Aliases for YARS2 Gene
External Ids for YARS2 Gene
Previous GeneCards Identifiers for YARS2 Gene
This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011]
GeneCards Summary for YARS2 Gene
YARS2 (Tyrosyl-TRNA Synthetase 2) is a Protein Coding gene. Diseases associated with YARS2 include Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2 and Myopathy, Lactic Acidosis, And Sideroblastic Anemia 1. Among its related pathways are tRNA Aminoacylation and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleotide binding.
UniProtKB/Swiss-Prot Summary for YARS2 Gene
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).