplasmic granule. Secreted. Secreted, extracellular exosome. Note=Predominantly cytoplasmic in proliferating cells (PubMed:12604611). Cytotoxic stress and DNA damage enhance translocation to the nucleus (PubMed:14718551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:25229427). Shuttles between nucleus and cytoplasm (PubMed:25229427). Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress (PubMed:18335541). Secreted by mesangial and monocytic cells after inflammatory challenges (PubMed:19483673). {ECO:0000269 PubMed:12604611, ECO:0000269 PubMed:14718551, ECO:0000269 PubMed:18335541, ECO:0000269 PubMed:19483673, ECO:0000269 PubMed:25229427}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| peroxisome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (4)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | TAS,IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005689 | U12-type spliceosomal complex | IDA | 15146077 |
| GO:0005737 | cytoplasm | IDA | 24965446 |
Pathways & Interactions for YBX1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.41
|
| 2 | PI3K / Akt Signaling | ||
| 3 | Translational Control | ||
| 4 | MAPK Erk Pathway |
.32
|
|
| 5 | Gene Expression |
.48
|
|
Pathways by source for YBX1 Gene
1 Sino Biological pathway for YBX1 Gene
5 Reactome pathways for YBX1 Gene
2 Cell Signaling Technology pathways for YBX1 Gene
Interacting Proteins for YBX1 Gene
Selected Interacting proteins:
P67809-YBOX1_HUMAN
ENSP00000361626
for YBX1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for YBX1
SIGNOR curated interactions for YBX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 18809583 |
| GO:0006366 | transcription by RNA polymerase II | TAS | 3174636 |
Transcripts for YBX1 Gene
mRNA/cDNA for YBX1 Gene
- 1 REFSEQ mRNAs :
- 23 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000321358 2979 nts (view in UCSC)
- ENST00000332220 776 nts (view in UCSC)
- ENST00000436427 1524 nts (view in UCSC)
- ENST00000467957 770 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for YBX1 - Select products 50% OFF >
- * YBX1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for YBX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for YBX1
-
Santa Cruz Biotechnology (SCBT) CRISPR for YBX1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for YBX1
- Browse OriGene Inhibitory RNA Products For YBX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YBX1
Clone Products
- Applied Biological Materials (abm): Clones for YBX1 - Select products 50% OFF >
- * YBX1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for YBX1
- Addgene plasmids for YBX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for YBX1
Relevant External Links for YBX1 Gene
- GeneLoc Exon Structure for
- YBX1
Expression for YBX1 Gene
This gene is overexpressed in Nasal epithelium (10.6) and Bone marrow stromal cell (8.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for YBX1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for YBX1
SOURCE GeneReport for Unigene cluster for YBX1 Gene:
Hs.473583Evidence on tissue expression from TISSUES for YBX1 Gene
- Nervous system(4.9)
- Liver(4.8)
- Eye(4.6)
- Lung(4.6)
- Skin(4.6)
- Bone marrow(4.6)
- Pancreas(4.4)
- Blood(4.3)
- Stomach(4.1)
- Intestine(3.9)
- Bone(3.8)
- Kidney(3.8)
- Muscle(3.7)
- Heart(3.7)
- Spleen(3.5)
- Lymph node(3)
- Thyroid gland(2.7)
- Adrenal gland(2.4)
Primer Products
-
OriGene qPCR primer pairs for YBX1
-
OriGene qPCR primer pairs and template standards for YBX1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YBX1 Gene
Orthologs for YBX1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | YBX1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | YBX1 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LOC607025 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | YBX1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ybx1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ybx1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | YBX1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | YBX1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ybx1 30 |
|
||
| Str.8793 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | nsep1-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ybx1 30 31 |
|
OneToOne | |
| nsep1 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8781 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | yps 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | cey-1 31 |
|
ManyToMany | |
| cey-4 31 |
|
ManyToMany | |||
| cey-2 31 |
|
ManyToMany | |||
| cey-3 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10127 31 |
|
OneToMany |
- Species where no ortholog for YBX1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for YBX1 Gene
- ENSEMBL:
- Gene Tree for YBX1 (if available)
- TreeFam:
- Gene Tree for YBX1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for YBX1: view image
Paralogs for YBX1 Gene
(3) SIMAP similar genes for YBX1 Gene using alignment to 6 proteins:
- YBOX1_HUMAN
- A0JLU4_HUMAN
- C9J5V9_HUMAN
- H0Y449_HUMAN
- Q05D43_HUMAN
- Q6PKI6_HUMAN
Pseudogenes.org Pseudogenes for YBX1 Gene
Variants for YBX1 Gene
Residual Variation Intolerance Score:
36.1% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for YBX1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- YBX1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for YBX1 Gene
Disorders for YBX1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spinal chordoma |
|
|
| liposarcoma |
|
|
| rett syndrome |
|
|
| myxoid liposarcoma |
|
|
| ovarian cancer |
|
Search YBX1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for YBX1
No data available for UniProtKB/Swiss-Prot and Genatlas for YBX1 Gene
Publications for YBX1 Gene
- Y-box protein-1 is actively secreted through a non-classical pathway and acts as an extracellular mitogen. (PMID: 19483673) Frye BC … Mertens PR (EMBO reports 2009) 3 4 23
- Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. (PMID: 15806160) Sutherland BW … Dunn SE (Oncogene 2005) 3 4 23
- The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. (PMID: 15136035) Kojic S … Faulkner G (Journal of molecular biology 2004) 3 4 23
- YB-1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds several DNA repair proteins. (PMID: 14718551) Gaudreault I … Lebel M (Nucleic acids research 2004) 3 4 23
- Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection. (PMID: 12604611) Raffetseder U … Mertens PR (The Journal of biological chemistry 2003) 3 4 23
ExternalLinks
Products for YBX1 Gene
- Custom Antibody ServicesOriGene Antibodies for YBX1
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Browse OriGene Inhibitory RNA Products For YBX1
- OriGene qPCR primer pairs for YBX1
- OriGene qPCR primer pairs and template standards for YBX1
- OriGene CRISPR knockouts for YBX1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Novus Biologicals proteins and lysates for YBX1
- Browse Antibodies
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- VectorBuilder Stable cell line generation for YBX1
- Addgene plasmids for YBX1
- antibodies-online: Show 41 available YBX1 Antibodies ranked by validation data
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- 124 WB Antibodies (anti-human)
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- 2 IHC Antibodies (anti-rat)
- 57 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
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- antibodies-online: Show 7 available YBX1 Elisa Kits ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for YBX1
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for YBX1
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- Boster Bio Antibodies for YBX1
- Browse Boster Bio ELISA Kits
Sources for YBX1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
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- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
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- (109) Disease Ontology
- (110) Genetics Home Reference
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- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
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- (159) GeneImprint
- (160) Synthego
- (161) ENA
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- (163) LncBase
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- (172) GENCODE
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- (175) Open Targets Platform
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- (177) snoDB
- (178) MirGeneDB