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This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of m... See more...
Aliases for YBX1 Gene
Aliases for YBX1 Gene
External Ids for YBX1 Gene
- HGNC: 8014
- Entrez Gene: 4904
- Ensembl: ENSG00000065978
- OMIM: 154030
- UniProtKB: P67809
Previous HGNC Symbols for YBX1 Gene
- NSEP1
Previous GeneCards Identifiers for YBX1 Gene
- GC01P042818
- GC01P042920
- GC01P043148
- GC01P041268
Summaries for YBX1 Gene
-
This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]
GeneCards Summary for YBX1 Gene
YBX1 (Y-Box Binding Protein 1) is a Protein Coding gene. Diseases associated with YBX1 include Spinal Chordoma and Liposarcoma. Among its related pathways are Gene Expression and Signaling events mediated by PTP1B. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is YBX3.
UniProtKB/Swiss-Prot Summary for YBX1 Gene
-
DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:8188694, PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:8188694, PubMed:18809583). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673).
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for YBX1 Gene
Genomics for YBX1 Gene
GeneHancer (GH) Regulatory Elements for YBX1 Gene
Promoters and enhancers for YBX1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around YBX1 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for YBX1
- Top Transcription factor binding sites by QIAGEN in the YBX1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- CBF(2)
- FAC1
- LCR-F1
- Max1
- NF-1
- NF-Y
- YY1
Genomic Locations for YBX1 Gene
Genomic Locations for YBX1 Gene
- chr1:42,682,389-42,703,805
- (GRCh38/hg38)
- Size:
- 21,417 bases
- Orientation:
- Plus strand
- chr1:43,148,066-43,168,020
- (GRCh37/hg19)
- Size:
- 19,955 bases
- Orientation:
- Plus strand
Genomic View for YBX1 Gene
Genes around YBX1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.2 by HGNC
- 1p34.2 by Entrez Gene
- 1p34.2 by Ensembl
YBX1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for YBX1 Gene
Proteins for YBX1 Gene
-
Protein details for YBX1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P67809-YBOX1_HUMAN
- Recommended name:
- Y-box-binding protein 1
- Protein Accession:
- P67809
- P16990
- P16991
- Q14972
- Q15325
- Q5FVF0
Protein attributes for YBX1 Gene
- Size:
- 324 amino acids
- Molecular mass:
- 35924 Da
- Quaternary structure:
-
- Homodimer in the presence of ATP (PubMed:10817758, PubMed:11851341). Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1 (PubMed:19029303). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (PubMed:15146077). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Interacts with IGF2BP1 and RBBP6 (PubMed:17289661, PubMed:18851979). Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs) (PubMed:19029303). Interacts with AKT1, MBNL1, SFRS9, SFRS12, ALYREF/THOC4, MSH2, XRCC5, WRN and NCL (PubMed:12604611, PubMed:14559993, PubMed:14718551, PubMed:15806160, PubMed:18335541). Interacts (via C-terminus) with APEX1 (via N-terminus); the interaction is increased with APEX1 acetylated at 'Lys-6' and 'Lys-7' (PubMed:18809583). Interacts with AGO1 and AGO2 (PubMed:17932509). Interacts with ANKRD2 (PubMed:15136035). Interacts with DERA (PubMed:25229427). Interacts with FMR1; this interaction occurs in association with polyribosome (By similarity). Interacts with ZBTB7B (By similarity). Interacts with HDGF (isoform 1) (PubMed:26845719). Interacts with ELAVL1; leading to ELAVL1 recruitment on C5-methylcytosine (m5C)-containing mRNAs and subsequent mRNA stability (PubMed:31358969).
- SequenceCaution:
-
- Sequence=AAA35750.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAA59949.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAA61308.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for YBX1 Gene
Post-translational modifications for YBX1 Gene
- Ubiquitinated by RBBP6; leading to a decrease of YBX1 transcactivational ability.
- In the absence of phosphorylation the protein is retained in the cytoplasm.
- Cleaved by a 20S proteasomal protease in response to agents that damage DNA. Cleavage takes place in the absence of ubiquitination and ATP. The resulting N-terminal fragment accumulates in the nucleus (By similarity).
-
Ubiquitination at Lys137, Lys170, and Lys264
- NX_P67809 (NX_P67809-1)
- Modification sites at PhosphoSitePlus
Other Protein References for YBX1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ YB1 Antibody
- NSJ Bioreagents YB1 Antibody
- Creative Diagnostics Anti-YBX1 (aa 51-139) polyclonal antibody
- Novus Biologicals Antibodies for YBX1
-
Abcam antibodies for YBX1
- Invitrogen Antibodies for YBX1 (AFLGC-YBX1)
- antibodies-online: Show 41 available YBX1 Antibodies ranked by validation data
- Compare Top YBX1 Antibodies
-
Recommended
- 124 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 51 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 57 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for YBX1
- Sino Biological Antibodies for YBX1
Protein Products
- Creative Biomart Recombinant Human YBX1, His-tagged
- Search Origene for MassSpec and Protein Over-expression Lysates for YBX1
- Origene Custom Protein Services for YBX1
- ProSpec Recombinant Proteins for YBX1
-
Abcam proteins for YBX1
Assay Products
- Aviva Systems Biology YBX1 ELISA Kit (Human) (OKDD00598) and YBX1 ELISA Kit (Human) (OKCD08204)
- antibodies-online: Show 7 available YBX1 Elisa Kits ranked by validation data
- Compare Top YBX1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for YBX1 Gene
Domains & Families for YBX1 Gene
Gene Families for YBX1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for YBX1 Gene
- Blocks:
-
- Cold-shock DNA-binding domain
- Cold shock protein
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for YBX1 Gene
- GenScript: Design optimal peptide antigens:
-
- YBX1 protein (A0JLU4_HUMAN)
- YBX1 protein (Q05D43_HUMAN)
- YB-1 protein (Q15905_HUMAN)
- YBX1 protein (Q6PKI6_HUMAN)
- Y-box-binding protein 1 (YBOX1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P67809UniProtKB/Swiss-Prot:
YBOX1_HUMAN :- In the CSD domain, Trp-65 specifically recognizes C5-methylcytosine (m5C) modification through its indole ring.
- Belongs to the YBX1 family.
- Domain:
-
- In the CSD domain, Trp-65 specifically recognizes C5-methylcytosine (m5C) modification through its indole ring.
- Family:
-
- Belongs to the YBX1 family.
Function for YBX1 Gene
Molecular function for YBX1 Gene
- UniProtKB/Swiss-Prot Function:
- DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:8188694, PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:8188694, PubMed:18809583). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673).
Phenotypes From GWAS Catalog for YBX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 18809583 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 18809583 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | TAS | 2977358 |
Phenotypes for YBX1 Gene
- MGI mutant phenotypes for YBX1:
-
inferred from 3 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- integument phenotype
- mortality/aging
- cellular phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for YBX1:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased virus production
- Decreased HIV-1 infection
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased Nanog expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- shRNA abundance <= 50%
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for YBX1 - Select products 50% OFF >
- * YBX1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for YBX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for YBX1
- genomics-online: gRNA clones - Search results for available YBX1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for YBX1
miRNA for YBX1 Gene
- miRTarBase miRNAs that target YBX1
-
- hsa-mir-137 (MIRT007092)
- hsa-mir-124-3p (MIRT022450)
- hsa-mir-16-5p (MIRT031527)
- hsa-mir-1307-3p (MIRT035821)
- hsa-mir-1292-5p (MIRT035829)
- hsa-mir-1296-5p (MIRT036078)
- hsa-mir-935 (MIRT036695)
- hsa-mir-744-5p (MIRT037523)
- hsa-mir-615-3p (MIRT039737)
- hsa-mir-605-5p (MIRT040476)
- hsa-mir-484 (MIRT041860)
- hsa-mir-106b-5p (MIRT044272)
- hsa-mir-149-5p (MIRT045400)
- hsa-mir-34a-5p (MIRT047343)
- hsa-mir-25-3p (MIRT050297)
- hsa-mir-20a-5p (MIRT050595)
- hsa-mir-4451 (MIRT341355)
- hsa-mir-6744-5p (MIRT341357)
- hsa-mir-6832-5p (MIRT341358)
- hsa-mir-4650-3p (MIRT463786)
- hsa-mir-8069 (MIRT463787)
- hsa-mir-6831-3p (MIRT463788)
- hsa-mir-1537-3p (MIRT463789)
- hsa-mir-3529-5p (MIRT463790)
- hsa-mir-379-5p (MIRT463791)
- hsa-mir-382-5p (MIRT731079)
Transcription Factor Targets for YBX1 Gene
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for YBX1
- Browse OriGene Inhibitory RNA Products For YBX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YBX1
- genomics-online: shRNA clones - Search results for available YBX1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for YBX1 - Select products 50% OFF >
- * YBX1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for YBX1
- Addgene plasmids for YBX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for YBX1
- genomics-online: cdna clones - Search results for available YBX1 gene related products
- orf clones - Search results for available YBX1 gene related products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for YBX1 Gene
Localization for YBX1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for YBX1 Gene
- Cytoplasm. Nucleus. Cytoplasmic granule. Secreted. Secreted, extracellular exosome. Note=Predominantly cytoplasmic in proliferating cells (PubMed:12604611). Cytotoxic stress and DNA damage enhance translocation to the nucleus (PubMed:14718551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:25229427). Shuttles between nucleus and cytoplasm (PubMed:25229427). Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress (PubMed:18335541). Secreted by mesangial and monocytic cells after inflammatory challenges (PubMed:19483673). {ECO:0000269 PubMed:12604611, ECO:0000269 PubMed:14718551, ECO:0000269 PubMed:18335541, ECO:0000269 PubMed:19483673, ECO:0000269 PubMed:25229427}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (4)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | TAS | 3174636 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005689 | U12-type spliceosomal complex | IDA | 15146077 |
| GO:0005737 | cytoplasm | IDA | 24965446 |
Pathways & Interactions for YBX1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.41
|
| 2 | PI3K / Akt Signaling | ||
| 3 | Translational Control | ||
| 4 | MAPK-Erk Pathway |
.38
|
|
| 5 | Gene Expression |
.48
|
|
Pathways by source for YBX1 Gene
1 Sino Biological pathway for YBX1 Gene
5 Reactome pathways for YBX1 Gene
2 Cell Signaling Technology pathways for YBX1 Gene
Interacting Proteins for YBX1 Gene
Selected Interacting proteins:
P67809-YBOX1_HUMAN
ENSP00000361626
for YBX1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for YBX1
SIGNOR curated interactions for YBX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 18809583 |
| GO:0006366 | transcription by RNA polymerase II | TAS | 3174636 |
Drugs & Compounds for YBX1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Creative Biomart Recombinant Human YBX1, His-tagged
Transcripts for YBX1 Gene
mRNA/cDNA for YBX1 Gene
- 1 REFSEQ mRNAs :
- 23 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000321358 2979 bps (ENST00000321358.12)
- ENST00000332220 776 bps (ENST00000332220.10)
- ENST00000436427 1524 bps (ENST00000436427.1)
- ENST00000467957 770 bps (ENST00000467957.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for YBX1 - Select products 50% OFF >
- * YBX1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for YBX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for YBX1
- genomics-online: gRNA clones - Search results for available YBX1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for YBX1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for YBX1
- Browse OriGene Inhibitory RNA Products For YBX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YBX1
- genomics-online: shRNA clones - Search results for available YBX1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for YBX1 - Select products 50% OFF >
- * YBX1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for YBX1
- Addgene plasmids for YBX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for YBX1
- genomics-online: cdna clones - Search results for available YBX1 gene related products
- orf clones - Search results for available YBX1 gene related products
Relevant External Links for YBX1 Gene
- GeneLoc Exon Structure for
- YBX1
Expression for YBX1 Gene
This gene is overexpressed in Nasal epithelium (10.6) and Bone marrow stromal cell (8.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for YBX1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for YBX1
SOURCE GeneReport for Unigene cluster for YBX1 Gene:
Hs.473583Evidence on tissue expression from TISSUES for YBX1 Gene
- Liver(4.8)
- Nervous system(4.8)
- Bone marrow(4.5)
- Eye(4.5)
- Lung(4.5)
- Skin(4.4)
- Blood(4.1)
- Pancreas(4.1)
- Stomach(3.8)
- Intestine(3.6)
- Kidney(3.5)
- Bone(3.4)
- Muscle(3.4)
- Heart(3.3)
- Spleen(3.2)
- Lymph node(2.6)
Primer Products
-
OriGene qPCR primer pairs for YBX1
-
OriGene qPCR primer pairs and template standards for YBX1
- genomics-online: primer clones - Search results for available YBX1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YBX1 Gene
Orthologs for YBX1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | YBX1 31 30 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | YBX1 31 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LOC607025 30 |
|
||
| -- 31 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | YBX1 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ybx1 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Ybx1 17 31 30 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | YBX1 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | YBX1 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ybx1 30 |
|
||
| Str.8793 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | nsep1-prov 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ybx1 31 30 |
|
OneToOne | |
| nsep1 30 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8781 30 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | yps 31 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | cey-1 31 |
|
ManyToMany | |
| cey-4 31 |
|
ManyToMany | |||
| cey-2 31 |
|
ManyToMany | |||
| cey-3 31 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10127 31 |
|
OneToMany |
- Species where no ortholog for YBX1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for YBX1 Gene
- ENSEMBL:
- Gene Tree for YBX1 (if available)
- TreeFam:
- Gene Tree for YBX1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for YBX1: view image
Paralogs for YBX1 Gene
(3) SIMAP similar genes for YBX1 Gene using alignment to 6 proteins:
- YBOX1_HUMAN
- A0JLU4_HUMAN
- C9J5V9_HUMAN
- H0Y449_HUMAN
- Q05D43_HUMAN
- Q6PKI6_HUMAN
Pseudogenes.org Pseudogenes for YBX1 Gene
Variants for YBX1 Gene
Residual Variation Intolerance Score:
36.1% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for YBX1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- YBX1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for YBX1 Gene
Disorders for YBX1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spinal chordoma |
|
|
| liposarcoma |
|
|
| myxoid liposarcoma |
|
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| rett syndrome |
|
|
| ovarian cancer |
|
Search YBX1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for YBX1
No data available for UniProtKB/Swiss-Prot and Genatlas for YBX1 Gene
Publications for YBX1 Gene
- Y-box protein-1 is actively secreted through a non-classical pathway and acts as an extracellular mitogen. (PMID: 19483673) Frye BC … Mertens PR (EMBO reports 2009) 3 4 23 54
- Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. (PMID: 15806160) Sutherland BW … Dunn SE (Oncogene 2005) 3 4 23 54
- YB-1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds several DNA repair proteins. (PMID: 14718551) Gaudreault I … Lebel M (Nucleic acids research 2004) 3 4 23 54
- Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection. (PMID: 12604611) Raffetseder U … Mertens PR (The Journal of biological chemistry 2003) 3 4 23 54
- A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes. (PMID: 8188694) Horwitz EM … Ley TJ (The Journal of biological chemistry 1994) 3 4 23 54
ExternalLinks
Products for YBX1 Gene
- Custom Antibody ServicesOriGene Antibodies for YBX1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for YBX1
- Origene Custom Protein Services for YBX1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for YBX1
- Browse OriGene Inhibitory RNA Products For YBX1
- OriGene qPCR primer pairs for YBX1
- OriGene qPCR primer pairs and template standards for YBX1
- OriGene CRISPR knockouts for YBX1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For YBX1
- Sino Biological Human cDNA Clone for YBX1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for YBX1
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for YBX1
- Novus Biologicals proteins and lysates for YBX1
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for YBX1
- Abcam proteins for YBX1
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for YBX1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for YBX1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for YBX1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for YBX1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for YBX1
- Addgene plasmids for YBX1
- antibodies-online: Show 41 available YBX1 Antibodies ranked by validation data
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- Recommended
- 124 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 51 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 57 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- antibodies-online: Show 7 available YBX1 Elisa Kits ranked by validation data
- Compare Top YBX1 Elisa Kits
- Quality Products:
- antibodies-online: Show 13 available YBX1 Proteins ranked by validation data
- Compare Top YBX1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for YBX1
- Search Santa Cruz Biotechnology (SCBT) for YBX1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for YBX1
- genomics-online: cdna clones - Search results for available YBX1 gene related products
- orf clones - Search results for available YBX1 gene related products
- genomics-online: gRNA clones - Search results for available YBX1 gene related products
- genomics-online: primer clones - Search results for available YBX1 gene related products
- genomics-online: shRNA clones - Search results for available YBX1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for YBX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for YBX1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for YBX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YBX1
Sources for YBX1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody