Aliases for YARS1 Gene
External Ids for YARS1 Gene
Previous HGNC Symbols for YARS1 Gene
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]
GeneCards Summary for YARS1 Gene
YARS1 (Tyrosyl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with YARS1 include Charcot-Marie-Tooth Disease, Dominant Intermediate C and Charcot-Marie-Tooth Disease. Among its related pathways are tRNA Aminoacylation and Tyrosine metabolism.
UniProtKB/Swiss-Prot Summary for YARS1 Gene
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).